A large sustained endemic outbreak of multiresistant Pseudomonas aeruginosa: A new epidemiological scenario for nosocomial acquisition

BMC Infectious Diseases

Volumn 11, Issue , 2011, Pages

  Suarez, Cristina ^a   Peña, Carmen ^a   Arch, Olga ^a   Dominguez, M Angeles ^a   Tubau, Fe ^a   Juan, Carlos ^b   Gavaldá, Laura ^a   Sora, Mercedes ^a   Oliver, Antonio ^b   Pujol, Miquel ^a   Ariza, Javier ^a  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZTREONAM; BETA LACTAM ANTIBIOTIC; CARBAPENEM DERIVATIVE; CEFEPIME; CEFTAZIDIME; CIPROFLOXACIN; GENTAMICIN; IMIPENEM; MEROPENEM; PENICILLIN DERIVATIVE; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TICARCILLIN; TOBRAMYCIN; ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; BACTERIUM CARRIER; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CLEANING; CLINICAL PROTOCOL; DISEASE SURVEILLANCE; DISINFECTION; ENDEMIC DISEASE; FEMALE; HOSPITAL INFECTION; HUMAN; INCIDENCE; INFECTION CONTROL; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; MULTIRESISTANT PSEUDOMONAS AERUGINOSA; MULTIRESISTANT PSEUDOMONAS AERUGINOSA INFECTION; NONHUMAN; PROSPECTIVE STUDY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; UROLOGY; AGED; CLASSIFICATION; CLUSTER ANALYSIS; CROSS INFECTION; DRUG EFFECT; EPIDEMIC; GENETICS; GENOTYPE; HETEROZYGOTE; ISOLATION AND PURIFICATION; METHODOLOGY; MICROBIOLOGY; MIDDLE AGED; MOLECULAR TYPING; MULTIDRUG RESISTANCE;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CARBAPENEMS; CARRIER STATE; CLUSTER ANALYSIS; CROSS INFECTION; DISEASE OUTBREAKS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENDEMIC DISEASES; FEMALE; GENOTYPE; HUMANS; INCIDENCE; INFECTION CONTROL; MALE; MIDDLE AGED; MOLECULAR TYPING; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 80053892799     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-11-272     Document Type: Article

References (37)

