ROCK is involved in vasculogenic mimicry formation in hepatocellular carcinoma cell line

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Zhang, Ji Gang ^a   Li, Xiao Yu ^a   Wang, Yu Zhu ^a   Zhang, Qi Di ^a   Gu, Sheng Ying ^a   Wu, Xin ^a   Zhu, Guan Hua ^a   Li, Qin ^a   Liu, Gao Lin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ERYTHROPOIETIN; ERYTHROPOIETIN PRODUCING HEPATOCELLULAR CARCINOMA A2; EXOENZYME C3; GELATINASE A; GELATINASE B; LAMININ; LAMININ 5GAMMA2 CHAIN; MATRIX METALLOPROTEINASE 14; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; RHEB PROTEIN; RHO ASSOCIATED COILED COIL CONTAINING PROTEIN KINASE 1; RHO ASSOCIATED COILED COIL CONTAINING PROTEIN KINASE 2; UNCLASSIFIED DRUG; UVOMORULIN; VASCULAR ENDOTHELIAL CADHERIN; VIMENTIN; AMIDE; PYRIDINE DERIVATIVE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ROCK1 PROTEIN, HUMAN; ROCK2 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; CELL INVASION ASSAY; CELL MIGRATION; CONTROLLED STUDY; ENZYME STRUCTURE; EPITHELIAL MESENCHYMAL TRANSITION; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; VASCULARIZATION; VASCULOGENIC MIMICRY FORMATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL MOTION; DRUG EFFECTS; GENETICS; HEPG2 CELL LINE; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; TUMOR INVASION; UMBILICAL VEIN ENDOTHELIAL CELL;

AMIDES; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; EPITHELIAL-MESENCHYMAL TRANSITION; HEP G2 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIVER NEOPLASMS; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; PYRIDINES; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; TUMOR MARKERS, BIOLOGICAL;

EID: 84907225883     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107661     Document Type: Article

References (40)

