메뉴 건너뛰기




Volumn 99, Issue 9, 2014, Pages 3070-3079

Effect of odanacatib on BMD and fractures: Estimates from bayesian univariate and bivariate meta-analyses

Author keywords

[No Author keywords available]

Indexed keywords

ODANACATIB; PLACEBO; BIPHENYL DERIVATIVE; CATHEPSIN K; CTSK PROTEIN, HUMAN;

EID: 84907201179     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-1162     Document Type: Review
Times cited : (7)

References (62)
  • 1
    • 80051471238 scopus 로고    scopus 로고
    • Cathepsin k: Its skeletal actions and role as a therapeutic target in osteoporosis
    • Costa AG, Cusano NE, Silva BC, Cremers S, Bilezikian JP. Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis. Nat Rev Rheumatol. 2011; 7(8): 447-456.
    • (2011) Nat Rev Rheumatol. , vol.7 , Issue.8 , pp. 447-456
    • Costa, A.G.1    Cusano, N.E.2    Silva, B.C.3    Cremers, S.4    Bilezikian, J.P.5
  • 2
    • 84907199557 scopus 로고    scopus 로고
    • Phase 3 fracture trial of odanacatib for osteoporosis-baseline characteristics and study design
    • Accessed December 2, 2013
    • Papapoulos S, Bone H, Dempster D, et al. Phase 3 fracture trial of odanacatib for osteoporosis-baseline characteristics and study design. J Bone Miner Res. 2012; 27(suppl 1). http://www.asbmr.org/Meetings/AnnualMeeting/AbstractDetail.aspx?aid-8dbc5fc5-2225-4249-8504-d02bb8663d10. Accessed December 2, 2013.
    • (2012) J Bone Miner Res. , vol.27
    • Papapoulos, S.1    Bone, H.2    Dempster, D.3
  • 4
    • 77953510486 scopus 로고    scopus 로고
    • Odanacatib, a cathepsin-k inhibitor for osteoporosis: A two-year study in postmenopausal women with low bone density
    • Bone HG, McClung MR, Roux C, et al. Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density. J Bone Miner Res. 2010; 25(5): 937-947.
    • (2010) J Bone Miner Res. , vol.25 , Issue.5 , pp. 937-947
    • Bone, H.G.1    McClung, M.R.2    Roux, C.3
  • 5
    • 84904703653 scopus 로고    scopus 로고
    • Effects of odanacatib on the radius and tibia of postmenopausal women: Improvements in bone geometry, microarchitecture and estimated bone strength [published online february 12, 2014]
    • Cheung AM, Majumdar S, Brixen K, et al. Effects of odanacatib on the radius and tibia of postmenopausal women: improvements in bone geometry, microarchitecture and estimated bone strength [published online February 12, 2014]. J Bone Miner Res. doi: 10.1002/jbmr.2194.
    • J Bone Miner Res
    • Cheung, A.M.1    Majumdar, S.2    Brixen, K.3
  • 6
    • 84889847492 scopus 로고    scopus 로고
    • Effects of odanacatib on bmdand safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate: A randomized placebocontrolled trial
    • Bonnick S, De Villiers T, Odio A, et al. Effects of odanacatib on BMDand safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate: a randomized placebocontrolled trial. J Clin Endocrinol Metab. 2013; 98(12): 4727-4735.
    • (2013) J Clin Endocrinol Metab. , vol.98 , Issue.12 , pp. 4727-4735
    • Bonnick, S.1    De Villiers, T.2    Odio, A.3
  • 7
    • 84891839676 scopus 로고    scopus 로고
    • Effect of the cathepsin k inhibitor odanacatib administered once weekly on bone mineral density in japanese patients with osteoporosis-A double-blind, randomized, dose-finding study
    • Nakamura T, Shiraki M, Fukunaga M, et al. Effect of the cathepsin K inhibitor odanacatib administered once weekly on bone mineral density in Japanese patients with osteoporosis-A double-blind, randomized, dose-finding study. Osteoporos Int. 2014; 25(1): 367-376.