1. Gruner E, Kropel A, Huebner J, Altwegg M, Pashner F. Ribotyping of Pseudomonas aeruginosa strains isolated from surgical intensive care patient. J Infect Dis 1993, 167:1216-1220. 10.1093/infdis/167.5.1216, 8098054.
2. Talon D, Capellier G, Boillot A, Michel-Briand Y. Use of pulsed-field gel electrophoresis as an epidemiological tool during an outbreak of Pseudomonas aeruginosa lung infections in an intensive care unit. Intensive Care Med 1995, 21:996-1002. 10.1007/BF01700661, 8750124.
3. Bonten M, Bergmans D, Speijer H, Stobberingh E. Characteristics of polyclonal endemicity of Pseudomonas aeruginosa colonization in Intensive Care Units. Am J Respir Crit Care Med 1999, 160:1212-1219.
4. Srinivasan A, Wolfenden LL, Song X, Mackie K, Hartsell TL, Jones HD, Diette GB, Orens JB, Yung RC, Ross TL, et al. An outbreak of Pseudomonas aeruginosa infections associated with flexible bronchoscopes. N Engl J Med 2003, 348:221-227. 10.1056/NEJMoa021808, 12529462.
5. Peña C, Dominguez MA, Pujol M, Verdaguer R, Gudiol F, Ariza J. An outbreak of carbapenem-resistant Pseudomonas aeruginosa in a urology ward. Clin Microbiol Infect 2003, 9:938-943. 10.1046/j.1469-0691.2003.00686.x, 14616682.
6. Gillespie JL, Arnold KE, Noble-Wang J, Jensen B, Arduino M, Hageman J, Srinivasan A. Outbreak of Pseudomonas aeruginosa infection after transrectal ultrasound-guided prostate biopsy. Urology 2007, 69:912-914. 10.1016/j.urology.2007.01.047, 17482933.
7. Eckmanns T, Oppert M, Martin M, Amorosa R, Zuschneid J, Frei U, Ruden H, Weist K. An outbreak of hospital-acquired Pseudomonas aeruginosa infection caused by contaminated bottles water in intensive care units. Clin Microbiol Infect 2008, 14:454-458. 10.1111/j.1469-0691.2008.01949.x, 18294245.
8. Sanchez-Carrillo C, Padilla B, Marín M, Rivera M, Cercenado E, Vigil D, Sanchez-Luna M, Bouza E. Contaminated feeding bottles: the source of an outbreak of Pseudomonas aeruginosa infections in a neonatal intensive care unit. Am J Infect Control 2009, 37:150-154. 10.1016/j.ajic.2008.04.259, 19059675.
9. Panzig B, Schroder G, Pitten FA, Grundling M. A large outbreak of multiresistant Pseudomonas aeruginosa strains in north-eastern Germany. J Antimicrob Chemother 1999, 43:415-418. 10.1093/jac/43.3.415, 10223600.
10. Bertrand X, Bailly P, Blasco G, Balvay P, Boillot A, Talon D. Large outbreak in a surgical intensive care unit of colonization or infection with Pseudomonas aeruginosa that overexpressed an active efflux pump. Clin Infect Dis 2000, 31:e9-14. 10.1086/318117, 11049805.
11. Landman D, Quale JM, Mayorga D, Adedeji A, Vangala K, Ravishankar J, Flores C, Brooks S. Citywide clonal outbreak of multiresistant Acinetobacter baumannii and Pseudomonas aeruginosa in Brooklyn, NY. Arch Intern Med 2002, 162:1515-1520. 10.1001/archinte.162.13.1515, 12090889.
12. Hocquet D, Bertrand X, Kohler T, Talon D, Plesiat P. Genetic and phenotypic variations of a resistant Pseudomonas aeruginosa epidemic clone. Antimicrob Agents Chemother 2003, 47:1887-1894. 10.1128/AAC.47.6.1887-1894.2003, 155826, 12760863.
13. Deplano A, Denis O, Poirel L, Hocquet D, Nonhoff C, Byl B, Nordmann P, Vincent JL, Struelens MJ. Molecular characterization of an epidemic clone of panantibiotic-resistant Pseudomonas aeruginosa. J Clin Microbiol 2005, 43:1198-1204. 10.1128/JCM.43.3.1198-1204.2005, 1081292, 15750083.
14. Hsueh PR, Tseng SP, Teng LJ, Ho SW. Pan-drug-resistant Pseudomonas aeruginosa causing nosocomial infection at a university hospital in Taiwan. Clin Microbiol Infect 2005, 11:670-673. 10.1111/j.1469-0691.2005.01196.x, 16008621.
15. Sekiguchi J, Asagi T, Miyoshi-Akiyama T, Kasai A, Mizuguchi Y, Araake M, Fujino T, Kikuchi H, Sasaki S, Watari H, et al. Outbreak of multidrug-resistant Pseuomonas aeruginosa in community hospitals in Japan. J Clin Microbiol 2007, 45:979-989. 10.1128/JCM.01772-06, 1829129, 17122009.
16. Corbella X, Montero A, Pujol M, Dominguez MA, Ayats J, Argerich MJ, Garrigosa F, Ariza J, Gudiol F. Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii. J Clin Microbiol 2000, 38:4086-4095. 87546, 11060073.
17. Paramythiotou E, Lucet JC, Timsit JF, Vanjak D, Paugam-Burtz C, Troillet JL, Belloc S, Kassis N, Karabinis A, Andremont A. Acquisition of multidrug-resistant Pseudomonas aeruginosa in patients in intensive care units: role of antibiotics with antipseudomonal activity. Clin Infect Dis 2004, 38:670-677. 10.1086/381550, 14986251.
18. Aloush V, Navon-Veenezia S, Seigman-Igra Y, Cabili S, Carmeli Y. Multidrug-resistant Pseudomonas aeruginosa: risk factors and clinic impact. Antimicrob Agents Chemother 2006, 50:43-48. 10.1128/AAC.50.1.43-48.2006, 1346794, 16377665.
