Combined measurement of synovial fluid a-defensin and C-reactive protein levels: Highly accurate for diagnosing periprosthetic joint infection

Journal of Bone and Joint Surgery - American Volume

Volumn 96, Issue 17, 2014, Pages 1439-1445

  Deirmengian, Carl ^a   Kardos, Keith ^b   Kilmartin, Patrick ^b   Cameron, Alexander ^b   Schiller, Kevin ^b   Parvizi, Javad ^a  

^a ROTHMAN INSTITUTE   (United States)

^b LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; ANTIBIOTIC AGENT; C REACTIVE PROTEIN; CHROMIUM; COBALT; BIOLOGICAL MARKER;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; C REACTIVE PROTEIN TEST KIT; COMORBIDITY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE CLASSIFICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEMALE; HUMAN; INFLAMMATORY DISEASE; INTERMETHOD COMPARISON; INTRAOPERATIVE PERIOD; JOINT ASPIRATION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEASUREMENT ACCURACY; METALLIC IMPLANT CORROSION; METALLOSIS; NEUTROPHIL; PERIPROSTHETIC JOINT INFECTION; PREOPERATIVE PERIOD; PROSPECTIVE STUDY; PROSTHESIS LOOSENING; PROTEIN BLOOD LEVEL; PSEUDOTUMOR; SENSITIVITY AND SPECIFICITY; SYNOVIAL FLUID LEVEL; VERY ELDERLY; AREA UNDER THE CURVE; CHEMISTRY; COHORT ANALYSIS; COMPARATIVE STUDY; CONFIDENCE INTERVAL; EVALUATION STUDY; HIP ARTHROPLASTY; INFECTION; KNEE ARTHROPLASTY; METHODOLOGY; MIDDLE AGED; RECEIVER OPERATING CHARACTERISTIC; SYNOVIAL FLUID;

ADULT; AGED; AGED, 80 AND OVER; ALPHA-DEFENSINS; AREA UNDER CURVE; ARTHROPLASTY, REPLACEMENT, HIP; ARTHROPLASTY, REPLACEMENT, KNEE; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; COHORT STUDIES; CONFIDENCE INTERVALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PROSTHESIS-RELATED INFECTIONS; ROC CURVE; SENSITIVITY AND SPECIFICITY; SYNOVIAL FLUID;

EID: 84907190258     PISSN: 00219355     EISSN: 15351386     Source Type: Journal    
DOI: 10.2106/JBJS.M.01316     Document Type: Article

References (21)