    • (2014) Osteoporos Int. , vol.25 , Issue.1 , pp. 367-376
    • Nakamura, T.1    Shiraki, M.2    Fukunaga, M.3
  • 8
    • 84873684246 scopus 로고    scopus 로고
    • Bone density, turnover, and estimated strength in postmenopausal women treated with odanacatib: A randomized trial
    • Brixen K, Chapurlat R, Cheung AM, et al. Bone density, turnover, and estimated strength in postmenopausal women treated with odanacatib: a randomized trial. J Clin Endocrinol Metab. 2013; 98: 571-580.
    • (2013) J Clin Endocrinol Metab. , vol.98 , pp. 571-580
    • Brixen, K.1    Chapurlat, R.2    Cheung, A.M.3
  • 9
    • 78049522060 scopus 로고    scopus 로고
    • Odanacatib in the treatment of postmenopausal women with low bone mineral density: Threeyear continued therapy and resolution of effect
    • Eisman JA, BoneHG,Hosking DJ, et al. Odanacatib in the treatment of postmenopausal women with low bone mineral density: threeyear continued therapy and resolution of effect. J Bone Miner Res. 2011; 26(2): 242-251.
    • (2011) J Bone Miner Res. , vol.26 , Issue.2 , pp. 242-251
    • Eisman, J.A.1    Bone, H.G.2    Hosking, D.J.3
  • 10
    • 84867526082 scopus 로고    scopus 로고
    • Odanacatib in the treatment of postmenopausalwomenwith low bone mineral density: Five years of continued therapy in a phase 2 study
    • Langdahl B, Binkley N, Bone H, et al. Odanacatib in the treatment of postmenopausalwomenwith low bone mineral density: five years of continued therapy in a phase 2 study. J Bone Miner Res. 2012; 27: 2251-2258.
    • (2012) J Bone Miner Res. , vol.27 , pp. 2251-2258
    • Langdahl, B.1    Binkley, N.2    Bone, H.3
  • 13
    • 0037186429 scopus 로고    scopus 로고
    • Advanced methods in meta-Analysis: Multivariate approach and meta-regression
    • van Houwelingen HC, Arends LR, Stijnen T. Advanced methods in meta-Analysis: multivariate approach and meta-regression. Stat Med. 2002; 21: 589-624.
    • (2002) Stat Med. , vol.21 , pp. 589-624
    • Van Houwelingen, H.C.1    Arends, L.R.2    Stijnen, T.3
  • 14
    • 33846216340 scopus 로고    scopus 로고
    • An evaluation of bivariate random-effects meta-Analysis for the joint synthesis of two correlated outcomes
    • Riley RD, Abrams KR, Lambert PC, Sutton AJ, Thompson JR. An evaluation of bivariate random-effects meta-Analysis for the joint synthesis of two correlated outcomes. Stat Med. 2007; 26: 78-97.
    • (2007) Stat Med. , vol.26 , pp. 78-97
    • Riley, R.D.1    Abrams, K.R.2    Lambert, P.C.3    Sutton, A.J.4    Thompson, J.R.5
  • 15
    • 80051781370 scopus 로고    scopus 로고
    • Multivariate meta-Analysis: Potential and promise
    • Jackson D, Riley R, White IR. Multivariate meta-Analysis: potential and promise. Stat Med. 2011; 30: 2481-2498.
    • (2011) Stat Med. , vol.30 , pp. 2481-2498
    • Jackson, D.1    Riley, R.2    White, I.R.3
  • 20
    • 70349508931 scopus 로고    scopus 로고
    • Multivariate meta-Analysis: The effect of ignoring withinstudy correlation
    • Riley RD. Multivariate meta-Analysis: the effect of ignoring withinstudy correlation. J R Stat Soc Ser A Stat Soc. 2009; 172: 789-811.