19. Paterson DL. The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species. Clin Infect Dis 2006, 43(Suppl. 2):543-548.
20. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988, 16:128-140. 10.1016/0196-6553(88)90053-3, 2841893.
21. Clinical and Laboratory Standards Institute Performance standards for antimicrobial susceptibility testing; 18th informational supplement, document M100-S18. Wayne, PA 2008, Clinical and Laboratory Standards Institute.
22. Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, Swaminathan B. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995, 33:2233-2239. 228385, 7494007.
23. van Belkum A, Tassios PT, Dijkshoom L, Haeggman S, Cookson B, Fry NK, Fussing V, Green J, Feil E, Gerner-Smidt P, et al. for the European Society of Clinical Microbiology and Infectious Diseases Study Group on Epidemiological Markers Guidelines for the validation and application of typing methods for use in bacterial epidemiology. Clin Microbiol Infect 2007, 13(suppl 3):1-46. for the European Society of Clinical Microbiology and Infectious Diseases Study Group on Epidemiological Markers.
24. Juan C, Moyá B, Pérez JL, Oliver A. Stepwise upregulation of the Pseudomonas aeruginosa chromosomal cephalosporinase conferring high level beta-lactam resistance involves three AmpD homologues. Antimicrob Agents Chemother 2006, 50:1780-1787. 10.1128/AAC.50.5.1780-1787.2006, 1472203, 16641450.
25. Oh H, Stenhoff J, Jalal S, Wretlind B. Role of efflux pumps and mutations in genes for topoisomerases II and IV in fluoroquinolone-resistant Pseudomonas aeruginosa strains. Microb Drug Res 2003, 8:323-328.
26. Gutiérrez O, Juan C, Cercenado E, Navarro F, Bouza E, Coll P, Perez JL, Oliver A. Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. Antimicrob Agents Chemother 2007, 51:4329-4335. 10.1128/AAC.00810-07, 2167976, 17938181.
27. Corbella X, Pujol M, Argerich MJ, Ayats J, Sendra M, Peña C, Ariza J. Environmental sampling of Acinetobacter baumanii: moistened swabs versus moistened sterile gauze pads. Infect Control Hosp Epidemiol 1999, 20:458-460.
28. WHO Collaborating Centre for Drug Statistics Methodology Guidelines for ATC classification and DDD assignment 2011. Oslo. 2010, WHO Collaborating Centre for Drug Statistics Methodology.
29. Wagner AK, Soumerai SB, Zhang F, Ross-Degnan D. Segmented regression analysis of interrupted time series studies in medication use research. J Clin Phar Ther 2002, 27:299-309.
30. Williams VR, Callery S, Vearncombe M, Simor AE. The role of colonization pressure in nosocomial transmission of methicillin-resistant Staphylococcus aureus. Am J Infect Control 2009, 37:106-110. 10.1016/j.ajic.2008.05.007, 18945520.
31. Ramsay C, Brown E, Hartman G, Davey P. Room improvement: a systematic review of the quality of evaluations of interventions to improve hospital antibiotic prescribing. J Antimicrob Chemother 2003, 52:764-771. 10.1093/jac/dkg460, 14563901.
32. Huang SS, Datta R, Platt R. Risk of acquiring antibiotic-resistant bacteria from prior room occupants. Arch Intern Med 2006, 166:1945-1951. 10.1001/archinte.166.18.1945, 17030826.
33. Corbella X, Pujol M, Ayats J, Sendra M, Ardanuy C, Dominguez MA, Liñares J, Ariza J, Gudiol F. Relevance of digestive tract colonization in the epidemiology of multiresistant Acinetobacter baumanii. Clin Infect Dis 1996, 23:329-334. 10.1093/clinids/23.2.329, 8842272.
34. Peña C, Pujol M, Ardanuy C, Ricart A, Pallarés R, Liñares J, Ariza J, Gudiol F. Epidemiology and successful control of a large outbreak due to Klebsiella pneumoniae producing extended-spectrum β-lactamases. Antimicrob Agents Chemother 1998, 42:53-58. 105455, 9449260.
35. Widmer AF, Wenzel RP, Trilla A, Bale MJ, Jones RN, Doebelling BN. Outbreak of Pseudomonas aeruginosa infections in a surgical intensive care unit: probable transmission via hands of a health care worker. Clin Infect Dis 1993, 16:372-376. 10.1093/clind/16.3.372, 8452949.
36. Peña C, Suarez C, Tubau F, Juan C, Moya B, Dominguez MA, Oliver A, Pujol M, Ariza J. Nosocomial outbreak of a cefepime-nonsusceptible ceftazidime susceptible Pseudomonas aeruginosa strain overexpressing MexXY-OprM and producing an integron-borne PSE-1 β-lactamase. J Clin Microbiol 2009, 47:2381-2387. 10.1128/JCM.00094-09, 2725653, 19494059.
37. Baquero F. From pieces to patterns: evolutionary engineering in bacterial pathogens. Nat Rev Microbiol 2004, 2:510-518. 10.1038/nrmicro909, 15152207.