Clinical significance of peripheral blood lymphocyte sensitivity to glucocorticoids for the differentiation of high-risk patients with decreased allograft function after glucocorticoid withdrawal in renal transplantation

Clinical Therapeutics

Volumn 36, Issue 8, 2014, Pages 1264-1272

  Muhetaer, Gulimire ^a,b   Takeuchi, Hironori ^c   Unezaki, Sakae ^c   Kawachi, Shigeyuki ^a   Iwamoto, Hitoshi ^a   Nakamura, Yuki ^a   Shimazu, Motohide ^a   Sugiyama, Kentaro ^c   Hirano, Toshihiko ^c  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b Department of Surgery Uygur Autonomous Region Peoples Hospital Xinjiang Uyghur Autonomous Region   (China)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

glucocorticoid withdrawal; immunosuppressive drugs; peripheral blood mononuclear cells; pharmacodynamics; renal transplantation; T cell mitogen

Indexed keywords

CYCLOSPORIN; GLUCOCORTICOID; HYDROCORTISONE; METHYLPREDNISOLONE; TACROLIMUS; BIOLOGICAL MARKER; IMMUNOSUPPRESSIVE AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; DRUG EFFECT; FEMALE; GRAFT RECIPIENT; HIGH RISK PATIENT; HUMAN; IC 50; KIDNEY ALLOGRAFT; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MALE; MIDDLE AGED; PERIPHERAL LYMPHOCYTE; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; TREATMENT RESPONSE; WITHDRAWAL SYNDROME; ALLOGRAFT; AREA UNDER THE CURVE; BLOOD; CELL CULTURE; CELL PROLIFERATION; CHEMICALLY INDUCED; DRUG EFFECTS; IC50; IMMUNOLOGY; KIDNEY; KIDNEY FAILURE; PATHOPHYSIOLOGY; PROCEDURES; RISK ASSESSMENT; TREATMENT WITHDRAWAL;

ADULT; ALLOGRAFTS; AREA UNDER CURVE; BIOMARKERS; CELL PROLIFERATION; CELLS, CULTURED; CYCLOSPORINE; FEMALE; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; IMMUNOSUPPRESSIVE AGENTS; INHIBITORY CONCENTRATION 50; KIDNEY; KIDNEY TRANSPLANTATION; LYMPHOCYTES; MALE; METHYLPREDNISOLONE; MIDDLE AGED; RENAL INSUFFICIENCY; RETROSPECTIVE STUDIES; RISK ASSESSMENT; ROC CURVE; TACROLIMUS; WITHHOLDING TREATMENT;

EID: 84906939605     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2014.06.019     Document Type: Article

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