An outbreak of extremely drug-resistant Pseudomonas aeruginosa in a tertiary care pediatric hospital in Italy

BMC Infectious Diseases

Volumn 14, Issue 1, 2014, Pages 1-8

  Ciofi Degli Atti, Marta ^a   Bernaschi, Paola ^a   Carletti, Michaela ^a   Luzzi, Ida ^b   García Fernández, Aurora ^b   Bertaina, Alice ^a   Sisto, Annamaria ^a   Locatelli, Franco ^a   Raponi, Massimiliano ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Children; Extensively drug resistance; Healthcare associated infections; Pseudomonas aeruginosa

Indexed keywords

AMIKACIN; ANTIINFECTIVE AGENT; BETA LACTAMASE INHIBITOR; CARBAPENEM DERIVATIVE; CARBAPENEMASE; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; COLISTIN; GENTAMICIN; MEROPENEM; METALLO BETA LACTAMASE; PENICILLIN DERIVATIVE; PHARMACOLOGY; PIPERACILLIN PLUS TAZOBACTAM; TOBRAMYCIN;

ACUTE LEUKEMIA; ADOLESCENT; ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTEREMIA; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; BACTERIUM CARRIER; BACTERIUM ISOLATE; BLOODSTREAM INFECTION; CARBAPENEMASE GENE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS INFECTION; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFECTS; DRUG THERAPY; ENVIRONMENTAL FACTOR; ENZYME SYNTHESIS; EPIDEMIC; EPIDEMIOLOGY; EXTENSIVELY DRUG RESISTANT PSEUDOMONAS AERUGINOSA; FEMALE; GENE CLUSTER; GENETICS; GENOTYPE; HEALTHCARE ASSOCIATED INFECTION; HIGH RISK POPULATION; HOSPITAL; HUMAN; INFANT; INFECTION; INFECTION CONTROL; ISOLATION AND PURIFICATION; ITALY; LYMPHOMA; MALE; MICROBIOLOGY; MORTALITY; MULTIPLEX POLYMERASE CHAIN REACTION; NEUTROPENIA; NONHUMAN; PEDIATRIC HOSPITAL; PHENOTYPE; PHYSIOLOGY; PRESCHOOL CHILD; PROTECTION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; PSEUDOMONAS INFECTIONS; PULSED FIELD GEL ELECTROPHORESIS; STATISTICS AND NUMERICAL DATA; TERTIARY CARE CENTER; TERTIARY HEALTH CARE; VULNERABLE POPULATION; YOUNG ADULT;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; CARBAPENEMS; CHILD; CHILD, PRESCHOOL; CROSS INFECTION; DISEASE OUTBREAKS; DRUG EFFECTS; DRUG RESISTANCE, BACTERIAL; DRUG THERAPY; ELECTROPHORESIS, GEL, PULSED-FIELD; EPIDEMIOLOGY; FEMALE; GENETICS; HOSPITALS, PEDIATRIC; HUMANS; INFANT; ISOLATION AND PURIFICATION; ITALY; MALE; MICROBIOLOGY; PHARMACOLOGY; PHYSIOLOGY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; STATISTICS AND NUMERICAL DATA; TERTIARY HEALTHCARE; YOUNG ADULT;

EID: 84907292321     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-14-494     Document Type: Article

References (32)