    • (2009) J R Stat Soc Ser A Stat Soc. , vol.172 , pp. 789-811
    • Riley, R.D.1
  • 21
    • 84875731412 scopus 로고    scopus 로고
    • The choice of a noninformative prior on between-study variance strongly affects predictions of future treatment effect
    • Gajic-Veljanoski O, Cheung AM, Bayoumi AM, Tomlinson G. The choice of a noninformative prior on between-study variance strongly affects predictions of future treatment effect. Med Decis Making. 2013; 33: 356-368.
    • (2013) Med Decis Making. , vol.33 , pp. 356-368
    • Gajic-Veljanoski, O.1    Cheung, A.M.2    Bayoumi, A.M.3    Tomlinson, G.4
  • 23
    • 67650348228 scopus 로고    scopus 로고
    • Metaanalysis of diagnostic test studies using individual patient data and aggregate data
    • Riley RD, Dodd SR, Craig JV, Thompson JR, Williamson PR. Metaanalysis of diagnostic test studies using individual patient data and aggregate data. Stat Med. 2008; 27: 6111-6136.
    • (2008) Stat Med. , vol.27 , pp. 6111-6136
    • Riley, R.D.1    Dodd, S.R.2    Craig, J.V.3    Thompson, J.R.4    Williamson, P.R.5
  • 25
    • 0006407254 scopus 로고    scopus 로고
    • Winbugs -A bayesian modelling framework: Concepts, structure, and extensibility
    • Lunn DJ, Thomas A, Best N, Spiegelhalter D.WinBUGS -A Bayesian modelling framework: concepts, structure, and extensibility. Stat Comput. 2000; 10: 325-337.
    • (2000) Stat Comput. , vol.10 , pp. 325-337
    • Lunn, D.J.1    Thomas, A.2    Best, N.3    Spiegelhalter, D.4
  • 27
    • 41149087694 scopus 로고    scopus 로고
    • Coda: Convergence diagnosis and output analysis for mcmc
    • Plummer M, Best N, Cowles K, Vines K. CODA: convergence diagnosis and output analysis for MCMC. R News. 2006; 6(1): 7-11.
    • (2006) R News. , vol.6 , Issue.1 , pp. 7-11
    • Plummer, M.1    Best, N.2    Cowles, K.3    Vines, K.4
  • 28
    • 0032273615 scopus 로고    scopus 로고
    • General methods for monitoring convergence of iterative simulations
    • Brooks S, Gelman A. General methods for monitoring convergence of iterative simulations. J Comput Graph Stat. 1998; 7: 434-455.
    • (1998) J Comput Graph Stat. , vol.7 , pp. 434-455
    • Brooks, S.1    Gelman, A.2
  • 29
    • 84907209857 scopus 로고    scopus 로고
    • Effects of odanacatib on the distal radius and tibia in postmenopausal women: Improvements in cortical geometry and estimated bone strength
    • Accessed December 2, 2013
    • De Papp AE, Cheung A, Majumdar S, et al. Effects of odanacatib on the distal radius and tibia in postmenopausal women: improvements in cortical geometry and estimated bone strength. J Bone Miner Res. 2012; 27(suppl 1). http://www.asbmr.org/Meetings/AnnualMeeting/AbstractDetail.aspx?aid-1e016235-b279-4685-Ab67-0b176c840cbd. Accessed December 2, 2013.
    • (2012) J Bone Miner Res. , vol.27
    • De Papp, A.E.1    Cheung, A.2    Majumdar, S.3
  • 30
    • 84907199556 scopus 로고    scopus 로고
    • Odanacatib improved estimated femoral strength in postmenopausal women. Results of a 2-year placebo-controlled trial
    • Accessed December 2, 2013
    • Keaveny T, Brixen K, Chapurlat R, et al. Odanacatib improved estimated femoral strength in postmenopausal women. Results of a 2-year placebo-controlled trial. J Bone Miner Res. 2012; 27(suppl 1). http://www.asbmr.org/Meetings/AnnualMeeting/AbstractDetail.aspx?aid-40c6b422-7703-49b8-Ad03-63ae4cbf4722. Accessed December 2, 2013.
