Pregnancy-associated plasma protein A associates with cardiovascular events in diabetic hemodialysis patients

Atherosclerosis

Volumn 236, Issue 2, 2014, Pages 263-269

  Kalousová, Marta ^a   Zima, Tomáš ^a   Krane, Vera ^b,c   März, Winfried ^d,e,f   Wanner, Christoph ^b,c   Tesarˇ, Vladimír ^g   Drechsler, Christiane ^b,c  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

^f SYNLAB ACADEMY   (Germany)

^g CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Atherosclerosis; Cardiovascular disease; Diabetes mellitus; Stroke; Sudden death

Indexed keywords

PREGNANCY ASSOCIATED PLASMA PROTEIN A; ATORVASTATIN; HEPTANOIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; PAPPA1 PROTEIN, HUMAN; PYRROLE DERIVATIVE;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CEREBROVASCULAR ACCIDENT; DIABETIC PATIENT; FEMALE; FOLLOW UP; HEART INFARCTION; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; INFECTION; INFECTIOUS COMPLICATION; MAJOR CLINICAL STUDY; MALE; PATIENT MONITORING; RISK ASSESSMENT; SEX DIFFERENCE; SUDDEN CARDIAC DEATH; SUDDEN DEATH; VERY ELDERLY; ADOLESCENT; BLOOD; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; CLINICAL TRIAL; COMORBIDITY; COMPARATIVE STUDY; CONTROLLED STUDY; DEATH, SUDDEN, CARDIAC; DIABETES COMPLICATIONS; DIABETIC NEPHROPATHIES; GERMANY; KIDNEY FAILURE, CHRONIC; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; MYOCARDIAL INFARCTION; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RENAL REPLACEMENT THERAPY; SMOKING; STROKE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ATORVASTATIN CALCIUM; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; COMORBIDITY; DEATH, SUDDEN, CARDIAC; DIABETES COMPLICATIONS; DIABETIC NEPHROPATHIES; FEMALE; FOLLOW-UP STUDIES; GERMANY; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFECTION; KIDNEY FAILURE, CHRONIC; LIPIDS; MALE; MIDDLE AGED; MORTALITY; MYOCARDIAL INFARCTION; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; PYRROLES; RENAL DIALYSIS; RISK ASSESSMENT; SMOKING; STROKE; YOUNG ADULT;

EID: 84907073233     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.07.003     Document Type: Article

References (40)

