Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: A case-control study in a Chinese Han population

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 8, 2014, Pages 5154-5159

  Lou, Suliang ^a   Zhao, Zhifang ^a   Qian, Jinqian ^a   Zhao, Kefeng ^a   Wang, Ran ^a  

^a The 117th Hospital of Chinese PLA   (China)

Author keywords

ADAM12 gene; osteoarthritis; Single nucleotide polymorphisms; susceptibility

Indexed keywords

ADAM 12 PROTEIN; ADAM PROTEIN; MEMBRANE PROTEIN;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; KNEE OSTEOARTHRITIS; MALE; MIDDLE AGED; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAM PROTEINS; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; OSTEOARTHRITIS, KNEE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84906962944     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Zhuo Q, Yang W, Chen J, Wang Y. Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol 2012; 8: 729-737.
2. Felson DT. Developments in the clinical understanding of osteoarthritis. Arthritis Res Ther 2009; 11: 203.
3. Yamada Y. Association of a Leu(10)→Pro polymorphism of the transforming growth factor-beta1 with genetic susceptibility to osteoporosis and spinal osteoarthritis. Mech Ageing Dev 2000; 116: 113-123.
4. Meulenbelt I, Bijkerk C, Miedema HS, Breedveld FC, Hofman A, Valkenburg HA, Pols HA, Slagboom PE, van Duijn CM. A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam Study). Ann Rheum Dis 1998; 57: 371-374.
5. Zhai G, Rivadeneira F, Houwing-Duistermaat JJ, Meulenbelt I, Bijkerk C, Hofman A, van Meurs JB, Uitterlinden AG, Pols HA, Slagboom PE, van Duijn CM. Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study. Ann Rheum Dis 2004; 63: 544-548.
6. Moos V, Rudwaleit M, Herzog V, Hohlig K, Sieper J, Mu¨ller B. Association of genotypes affecting the expression of interleukin-1beta or interleukin-1 receptor antagonist with osteoarthritis. Arthritis Rheum 2000; 43: 2417-2422.
7. Pola E, Papaleo P, Pola R, Gaetani E, Tamburelli FC, Aulisa L, Logroscino CA. Interleukin-6 gene polymorphism and risk of osteoarthritis of the hip: a case-control study. Osteoarthritis Cartilage 2005; 13: 1025-1028.
8. Valdes AM, Hart DJ, Jones KA, Surdulescu G, Swarbrick P, Doyle DV, Schafer AJ, Spector TD. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Arthritis Rheum 2004; 50: 2497-2507.
9. Valdes AM, Hassett G, Hart DJ, Spector TD. Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes: a candidate SNP association study in the Chingford cohort. Spine (Phila Pa 1976) 2005; 30: 2445-2451.
10. Valdes AM, Loughlin J, Oene MV, Chapman K, Surdulescu GL, Doherty M, Spector TD. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum 2007; 56: 137-146.
11. Seals DF, Courtneidge SA. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 2003; 17: 7-30.
12. Kveiborg M, Albrechtsen R, Couchman JR, Wewer UM. Cellular roles of ADAM12 in health and disease. Int J Biochem Cell Biol 2008; 40: 1685-1702.
13. Kerna I, Kisand K, Laitinen P, Tamm AE, Kumm J, Lintrop M, Tamm AO. Association of ADAM12-S protein with radiographic features of knee osteoarthritis and bone and cartilage markers. Rheumatol Int 2012; 32: 519-523.
14. Kerna I, Kisand K, Tamm AE, Lintrop M, Veske K, Tamm AO. Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. Osteoarthritis Cartilage 2009; 17: 1093-1098.
15. Valdes AM, Van Oene M, Hart DJ, Surdulescu GL, Loughlin J, Doherty M, Spector TD. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum 2006; 54: 533-539.
16. Shin MH, Lee SJ, Kee SJ, Song SK, Kweon SS, Park DJ, Park YW, Lee SS, Kim TJ. Genetic association analysis of GDF5 and ADAM12 forknee osteoarthritis. Joint Bone Spine 2012; 79: 488-491.
17. Limer KL, Tosh K, Bujac SR, McConnell R, Doherty S, Nyberg F, Zhang W, Doherty M, Muir KR, Maciewicz RA. Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study). Osteoarthritis Cartilage 2009; 17: 782-789.
18. Walsh PS, Metzger DA, Higuchi R. Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques 1991; 10: 506-513.
19. Rodriguez-Lopez J, Pombo-Suarez M, Loughlin J, Tsezou A, Blanco FJ, Meulenbelt I, Slagboom PE, Valdes AM, Spector TD, Gomez-Reino JJ, Gonzalez A. Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. Osteoarthritis Cartilage 2009; 17: 321-327.
20. Kerna I, Kisand K, Tamm AE, Kumm J, Tamm AO. Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population. Arthritis 2013; 2013: 878126.
21. Sandell LJ, Aigner T. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res 2001; 3: 107-113.
22. Aigner T, Soeder S, Haag J. IL-1beta and BMPs--interactive players of cartilage matrix degradation and regeneration. Eur Cell Mater 2006; 12: 49-56; discussion 56.
23. Okada A, Mochizuki S, Yatabe T, Kimura T, Shiomi T, Fujita Y, Matsumoto H, Sehara-Fujisawa A, Iwamoto Y, Okada Y. ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage. Arthritis Rheum 2008; 58: 778-789.
24. Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis 2005; 64: 1263-1267.
25. Kerna I, Kisand K, Suutre S, Murde M, Tamm A, Kumm J, Tamm A. The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis. Joint Bone Spine 2014; 81: 51-56.
26. Abe E, Mocharla H, Yamate T, Taguchi Y, Manolagas SC. Meltrin-alpha, a fusion protein involved in multinucleated giant cell and osteoclast formation. Calcif Tissue Int 1999; 64: 508-515.