1. Caselli D, Cesaro S, Ziino O, Zanazzo G, Manicone R, Livadiotti S, Cellini M, Frenos S, Milano GM, Cappelli B, Licciardello M, Beretta C, Aricò M, Castagnola E, . Infection Study Group of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) Multidrug resistant Pseudomonas Aeruginosa infection in children undergoing chemotherapy and hematopoietic stem cell transplantation. Haematologica 2010, 95:1612-1615. 10.3324/haematol.2009.020867, 2930967, 20305140, Infection Study Group of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP).
2. Yang MA, Lee J, Choi EH, Lee HJ. Pseudomonas aeruginosa bacteremia in children over ten consecutive years: analysis of clinical characteristics, risk factors of multi-drug resistance and clinical outcomes. J Korean Med Sci 2011, 26:612-618. 10.3346/jkms.2011.26.5.612, 3082111, 21532850.
3. Bertrand X, Thouverez M, Talon D, Boillot A, Capellier G, Floriot C, Hélias JP. Endemicity, molecular diversity and colonisation routes of Pseudomonas aeruginosa in intensive care units. Intensive Care Med 2001, 27:1263-1268. 10.1007/s001340100979, 11511937.
4. DiazGranados CA, Jones MY, Kongphet-Tran T, White N, Shapiro M, Wang YF, Ray SM, Blumberg HM. Outbreak of Pseudomonas aeruginosa infection associated with contamination of a flexible bronchoscope. Infect Control Hosp Epidemiol 2009, 30:550-555. 10.1086/597235, 19379099.
5. Kerr KG, Snelling AM. Pseudomonas aeruginosa: a formidable and ever-present adversary. J Hosp Infect 2009, 73:338-344. 10.1016/j.jhin.2009.04.020, 19699552.
6. Lanini S, D'Arezzo S, Puro V, Martini L, Imperi F, Piselli P, Montanaro M, Paoletti S, Visca P, Ippolito G. Molecular epidemiology of a Pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser. PLoS One 2011, 6:e17064. 10.1371/journal.pone.0017064, 3040201, 21359222.
7. Buttery JP, Alabaster SJ, Heine RG, Scott SM, Crutchfield RA, Bigham A, Tabrizi SN, Garland SM. Multiresistant Pseudomonas aeruginosa outbreak in a pediatric oncology ward related to bath toys. Pediatr Infect Dis J 1998, 17:509-513. 10.1097/00006454-199806000-00015, 9655544.
8. Micol JB, de Botton S, Guieze R, Coiteux V, Darre S, Dessein R, Leroy O, Yakoub-Agha I, Quesnel B, Bauters F, Beaucaire G, Alfandari S. An 18-case outbreak of drug-resistant Pseudomonas aeruginosa bacteriemia in hematology patients. Haematologica 2006, 91:1134-1138.
9. Deplano A, Rodriguez-Villalobos H, Glupczynski Y, Bogaerts P, Allemeersch D, Grimmelprez A, Mascart G, Bergès L, Byl B, Laurent C, Struelens MJ. Emergence and dissemination of multidrug resistant clones of Pseudomonas aeruginosa producing VIM-2 metallo-beta-lactamase in Belgium. Euro Surveill 2007, 12:e070118.2.
10. Kohlenberg A, Weitzel-Kage D, van der Linden P, Sohr D, Vögeler S, Kola A, Halle E, Rüden H, Weist K. Outbreak of carbapenem-resistant Pseudomonas aeruginosa infection in a surgical intensive care unit. J Hosp Infect 2010, 74:350-357. 10.1016/j.jhin.2009.10.024, 20170982.
11. Jefferies JMC, Cooper T, Yam T, Clarke SC. Pseudomonas aeruginosa outbreaks in the neonatal intensive care unit - a systematic review of risk factors and environmental sources. J Med Microbiol 2012, 61:1052-1061. 10.1099/jmm.0.044818-0, 22683659.
12. Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, Paterson DL, Rice LB, Stelling J, Struelens MJ, Vatopoulos A, Weber JT, Monnet DL. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 2012, 18:268-281. 10.1111/j.1469-0691.2011.03570.x, 21793988.
13. Deplano A, Denis O, Poirel L, Hocquet D, Nonhoff C, Byl B, Nordmann P, Vincent JL, Struelens MJ. Molecular characterization of an epidemic clone of panantibiotic-resistant Pseudomonas aeruginosa. J Clin Microbiol 2005, 43:1198-1204. 10.1128/JCM.43.3.1198-1204.2005, 1081292, 15750083.
14. Yakupogullari Y, Otlu B, Dogukan M, Gursoy C, Korkmaz E, Kizirgil A, Ozden M, Durmaz R. Investigation of a nosocomial outbreak by alginate-producing pan-antibiotic resistant Pseudomonas aeruginosa. Am J Infect Control 2008, 36:e13-e18.
15. Ciofi degli Atti ML, Cuttini M, Ravà L, Ceradini J, Paolini V, Ciliento G, Pomponi M, Raponi M. Trend of healthcare-associated infections in children: annual prevalence surveys in a research hospital in Italy, 2007-2010. J Hosp Infect 2012, 80:6-12. 10.1016/j.jhin.2011.11.004, 22133896.
16. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008, 36:309-332. 10.1016/j.ajic.2008.03.002, 18538699.
