Semi-synthesis of oxygenated dolabellane diterpenes with highly in vitro anti-HIV-1 activity

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 18, 2014, Pages 4381-4383

  Pardo Vargas, Alonso ^a   Ramos, Freddy A ^a   Cirne Santos, Claudio Cesar ^b,c   Stephens, Paulo Roberto ^b,c   Paixão, Izabel Christina Palmer ^c   Teixeira, Valeria Laneuville ^c   Castellanos, Leonardo ^a  

^a UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

Antivirals; Dolabellane diterpenes; Eunicea laciniata; HIV 1; Marine natural products

Indexed keywords

13 KETO 1,11 DOLABELLA 3,7,12(18)TRIENE; 13 KETO 3,4,7 TRIHYDROXYDOLABELLA 8(17),12(18)DIENE; ANTIVIRUS AGENT; BETA ARANEOSENE; DITERPENE; EPOXIDE; NEVIRAPINE; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DOLABELLANE; OXYGEN;

ALGA; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG POTENCY; DRUG SYNTHESIS; EPOXIDATION; EUNICEA LACINIATA; IN VITRO STUDY; NONHUMAN; OXIDATION; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TRANSFORMED CELL LINE;

ANTI-HIV AGENTS; CELL LINE, TRANSFORMED; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; OXYGEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906961596     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.08.019     Document Type: Article

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