    • (2012) J Bone Miner Res. , vol.27
    • Keaveny, T.1    Brixen, K.2    Chapurlat, R.3
  • 31
    • 84907199555 scopus 로고    scopus 로고
    • The results of a double-blind, randomized, phase 2 dose-finding study of odanacatib, a potent cathepsin-k inhibitor, in japanese patients with osteoporosis with a modelbased pharmacokinetic (pk) analysis
    • Accessed December 2, 2013
    • Uchida S, Shiraki M, Fukunaga M, et al. The results of a double-blind, randomized, phase 2 dose-finding study of odanacatib, a potent cathepsin-K inhibitor, in Japanese patients with osteoporosis with a modelbased pharmacokinetic (PK) analysis. J Bone Miner Res. 2012; 27(suppl 1). http://www.asbmr.org/Meetings/AnnualMeeting/AbstractDetail.aspx?aid-42973cf1-376a-4fc7-9629-d489950434de. Accessed December 2, 2013.
    • (2012) J Bone Miner Res. , vol.27
    • Uchida, S.1    Shiraki, M.2    Fukunaga, M.3
  • 32
    • 84907189117 scopus 로고    scopus 로고
    • Femur qct analysis using miaf in postmenopausal women treated with odanacatib-results of a 2-year placebo-controlled trial
    • Accessed December 2, 2013
    • Engelke K, Fuerst T, Dardzinski B, et al. Femur QCT analysis using MIAF in postmenopausal women treated with odanacatib-results of a 2-year placebo-controlled trial. J Bone Miner Res. 2012; 27(suppl 1). http://www.asbmr.org/Meetings/AnnualMeeting/AbstractDetail.aspx? aid-f0d72632-5a5f-48e5-8c31-102cb0a451b7. Accessed December 2, 2013.
    • (2012) J Bone Miner Res. , vol.27
    • Engelke, K.1    Fuerst, T.2    Dardzinski, B.3
  • 33
    • 84907220007 scopus 로고    scopus 로고
    • Effects of odanacatib on bmd and overall safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate
    • Accessed December 2, 2013
    • De Villiers T, Bonnick S, Odio A, et al. Effects of odanacatib on BMD and overall safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate. J Bone Miner Res. 2012; 27(suppl 1). http://www.asbmr.org/Meetings/AnnualMeeting/AbstractDetail.aspx?aid-7cac73ab-A522-4500-8554-552e73bb7944. Accessed December 2, 2013.
    • (2012) J Bone Miner Res. , vol.27
    • De Villiers, T.1    Bonnick, S.2    Odio, A.3
  • 34
    • 67651180563 scopus 로고    scopus 로고
    • Effect of the cathepsin k inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: Two double-blind, randomized, placebo-controlled phase i studies
    • Stoch SA, Zajic S, Stone J, et al. Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: Two double-blind, randomized, placebo-controlled phase I studies. Clin Pharmacol Ther. 2009; 86(2): 175-182.
    • (2009) Clin Pharmacol Ther. , vol.86 , Issue.2 , pp. 175-182
    • Stoch, S.A.1    Zajic, S.2    Stone, J.3
  • 35
    • 84907227011 scopus 로고    scopus 로고
    • Odanacatib in the treatment of postmenopausal women with low bone mineral density: 3-year continued therapy and resolution of effect
    • McClung MR, Eisman JA, Bone HG, et al. Odanacatib in the treatment of postmenopausal women with low bone mineral density: 3-year continued therapy and resolution of effect. J Clin Densitom. 2010; 13(1): 133.
