메뉴 건너뛰기




Volumn 41, Issue 10, 2014, Pages 1870-1878

Correlation between 18F-fluoromisonidazole PET and expression of HIF-1α and VEGF in newly diagnosed and recurrent malignant gliomas

Author keywords

Fluoromisonidazole; Hypoxia; Hypoxia inducible factor 1 (HIF 1); Malignant glioma; Positron emission tomography; Vascular endothelial growth factor (VEGF)

Indexed keywords

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KI 67 ANTIGEN; VASCULOTROPIN; 1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; HIF1A PROTEIN, HUMAN; MISONIDAZOLE; RADIOPHARMACEUTICAL AGENT; VASCULOTROPIN A;

EID: 84907254721     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-014-2776-9     Document Type: Article
Times cited : (65)

References (35)
  • 1
    • 84866510711 scopus 로고    scopus 로고
    • Mechanism of glioma-associated neovascularization
    • COI: 1:CAS:528:DC%2BC38XhsF2nsLfL, PID: 22858156
    • Hardee ME, Zagzag D. Mechanism of glioma-associated neovascularization. Am J Pathol. 2012;181:1126–41.
    • (2012) Am J Pathol , vol.181 , pp. 1126-1141
    • Hardee, M.E.1    Zagzag, D.2
  • 2
    • 17844371306 scopus 로고    scopus 로고
    • Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
    • COI: 1:CAS:528:DC%2BD2MXjvV2qsLk%3D, PID: 15831232
    • Kaur B, Khwaja FW, Severson EA, Matheny SL, Brat DJ, Van Meir EG. Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. Neuro Oncol. 2005;7:134–53.
    • (2005) Neuro Oncol , vol.7 , pp. 134-153
    • Kaur, B.1    Khwaja, F.W.2    Severson, E.A.3    Matheny, S.L.4    Brat, D.J.5    Van Meir, E.G.6
  • 3
    • 65249131228 scopus 로고    scopus 로고
    • Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target
    • COI: 1:CAS:528:DC%2BD1MXkt1yitL4%3D, PID: 19357959
    • Jensen RL. Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target. J Neurooncol. 2009;92:317–35.
    • (2009) J Neurooncol , vol.92 , pp. 317-335
    • Jensen, R.L.1
  • 4
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • COI: 1:CAS:528:DyaK28XltFKjsrc%3D, PID: 8756616
    • Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16:4604–13.
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6
  • 5
    • 33745784386 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis in gliomas
    • COI: 1:CAS:528:DC%2BD28Xpt1ylt7Y%3D, PID: 16554966
    • Kargiotis O, Rao JS, Kyritsis AP. Mechanisms of angiogenesis in gliomas. J Neurooncol. 2006;78:281–93.
    • (2006) J Neurooncol , vol.78 , pp. 281-293
    • Kargiotis, O.1    Rao, J.S.2    Kyritsis, A.P.3
  • 6
    • 65549093775 scopus 로고    scopus 로고
    • Angiogenesis and anti-angiogenic molecularly targeted therapies in malignant gliomas
    • COI: 1:CAS:528:DC%2BD1MXot12ktro%3D, PID: 19439998
    • Argyriou AA, Giannopoulou E, Kalofonos HP. Angiogenesis and anti-angiogenic molecularly targeted therapies in malignant gliomas. Oncology. 2009;77:1–11.
    • (2009) Oncology , vol.77 , pp. 1-11
    • Argyriou, A.A.1    Giannopoulou, E.2    Kalofonos, H.P.3
  • 7
    • 0030249455 scopus 로고    scopus 로고
    • Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients
    • COI: 1:STN:280:DyaK2s%2FkslGntQ%3D%3D, PID: 8892467
    • Rasey JS, Koh WJ, Evans ML, Peterson LM, Lewellen TK, Graham MM, et al. Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients. Int J Radiat Oncol Biol Phys. 1996;36:417–26.
    • (1996) Int J Radiat Oncol Biol Phys , vol.36 , pp. 417-426
    • Rasey, J.S.1    Koh, W.J.2    Evans, M.L.3    Peterson, L.M.4    Lewellen, T.K.5    Graham, M.M.6
  • 8
    • 0026475672 scopus 로고
    • Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole
    • COI: 1:STN:280:DyaK3s%2FpsV2isQ%3D%3D, PID: 1334136
    • Valk PE, Mathis CA, Prados MD, Gilbert JC, Budinger TF. Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole. J Nucl Med. 1992;33:2133–7.