1. Barrack RL, Burnett RS, Sharkey P, Parvizi J. Diagnosing an infection: an unsolved problem. Orthopedics. 2007 Sep;30(9):777-8.
2. Della Valle CJ, Sporer SM, Jacobs JJ, Berger RA, Rosenberg AG, Paprosky WG. Preoperative testing for sepsis before revision total knee arthroplasty. J Arthroplasty. 2007 Sep; 22(6 Suppl 2):90-3. Epub 2007 Jul 26.
3. Ghanem E, Antoci V Jr, Pulido L, Joshi A, Hozack W, Parvizi J. The use of receiver operating characteristics analysis in determining erythrocyte sedimentation rate and C-reactive protein levels in diagnosing periprosthetic infection prior to revision total hip arthroplasty. Int J Infect Dis. 2009 Nov;13(6):e444-9. Epub 2009 May 27.
4. Ghanem E, Parvizi J, Burnett RS, Sharkey PF, Keshavarzi N, Aggarwal A, Barrack RL. Cell count and differential of aspirated fluid in the diagnosis of infection at the site of total knee arthroplasty. J Bone Joint Surg Am. 2008 Aug;90(8):1637-43.
5. Workgroup Convened by the Musculoskeletal Infection Society. New definition for periprosthetic joint infection. J Arthroplasty. 2011 Dec;26(8):1136-8.
6. Deirmengian C, Hallab N, Tarabishy A, Della Valle C, Jacobs JJ, Lonner J, Booth RE Jr. Synovial fluid biomarkers for periprosthetic infection. Clin Orthop Relat Res. 2010 Aug;468(8):2017-23.
7. Jacovides CL, Parvizi J, Adeli B, Jung KA. Molecular markers for diagnosis of periprosthetic joint infection. J Arthroplasty. 2011 Sep;26(6 Suppl):99-103.e1. Epub 2011 May 13.
8. Gollwitzer H, Dombrowski Y, Prodinger PM, Peric M, Summer B, Hapfelmeier A, Saldamli B, Pankow F, von Eisenhart-Rothe R, Imhoff AB, Schauber J, Thomas P, Burgkart R, Banke IJ. Antimicrobial peptides and proinflammatory cytokines in periprosthetic joint infection. J Bone Joint Surg Am. 2013 Apr 3;95(7):644-51.
9. Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI. Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest. 1985 Oct;76(4):1427-35.
10. Chalifour A, Jeannin P, Gauchat JF, Blaecke A, Malissard M, N'Guyen T, Thieblemont N, Delneste Y. Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production. Blood. 2004 Sep 15;104(6):1778-83. Epub 2004 May 27.
11. Di Cesare PE, Chang E, Preston CF, Liu CJ. Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty. J Bone Joint Surg Am. 2005 Sep;87(9):1921-7.
12. Schinsky MF, Della Valle CJ, Sporer SM, Paprosky WG. Perioperative testing for joint infection in patients undergoing revision total hip arthroplasty. J Bone Joint Surg Am. 2008 Sep;90(9):1869-75.
13. Bottner F, Wegner A, Winkelmann W, Becker K, Erren M, Götze C. Interleukin-6, procalcitonin and TNF-alpha: markers of peri-prosthetic infection following total joint replacement. J Bone Joint Surg Br. 2007 Jan;89(1):94-9.
14. Parvizi J, Jacovides C, Antoci V, Ghanem E. Diagnosis of periprosthetic joint infection: the utility of a simple yet unappreciated enzyme. J Bone Joint Surg Am. 2011 Dec 21;93(24):2242-8.
15. Austin MS, Ghanem E, Joshi A, Lindsay A, Parvizi J. A simple, cost-effective screening protocol to rule out periprosthetic infection. J Arthroplasty. 2008 Jan;23(1):65-8.
16. Berbari E, Mabry T, Tsaras G, Spangehl M, Erwin PJ, Murad MH, Steckelberg J, Osmon D. Inflammatory blood laboratory levels as markers of prosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am. 2010 Sep 1;92(11):2102-9.
17. Bozic KJ, Kurtz SM, Lau E, Ong K, Chiu V, Vail TP, Rubash HE, Berry DJ. The epidemiology of revision total knee arthroplasty in the United States. Clin Orthop Relat Res. 2010 Jan;468(1):45-51. Epub 2009 Jun 25.
18. Bozic KJ, Kurtz SM, Lau E, Ong K, Vail TP, Berry DJ. The epidemiology of revision total hip arthroplasty in the United States. J Bone Joint Surg Am. 2009 Jan;91(1):128-33.
19. Cats-Baril W, Gehrke T, Huff K, Kendoff D, Maltenfort M, Parvizi J. International consensus on periprosthetic joint infection: description of the consensus process. Clin Orthop Relat Res. 2013 Dec;471(12):4065-75. Epub 2013 Oct 24.
20. Gomez E, Cazanave C, Cunningham SA, Greenwood-Quaintance KE, Steckelberg JM, Uhl JR, Hanssen AD, Karau MJ, Schmidt SM, Osmon DR, Berbari EF, Mandrekar J, Patel R. Prosthetic joint infection diagnosis using broad-range PCR of biofilms dislodged from knee and hip arthroplasty surfaces using sonication. J Clin Microbiol. 2012 Nov;50(11):3501-8. Epub 2012 Aug 15.
21. Wetters NG, Berend KR, Lombardi AV, Morris MJ, Tucker TL, Della Valle CJ. Leukocyte esterase reagent strips for the rapid diagnosis of periprosthetic joint infection. J Arthroplasty. 2012 Sep;27(8 Suppl):8-11. Epub 2012 May 17.