1. Maniotis AJ, Folberg R, Hess A, Seftor EA, Gardner LM, et al. (1999) Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry. Am J Pathol 155: 739-752.
2. Sun T, Zhao N, Zhao XL, Gu Q, Zhang SW, et al. (2010) Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry. Hepatology 51: 545-556.
3. Wong CCL, Wong CM, Tung EKK, Man K, Ng IOL (2009) Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion. Hepatology 49: 1583-1594.
4. Jin LM, Su XH, Qing Z, Jing Z, Dan Z, et al. (2011) Role of Twist in vasculogenic mimicry formation in hypoxic hepatocellular carcinoma cells in vitro. Biochem Biophys Res Commun 408: 686-691.
5. El-Serag HB, Rudolph KL (2007) Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis. Gastroenterology 132: 2557-2576.
6. Karlsson R, Pedersen ED, Wang Z, Brakebusch C (2009) Rho GTPase function in tumorigenesis. Biochim Biophys Acta 1796: 91-98.
7. Kirschmann DA, Seftor EA, Hardy KM, Seftor RE, Hendrix MJ (2012) Molecular Pathways: Vasculogenic Mimicry in Tumor Cells: Diagnostic and Therapeutic Implications. Clin Cancer Res 18: 2726-2732.
8. Wang SY, Yu L, Ling GQ, Xiao S, Sun XL, et al. (2012) Vasculogenic mimicry and its clinical significance in medulloblastoma. Cancer Biol Ther 13: 341-348.
9. Quigley JP, Armstrong PB (1998) Tumor cell intravasation alu-cidated: the chick embryo opens the window. Cell 94: 281-284.
10. Grise F, Bidaud A (2009) Moreau V. Rho GTPases in hepatocellular carcinoma. Biochim Biophys Acta 1795: 137-151.
11. Shi J, Wu X, Surma M, Vemula S, Zhang L, et al. (2013) Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment. Cell Death Dis 4: 483
12. Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
13. Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, et al. (2011) mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways. Cancer Res 71: 3246-3256.
14. Lee J, Moon HJ, Lee JM, Joo CK (2010) Smad3 Regulates Rho Signaling via NET1 in the Transforming Growth Factor-b-induced Epithelial-Mesenchymal Transition of Human Retinal Pigment Epithelial Cells. J Biol Chem 285: 26618-26627.
15. Hendrix MJ, Seftor EA, Meltzer PS, Gardner LM, Hess AR, et al. (2001) Expression and functional significance of VE-cadherin in aggressive human melanoma cells: role in vasculogenic mimicry. Proc Nat Acad Sci USA 98: 8018-8023.
16. Seftor RE, Seftor EA, Koshikawa N, Meltzer PS, Gardner LM, et al. (2001) Cooperative Interactions of Laminin 5γ2 Chain, Matrix Metalloproteinase-2, and Membrane Type-1-Matrix/Metalloproteinase Are Required for Mimicry of Embryonic Vasculogenesis by Aggressive Melanoma. Cancer Res 61: 6322-6327.
17. Paulis YW, Soetekouw PM, Verheul HM, Tjan-Heijnen VC, Griffioen AW (2010) Signalling pathways in vasculogenic mimicry. Biochim Biophys Acta 1806: 18-28.
18. Vega FM, Ridley AJ (2008) Rho GTPases in cancer cell biology. FEBS Lett 582: 2093-2101
19. Wheeler AP, Ridley AJ (2004) Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res 301: 43-49
20. Hendrix MJ, Seftor EA, Hess AR, Seftor RE (2003) Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma. Nat Rev Cancer 3: 411-421.
21. Sun B, Qie S, Zhang S, Sun T, Zhao X, et al. (2008) Role and mechanism of vasculogenic mimicry in gastrointestinal stromal tumors. Hum Pathol 39: 444-451.
22. Noma K, Kihara Y, Higashi Y (2012) Striking crosstalk of ROCK signaling with endothelial function. J Cardiol 60: 1-6.
23. Lin MT, Lin BR, Chang CC, Chu CY, Su HJ, et al. (2007) IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/ROCK signaling pathway. Int J Cancer 120: 2600-2608.
24. Sun HW, Tong SL, He J, Wang Q, Zou L, et al. (2007) RhoA and RhoC - siRNA inhibit the proliferation and invasiveness activity of human gastric carcinoma by Rho/PI3K/Akt pathway. World J Gastroenterol 13: 3517-3522.
25. Nunes KP, Rigsby CS, Webb RC (2010) RhoA/Rho-kinase and vascular diseases: what is the link? Cell Mol Life Sci 67: 3823-3836.
26. Riento K, Totty N, Villalonga P, Garg R, Guasch R, et al. (2005) RhoE function is regulated by ROCK I-mediated phosphorylation. EMBO J 24: 1170-1180.
27. Komander D, Garg R, Wan PT, Ridley AJ, Barford D (2008) Mechanism of multi-site phosphorylation from a ROCK-I: RhoE complex structure. EMBO J 27: 3175-3185.
28. Carton I, Trouet D, Hermans D, Barth H, Aktories K, et al. (2002) RhoA exerts a permissive effect on volume-regulated anion channels in vascular endothelial cells. Am J Physiol Cell Physiol 283: C115-125.
29. Leung T, Chen XQ, Manser E, Lim L (1996) The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol 16: 5313-5327.
30. Shi J, Wei L (2013) Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil. J Cardiovasc Pharmacol 62: 341-354.
31. Zhao Xl, Sun T, Che N, Sun D, Zhao N, et al. (2011) Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal transition regulator Twist1. J Cell Mol Med 15: 691-700.
32. Wang JY, Sun T, Zhao XL, Zhang SW, Zhang DF, et al. (2008) Functional significance of VEGF-a in human ovarian carcinoma: role in vasculogenic mimicry. Cancer Biol Ther 7: 758-766.
33. Sun H, Breslin JW, Zhu J, Yuan SY, Wu MH (2006) Rho and ROCK Signaling in VEGF-Induced Microvascular Endothelial Hyperpermeability. Microcirculation 13: 237-247.
34. Chang C, Werb Z (2001) The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol 11: S37-43.
35. Xu B, Nakhla S, Makris A, Hennessy A (2011) TNF-α inhibits trophoblast integration into endothelial cellular networks. Placenta 32: 241-246.
36. Koga T, Koga T, Awai M, Tsutsui J, Yue BY, et al. (2006) Rho-associated protein kinase inhibitor, Y-27632, induces alterations in adhesion, contraction and motility in cultured human trabecular meshwork cells. Exp Eye Res 82: 362-370.
37. Bryan BA, Dennstedt E, Mitchell DC, Walshe TE, Noma K, et al. (2010) RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis. FASEB J 24: 3186-3195.
38. Vega FM, Fruhwirth G, Ng T, Ridley AJ (2011) RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. J Cell Biol 193: 655-665.
39. Narumiya S, Tanji M, Ishizaki T (2009) Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev 28: 65-76.
40. Lirdprapamongkol K, Kramb JP, Suthiphongchai T, Surarit R, Srisomsap C, et al. (2009) Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo. J Agric Food Chem 57: 3055-3063.