Odanacatib: Location and timing are everything

Journal of Bone and Mineral Research

Volumn 27, Issue 3, 2012, Pages 506-508

  Khosla, Sundeep ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; ALKALINE PHOSPHATASE; AMINO TERMINAL TELOPEPTIDE; BIOLOGICAL MARKER; BISPHOSPHONIC ACID DERIVATIVE; BONE MORPHOGENETIC PROTEIN 6; CARBOXY TERMINAL TELOPEPTIDE; DENOSUMAB; EPHRIN B2; ODANACATIB; SPHINGOSINE 1 PHOSPHATE; WNT10B PROTEIN;

BONE MATRIX; CORTICAL BONE; DRUG EFFICACY; DRUG SAFETY; FEMUR; FEMUR NECK; HIP; HUMAN; ILIAC CREST; NONHUMAN; NOTE; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOPOROSIS; POSTMENOPAUSE OSTEOPOROSIS; SPINE; TRABECULAR BONE;

ANIMALS; BIPHENYL COMPOUNDS; BONE DENSITY CONSERVATION AGENTS; BONE REMODELING; FEMALE; HUMANS; LUMBAR VERTEBRAE; ORGAN SIZE; OVARIECTOMY;

EID: 84857314155     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1541     Document Type: Note

References (16)

1. Khosla S., Increasing options for the treatment of osteoporosis. N Engl J Med. 2009; 361: 818-20.
2. Masarachia PJ, Pennypacker BL, Pickarski M, Scott KR, Wesolowski GA, Smith SY, Samadfam R, Goetzmann JE, Scott BB, Kimmel DB, Duong LT., Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys. J Bone Miner Res. 2012; 27: 509-23.
3. Cusick T, Chen CM, Pennypacker BL, Pickarski M, Kimmel DB, Scott BB, Duong LT., Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey. J Bone Miner Res. 2012; 27: 524-37.
4. Costa AG, Cusano NE, Silva BC, Cremers S, Bilezikian JP., Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis. Nat Rev Rheumatol. 2011; 7: 447-56.
5. Weinstein RS, Roberson PK, Manolagas SC., Giant osteoclast formation and long-term oral bisphosphonate therapy. N Engl J Med. 2009; 360: 53-62.
6. Reid I, Miller P, Brown J, Kendler D, Fahrleitner-Pammer A, Valter I, Massalu K, Bolognese M, Woodson G, Bone H, Ding B, Wagman R, Martin JS, Ominsky M, Dempster D., Effects of denosumab on bone histomorphometry: the FREEDOM and STAND studies. J Bone Miner Res. 2010; 25: 2256-65.
7. Jerome C, Missbach M, Gamse R., Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Osteoporosis Int. 2011; 22: 3001-11.
8. Bone HG, McClung MR, Roux C, Recker RR, Eisman JA, Verbruggen N, Hustad CM, DaSilva C, Santora AC, Ince BA., Odanacatib, a cathespin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density. J Bone Miner Res. 2010; 25: 937-47.
9. Tang Y, Wu X, Lei W, Pang L, Wan C, Shi Z, Zhao L, Nagy TR, Peng X, Hu J, Feng X, Van Hul W, Cao X., TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med. 2009; 15: 757-65.
10. Baron R, Ferrari S, Russell RG., Denosumab and bisphosphonates: different mechanisms of action and effects. Bone. 2011; 48: 677-92.
11. Zhao C, Irie N, Takada Y, Shimoda K, Miyamoto T, Nishiwaki T, Suda T, Matsuo K., Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab. 2006; 4: 111-21.
12. Pederson L, Ruan M, Westendorf JJ, Khosla S, Oursler MJ., Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. Proc Natl Acad Sci USA. 2009; 105: 20764-9.
13. Balena R, Shih MS, Parfitt AM., Bone resorption and formation on the periosteal envelope of the ilium: a histomorphometric study in healthy women. J Bone Miner Res. 1992; 7: 1475-82.
14. Bliziotes M, Sibonga JD, Turner RT, Orwoll E., Periosteal remodeling at the femoral neck in nonhuman primates. J Bone Miner Res. 2006; 21: 1060-7.
15. Khosla S, Burr D, Cauley J, Dempster DW, Ebeling PR, Felsenberg D, Gagel RF, Gilsanz V, Guise T, Koka S, McCauley LK, McGowan J, McKee MD, Mohla S, Pendrys DG, Raisz LG, Ruggiero SL, Shafer DM, Shum L, Silverman SL, Van Poznak CH, Watts N, Woo SB, Shane E., Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2007; 22: 1479-91.
16. Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster D, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Sen HT, van der Meulen MC, Weinstein RS, Whyte M., Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2010; 25: 2267-94.