    • (1992) J Nucl Med , vol.33 , pp. 2133-2137
    • Valk, P.E.1    Mathis, C.A.2    Prados, M.D.3    Gilbert, J.C.4    Budinger, T.F.5
  • 9
    • 58249121592 scopus 로고    scopus 로고
    • Complementary but distinct roles for MRI and 18F-fluoromisonidazole PET in the assessment of human glioblastomas
    • PID: 19091885
    • Swanson KR, Chakraborty G, Wang CH, Rockne R, Harpold HLP, Muzi M, et al. Complementary but distinct roles for MRI and 18F-fluoromisonidazole PET in the assessment of human glioblastomas. J Nucl Med. 2009;50:36–44.
    • (2009) J Nucl Med , vol.50 , pp. 36-44
    • Swanson, K.R.1    Chakraborty, G.2    Wang, C.H.3    Rockne, R.4    Harpold, H.L.P.5    Muzi, M.6
  • 10
    • 79953734435 scopus 로고    scopus 로고
    • Correlation of biological aggressiveness assessed by 11C-methionine PET and hypoxic burden assessed by 18F-fluoromisonidazole PET in newly diagnosed glioblastoma
    • COI: 1:CAS:528:DC%2BC3MXhs1Gjs7o%3D, PID: 21072512
    • Kawai N, Maeda Y, Kudomi N, Miyake K, Okada M, Yamamoto Y, et al. Correlation of biological aggressiveness assessed by 11C-methionine PET and hypoxic burden assessed by 18F-fluoromisonidazole PET in newly diagnosed glioblastoma. Eur J Nucl Med Mol Imaging. 2011;38:441–50.
    • (2011) Eur J Nucl Med Mol Imaging , vol.38 , pp. 441-450
    • Kawai, N.1    Maeda, Y.2    Kudomi, N.3    Miyake, K.4    Okada, M.5    Yamamoto, Y.6
  • 11
    • 0037700084 scopus 로고    scopus 로고
    • Methyl-[11C]- l-methionine uptake as measured by positron emission tomography correlates to microvessel density in patients with glioma
    • COI: 1:CAS:528:DC%2BD3sXjvF2lsL0%3D, PID: 12692687
    • Kracht LW, Friese M, Herholz K, Schroeder R, Bauer B, Jacobs A, et al. Methyl-[11C]- l-methionine uptake as measured by positron emission tomography correlates to microvessel density in patients with glioma. Eur J Nucl Med Mol Imaging. 2003;30:868–73.
    • (2003) Eur J Nucl Med Mol Imaging , vol.30 , pp. 868-873
    • Kracht, L.W.1    Friese, M.2    Herholz, K.3    Schroeder, R.4    Bauer, B.5    Jacobs, A.6
  • 12
    • 77956060344 scopus 로고    scopus 로고
    • Correlation of L-methyl-11C-methionine (MET) uptake with L-type amino acid transporter 1 in human gliomas
    • COI: 1:CAS:528:DC%2BC3cXhtVGmtLbO, PID: 20091333
    • Okubo S, Zhen HN, Kawai N, Nishiyama Y, Haba R, Tamiya T. Correlation of L-methyl-11C-methionine (MET) uptake with L-type amino acid transporter 1 in human gliomas. J Neurooncol. 2010;99:217–25.
    • (2010) J Neurooncol , vol.99 , pp. 217-225
    • Okubo, S.1    Zhen, H.N.2    Kawai, N.3    Nishiyama, Y.4    Haba, R.5    Tamiya, T.6
  • 13
    • 33645969631 scopus 로고    scopus 로고
    • Correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in gliomas using 18F-fluoromisonidazole, 18F-FDG PET, and immunohistochemical studies
    • COI: 1:CAS:528:DC%2BD28Xlt1Kms7g%3D, PID: 16513609
    • Cher LM, Murone C, Lawrentschuk N, Ramdave S, Papenfuss A, Hannah A, et al. Correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in gliomas using 18F-fluoromisonidazole, 18F-FDG PET, and immunohistochemical studies. J Nucl Med. 2006;47:410–8.
