Improved ataxia telangiectasia mutated kinase inhibitor KU60019 provides a promising treatment strategy for non-invasive breast cancer

Oncology Letters

Volumn 8, Issue 5, 2014, Pages 2043-2048

  Zhu, Ying ^a   Mao, Changfei ^a   Wu, Jianzhong ^a   Li, Shuchun ^b   Ma, Rong ^a   Cao, Haixia ^a   Ji, Minghua ^a   Jing, Changwen ^a   Tang, Jinhai ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANJING TECH UNIVERSITY   (China)

Author keywords

Ataxia telangiectasia mutated; Chemosensitivity; Doxorubicin; KU60019; P p53 (Ser15)

Indexed keywords

ATM PROTEIN; DOXORUBICIN; KU 60019; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; UVOMORULIN;

APOPTOSIS ASSAY; ARTICLE; BREAST CANCER; CARCINOMA IN SITU; CELL INVASION; CELL INVASION ASSAY; CELL MIGRATION ASSAY; CELL MOTILITY; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CHEMOSENSITIZATION; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFICACY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84907151689     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2444     Document Type: Article

References (22)

1. Jeng KS, Sheen IS, Jeng WJ, et al: High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma. Onco Targets Ther 7: 79-86,2013.
2. Binaschi M, Capranico G, Dal Bo L and Zunino F: Relationship between lethal effects and topoisomerase II-mediated double-stranded DNA breaks produced by anthracyclines with different sequence specificity. Mol Pharmacol 51: 1053-1059, 1997.
3. Violet JA and Harmer C: Breast cancer: improving outcome following adjuvant radiotherapy. Br J Radiol 77: 811-820, 2004.
4. Valerie K and Povirk LF: Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22: 5792-5812, 2003.
5. Lavin MF: Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat Rev Mol Cell Biol 9: 759-769, 2008.
6. Hickson I, Zhao Y, Richardson CJ, et al: Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res 64: 9152-9159, 2004.
7. Ramachandran S, Tran DD, Klebba-Faerber S, et al: An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. RNA 17: 1957-1966, 2011.
8. Helleday T, Petermann E, Lundin C, et al: DNA repair pathways as targets for cancer therapy. Nat Rev Cancer 8: 193-204, 2008.
9. Golding SE, Rosenberg E, Valerie N, et al: Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther 8: 2894-2902, 2009.
10. Saito S, Goodarzi AA, Higashimoto Y, et al: ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. J Biol Chem 277: 12491-12494, 2002.
11. Saito S, Yamaguchi H, Higashimoto Y, et al: Phosphorylation site interdependence of human p53 post-translational modifications in response to stress. J Biol Chem 278: 37536-37544, 2003.
12. Park BK, Zeng X and Glazer RI: Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells. Cancer Res 61: 7647-7653, 2001.
13. Kim D, Kim S, Koh H, et al: Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J 15: 1953-1962, 2001.
14. Tanno S, Tanno S, Mitsuuchi Y, et al: AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Res 61: 589-593, 2001.
15. Arboleda MJ, Lyons JF, Kabbinavar FF, et al: Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 63: 196-206, 2003.
16. Grille SJ, Bellacosa A, Upson J, et al: The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 63: 2172-2178, 2003.
17. Andjelković M, Alessi DR, Meier R, et al: Role of translocation in the activation and function of protein kinase B. J Biol Chem 272: 31515-31524, 1997.
18. Bellacosa A, Chan TO, Ahmed NN, et al: Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 17: 313-325, 1998.
19. Hazan RB, Phillips GR, Qiao RF, et al: Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol 148: 779-790, 2000.
20. Ciciarello M, Mangiacasale R, Casenghi M, et al p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle. J Biol Chem 276: 19205-19213, 2001.
21. Zhang T, Tan Y, Zhao R and Liu Z: DNA damage induced by oridonin involves cell cycle arrest at G2/M phase in human MCF-7 cells. Contemp Oncol (Pozn) 17: 38-44, 2013.
22. Abraham RT: Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15: 2177-2196, 2001.