    • (2010) J Clin Densitom. , vol.13 , Issue.1 , pp. 133
    • McClung, M.R.1    Eisman, J.A.2    Bone, H.G.3
  • 36
    • 79952278967 scopus 로고    scopus 로고
    • The cathepsin k inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: Results of a 4-week, double-blind, randomized, controlled trial
    • Jensen AB, Wynne C, Ramirez G, et al. The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: results of a 4-week, double-blind, randomized, controlled trial. Clin Breast Cancer. 2010; 10(6): 452-458.
    • (2010) Clin Breast Cancer. , vol.10 , Issue.6 , pp. 452-458
    • Jensen, A.B.1    Wynne, C.2    Ramirez, G.3
  • 37
    • 84907198053 scopus 로고    scopus 로고
    • Effect of odanacatib on bone density and bone turnover markers in postmenopausal women with low bone mineral density: Year 4 results
    • Eisman JA, Binkley N, Bone H, et al. Effect of odanacatib on bone density and bone turnover markers in postmenopausal women with low bone mineral density: year 4 results. Osteoporos Int. 2011; 22(suppl 4): S526.
    • (2011) Osteoporos Int. , vol.22 , pp. S526
    • Eisman, J.A.1    Binkley, N.2    Bone, H.3
  • 38
    • 84907226967 scopus 로고    scopus 로고
    • Treatment with the cathepsin k inhibitor odanacatib in postmenopausal women with low bmd: 5 year results of a phase 2 trial
    • Denker A, Binkley N, Bone H, et al. Treatment with the cathepsin K inhibitor odanacatib in postmenopausal women with low BMD: 5 year results of a phase 2 trial. Menopause. 2011; 18(12): 1344.
    • (2011) Menopause. , vol.18 , Issue.12 , pp. 1344
    • Denker, A.1    Binkley, N.2    Bone, H.3
  • 39
    • 84907227482 scopus 로고    scopus 로고
    • Four-year results of a phase 2 study of the cathepsin k inhibitor odanacatib in postmenopausal women with low bone mineral density: Effects on bone mineral density and bone turnover markers
    • Miller P, Binkley N, Bone H, et al. Four-year results of a phase 2 study of the cathepsin K inhibitor odanacatib in postmenopausal women with low bone mineral density: Effects on bone mineral density and bone turnover markers. Osteoporos Int. 2011; 22(Suppl 2): S426.
    • (2011) Osteoporos Int. , vol.22 , pp. S426
    • Miller, P.1    Binkley, N.2    Bone, H.3
  • 40
    • 84907189453 scopus 로고    scopus 로고
    • Treatment with the cathepsin k inhibitor odanacatib in postmenopausal women with low bmd: 5-year results of a phase 2 trial
    • Badsha H, Binkley N, Bone H, et al. Treatment with the cathepsin K inhibitor odanacatib in postmenopausal women with low BMD: 5-year results of a phase 2 trial. Osteoporos Int. 2011; 22(suppl 5): S691.
    • (2011) Osteoporos Int. , vol.22 , pp. S691
    • Badsha, H.1    Binkley, N.2    Bone, H.3
  • 41
    • 84907220457 scopus 로고    scopus 로고
    • Treatment with the cathepsin k inhibitor odanacatib in postmenopausal women with low bmd: 5 year results of a phase 2 trial
    • Binkley N, Bone H, Gilchrist N, et al. Treatment with the cathepsin K inhibitor odanacatib in postmenopausal women with low BMD: 5 year results of a phase 2 trial. Int Med J. 2012; 42(suppl 1): 28.
    • (2012) Int Med J. , vol.42 , pp. 28
    • Binkley, N.1    Bone, H.2    Gilchrist, N.3
  • 42
    • 84907219541 scopus 로고    scopus 로고
    • Bmdresponse in the odanacatib phase 2 trial: Prespecified threshold and subgroup analyses
    • 03-MeetingAbstracts
    • McClung M, Binkley N, Bone H, et al.BMDresponse in the odanacatib phase 2 trial: prespecified threshold and subgroup analyses. Endocr Rev. 2012; 33 (03-MeetingAbstracts): OR08-2.
