Screening and identification of novel compounds with potential anti-proliferative effects on gallium-resistant lung cancer through an AXL kinase pathway

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 18, 2014, Pages 4553-4556

  Oyewumi, Moses O ^a   Alazizi, Adnan ^a   Liva, Sophia ^a,b   Lin, Li ^a   Geldenhuys, Werner J ^a  

^a NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

^b MUSKINGUM COLLEGE   (United States)

Author keywords

AXL; Gallium; Gallium resistance; Lung cancer; Virtual screening

Indexed keywords

5476423; 7655826; 7697413; 7730595; 7909619; 7919469; 7929249; 7954103; ANTINEOPLASTIC AGENT; AXL KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; 5476423 COMPOUND; 7919469 COMPOUND; AXL RECEPTOR TYROSINE KINASE; GALLIUM; NAPHTHALENE DERIVATIVE; ONCOPROTEIN; PROTEIN TYROSINE KINASE; PYRAZOLE DERIVATIVE; QUINOLINE DERIVATIVE; TETRAZOLE DERIVATIVE;

ADENOCARCINOMA CELL LINE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL VIABILITY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; IC50; LUNG CANCER; PROTEIN EXPRESSION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; ENZYMOLOGY; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GALLIUM; HUMANS; LUNG NEOPLASMS; MOLECULAR STRUCTURE; NAPHTHALENES; PROTO-ONCOGENE PROTEINS; PYRAZOLES; QUINOLINES; RECEPTOR PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 84906967109     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.07.072     Document Type: Article

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