Intense exercise can cause excessive apoptosis and synapse plasticity damage in rat hippocampus through Ca2+ overload and endoplasmic reticulum stress-induced apoptosis pathway

Chinese Medical Journal

Volumn 127, Issue 18, 2014, Pages 3265-3271

  Ding, Yi ^a   Chang, Cun Qing ^a   Xie, Lan ^a   Chen, Zhi Min ^a   Ai, Hua ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

Astrocytes activation; Endoplasmic reticulum stress induced apoptosis; Exhaustion; Hippocampus; Intense exercise; Synapse plasticity

Indexed keywords

CASPASE 12; CASPASE 3; GLIAL FIBRILLARY ACIDIC PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN BAX; PROTEIN BCL 2; SYNAPTOPHYSIN; CALCIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN DAMAGE; CALCIUM TRANSPORT; CELL ACTIVATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; EXERCISE; HIPPOCAMPUS; IMMUNOFLUORESCENCE TEST; IMMUNOREACTIVITY; MALE; NERVE CELL PLASTICITY; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SWIMMING; WESTERN BLOTTING; ANIMAL; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TUNEL ASSAY;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; ENDOPLASMIC RETICULUM STRESS; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; IN SITU NICK-END LABELING; MALE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTOPHYSIN;

EID: 84907289381     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20141191     Document Type: Article

References (26)

1. Wu GL, Chen YS, Huang XD, Zhang LX. Exhaustive swimming exercise related kidney injury in rats — protective effects of acetylbritannilactone. Int J Sports Med 2012; 33: 1-7.
2. Tuan TC, Hsu TG, Fong MC, Hsu CF, Tsai KK, Lee CY, et al. Deleterious effects of short-term, high-intensity exercise on immune function: evidence from leucocyte mitochondrial alterations and apoptosis. Br J Sports Med 2008; 42: 11-15.
3. Kerr AL, Swain RA. Rapid cellular genesis and apoptosis: effects of exercise in the adult rat. Behav Neurosci 2011; 125: 1-9.
4. Griesbach GS, Gomez-Pinilla F, Hovda DA. The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exercise. Brain Res 2004; 1016: 154-162.
5. Eich TS, Metcalfe J. Effects of the stress of marathon running on implicit and explicit memory. Psychon Bull Rev 2009; 16: 475-479.
6. Cull-Candy S, Brickley S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 2001; 11: 327-335.
7. 2+ signals and death programmes in neurons. Philos Trans R Soc Lond B Biol Sci 2005; 360: 2255-2258.
8. Albensi BC. The NMDA receptor/Ion channel complex: a drug target for modulating synaptic plasticity and excitotoxicity. Curr Pharm Des 2007; 13: 3185-3194.
9. Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006; 7: 880-885.
10. Ishibashi H. Increased synaptophysin expression through whisker stimulation in rat. Cell Mol Neurobiol 2002; 22: 191-195.
11. Masliah E, Terry RD, DeTeresa RM, Hansen LA. Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neurosci Lett 1989; 103: 234-239.
12. Thomas DP, Marshall KI. Effects of repeated exhaustive exercise on myocardial subcellular membrane structures. Int J Sports Med 1988; 9: 257-260.
13. Li YF, Liu YQ, Yang M, Wang HL, Huang WC, Zhao YM, et al. The cytoprotective effect of inulin-type hexasaccharide extracted from Morinda officinalis on PC12 cells against the lesion induced by corticosterone. Life Sci 2004; 75: 1531-1538.
14. Tomás Pereira I, Coletta CE, Perez EV, Kim DH, Gallagher M, Goldberg IG, et al. CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging. Neurobiol Aging 2013; 34: 832-844.
15. Oliveira-da-Silva A, Vieira FB, Cristina-Rodrigues F, Filgueiras CC, Manhães AC, Abreu-Villaça Y. Increased apoptosis and reduced neuronal and glial densities in the hippocampus due to nicotine and ethanol exposure in adolescent mice. Int J Dev Neurosci 2009; 276: 539-548.
16. Gerecke KM, Kolobova A, Allen S, Fawer JL. Exercise protects against chronic restraint stress-induced oxidative stress in the cortex and hippocampus. Brain Res 2013; 1509: 66-78.
17. Sampedro-Piquero P, Zancada-Menendez C, Begega A, Mendez M, Arias JL. Effects of forced exercise on spatial memory and cytochrome c oxidase activity in aged rats. Brain Res 2013; 1502: 20-29.
18. Fernandes J, Baliego LG, Peixinho-Pena LF, de Almeida AA, Venancio DP, Scorza FA, et al. Aerobic exercise attenuates inhibitory avoidance memory deficit induced by paradoxical sleep deprivation in rats. Brain Res 2013; 1529: 66-73.
19. Wyllie DJ, Johnston AR, Lipscombe D, Chen PE. Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit. J Physiol 2006; 574: 477-489.
20. Hardingham GE, Bading H. The Yin and Yang of NMDA receptor signalling. Trends Neurosci 2003; 26: 81-89.
21. Pekny M, Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005; 50: 427-434.
22. Sofroniew MV. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 2009; 32: 638-647.
23. Tarsa L, Goda Y. Synaptophysin regulates activity-dependent synapse formation in cultured hippocampal neurons. Proc Natl Acad Sci USA 2002; 99: 1012-1016.
24. Amaral D, Lavenex P. Hippocampal Neuroanatomy. In: Andersen P, Morris R, Amaral D, Bliss T, O’Keefe J, Eds. The Hippocampus Book. New York: Oxford University Press Inc 2007; 37-113.
25. Aras R, Barron AM, Pike CJ. Caspase activation contributes to astrogliosis. Brain Res 2012; 1450: 102-115.
26. Kumar S. Caspase function in programmed cell death. Cell Death Differ 2006; 14: 32-43.