Homer2 protein regulates plasma membrane Ca2+-ATPase-mediated Ca2+signaling in mouse parotid gland acinar cells

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 24971-24979

  Yang, Yu Mi ^a   Lee, Jiae ^a   Jo, Hae ^b   Park, Soonhong ^a   Chang, Inik ^a   Muallem, Shmuel ^c   Shin, Dong Min ^a  

^a Yonsei University College of Dentistry   (South Korea)

^b Kyung Hee University   (South Korea)

^c NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; AMINO ACIDS; BIOCHEMISTRY; CALCIUM; CELL MEMBRANES; CYTOLOGY; MAMMALS; POLES; POLYOLS; PROTEINS; SCAFFOLDS (BIOLOGY); SIGNALING; SUGARS;

CO-IMMUNOPRECIPITATIONS; G PROTEIN COUPLED RECEPTORS; HUMAN EMBRYONIC KIDNEYS; INOSITOL 1 ,4 ,5-TRIPHOSPHATE; NON-EXCITABLE CELLS; PAROTID ACINAR CELLS; RECEPTOR LOCALIZATION; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

CELL SIGNALING;

CALCIUM ION; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PLASMA MEMBRANE CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; PROTEIN HOMER 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; ATP2A2 PROTEIN, MOUSE; CALCIUM; CARRIER PROTEIN; PROTEIN BINDING; PROTEIN HOMER;

ACINAR CELL; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENE DELETION; HOMER2 GENE; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PAROTID GLAND; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CONFOCAL MICROSCOPY; CYTOLOGY; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; WESTERN BLOTTING;

ACINAR CELLS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CALCIUM; CALCIUM SIGNALING; CARRIER PROTEINS; HEK293 CELLS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; PAROTID GLAND; PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASES; PROTEIN BINDING; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84906969161     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.577221     Document Type: Article

References (44)