    • (2006) J Nucl Med , vol.47 , pp. 410-418
    • Cher, L.M.1    Murone, C.2    Lawrentschuk, N.3    Ramdave, S.4    Papenfuss, A.5    Hannah, A.6
  • 14
    • 52049120148 scopus 로고    scopus 로고
    • Regional hypoxia in glioblastoma multiforme quantified with [18F]fluoromisonidazole positron emission tomography before radiotherapy: correlation with time to progression and survival
    • COI: 1:CAS:528:DC%2BD1cXlsV2qtr8%3D, PID: 18451225
    • Spence AM, Muzi M, Swanson KR, O’Sullivan F, Rockhill JK, Rajendran JG, et al. Regional hypoxia in glioblastoma multiforme quantified with [18F]fluoromisonidazole positron emission tomography before radiotherapy: correlation with time to progression and survival. Clin Cancer Res. 2008;14:2623–30.
    • (2008) Clin Cancer Res , vol.14 , pp. 2623-2630
    • Spence, A.M.1    Muzi, M.2    Swanson, K.R.3    O’Sullivan, F.4    Rockhill, J.K.5    Rajendran, J.G.6
  • 15
    • 84893173949 scopus 로고    scopus 로고
    • Update on anti-angiogenic treatment for malignant gliomas
    • PID: 24510742
    • de Groot JF, Mandel JJ. Update on anti-angiogenic treatment for malignant gliomas. Curr Oncol Rep. 2014;16:380. doi:10.1007/s11912-014-0380-6.
    • (2014) Curr Oncol Rep , vol.16 , pp. 380
    • de Groot, J.F.1    Mandel, J.J.2
  • 16
    • 84860833963 scopus 로고    scopus 로고
    • Hypoxia assessed by 18F-fluoromisonidazole positron emission tomography in newly diagnosed gliomas
    • COI: 1:CAS:528:DC%2BC38XpvFeqsr4%3D, PID: 22422099
    • Yamamoto Y, Maeda Y, Kawai N, Kudomi N, Aga F, Ono Y, et al. Hypoxia assessed by 18F-fluoromisonidazole positron emission tomography in newly diagnosed gliomas. Nucl Med Commun. 2012;33:621–5.
    • (2012) Nucl Med Commun , vol.33 , pp. 621-625
    • Yamamoto, Y.1    Maeda, Y.2    Kawai, N.3    Kudomi, N.4    Aga, F.5    Ono, Y.6
  • 17
    • 27144504703 scopus 로고    scopus 로고
    • Fully automated synthesis of [18F]fluoromisonidazole using a conventional [18F]FDG module
    • COI: 1:CAS:528:DC%2BD2MXhtFKhsbzP, PID: 16253816
    • Oh SJ, Chi DY, Mosdzianowski C, Kim JY, Gil HS, Kang SH, et al. Fully automated synthesis of [18F]fluoromisonidazole using a conventional [18F]FDG module. Nucl Med Biol. 2005;32:899–905.
    • (2005) Nucl Med Biol , vol.32 , pp. 899-905
    • Oh, S.J.1    Chi, D.Y.2    Mosdzianowski, C.3    Kim, J.Y.4    Gil, H.S.5    Kang, S.H.6
  • 18
    • 39149124801 scopus 로고    scopus 로고
    • Identification of 14-3-3 protein isoforms in human astrocytoma by immunohistochemistry
    • COI: 1:CAS:528:DC%2BD1cXitVeguro%3D, PID: 18242847
    • Cao L, Cao W, Zhang W, Lin H, Yang X, Zhen H, et al. Identification of 14-3-3 protein isoforms in human astrocytoma by immunohistochemistry. Neurosci Lett. 2008;432:94–9.
    • (2008) Neurosci Lett , vol.432 , pp. 94-99
    • Cao, L.1    Cao, W.2    Zhang, W.3    Lin, H.4    Yang, X.5    Zhen, H.6
  • 19
    • 84862587185 scopus 로고    scopus 로고
    • 18F-Fluoromisonidazole positron emission tomography may differentiate glioblastoma multiforme from less malignant gliomas
    • COI: 1:CAS:528:DC%2BC38XlvVShsLw%3D, PID: 22307533
    • Hirata K, Terasaka S, Shiga T, Hattori N, Magota K, Kobayashi H, et al. 18F-Fluoromisonidazole positron emission tomography may differentiate glioblastoma multiforme from less malignant gliomas. Eur J Nucl Med Mol Imaging. 2012;39:760–70.
