Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Suenaga, Kaori ^a,b   Kitahara, Shuji ^c   Suzuki, Yasuhiro ^a   Kobayashi, Miho ^a   Horie, Sachiko ^a   Sugawara, Junichi ^a,b   Yaegashi, Nobuo ^a,b   Sato, Yasufumi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; FORSKOLIN; GLYCOPROTEIN; REGULATOR PROTEIN; SYNCYTIN 1; SYNCYTIN 2; UNCLASSIFIED DRUG; VASOHIBIN; VASOHIBIN 1; VASOHIBIN 2; ANGIOGENIC PROTEIN; CELL CYCLE PROTEIN; GCM1 PROTEIN, HUMAN; NUCLEAR PROTEIN; PLACENTA PROTEIN; SYNCYTIN; SYNCYTIN 2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; VASH1 PROTEIN, HUMAN; VASH2 PROTEIN, HUMAN; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUSION; CHORIOCARCINOMA CELL LINE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; FETOPLACENTAL UNIT; GENE; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE SILENCING; GENETIC CODE; GLIA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOUSE; NONHUMAN; PLACENTA CIRCULATION; PROTEIN FUNCTION; REGULATORY MECHANISM; SYNCYTIOTROPHOBLAST; TROPHOBLAST; VASH1 GENE; VASH2 GENE; ADENOVIRIDAE; ADULT; ANGIOGENESIS; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; KNOCKOUT MOUSE; METABOLISM; PREGNANCY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADENOVIRIDAE; ADULT; ANGIOGENIC PROTEINS; ANIMALS; CELL CYCLE PROTEINS; CELL FUSION; CELL LINE, TUMOR; COLFORSIN; FEMALE; GENE EXPRESSION REGULATION; GENE PRODUCTS, ENV; GENETIC VECTORS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOVASCULARIZATION, PHYSIOLOGIC; NUCLEAR PROTEINS; PREGNANCY; PREGNANCY PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TROPHOBLASTS;

EID: 84906960115     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104728     Document Type: Article

References (35)