    • (2012) Endocr Rev. , vol.33 , pp. OR08-OR12
    • McClung, M.1    Binkley, N.2    Bone, H.3
  • 43
    • 84907188952 scopus 로고    scopus 로고
    • A double-blind, randomized, dose-finding, phase 2 study of odanacatib, a potent cathepsin-k inhibitor, in japanese patients with osteoporosis
    • Nakamura T, Shiraki M, Fukunaga M, et al. A double-blind, randomized, dose-finding, phase 2 study of odanacatib, a potent cathepsin-K inhibitor, in Japanese patients with osteoporosis. Osteoporos Int. 2012; 23(Suppl 2): S237.
    • (2012) Osteoporos Int. , vol.23 , pp. S237
    • Nakamura, T.1    Shiraki, M.2    Fukunaga, M.3
  • 44
    • 84887481849 scopus 로고    scopus 로고
    • Imaging and finite element analysis of the spine and hip following 2 years of treatment with odanacatib in postmenopausal women
    • Brixen K, Chapurlat R, Cheung AM, et al. Imaging and finite element analysis of the spine and hip following 2 years of treatment with odanacatib in postmenopausal women. Osteoporos Int. 2012; 23(Suppl 2): S62.
    • (2012) Osteoporos Int. , vol.23 , pp. S62
    • Brixen, K.1    Chapurlat, R.2    Cheung, A.M.3
  • 45
    • 84907215570 scopus 로고    scopus 로고
    • Treatment with the cathepsin k inhibitor odanacatib in postmenopausal women with low bmd: 5 year results of a phase 2 trial
    • Resch H, Binkley N, Bone H, et al. Treatment with the cathepsin K inhibitor odanacatib in postmenopausal women with low BMD: 5 year results of a phase 2 trial. Osteoporos Int. 2012; 23(Suppl 2): S61.
    • (2012) Osteoporos Int. , vol.23 , pp. S61
    • Resch, H.1    Binkley, N.2    Bone, H.3
  • 46
    • 84875295907 scopus 로고    scopus 로고
    • Odanacatib, a selective cathepsin k inhibitor to treat osteoporosis: Safety, tolerability, pharmacokinetics and pharmacodynamics-results from single oral dose studies in healthy volunteers
    • Stoch SA, Zajic S, Stone JA, et al. Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: Safety, tolerability, pharmacokinetics and pharmacodynamics-results from single oral dose studies in healthy volunteers. Br J Clin Pharmacol. 2013; 75(5): 1240-1254.
    • (2013) Br J Clin Pharmacol. , vol.75 , Issue.5 , pp. 1240-1254
    • Stoch, S.A.1    Zajic, S.2    Stone, J.A.3
  • 47
    • 84907223530 scopus 로고    scopus 로고
    • Effects of odanacatib on bmd and overall safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate
    • Smith E, Chapurlat R, Bonnick S, et al. Effects of odanacatib on BMD and overall safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate. Int Med J. 2013; 43(suppl 2): 29.
    • (2013) Int Med J. , vol.43 , pp. 29
    • Smith, E.1    Chapurlat, R.2    Bonnick, S.3
  • 48
    • 84907208011 scopus 로고    scopus 로고
    • Effect of odanacatib on bone density and bone turnover markers in postmenopausal women with low bone mineral density: Year 4 results
    • Leung A, Petrovic R, DaSilva C, Rosenberg E, Santora A, Lombardi A. Effect of odanacatib on bone density and bone turnover markers in postmenopausal women with low bone mineral density: Year 4 results. Reumatol Clin. 2011; 7 (Suppl 1): 170.