    • (2012) Eur J Nucl Med Mol Imaging , vol.39 , pp. 760-770
    • Hirata, K.1    Terasaka, S.2    Shiga, T.3    Hattori, N.4    Magota, K.5    Kobayashi, H.6
  • 20
    • 2942707871 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis
    • COI: 1:CAS:528:DC%2BD2cXlslymtbc%3D, PID: 15175080
    • Korkolopoulou P, Patsouris E, Konstantinidou AE, Pavlopoulos PM, Kavantzas N, Boviatsis E, et al. Hypoxia-inducible factor 1alpha/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis. Neuropathol Appl Neurobiol. 2004;30:267–78.
    • (2004) Neuropathol Appl Neurobiol , vol.30 , pp. 267-278
    • Korkolopoulou, P.1    Patsouris, E.2    Konstantinidou, A.E.3    Pavlopoulos, P.M.4    Kavantzas, N.5    Boviatsis, E.6
  • 21
    • 79952187104 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1α expression is a prognostic biomarker in patients with astrocytic tumors associated with necrosis on MR image
    • COI: 1:CAS:528:DC%2BC3MXit1ygtLs%3D, PID: 20596750
    • Mashiko R, Takano S, Ishikawa E, Yamamoto T, Nakai K, Matsumura A. Hypoxia-inducible factor 1α expression is a prognostic biomarker in patients with astrocytic tumors associated with necrosis on MR image. J Neurooncol. 2011;102:43–50.
    • (2011) J Neurooncol , vol.102 , pp. 43-50
    • Mashiko, R.1    Takano, S.2    Ishikawa, E.3    Yamamoto, T.4    Nakai, K.5    Matsumura, A.6
  • 22
    • 52049107208 scopus 로고    scopus 로고
    • Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme
    • PID: 18618497
    • Flynn JR, Wang L, Gillespie DL, Stoddard GJ, Reid JK, Owens J, et al. Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme. Cancer. 2008;113:1032–42.
    • (2008) Cancer , vol.113 , pp. 1032-1042
    • Flynn, J.R.1    Wang, L.2    Gillespie, D.L.3    Stoddard, G.J.4    Reid, J.K.5    Owens, J.6
  • 23
    • 0034757675 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression correlates with tumour grade and vascularity in gliomas
    • COI: 1:STN:280:DC%2BD3MngvFGgtQ%3D%3D, PID: 11683943
    • Chaudhry IH, O’Donovan DG, Brenchley PEC, Reid H, Roberts ISD. Vascular endothelial growth factor expression correlates with tumour grade and vascularity in gliomas. Histopathology. 2001;39:409–15.
    • (2001) Histopathology , vol.39 , pp. 409-415
    • Chaudhry, I.H.1    O’Donovan, D.G.2    Brenchley, P.E.C.3    Reid, H.4    Roberts, I.S.D.5
  • 24
    • 26944445860 scopus 로고    scopus 로고
    • Angiogenesis of glioma: evaluation of ultrastructural characteristics of microvessels and tubular bodies (Weibel-Palade) in endothelial cells and immunohistochemical findings with VEGF and p53 protein
    • PID: 16158178
    • Miyagami M, Katayama Y. Angiogenesis of glioma: evaluation of ultrastructural characteristics of microvessels and tubular bodies (Weibel-Palade) in endothelial cells and immunohistochemical findings with VEGF and p53 protein. Med Mol Morphol. 2005;38:36–42.
    • (2005) Med Mol Morphol , vol.38 , pp. 36-42
    • Miyagami, M.1    Katayama, Y.2
  • 25
    • 84863796187 scopus 로고    scopus 로고
    • Bevacizumab for the treatment of high-grade glioma
    • COI: 1:CAS:528:DC%2BC38XhtVemurvM, PID: 22663137
    • Khasraw M, Simeonovic M, Grommes C. Bevacizumab for the treatment of high-grade glioma. Expert Opin Biol Ther. 2012;12:1101–11.
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 1101-1111
    • Khasraw, M.1    Simeonovic, M.2    Grommes, C.3
  • 26
    • 79951984402 scopus 로고    scopus 로고
    • Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
    • COI: 1:CAS:528:DC%2BC3MXhvVahtb0%3D, PID: 21135282
    • Lai A, Tran A, Nghiemphu PL, Pope WB, Solis OE, Selch M, et al. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol. 2011;29:142–8.
