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Volumn 8, Issue 5, 2014, Pages 1993-1999

Regulation of insulin-like growth factor signaling by metformin in endometrial cancer cells

Author keywords

Apoptosis; Cell proliferation; Endometrial cancer; Insulin like growth factor system; Metformin

Indexed keywords

ADENOSINE PHOSPHATE; BROXURIDINE; MESSENGER RNA; METFORMIN; PROTEIN KINASE INHIBITOR; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN C RECEPTOR;

EID: 84907145784     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2466     Document Type: Article
Times cited : (43)

References (40)
  • 1
    • 33749128535 scopus 로고    scopus 로고
    • Management of endometrial cancer
    • Kitchener H: Management of endometrial cancer. Eur J Surg Oncol 32: 838-843, 2006.
    • (2006) Eur J Surg Oncol , vol.32 , pp. 838-843
    • Kitchener, H.1
  • 2
    • 33947195839 scopus 로고    scopus 로고
    • Obesity, diabetes, and other factors in relation to survival after endometrial cancer diagnosis
    • Chia VM, Newcomb PA, Trentham-Dietz A and Hampton JM: Obesity, diabetes, and other factors in relation to survival after endometrial cancer diagnosis. Int J Gynecol Cancer 17: 441-446, 2007.
    • (2007) Int J Gynecol Cancer , vol.17 , pp. 441-446
    • Chia, V.M.1    Newcomb, P.A.2    Trentham-Dietz, A.3    Hampton, J.M.4
  • 3
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle EE, Rodriguez C, Walker-Thurmond K and Thun MJ: Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348: 1625-1638, 2003.
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 4
    • 34247895474 scopus 로고    scopus 로고
    • Diabetes mellitus is a multivariate independent prognostic factor in endometrial carcinoma: A clinicopathologic study on 313 patients
    • Steiner E, Plata K, Interthal C, et al: Diabetes mellitus is a multivariate independent prognostic factor in endometrial carcinoma: a clinicopathologic study on 313 patients. Eur J Gynaecol Oncol 28: 95-97, 2007.
    • (2007) Eur J Gynaecol Oncol , vol.28 , pp. 95-97
    • Steiner, E.1    Plata, K.2    Interthal, C.3
  • 5
    • 5644268978 scopus 로고    scopus 로고
    • Association between components of the insulin-like growth factor system and endometrial cancer risk
    • Augustin LS, Dal Maso L, Franceschi S, et al: Association between components of the insulin-like growth factor system and endometrial cancer risk. Oncology 67: 54-59, 2004.
    • (2004) Oncology , vol.67 , pp. 54-59
    • Augustin, L.S.1    Dal Maso, L.2    Franceschi, S.3
  • 6
    • 33745069283 scopus 로고    scopus 로고
    • Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II
    • Schernhammer ES, Holly JM, Hunter DJ, Pollak MN and Hankinson SE: Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II. Endocr Relat Cancer 13: 583-592, 2006.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 583-592
    • Schernhammer, E.S.1    Holly, J.M.2    Hunter, D.J.3    Pollak, M.N.4    Hankinson, S.E.5
  • 7
    • 0033587628 scopus 로고    scopus 로고
    • Discordant expression of insulin-like growth factors and their receptor messenger ribonucleic acids in endometrial carcinomas relative to normal endometrium
    • Roy RN, Gerulath AH, Cecutti A and Bhavnani BR: Discordant expression of insulin-like growth factors and their receptor messenger ribonucleic acids in endometrial carcinomas relative to normal endometrium. Mol Cell Endocrinol 153: 19-27, 1999.
    • (1999) Mol Cell Endocrinol , vol.153 , pp. 19-27
    • Roy, R.N.1    Gerulath, A.H.2    Cecutti, A.3    Bhavnani, B.R.4
  • 8
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor I receptor
    • LeRoith D, Werner H, Beitner-Johnson D and Roberts CT Jr: Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 16: 143-163, 1995.
    • (1995) Endocr Rev , vol.16 , pp. 143-163
    • Leroith, D.1    Werner, H.2    Beitner-Johnson, D.3    Roberts, C.T.4
  • 10
    • 80052531550 scopus 로고    scopus 로고
    • The molecular basis of IGF-I receptor gene expression in human cancer