    • (2011) Reumatol Clin. , vol.7 , pp. 170
    • Leung, A.1    Petrovic, R.2    DaSilva, C.3    Rosenberg, E.4    Santora, A.5    Lombardi, A.6
  • 49
    • 84907187573 scopus 로고    scopus 로고
    • Treatment with the cathepsin k inhibitor odanacatib in postmenopausal women with low bmd: 5 year results of a phase 2 trial
    • Miller P, Binkley N, Bone H, et al. Treatment with the cathepsin K inhibitor odanacatib in postmenopausal women with low BMD: 5 year results of a phase 2 trial. Osteoporos Int. 2012; 23(Suppl 3): S456.
    • (2012) Osteoporos Int. , vol.23 , pp. S456
    • Miller, P.1    Binkley, N.2    Bone, H.3
  • 50
    • 84907207537 scopus 로고    scopus 로고
    • Effects of odanacatib on bmd and overall safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate
    • Chapurlat R, Bonnick S, De Villiers T, et al. Effects of odanacatib on BMD and overall safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate. Arthritis Rheum. 2012; 64(10): S312.
    • (2012) Arthritis Rheum. , vol.64 , Issue.10 , pp. S312
    • Chapurlat, R.1    Bonnick, S.2    De Villiers, T.3
  • 51
    • 84893275877 scopus 로고    scopus 로고
    • Effects of odanacatib on the distal radius and tibia in postmenopausal women: Improvements in cortical geometry and estimated bone strength
    • Chapurlat R, Brixen K, Cheung AM, et al. Effects of odanacatib on the distal radius and tibia in postmenopausal women: Improvements in cortical geometry and estimated bone strength. Arthritis Rheum. 2012; 64(10): S844.
    • (2012) Arthritis Rheum. , vol.64 , Issue.10 , pp. S844
    • Chapurlat, R.1    Brixen, K.2    Cheung, A.M.3
  • 52
    • 84907220006 scopus 로고    scopus 로고
    • Safety pharmacokinetics and pharmacodynamics (bone turnover) of odanacatib: Two double-blind randomized placebo-controlled phase i studies in japanese men and postmenopausal women
    • March 5-9; Indianapolis, IN
    • Uemura N, Willmer JP, Nakamichi N, et al. Safety, pharmacokinetics and pharmacodynamics (bone turnover) of odanacatib: two double-blind, randomized, placebo-controlled phase I studies in Japanese men and postmenopausal women. In: Proceedings from the American Society for Clinical Pharmacology and Therapeutics; March 5-9, 2013; Indianapolis, IN. Abstract S88.
    • (2013) Proceedings from the American Society for Clinical Pharmacology and Therapeutics
    • Uemura, N.1    Willmer, J.P.2    Nakamichi, N.3
  • 53
    • 0036677983 scopus 로고    scopus 로고
    • Meta-Analyses of therapies for postmenopausal osteoporosis. Ii. Meta-Analysis of alendronate for the treatment of postmenopausal women
    • Cranney A, Wells G, Willan A, et al. Meta-Analyses of therapies for postmenopausal osteoporosis. II. Meta-Analysis of alendronate for the treatment of postmenopausal women. Endocr Rev. 2002; 23: 508-516.
    • (2002) Endocr Rev. , vol.23 , pp. 508-516
    • Cranney, A.1    Wells, G.2    Willan, A.3
  • 54
    • 0036678488 scopus 로고    scopus 로고
    • Meta-Analyses of therapies for postmenopausal osteoporosis. Iii. Meta-Analysis of risedronate for the treatment of postmenopausal osteoporosis
    • Cranney A, Tugwell P, Adachi J, et al. Meta-Analyses of therapies for postmenopausal osteoporosis. III. Meta-Analysis of risedronate for the treatment of postmenopausal osteoporosis. Endocr Rev. 2002; 23: 517-523.
    • (2002) Endocr Rev. , vol.23 , pp. 517-523
    • Cranney, A.1    Tugwell, P.2    Adachi, J.3
  • 55
    • 34247866550 scopus 로고    scopus 로고
    • Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis
    • Black DM, Delmas PD, Eastell R, et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis.NEngl J Med. 2007; 356: 1809-1822.
