Differential β-catenin expression levels are associated with morphological features and prognosis of colorectal cancer

Oncology Letters

Volumn 8, Issue 5, 2014, Pages 2069-2076

  Gao, Zhao Hua ^a,b,c   Lu, Chong ^a   Wang, Mei Xian ^a   Han, Yi ^b   Guo, Li Juan ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b Shenyang Red Cross Hospital   (China)

^c LIAONING CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Colorectal cancer; Epithelial mesenchymal transition; Invasive front; Tumor budding; catenin

Indexed keywords

BETA CATENIN;

ADULT; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CLINICAL FEATURE; COLORECTAL CANCER; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; QUESTIONNAIRE; TUMOR INVASION;

EID: 84907146707     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2433     Document Type: Article

References (25)

1. de Krijger I, Mekenkamp LJ, Punt CJ and Nagtegaal ID: MicroRNAs in colorectal cancer metastasis. J Pathol 224: 438-447, 2011.
2. Xu AG, Yu ZJ, Jiang B, et al: Colorectal cancer in Guangdong Province of China: a demographic and anatomic survey. World J Gastroenterol 16: 960-965, 2010.
3. Zlobec I and Lugli A: Invasive front of colorectal cancer: dynamic interface of pro-/anti-tumor factors. World J Gastroenterol 15: 5898-5906, 2009.
4. Natalwala A, Spychal R and Tselepis C: Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract. World J Gastroenterol 14: 3792-3797, 2008.
5. Brabletz T, Jung A, Hermann K, et al: Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 194: 701-704, 1998.
6. Guarino M, Rubino B and Ballabio G: The role of epithelial-mesenchymal transition in cancer pathology. Pathology 39: 305-318, 2007.
7. Sánchez-Tilló E, de Barrios O, Siles L, Cuatrecasas M, Castells A and Postigo A: Beta-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness. Proc Natl Acad Sci USA 108: 19204-19209, 2011.
8. Jang TJ: Expression of E-cadherin and β-catenin is altered at tumor budding sites, whose number is associated with the progression of colorectal carcinoma. Korean J Pathol 43: 523-527, 2009.
9. International Agency for Research on Cancer: World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system. IARC Press, Lyon, France, 2000.
10. Edge SBD and Compton C. AJCC Cancer Staging Manual. 7th edition. JAMA 304: 1726-1727, 2010.
11. Ru GQ, Wang HJ, Xu WJ and Zhao ZS: Upregulation of Twist in gastric carcinoma associated with tumor invasion and poor prognosis. Pathol Oncol Res 17: 341-347, 2011.
12. Sinicrope FA, Ruan SB, Cleary KR, et al: bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res 55: 237-241, 1995.
13. Zhu JL, Song YX, Wang ZN, et al: The clinical significance of mesenchyme forkhead 1 (FoxC2) in gastric carcinoma. Histopathology 62: 1038-1048, 2013
14. Boo YJ, Park JM, Kim J, et al: L1 expression as a marker for poor prognosis, tumor progression, and short survival in patients with colorectal cancer. Ann Surg Oncol 14: 1703-1711, 2007.
15. Baldus SE, Mönig SP, Huxel S, et al: MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis. Clin Cancer Res 10: 2790-2796, 2004.
16. Grünert S, Jechlinger M and Beug H: Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 4: 657-665, 2003.
17. Hugo H, Ackland ML, Blick T, et al: Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol 213: 374-383, 2007.
18. Conacci-Sorrell M, Simcha I, Ben-Yedidia T, et al: Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol 163: 847-857, 2003.
19. Gavert N and Ben-Ze'ev A: Epithelial-mesenchymal transition and the invasive potential of tumors. Trends Mol Med 14: 199-209, 2008.
20. Mårtensson A, Oberg A, Jung A, et al: Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer. Oncol Rep 17: 447-452, 2007.
21. Chen Z, He X, Jia M, et al: Beta-catenin overexpression in the nucleus predicts progress disease and unfavourable survival in colorectal cancer: a meta-analysis. PloS One 8: e63854, 2013.
22. Hörkkö TT, Klintrup K, Mäkinen JM, et al: Budding invasive margin and prognosis in colorectal cancer - no direct association with beta-catenin expression. Eur J Cancer 42: 964-971, 2006.
23. Roca F, Mauro LV, Morandi A, et al: Prognostic value of E-cadherin, beta-catenin, MMPs (7 and 9), and TIMPs (1 and 2) in patients with colorectal carcinoma. J Surg Oncol 93: 151-160, 2006.
24. Lee SJ, Choi SY, Kim WJ, et al: Combined aberrant expression of E-cadherin and S100A4, but not beta-catenin is associated with disease-free survival and overall survival in colorectal cancer patients. Diagn Pathol 8: 99, 2013.
25. Wangefjord S, Brändstedt J, Lindquist KE, et al: Associations of beta-catenin alterations and MSI screening status with expression of key cell cycle regulating proteins and survival from colorectal cancer. Diagn Pathol 8: 10, 2013.