    • LeRoith D, Zumkeller W and Baxter RC (eds). Landes Bioscience, Austin, TX
    • Werner H: The molecular basis of IGF-I receptor gene expression in human cancer. In: Insulin-Like Growth Factors. LeRoith D, Zumkeller W and Baxter RC (eds). Landes Bioscience, Austin, TX, pp346-356, 2003.
    • (2003) In: Insulin-Like Growth Factors , pp. 346-356
    • Werner, H.1
  • 11
    • 0035090634 scopus 로고    scopus 로고
    • Limited redundancy of survival signals from the type 1 insulin-like growth factor receptor
    • Navarro M and Baserga R: Limited redundancy of survival signals from the type 1 insulin-like growth factor receptor. Endocrinology 142: 1073-1081, 2001.
    • (2001) Endocrinology , vol.142 , pp. 1073-1081
    • Navarro, M.1    Baserga, R.2
  • 12
    • 0032457024 scopus 로고    scopus 로고
    • Insulin-like growth factors in endometrial function
    • Rutanen EM: Insulin-like growth factors in endometrial function. Gynecol Endocrinol 12: 399-406, 1998.
    • (1998) Gynecol Endocrinol , vol.12 , pp. 399-406
    • Rutanen, E.M.1
  • 13
    • 2942571206 scopus 로고    scopus 로고
    • Increased plasma levels of insulin-like growth factor 2 and insulin-like growth factor binding protein 3 are associated with endometrial cancer risk
    • Oh JC, Wu W, Tortolero-Luna G, et al: Increased plasma levels of insulin-like growth factor 2 and insulin-like growth factor binding protein 3 are associated with endometrial cancer risk. Cancer Epidemiol Biomarkers Prev 13: 748-752, 2004.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 748-752
    • Oh, J.C.1    Wu, W.2    Tortolero-Luna, G.3
  • 14
    • 34248389804 scopus 로고    scopus 로고
    • Insulin-like growth factor 2 and its receptors (IGF 1R and IGF 2R/mannose 6-phosphate) in endometrial adenocarcinoma
    • Pavelić J, Radaković B and Pavelić K: Insulin-like growth factor 2 and its receptors (IGF 1R and IGF 2R/mannose 6-phosphate) in endometrial adenocarcinoma. Gynecol Oncol 105: 727-735, 2007.
    • (2007) Gynecol Oncol , vol.105 , pp. 727-735
    • Pavelić, J.1    Radaković, B.2    Pavelić, K.3
  • 15
    • 33751278008 scopus 로고    scopus 로고
    • Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium
    • McCampbell AS, Broaddus RR, Loose DS and Davies PJ: Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium. Clin Cancer Res 12: 6373-6378, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 6373-6378
    • McCampbell, A.S.1    Broaddus, R.R.2    Loose, D.S.3    Davies, P.J.4
  • 16
    • 84855511518 scopus 로고    scopus 로고
    • Expression of IGF-1R, VEGF-C and D2-40 and their correlation with lymph node metastasis in endometrial adenocarcinoma
    • Pengchong H and Tao H: Expression of IGF-1R, VEGF-C and D2-40 and their correlation with lymph node metastasis in endometrial adenocarcinoma. Eur J Gynaecol Oncol 32: 660-664, 2011.
    • (2011) Eur J Gynaecol Oncol , vol.32 , pp. 660-664
    • Pengchong, H.1    Tao, H.2
  • 17
    • 68149103024 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor as an oncogene
    • Werner H and Bruchim I: The insulin-like growth factor-I receptor as an oncogene. Arch Physiol Biochem 115: 58-71, 2009.
    • (2009) Arch Physiol Biochem , vol.115 , pp. 58-71
    • Werner, H.1    Bruchim, I.2
  • 18
    • 70749106139 scopus 로고    scopus 로고
    • Metformin is a potent inhibitor of endometrial cancer cell proliferation - implications for a novel treatment strategy
    • Cantrell LA, Zhou C, Mendivil A, Malloy KM, Gehrig PA and Bae-Jump VL: Metformin is a potent inhibitor of endometrial cancer cell proliferation - implications for a novel treatment strategy. Gynecol Oncol 116: 92-98, 2010.
    • (2010) Gynecol Oncol , vol.116 , pp. 92-98
    • Cantrell, L.A.1    Zhou, C.2    Mendivil, A.3    Malloy, K.M.4    Gehrig, P.A.5    Bae-Jump, V.L.6
  • 19
    • 79959207505 scopus 로고    scopus 로고
    • Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth
    • Rocha GZ, Dias MM, Ropelle ER, et al: Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth. Clin Cancer Res 17: 3993-4005, 2011.
    • (2011) Clin Cancer Res , vol.17 , pp. 3993-4005
    • Rocha, G.Z.1    Dias, M.M.2    Ropelle, E.R.3
  • 20
    • 79953644936 scopus 로고    scopus 로고
    • Metformin promotes progesterone receptor expression via inhibition of mammalian target of rapamycin (mTOR) in endometrial cancer cells
    • Xie Y, Wang YL, Yu L, et al: Metformin promotes progesterone receptor expression via inhibition of mammalian target of rapamycin (mTOR) in endometrial cancer cells. J Steroid Biochem Mol Biol 126: 113-120, 2011.
    • (2011) J Steroid Biochem Mol Biol , vol.126 , pp. 113-120
    • Xie, Y.1    Wang, Y.L.2    Yu, L.3
  • 21
    • 0032963713 scopus 로고    scopus 로고
    • Diabetes and endometrial cancer: An Italian case-control study
    • Parazzini F, La Vecchia C, Negri E, et al: Diabetes and endometrial cancer: an Italian case-control study. Int J Cancer 81: 539-542, 1999.
    • (1999) Int J Cancer , vol.81 , pp. 539-542
    • Parazzini, F.1    La Vecchia, C.2    Negri, E.3
  • 22
    • 0000360867 scopus 로고    scopus 로고
    • Endometrial cancer
    • Schottenfeld D and Fraumeni JF (eds). 2nd edition. Oxford University Press, Oxford
    • Grady D and Ernster VL: Endometrial cancer. In: Cancer Epidemiology and Prevention. Schottenfeld D and Fraumeni JF (eds). 2nd edition. Oxford University Press, Oxford, pp1058-1089, 1996.
    • (1996) In: Cancer Epidemiology and Prevention , pp. 1058-1089
    • Grady, D.1    Ernster, V.L.2
  • 23
    • 0042889104 scopus 로고    scopus 로고
    • Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas
    • Ouban A, Muraca P, Yeatman T and Coppola D: Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas. Hum Pathol 34: 803-808, 2003.
    • (2003) Hum Pathol , vol.34 , pp. 803-808
    • Ouban, A.1    Muraca, P.2    Yeatman, T.3    Coppola, D.4
  • 25
    • 84879023685 scopus 로고    scopus 로고
    • Metformin inhibits proliferation and promotes apoptosis of HER2 positive breast cancer cells by downregulating HSP90
    • Chen TW, Liang YN, Feng D, et al: Metformin inhibits proliferation and promotes apoptosis of HER2 positive breast cancer cells by downregulating HSP90. J BUON 18: 51-56, 2013.
    • (2013) J BUON , vol.18 , pp. 51-56
    • Chen, T.W.1    Liang, Y.N.2    Feng, D.3
  • 26
    • 84858036346 scopus 로고    scopus 로고
    • Metformin differentially activates ER stress signaling pathways without inducing apoptosis
    • Quentin T, Steinmetz M, Poppe A and Thoms S: Metformin differentially activates ER stress signaling pathways without inducing apoptosis. Dis Model Mech 5: 259-269, 2012.
    • (2012) Dis Model Mech , vol.5 , pp. 259-269
    • Quentin, T.1    Steinmetz, M.2    Poppe, A.3    Thoms, S.4
  • 27
    • 79959265311 scopus 로고    scopus 로고
    • Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations
    • Olmos D, Martins AS, Jones RL, Alam S, Scurr M and Judson IR: Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations. Sarcoma 2011: 402508, 2011.
    • (2508) Sarcoma , vol.2011 , Issue.40 , pp. 2011
    • Olmos, D.1    Martins, A.S.2    Jones, R.L.3    Alam, S.4    Scurr, M.5    Judson, I.R.6
  • 28
    • 78650858388 scopus 로고    scopus 로고
    • Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab
    • Gualberto A, Hixon ML, Karp DD, et al: Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab. Br J Cancer 104: 68-74, 2011.
    • (2011) Br J Cancer , vol.104 , pp. 68-74
    • Gualberto, A.1    Hixon, M.L.2    Karp, D.D.3
  • 29
    • 34250783291 scopus 로고    scopus 로고
    • Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor
    • de Bono JS, Attard G, Adjei A, et al: Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor. Clin Cancer Res 13: 3611-3616, 2007.
    • (2007) Clin Cancer Res , vol.13 , pp. 3611-3616
    • De Bono, J.S.1    Attard, G.2    Adjei, A.3
  • 30
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