    • (2007) NEngl J Med. , vol.356 , pp. 1809-1822
    • Black, D.M.1    Delmas, P.D.2    Eastell, R.3
  • 56
    • 80053196423 scopus 로고    scopus 로고
    • Effects of antiresorptive treatment on nonvertebral fracture outcomes
    • Mackey DC, Black DM, Bauer DC, et al. Effects of antiresorptive treatment on nonvertebral fracture outcomes. J Bone Miner Res. 2011; 26: 2411-2418.
    • (2011) J Bone Miner Res. , vol.26 , pp. 2411-2418
    • Mackey, D.C.1    Black, D.M.2    Bauer, D.C.3
  • 57
    • 78751701571 scopus 로고    scopus 로고
    • The efficacy of bisphosphonates in the prevention of vertebral, hip, and nonvertebralnonhip fractures in osteoporosis: A network meta-Analysis
    • e1-e2
    • Jansen JP, Bergman GJ, Huels J, Olson M. The efficacy of bisphosphonates in the prevention of vertebral, hip, and nonvertebralnonhip fractures in osteoporosis: a network meta-Analysis. Semin Arthritis Rheum. 2011; 40: 275-284.e1-e2.
    • (2011) Semin Arthritis Rheum. , vol.40 , pp. 275-284
    • Jansen, J.P.1    Bergman, G.J.2    Huels, J.3    Olson, M.4
  • 58
    • 84886847538 scopus 로고    scopus 로고
    • The search for the optimal anabolic osteoporosis therapy
    • Black DM, Schafer AL. The search for the optimal anabolic osteoporosis therapy. J Bone Miner Res. 2013; 28: 2263-2265.
    • (2013) J Bone Miner Res. , vol.28 , pp. 2263-2265
    • Black, D.M.1    Schafer, A.L.2
  • 59
    • 84871692621 scopus 로고    scopus 로고
    • Potential role of odanacatib in the treatment of osteoporosis
    • Ng KW. Potential role of odanacatib in the treatment of osteoporosis. Clin Interv Aging. 2012; 7: 235-247.
    • (2012) Clin Interv Aging. , vol.7 , pp. 235-247
    • Ng, K.W.1
  • 60
    • 84857314155 scopus 로고    scopus 로고
    • Odanacatib: Location and timing are everything
    • Khosla S. Odanacatib: location and timing are everything. J Bone Miner Res. 2012; 27: 506-508.
    • (2012) J Bone Miner Res. , vol.27 , pp. 506-508
    • Khosla, S.1
  • 61
    • 84907207701 scopus 로고    scopus 로고
    • Imaging and finite element analysis of the spine, hip, radius, and tibia following 2 years of treatment with odanacatib in postmenopausal women
    • Cheung AM, Brixen K, Chapurlat R, Keaveny T, Majumdar S, De Papp A. Imaging and finite element analysis of the spine, hip, radius, and tibia following 2 years of treatment with odanacatib in postmenopausal women. J Clin Densitom. 2013; 16(3): 263.
    • (2013) J Clin Densitom. , vol.16 , Issue.3 , pp. 263
    • Cheung, A.M.1    Brixen, K.2    Chapurlat, R.3    Keaveny, T.4    Majumdar, S.5    De Papp, A.6
  • 62
    • 84907209856 scopus 로고    scopus 로고
    • Whitehouse Station, NJ: Merck & Co, Inc. Published July 11, 2012. Accessed December 2
    • Update on phase III trial for odanacatib, Merck's investigational Cat-K inhibitor for osteoporosis. http://www.mercknewsroom.com/pressrelease/research-development-news/update-phase-iii-Trial-odanacatibmercks-investigational-cat. Whitehouse Station, NJ: Merck & Co, Inc. Published July 11, 2012. Accessed December 2, 2013.
    • (2013) Update on Phase III Trial for Odanacatib, Merck'S Investigational Cat-K Inhibitor for Osteoporosis.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.