1. US Renal Data System USRDS 2012 annual data report 2013, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
2. ERA-EDTA Registry ERA-EDTA registry 2005 annual report 2007, Academic Medical Center, Department of Medical Informatics, Amsterdam, The Netherlands.
3. Lawrence J.B., Oxvig C., Overgaard M.T., Sottrup-Jensen L., Gleich G.J., Hays L.G., et al. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts in pregnancy-associated plasma protein-A. Proc Natl Acad Sci U S A 1999, 96:3149-3153.
4. Lin T.M., Halbert S.P., Kiefer D., Spellacy W.N., Gall S. Characterization of four pregnancy-associated plasma proteins. Am J Obstet Gynecol 1974, 118:223-236.
5. Bayes-Genis A., Conover C.A., Overgaard M.T., Bailey K.R., Christiansen M., Holmes D.R., et al. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med 2001, 345:1022-1029.
6. Kalousova´ M., Sulkova´ S., Fialova´ L., Soukupova´ J., Malbohan I.M., Spacek P., et al. Glycoxidation and inflammation in chronic haemodialysis patients. Nephrol Dial Transplant 2003, 18:2577-2581.
7. Wald N.J., Kennard A., Hackshaw A.K. First trimester serum screening for down's syndrome. Prenat Diagn 1995, 15:1227-1240.
8. Kalousova´ M., Horejsi´ M., Fialova´ L., Soukupova´ J., Sulkova´ S., Malbohan I., et al. Increased levels of pregnancy-associated plasma protein A are associated with mortality in hemodialysis patients: preliminary results. Blood Purif 2004, 22:298-300.
9. Etter C., Straub Y., Hersberger M., Ra¨z H.R., Kistler T., Kiss D., et al. Pregnancy-associated plasma protein-A is an independent short-time predictor of mortality in patients on maintenance haemodialysis. Eur Heart J 2010, 31:354-359.
10. Kalousova´ M., Bena´kova´ H., Kubena A.A., Dusilova´-Sulkova´ S., Tesar V., Zima T. Pregnancy-associated plasma protein a as an independent mortality predictor in long-term hemodialysis patients. Kidney Blood Press Res 2012, 35:192-201.
11. Boldt H.B., Conover C.A. Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs. Growth Horm IGF Res 2007, 17:10-18.
12. Kalousova´ M., Tesarˇ V., Muravska´ A., Zima T. Pregnancy-associated plasma protein A: spotlight on kidney diseases. Clin Chem Lab Med 2012, 50:1183-1190.
13. von Haehling S., Doehner W., Jankowska E.A., Ponikowski P., Stellos K., Puntmann V.O., et al. Value of serum pregnancy-associated plasma protein A for predicting cardiovascular events among patients presenting with cardiac chest pain. Can Med Assoc J 2013, 185(7):E295-E303.
14. Lauzurica R., Pastor C., Baye´s B., Herna´ndez J.M., Romero R. Pretransplant pregnancy-associated plasma protein-a as a predictor of chronic allograft nephropathy and posttransplant cardiovascular events. Transplantation 2005, 80:1441-1446.
15. Wanner C., Krane V., Ma¨rz W., Olschewski M., Mann J.F., Ruf G., et al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N Engl J Med 2005, 353:238-248. German Diabetes and Dialysis Study Investigators.
16. Fialova´ L., Pileckova´ N., Bauer J., Soukupova´ J., Kalousova´ M., Malbohan I., et al. Pregnancy-associated plasma protein-A in patients with cerebrovascular diseases-a pilot study. Prague Med Rep 2006, 107:37-45.
17. Conover C.A. Key questions and answers about pregnancy-associated plasma protein-A. Trends Endocrinol Metab 2012, 23:242-249.
18. Conover C.A., Harrington S.C., Bale L.K., Oxvig C. Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages. Am J Physiol Heart Circ Physiol 2007, 292:H994-H1000.
19. Resch Z.T., Chen B.K., Bale L.K., Oxvig C., Overgaard M.T., Conover C.A. Pregnancy-associated plasma protein a gene expression as a target of inflammatory cytokines. Endocrinology 2004, 145:1124-1129.
20. Jones J.I., Prevette T., Gockerman A., Clemmons D.R. Ligand occupancy of the αVβ3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor. Proc Natl Acad Sci U S A 1996, 93:2482-2487.
21. Renier G., Clement I., Desfaits A.C., Lambert A. Direct stimulatory effect of insulin-like growth factor-I on monocyte and macrophage tumor necrosis factor-α production. Endocrinology 1996, 137:4611-4618.
22. Conti E., Carrozza C., Capoluongo E., Volpe M., Crea F., Zuppi C., et al. Insulin-like growth factor-1 as a vascular protective factor. Circulation 2004, 110:2260-2265.
23. Crea F., Andreatti F. Pregnancy-associated plasma protein-A and coronary atherosclerosis: marker, friend or foe?. Eur Heart J 2005, 26:2075-2076.
24. Harrington S.C., Simari R.D., Conover C.A. Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Circ Res 2007, 100:1696-1702.
25. Conover C.A., Mason M.A., Bale L.K., Harrington S.C., Nyegaard M., Oxvig C., et al. Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development. Am J Physiol Heart Circ Physiol 2010, 299:H284-H291.
26. Chen B.K., Leiferman K.M., Pittelkow M.R., Overgaard M.T., Oxvig C., Conover C.A. Localization and regulation of pregnancy-associated plasma protein a expression in healing human skin. J Clin Endocrinol Metab 2003, 88:4465-4471.
27. Miller B.S., Bronk J.T., Nishiyama T., Yamagiwa H., Srivastava A., Bolander M.E., et al. Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice. J Endocrinol 2007, 192:505-513.
28. Resch Z.T., Simari R.D., Conover C.A. Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury. Endocrinology 2006, 147:5634-5640.
29. Bale L.K., Resch Z.T., Harstad S.L., Overgaard M.T., Conover C.A. Constitutive expression of pregnancy-associated plasma protein-A in arterial smooth muscle reduces the vascular response to injury in vivo. Am J Physiol Endocrinol Metab 2013, 304:E139-E144.
30. Sangiorgi G., Mauriello A., Bonanno E., Oxvig C., Conover C.A., Christiansen M., et al. Pregnancy-associated plasma protein-a is markedly expressed by monocyte-macrophage cells in vulnerable and ruptured carotid atherosclerotic plaques: a link between inflammation and cerebrovascular events. J Am Coll Cardiol 2006, 47:2201-2211.
31. Tertti R., Wittfooth S., Porela P., Airaksinen K.E., Metsa¨rinne K., Pettersson K. Intravenous administration of low molecular weight and unfractionated heparin elicits a rapid increase in serum pregnancy-associated plasma protein A. Clin Chem 2009, 55:1214-1217.
32. Iversen K.K., Teisner A.S., Teisner B., Kliem A., Thanning P., Nielsen H., et al. Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome. Clin Biochem 2009, 42:828-834.
33. Iversen K., Teisner A., Dalager S., Olsen K.E., Floridon C., Teisner B. Pregnancy associated plasma protein-A (PAPP-A) is not a marker of the vulnerable atherosclerotic plaque. Clin Biochem 2011, 44:312-318.
34. Ha´jek P., Macek M., Pesˇkova´ M., Hladi´kova´ M., Hansvenclova´ E., Maly´ M., et al. High positive predictive value of PAPP-A for acute coronary syndrome diagnosis in heparin-nai¨ve patients. J Thromb Thrombolysis 2012, 34:99-105.
35. Hodkova M., Kalousova M., Dusilova-Sulkova S., Malbohan I.M., Zima T. Intravenous iron gluconate administration increases circulating PAPP-A in hemodialysis patients. Ren Fail 2005, 27:707-711.
36. Oxvig C., Sand O., Kristensen T., Gleich G.J., Sottrup-Jensen L. Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein. J Biol Chem 1993, 268:12243-12246.
37. Qin Q.P., Kokkala S., Lund J., Tamm N., Voipio-Pulkki L.M., Pettersson K. Molecular distinction of circulating pregnancy-associated plasma protein A in myocardial infarction and pregnancy. Clin Chem 2005, 51:75-83.
38. Kalousova´ M., Hodkova´ M., Dusilova´-Sulkova´ S., Uhrova´ J., Tesar V., Zima T. Effect of hemodiafiltration on pregnancy-associated plasma protein A (PAPP-A) and related parameters. Ren Fail 2006, 28:715-721.
39. Kalousova´ M., Lachmanova´ J., Mokrejsova´ M., Mi´kova´ B., Fialova´ L., Malbohan I.M., et al. Pregnancy-associated plasma protein A during hemodialysis with polyamide and diacetate cellulosic membranes. Int J Artif Organs 2004, 27:943-948.
40. Wittfooth S., Tertti R., Lepa¨ntalo M., Porela P., Qin Q.P., Tynja¨la¨ J., et al. Studies on the effects of heparin products on pregnancy-associated plasma protein A. Clin Chim Acta 2011, 412:376-381.