New insights into the functions of PIGF, a protein involved in the ethanolamine phosphate transfer steps of glycosylphosphatidylinositol biosynthesis

Biochemical Journal

Volumn 463, Issue 2, 2014, Pages 249-256

  Stokes, Matthew J ^a   Murakami, Yoshiko ^a,b   Maeda, Yusuke ^a,b   Kinoshita, Taroh ^a,b   Morita, Yasu S ^a,b,c  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Ethanolamine phosphate transferase; Glycosyl phosphatidylinositol; Membrane protein; Metabolism; PIGF; Trypanosoma brucei

Indexed keywords

ALDEHYDE DEHYDROGENASE; HETERODIMER; PIGF PROTEIN; PIGG PROTEIN; PIGO PROTEIN; PROTEIN; UNCLASSIFIED DRUG; ETHANOLAMINE DERIVATIVE; ETHANOLAMINE PHOSPHOTRANSFERASE; GLYCOSYLPHOSPHATIDYLINOSITOL; MEMBRANE PROTEIN; PHOSPHOETHANOLAMINE; PIGF PROTEIN, HUMAN; PROTEIN BINDING;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CELL MUTANT; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; HYDROPHOBICITY; IMMUNOPRECIPITATION; MAMMAL CELL; NONHUMAN; POINT MUTATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; TRYPANOSOMA BRUCEI; WESTERN BLOTTING; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR EVOLUTION; MOUSE; PROTEIN TERTIARY STRUCTURE; TRYPANOSOMA BRUCEI BRUCEI;

ANIMALS; CELL LINE; ETHANOLAMINEPHOSPHOTRANSFERASE; ETHANOLAMINES; EVOLUTION, MOLECULAR; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; MEMBRANE PROTEINS; MICE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TRYPANOSOMA BRUCEI BRUCEI;

EID: 84907225962     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140541     Document Type: Article

References (24)

1. Ferguson, M. A. J., Low, M. G. and Cross, G. A. M. (1985) Glycosyl-sn-1, 2-dimyristylphosphatidylinositol is covalently linked to Trypanosoma brucei variant surface glycoprotein. J. Biol. Chem. 260, 14547-14555
2. Ferguson, M. A., and Homans., S. W., Dwek, R. A. and Rademacher, T. W. (1988) Glycosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane. Science 239, 753-759
3. Kinoshita, T, Fujita, M. and Maeda, Y (2008) Biosynthesis, remodelling and functions of mammalian GPI-anchored proteins: recent progress. J. Biochem. 144, 287-294
4. Hong, Y, Maeda, Y, Watanabe, R., Inoue, N., Ohishi, K. and Kinoshita, T. (2000) Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. J. Biol. Chem. 275, 20911-20919
5. Flury I., Benachour, A. and Conzelmann, A. (2000) YLL031c belongs to a novel family of membrane proteins involved in the transfer of ethanolaminephosphate onto the core structure of glycosylphosphatidylinositol anchors in yeast. J. Biol. Chem. 275, 24458-24465
6. Taron, C. H., and Wiedman., J. M., Grimme, S. J. and Orlean, P. (2000) Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose. Mol. Biol. Cell 11, 1611-1630
7. Menon, A. K., Eppinger, M., Mayor, S. and Schwarz, R. T. (1993) Phosphatidylethanolamine is the donor of the terminal phosphoethanolamine group in trypanosome glycosylphosphatidylinositols. EMBO J. 12, 1907-1914
8. Menon, A. K. and Stevens, V. L. (1992) Phosphatidylethanolamine is the donor of the ethanolamine residue linking a glycosylphosphatidylinositol anchor to protein. J. Biol. Chem. 267, 15277-15280
9. Hong, Y, Maeda, Y, Watanabe, R., Ohishi, K., Mishkind, M., Riezman, H. and Kinoshita, T. (1999) Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol. J. Biol. Chem. 274, 35099-35106
10. Shishioh, N., Hong, Y, Ohishi, K, Ashida, H., Maeda, Y and Kinoshita, T. (2005) GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. J. Biol. Chem. 280, 9728-9734
11. Benachour, A., Sipos, G., Flury, I., Reggiori, F, Canivenc-Gansel, E., Vionnet, C, Conzelmann, A. and Benghezal, M. (1999) Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity. J. Biol. Chem. 274, 15251-15261
12. Gaynor, E. C, Mondésert, G., and Grimme., S. J., Reed, S. I., Orlean, P. and Emr, S. D. (1999) MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast. Mol. Biol. Cell 10, 627-648
13. Imhof, I., Flury, I., Vionnet, C, Roubaty, C, Egger, D. and Conzelmann, A. (2004) Glycosylphosphatidylinositol (GPI) proteins of Saccharomyces cerevisiae contain ethanolamine phosphate groups on the α1, 4-linked mannose of the GPI anchor. J. Biol. Chem. 279, 19614-19627
14. Sütterlin, C, Horvath, A., Gerold, P., Schwarz, R. T, Wang, Y, Dreyfuss, M. and Riezman, H. (1997) Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis. EMBO J. 16, 6374-6383
15. Maydan, G., Noyman, I., Har-Zahav, A., Neriah, Z. B., Pasmanik-Chor, M., Yeheskel, A., Albin-Kaplanski, A., Maya, I., Magal, N., Birk, E. et al. (2011) Multiple congenital anomalies-hypotonia-seizures syndrome is caused by a mutation in PIGN. J. Med. Genet. 48, 383-389
16. McKean, D. M. and Niswander, L. (2012) Defects in GPI biosynthesis perturb cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol. Open 1, 874-883
17. Ohba, C., Okamoto, N., Murakami, Y., Suzuki, Y., Tsurusaki, Y., Nakashima, M., Miyake, N., Tanaka, F., Kinoshita, T., Matsumoto, N. and Saitsu, H. (2014) PIGN mutations cause congenital anomalies, developmental delay, hypotonia, epilepsy, and progressive cerebellar atrophy. Neurogenetics 15, 85-92
18. Fujita, M., Yoko-o, T., Okamoto, M. and Jigami, Y. (2004) GPI7 involved in glycosylphosphatidylinositol biosynthesis is essential for yeast cell separation. J. Biol. Chem. 279, 51869-51879
19. Fujita, M., Maeda, Y., Ra, M., Yamaguchi, Y., Taguchi, R. and Kinoshita, T. (2009) GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi. Cell 139, 352-365
20. Inoue, N., Kinoshita, T., Orii, T. and Takeda, J. (1993) Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy. J. Biol. Chem. 268, 6882-6885
21. Hirokawa, T., Boon-Chieng, S. and Mitaku, S. (1998) SOSUI: classification and secondary structure prediction system for membrane proteins. Bioinformatics 14, 378-379
22. Sonnhammer, E. L., von Heijne, G. and Krogh, A. (1998) A hidden Markov model for predicting transmembrane helices in protein sequence. Proc. Int. Conf. Intell. Syst. Mol. Biol. 6, 175-182
23. Hong, Y., Ohishi, K., Inoue, N., Kang, J. Y., Shime, H., Horiguchi, Y., van der Goot, F. G., Sugimoto, N. and Kinoshita, T. (2002) Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum alpha-toxin. EMBO J. 21, 5047-5056
24. Watanabe, R., Kinoshita, T., Masaki, R., Yamamoto, A., Takeda, J. and Inoue, N. (1996) PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum. J. Biol. Chem. 271, 26868-26875