1. Pötgens AJ, Drewlo S, Kokozidou M, Kaufmann P. (2004) Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its action. Hum Reprod Update 10: 487-496.
2. Wang A, Rana S, Karumanchi SA. (2009) Preeclampsia: the role of angiogenic factors in its pathogenesis. Physiology (Bethesda) 24: 147-158.
3. Bulmer JN, Innes BA, Levey J, Robson SC, Lash GE. (2012) The role of vascular smooth muscle cell apoptosis and migration during uterine spiral artery remodeling in normal human pregnancy. FASEB J 26: 2975-2985.
4. Burton GJ, Charnock-Jones DS, Jauniaux E. (2009) Regulation of vascular growth and function in the human placenta. Reproduction 138: 895-902.
5. Arroyo JA, Winn VD. (2008) Vasculogenesis and angiogenesis in the IUGR placenta. Semin Perinatol 32: 172-177.
6. Barut F, Barut A, Gun BD, Kandemir NO, Harma MI, et al. (2010) Intrauterine growth restriction and placental angiogenesis. Diagn Pathol 5: 24.
7. Watanabe K, Hasegawa Y, Yamashita H, Shimizu K, Ding Y, et al. (2004) Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis. J Clin Invest 114: 898-907.
8. Shibuya T, Watanabe K, Yamashita H, Shimizu K, Miyashita H, et al. (2006) Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin. Arterioscler Thromb Vasc Biol 26: 1051-1057.
9. Sato Y. (2013) The vasohibin family: a novel family for angiogenesis regulation. J Biochem 153: 5-11.
10. Suzuki Y, Kobayashi M, Miyashita H, Ohta H, Sonoda H, et al. (2010) Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion. J Cell Sci 123: 3094-4101.
11. Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, et al. (2009) Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis. Blood 113: 4810-4818.
12. Kitahara S, Morikawa S, Shimizu K, Abe H, Ezaki T. (2010) Alteration of angiogenic patterns on B16BL6 melanoma development promoted in Matrigel. Med Mol Morphol 43: 26-36.
13. Yoshie M, Kaneyama K, Kusama K, Higuma C, Nishi H, et al. (2010) Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells. Hum Reprod 25: 2229-2238.
14. Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, et al. (2011) Identification of a link between Wnt/b-catenin signalling and the cell fusion pathway. Nat Commun 2: 548.
15. Simmons DG, Natale DR, Begay V, Hughes M, Leutz A, et al. (2008) Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth. Development 135: 2083-2091.
16. Dupressoir A, Lavialle C, Heidmann T. (2012) From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentation. Placenta 33: 663-671.
17. Schubert SW, Lamoureux N, Kilian K, Klein-Hitpass L, Hashemolhosseini S. (2008) Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1. J Biol Chem 283: 5460-5465.
18. Mi S, Lee X, Li X, Veldman GM, Finnerty H, et al. (2000) Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 403: 785-789.
19. Chen CP, Chen LF, Yang SR, et al. Functional characterization of the human placental fusogenic membrane protein syncytin 2. Biol Reprod 2008;79:815-23.
20. Yu C, Shen K, Lin M, Chen CY, Ko CC, et al. (2002) GCMa regulates the syncytin-mediated trophoblastic fusion. J Biol Chem 277: 50062-50068.
21. Frendo JL, Olivier D, Cheynet V, Blond JL, Bouton O, et al. (2003) Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation. Mol Cell Biol 23: 3566-3574.
22. Holder BS, Tower CL, Abrahams VM, Aplin JD. (2012) Syncytin 1 in the human placenta. Placenta33: 460-466.
23. Yamashita H, Abe M, Watanabe K, Shimizu K, Moriya T, et al. (2006) Vasohibin prevents arterial neointimal formation through angiogenesis inhibition. Biochem Biophys Res Commun 345: 919-925.
24. Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, et al. (2008) Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer. Cancer Sci 99: 914-919.
25. Wakusawa R, Abe T, Sato H, Yoshida M, Kunikata H, et al. (2008) Expression of vasohibin, an antiangiogenic factor, in human choroidal neovascular membranes. Am J Ophthalmol 146: 235-243.
26. Tamaki K, Moriya T, Sato Y, Ishida T, Maruo Y, et al. (2009) Vasohibin-1 in human breast carcinoma: a potential negative feedback regulator of angiogenesis. Cancer Sci 100: 88-94.
27. Sato H, Abe T, Wakusawa R, Asai N, Kunikata H, et al. (2009) Vitreous levels of vasohibin-1 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy. Diabetologia 52: 359-361.
28. Hosaka T, Kimura H, Heishi T, Suzuki Y, Miyashita H, et al. (2009) Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis. Am J Pathol 175: 430-439.
29. Takahashi Y, Koyanagi T, Suzuki Y, Saga Y, Kanomata N, et al. (2012) Vasohibin-2 expressed in human serous ovarian adenocarcinoma accelerates tumor growth by promoting angiogenesis. Mol Cancer Res 10: 1135-1146.
30. Xue X, Gao W, Sun B, Xu Y, Han B, et al. (2013) Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma. Oncogene 32: 1724-1734
31. Dupressoir A, Vernochet C, Harper F, Guégan J, Dessen P, et al. (2011) A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast. Proc Natl Acad Sci U S A 108: E1164-1173.
32. Dupressoir A, Marceau G, Vernochet C, Bénit L, Kanellopoulos C, Sapin V, et al. (2005) Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae. Proc Natl Acad Sci U S A 102: 725-730.
33. Lavialle C, Cornelis G, Dupressoir A, Esnault C, Heidmann O, et al. (2013) Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation. Philos Trans R Soc Lond B Biol Sci 368: 20120507.
34. Larsson LI, Bjerregaard B, Talts JF. (2008) Cell fusions in mammals. Histochem Cell Biol 129: 551-561.
35. Dittmar T, Nagler C, Niggemann B, Zänker KS. (2013) The dark side of stem cells: triggering cancer progression by cell fusion. Curr Mol Med 13:735-750.