1. Berridge, M. J., Lipp, P., and Bootman, M. D. (2000) The versatility and universality of calcium signalling. Nat. Rev. Mol. Cell Biol. 1, 11-21
2. Petersen, O. H., and Tepikin, A. V. (2008) Polarized calcium signaling in exocrine gland cells. Annu. Rev. Physiol. 70, 273-299
3. Berridge, M. J., Bootman, M. D., and Roderick, H. L. (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat. Rev. Mol. Cell Biol. 4, 517-529
4. 2+stores and ion channels in neurons. Trends Neurosci. 23, 80-88
5. Szumlinski, K. K., Kalivas, P. W., and Worley, P. F. (2006) Homer proteins: implications for neuropsychiatric disorders. Curr. Opin. Neurobiol. 16, 251-257
6. 2+signalling. Cell. Signal. 15, 243-253
7. 2+signaling by excitable and non-excitable cells. Cell Calcium 42, 363-371
8. Fagni, L., Worley, P. F., and Ango, F. (2002) Homer as both a scaffold and transduction molecule. Sci. STKE 2002, re8
9. Kato, A., Ozawa, F., Saitoh, Y., Fukazawa, Y., Sugiyama, H., and Inokuchi, K. (1998) Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. J. Biol. Chem. 273, 23969-23975
10. 3receptors. Neuron 21, 717-726
11. Brakeman, P. R., Lanahan, A. A., O'Brien, R., Roche, K., Barnes, C. A., Huganir, R. L., and Worley, P. F. (1997) Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 386, 284-288
12. Yuan, J. P., Kiselyov, K., Shin, D. M., Chen, J., Shcheynikov, N., Kang, S. H., Dehoff, M. H., Schwarz, M. K., Seeburg, P. H., Muallem, S., and Worley, P. F. (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114, 777-789
13. Xiao, B., Tu, J. C., Petralia, R. S., Yuan, J. P., Doan, A., Breder, C. D., Ruggiero, A., Lanahan, A. A., Wenthold, R. J., and Worley, P. F. (1998) Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21, 707-716
14. Shin, D. M., Dehoff, M., Luo, X., Kang, S. H., Tu, J., Nayak, S. K., Ross, E. M., Worley, P. F., and Muallem, S. (2003) Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities. J. Cell Biol. 162, 293-303
15. Feng, W., Tu, J., Yang, T., Vernon, P. S., Allen, P. D., Worley, P. F., and Pessah, I. N. (2002) Homer regulates gain of ryanodine receptor type 1 channel complex. J. Biol. Chem. 277, 44722-44730
16. Tu, J. C., Xiao, B., Naisbitt, S., Yuan, J. P., Petralia, R. S., Brakeman, P., Doan, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., and Worley, P. F. (1999) Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23, 583-592
17. 2+homeostasis at dendritic spines in hippocampal neurons. J. Neurosci. 25, 4587-4592
18. Gray, N. W., Fourgeaud, L., Huang, B., Chen, J., Cao, H., Oswald, B. J., Hémar, A., and McNiven, M. A. (2003) Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. Curr. Biol. 13, 510-515
19. Bottai, D., Guzowski, J. F., Schwarz, M. K., Kang, S. H., Xiao, B., Lanahan, A., Worley, P. F., and Seeburg, P. H. (2002) Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression. J. Neurosci. 22, 167-175
20. Huang, G. N., Huso, D. L., Bouyain, S., Tu, J., McCorkell, K. A., May, M. J., Zhu, Y., Lutz, M., Collins, S., Dehoff, M., Kang, S., Whartenby, K., Powell, J., Leahy, D., and Worley, P. F. (2008) NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science 319, 476-481
21. Zeng, W., Lee, M. G., Yan, M., Diaz, J., Benjamin, I., Marino, C. R., Kopito, R., Freedman, S., Cotton, C., Muallem, S., and Thomas, P. (1997) Immuno and functional characterization of CFTR in submandibular and pancreatic acinar and duct cells. Am. J. Physiol. 273, C442-C455
22. 2+signaling complexes and regulates their activity. J. Cell Biol. 150, 1101-1112
23. Kim, J. Y., Zeng, W., Kiselyov, K., Yuan, J. P., Dehoff, M. H., Mikoshiba, K., Worley, P. F., and Muallem, S. (2006) Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J. Biol. Chem. 281, 32540-32549
24. +/-mice. EMBO J. 20, 2680-2689
25. 2+-ATPase in parotid acinar cells. J. Biol. Chem. 277, 48172-48181
26. Homann, V., Kinne-Saffran, E., Arnold, W. H., Gaengler, P., and Kinne, R. K. (2006) Calcium transport in human salivary glands: a proposed model of calcium secretion into saliva. Histochem. Cell Biol. 125, 583-591
27. Gorr, S. U., Venkatesh, S. G., and Darling, D. S. (2005) Parotid secretory granules: crossroads of secretory pathways and protein storage. J. Dent. Res. 84, 500-509
28. 2+-ATPase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. J. Biol. Chem. 276, 21594-21600
29. +exchanger regulatory factor 2 in apical plasma membranes. J. Biol. Chem. 277, 10506-10511
30. Schuh, K., Uldrijan, S., Telkamp, M., Rothlein, N., and Neyses, L. (2001) The plasma membrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I. J. Cell Biol. 155, 201-205
31. Sgambato-Faure, V., Xiong, Y., Berke, J. D., Hyman, S. E., and Strehler, E. E. (2006) The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump. Biochem. Biophys. Res. Commun. 343, 630-637
32. Kammermeier, P. J., Xiao, B., Tu, J. C., Worley, P. F., and Ikeda, S. R. (2000) Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channels. J. Neurosci. 20, 7238-7245
33. iwaves. J. Biol. Chem. 272, 15765-15770
34. 2+waves induced by muscarinic receptor stimulation in rat parotid acinar cells. Cell Calcium 22, 455-462
35. Zhang, X., Wen, J., Bidasee, K. R., Besch, H. R., Jr., Wojcikiewicz, R. J., Lee, B., and Rubin, R. P. (1999) Ryanodine and inositol trisphosphate receptors are differentially distributed and expressed in rat parotid gland. Biochem. J. 340, 519-527
36. 2+initiation sites evoked by muscarinic receptor stimulation in exocrine acinar cells. Biochem. Biophys. Res. Commun. 259, 656-660
37. Floyd, R., and Wray, S. (2007) Calcium transporters and signalling in smooth muscles. Cell Calcium 42, 467-476
38. 2+-ATPase by protein kinase A in parotid acinar cells. J. Biol. Chem. 282, 37678-37693
39. iwaves. J. Biol. Chem. 272, 15771-15776
40. Kurnellas, M. P., Lee, A. K., Li, H., Deng, L., Ehrlich, D. J., and Elkabes, S. (2007) Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neurons. Mol. Cell. Neurosci. 34, 178-188
41. Sandonà, D., Scolari, A., Mikoshiba, K., and Volpe, P. (2003) Subcellular distribution of Homer 1b/c in relation to endoplasmic reticulum and plasma membrane proteins in Purkinje neurons. Neurochem. Res. 28, 1151-1158
42. Genazzani, A. A., Carafoli, E., and Guerini, D. (1999) Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons. Proc. Natl. Acad. Sci. U.S.A. 96, 5797-5801
43. 2+. J. Biol. Chem. 274, 1667-1676
44. 2+pump in hippocampal neurons. Biochem. Biophys. Res. Commun. 424, 76-81