17. The European Committee on Antimicrobial Susceptibility Testing. Breakpoint Tables for Interpretation of MICs and Zone Diameters. Version 4.0 2014, [http://www.eucast.org].
18. Tsakris A, Poulou A, Pournaras S, Voulgari E, Vrioni G, Themeli-Digalaki K, Petropoulou D, Sofianou D. A simple phenotypic method for the differentiation of metallo-b-lactamases and class A KPC carbapenemases in Enterobacteriaceae clinical isolates. J Antimicrob Chemother 2010, 65:1664-1671. 10.1093/jac/dkq210, 20542902.
19. Poirel L, Walsh TR, Cuvillier V, Nordmann P. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis 2011, 70:119-123. 10.1016/j.diagmicrobio.2010.12.002, 21398074.
20. Ribot EM, Fair MA, Gautom R, Cameron DN, Hunter SB, Swaminathan B, Barrett TJ. Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet. Foodborne Pathog Dis 2006, 3:59-67. 10.1089/fpd.2006.3.59, 16602980.
21. Römling U, Tümmler B. Achieving 100% typeability of Pseudomonas aeruginosa by pulsed-field gel electrophoresis. J Clin Microbiol 2000, 38:464-465. 88754, 10618146.
22. Hunter SB, Vauterin P, Lambert-Fair MA, Van Duyne MS, Kubota K, Graves L, Wrigley D, Barrett T, Ribot E. Establishment of a universal size standard strain for use with the PulseNet standardized pulsed-field gel electrophoresis protocols: converting the national databases to the new size standard. J Clin Microbiol 2005, 43:1045-1050. 10.1128/JCM.43.3.1045-1050.2005, 1081233, 15750058.
23. van Belkum A, Tassios PT, Dijkshoorn L, Haeggman S, Cookson B, Fry NK, Fussing V, Green J, Feil E, Gerner-Smidt P, Brisse S, Struelens M, . European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group on Epidemiological Markers (ESGEM) Guidelines for the validation and application of typing methods for use in bacterial epidemiology. Clin Microbiol Infect 2007, 13(suppl 3):1-46. European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group on Epidemiological Markers (ESGEM).
24. Peña C, Gómez-Zorrilla S, Suarez C, Dominguez MA, Tubau F, Arch O, Oliver A, Pujol M, Ariza J. Extensively drug-resistant Pseudomonas aeruginosa: risk of bloodstream infection in hospitalized patients. Eur J Clin Microbiol Infect Dis 2012, 31:2791-2797. 10.1007/s10096-012-1629-3, 22552893.
25. Papp-Wallace KM, Endimiani A, Taracila MA, Bonomo RA. Carbapenems: past, present, and future. Antimicrob Agents Chemother 2011, 55(11):4943-4960. 10.1128/AAC.00296-11, 3195018, 21859938.
26. Lauretti L, Riccio ML, Mazzariol A, Cornaglia G, Amicosante G, Fontana R, Rossolini GM. Cloning and characterization of blaVIM, a new integron-borne metallo-lactamase gene from a Pseudomonas aeruginosa clinical isolate. Antimicrob Agents Chemother 1999, 43:1584-1590. 89328, 10390207.
27. Rossolini GM, Luzzaro F, Migliavacca R, Mugnaioli C, Pini B, De Luca F, Perilli M, Pollini S, Spalla M, Amicosante G, Toniolo A, Pagani L. First countrywide survey of acquired metallo-β-lactamases in gram-negative pathogens in Italy. Antimicrob Agents Chemother 2008, 52:4023-4029. 10.1128/AAC.00707-08, 2573113, 18809945.
28. Cornaglia G, Giamarellou H, Rossolini GM. Metallo-β-lactamases: a last frontier for β-lactams?. Lancet Infect Dis 2011, 11:381-393. 10.1016/S1473-3099(11)70056-1, 21530894.
29. Aloush V, Navon-Venezia S, Seigman-Igra Y, Cabili S, Carmeli Y. Multidrug-resistant pseudomonas aeruginosa: risk factors and clinical impact. Antimicrob Agents Chemother 2006, 50:43-48. 10.1128/AAC.50.1.43-48.2006, 1346794, 16377665.
30. Suarez C, Peña C, Arch O, Dominguez MA, Tubau F, Juan C, Gavaldá L, Sora M, Oliver A, Pujol M, Ariza J. A large sustained endemic outbreak of multiresistant pseudomonas aeruginosa: a new epidemiological scenario for nosocomial acquisition. BMC Infect Dis 2011, 11:272. 10.1186/1471-2334-11-272, 3203071, 21995287.
31. European Centre for Disease Prevention and Control Risk Assessment on the Spread of Carbapenemase-Producing Enterobacteriaceae (CPE) Through Patient Transfer Between Healthcare Facilities, With Special Emphasis on Cross-Border Transfer 2011, Stockholm: ECDC, European Centre for Disease Prevention and Control.
32. European Centre for Disease Prevention and Control Antimicrobial Resistance Surveillance in Europe 2012. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net) 2013, Stockholm: ECDC, European Centre for Disease Prevention and Control.