    • (2011) J Clin Oncol , vol.29 , pp. 142-148
    • Lai, A.1    Tran, A.2    Nghiemphu, P.L.3    Pope, W.B.4    Solis, O.E.5    Selch, M.6
  • 27
    • 11144337759 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators
    • PID: 15618010
    • Déry MA, Michaud MD, Richard DE. Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. Int J Biochem Cell Biol. 2005;37:535–40.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 535-540
    • Déry, M.A.1    Michaud, M.D.2    Richard, D.E.3
  • 29
    • 70549102512 scopus 로고    scopus 로고
    • Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress
    • COI: 1:CAS:528:DC%2BD1MXhsFCgurvP, PID: 19929412
    • Dewhirst MW. Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiat Res. 2009;172:653–65.
    • (2009) Radiat Res , vol.172 , pp. 653-665
    • Dewhirst, M.W.1
  • 30
    • 0035347260 scopus 로고    scopus 로고
    • Induction of HIF-1alpha in response to hypoxia is instantaneous
    • COI: 1:CAS:528:DC%2BD3MXlvVOrtLs%3D, PID: 11344124
    • Jewell UR, Kvietikova I, Scheid A, Bauer C, Wenger RH, Gassmann M. Induction of HIF-1alpha in response to hypoxia is instantaneous. FASEB J. 2001;15:1312–4.
    • (2001) FASEB J , vol.15 , pp. 1312-1314
    • Jewell, U.R.1    Kvietikova, I.2    Scheid, A.3    Bauer, C.4    Wenger, R.H.5    Gassmann, M.6
  • 31
    • 0035936886 scopus 로고    scopus 로고
    • HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation
    • COI: 1:CAS:528:DC%2BD3MXhsFShs7s%3D, PID: 11226425
    • Berra E, Richard DE, Gothié E, Pouysségur J. HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation. FEBS Lett. 2001;491:85–90.
    • (2001) FEBS Lett , vol.491 , pp. 85-90
    • Berra, E.1    Richard, D.E.2    Gothié, E.3    Pouysségur, J.4
  • 32
    • 0035159670 scopus 로고    scopus 로고
    • HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia
    • COI: 1:CAS:528:DC%2BD3MXoslSisbs%3D, PID: 11689469
    • Stroka DM, Burkhardt T, Desbaillets I, Wenger RH, Neil DA, Bauer C, et al. HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J. 2001;15:2445–53.
    • (2001) FASEB J , vol.15 , pp. 2445-2453
    • Stroka, D.M.1    Burkhardt, T.2    Desbaillets, I.3    Wenger, R.H.4    Neil, D.A.5    Bauer, C.6
  • 33
    • 0037847453 scopus 로고    scopus 로고
    • Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas
    • PID: 12758238
    • Nordsmark M, Loncaster J, Aquino-Parsons C, Chou SC, Ladekarl M, Havsteen H, et al. Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas. Radiother Oncol. 2003;67:35–44.
    • (2003) Radiother Oncol , vol.67 , pp. 35-44
    • Nordsmark, M.1    Loncaster, J.2    Aquino-Parsons, C.3    Chou, S.C.4    Ladekarl, M.5    Havsteen, H.6
  • 34
    • 0038642530 scopus 로고    scopus 로고
    • Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours
    • COI: 1:CAS:528:DC%2BD3sXlsVajsbo%3D, PID: 12865184
    • Bentzen L, Keiding S, Nordsmark M, Falborg L, Hansen SB, Keller J, et al. Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours. Radiother Oncol. 2003;67:339–44.
    • (2003) Radiother Oncol , vol.67 , pp. 339-344
    • Bentzen, L.1    Keiding, S.2    Nordsmark, M.3    Falborg, L.4    Hansen, S.B.5    Keller, J.6
  • 35
    • 20044390414 scopus 로고    scopus 로고
    • A kinetic model for dynamic [18F]-Fmiso PET data to analyse tumour hypoxia
    • PID: 15876662
    • Thorwarth D, Eschmann SM, Paulsen F, Alber M. A kinetic model for dynamic [18F]-Fmiso PET data to analyse tumour hypoxia. Phys Med Biol. 2005;50:2209–24.
    • (2005) Phys Med Biol , vol.50 , pp. 2209-2224
    • Thorwarth, D.1    Eschmann, S.M.2    Paulsen, F.3    Alber, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.