Antidiabetic effect of roselle calyces extract (Hibiscus Sabdariffa L.) in streptozotocin induced mice

International Journal of PharmTech Research

Volumn 6, Issue 5, 2014, Pages 1703-1711

  Rosemary, ^a   Rosidah, ^a   Haro, Ginda ^a  

^a UNIVERSITY OF SUMATERA UTARA   (Indonesia)

Author keywords

Antidiabetic; Blood glucose levels; Roselle calyces (Hibiscus sabdariffa L.); Streptozotocin

Indexed keywords

ALKALOID; FLAVONOID; GLIBENCLAMIDE; GLYCOSIDE; HIBISCUS SABDARIFFA EXTRACT; SAPONIN; STEROID; TANNIN DERIVATIVE; TRITERPENOID;

ANTIDIABETIC ACTIVITY; ARTICLE; DIABETES MELLITUS; DRUG DOSE COMPARISON; DRUG MEGADOSE; EXTRACTION; FLOWER; GLUCOSE BLOOD LEVEL; HIBISCUS SABDARIFFA; LOW DRUG DOSE; PHYTOCHEMISTRY;

EID: 84907266425     PISSN: 09744304     EISSN: 09744304     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Schoenfelder, T., Cirimbelli, T. M., and Citadini, Z. V. (2006). Acute effect of Trema micrantha on serum glukosa levels in normal and diabetic rats. J. Ethnopharmacol. 107(3): 456-459.
2. Anuradha, K., Hota, D., and Pandhi, P. (2001). Investigation of central mechanism of insulin-induced hypoglycemic convulsions in mice. Indian J Exp Biol. vol (39): 500-502.
3. Alarcon, F. J., Jimenez, M., Reyes, R., and Romans, R. (2000). Hypoglycemic effect of extracts and fractions from Psacalium decompositum in healthy and alloxan diabetic mice. J. Ethnopharmacol. 72(2): 21-27.
4. Rajagopal, K., and Sasikala, K. (2008). Antihyperglycaemic and antihyperlipidaemic effects of Nymphaea stellata in alloxan-induced diabetic rats. Singapore Med J. 49(2): 137-141.
5. Waltner Law, M. E., Wang, X. L., and Law, B. K. (2002). Epigallocatechin gallate, a constituent of green tea, represses hepatic glukosa production. J. Biol Chem. 277: 34933-34940.
6. Tzu, L. L., Hui, H. L, Chang, C. C., Ming, C. L., Ming C. C., and Chau, J. W. (2007). Hibiscus sabdariffa L. extract reduces serum cholesterol in men and women. Nutrition Research. 27: 140-145.
7. Chen, C. C., Hsu, J. D., Wang, S. F., Ching, H. C., Yang, M. Y., and Kao, E. S. (2003). Hibiscus sabdariffa L. extracts inhibits the development of atherosclerosis in cholesterol-fed rabbits. J. Agric. Food Chem. 51(18): 5472-5477.
8. Dahiru, D., Obi, O. J., and Umaru, H. (2003). Effect of Hibiscus sabdariffa L. calyx extract on carbon tetrachloride induced liver damage. Biokemistri. 15(1): 27-33.
9. Babalola, S. O., Babalola, A. O., and Aworh, O. C. (2001). Compositional attributes of the calyces of roselle (Hibiscus sabdariffa L.). The Journal of Food and Technology in Africa. 6(4): 133-134.
10. Wang, S. C., Lee, S. F., Wang, C. J., Lee, C. H., Lee, W. C., and Lee, H. J. (2011). Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Reglukosating Oxidative Status and Akt/Bad/14-3-3γ in an Experimental Animal Model. Hindawi Publishing Corporation: Evidence-Based Complementary and Alternative Medicine. Volume 2011. Artikel ID 938126. Page 9.
11. Omotuyi, I. O., Ologundudu, A., Onwubiko, V. O., Wogu M. D., and Obi, F. O. (2010). Hibiscus sabdariffa Linn. anthocyanins alter circulating reproductive hormones in rabbits (Oryctolagus cuniculus). Journal of Diabetes and Endocrinology. 1(3): 36-45.
12. Brahmachari, G. (2011). Bio-Flavonoids with promising antidiabetic potentials: A critical survey. Research Signpost India. 187-212.
13. Istudor, V., and Humadi, S. S. (2008). Quantitative analysis of bio-active compound in Hibiscus sabdariffa L. extracts. Note I Quantitative analysis of flavonoids. Farmacia. 56(6): 699-708.