    • Dowling RJ, Zakikhani M, Fantus IG, Pollak M and Sonenberg N: Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res 67: 10804-10812, 2007.
    • (2007) Cancer Res , vol.67 , pp. 10804-10812
    • Dowling, R.J.1    Zakikhani, M.2    Fantus, I.G.3    Pollak, M.4    Sonenberg, N.5
  • 31
    • 47249137423 scopus 로고    scopus 로고
    • Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells
    • Shell SA, Lyass L, Trusk PB, Pry KJ, Wappel RL and Bacus SS: Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells. Cell Cycle 7: 1769-1775, 2008.
    • (2008) Cell Cycle , vol.7 , pp. 1769-1775
    • Shell, S.A.1    Lyass, L.2    Trusk, P.B.3    Pry, K.J.4    Wappel, R.L.5    Bacus, S.S.6
  • 32
    • 61649095657 scopus 로고    scopus 로고
    • The antidiabetic drug metformin: A pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy
    • Vazquez-Martin A, Oliveras-Ferraros C, del Barco S, Martin-Castillo B and Menendez JA: The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy. Ann Oncol 20: 592-595, 2009.
    • (2009) Ann Oncol , vol.20 , pp. 592-595
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Del Barco, S.3    Martin-Castillo, B.4    Menendez, J.A.5
  • 33
    • 60749108023 scopus 로고    scopus 로고
    • The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells
    • Vazquez-Martin A, Oliveras-Ferraros C and Menendez JA: The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells. Cell Cycle 8: 88-96, 2009.
    • (2009) Cell Cycle , vol.8 , pp. 88-96
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Menendez, J.A.3
  • 34
    • 65349175605 scopus 로고    scopus 로고
    • Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
    • Alimova IN, Liu B, Fan Z, et al: Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle 8: 909-915, 2009.
    • (2009) Cell Cycle , vol.8 , pp. 909-915
    • Alimova, I.N.1    Liu, B.2    Fan, Z.3
  • 35
    • 67650514082 scopus 로고    scopus 로고
    • Metformin induces unique biological and molecular responses in triple negative breast cancer cells
    • Liu B, Fan Z, Edgerton SM, et al: Metformin induces unique biological and molecular responses in triple negative breast cancer cells. Cell Cycle 8: 2031-2040, 2009.
    • (2009) Cell Cycle , vol.8 , pp. 2031-2040
    • Liu, B.1    Fan, Z.2    Edgerton, S.M.3
  • 36
    • 44649104448 scopus 로고    scopus 로고
    • Targeting AMPK: A new therapeutic opportunity in breast cancer
    • Hadad SM, Fleming S and Thompson AM: Targeting AMPK: a new therapeutic opportunity in breast cancer. Crit Rev Oncol Hematol 67: 1-7, 2008.
    • (2008) Crit Rev Oncol Hematol , vol.67 , pp. 1-7
    • Hadad, S.M.1    Fleming, S.2    Thompson, A.M.3
  • 38
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M: Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 8: 915-928, 2008.
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 39
    • 58049200573 scopus 로고    scopus 로고
    • Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors
    • Carracedo A, Baselga J and Pandolfi PP: Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors. Cell Cycle 7: 3805-3809, 2008.
    • (2008) Cell Cycle , vol.7 , pp. 3805-3809
    • Carracedo, A.1    Baselga, J.2    Pandolfi, P.P.3
  • 40
    • 73949134418 scopus 로고    scopus 로고
    • If mammalian target of metformin indirectly is mammalian target of rapamycin, then the insulin-like growth factor-1 receptor axis will audit the efficacy of metformin in cancer clinical trials
    • Vazquez-Martin A, Oliveras-Ferraros C, Del Barco S, Martin-Castillo B and Menendez JA: If mammalian target of metformin indirectly is mammalian target of rapamycin, then the insulin-like growth factor-1 receptor axis will audit the efficacy of metformin in cancer clinical trials. J Clin Oncol 27: e207-e209, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. e207-e209
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Barco, D.S.3    Martin-Castillo, B.4    Menendez, J.A.5


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