Increased sensitivities of peripheral blood mononuclear cells to immunosuppressive drugs in cirrhosis patients awaiting liver transplantation

Cell Transplantation

Volumn 15, Issue 10, 2006, Pages 885-891

  Mijiti, Abuduxhukuer ^a,b   Matsuno, Naoto ^a   Iwahori, Tohru ^a   Takeuchi, Hironori ^c   Nagao, Takeshi ^a   Oka, Kitaro ^c   Hirano, Toshihiko ^c  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b Kashgar First People's Hospital   (China)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Cirrhosis patients; Immunosuppressive drugs; Individualized medicine; Liver transplantation; Peripheral blood mononuclear cells (PBMCs)

Indexed keywords

CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; METHYLPREDNISOLONE; PREDNISOLONE; TACROLIMUS;

ADULT; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SENSITIVITY; FEMALE; GRAFT REJECTION; HUMAN; IC 50; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; LYMPHOCYTE TRANSFORMATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RISK FACTOR; TREATMENT OUTCOME;

ADULT; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEUKOCYTES, MONONUCLEAR; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PREDNISOLONE; TACROLIMUS;

EID: 33846600467     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000006783981314     Document Type: Conference Paper

References (24)

1. Agrati, C.; Nisii, C.; Oliva, A.; D'Offizi, G.; Montesano, C.; Pucillo, L. P.; Poccia, F. Lymphocyte distribution and intrahepatic compartmentalization during HCV infection: A main role for MHC-unrestricted T cells. Arch. Immunol. Ther. Exp. (Warsz.) 50:307-316; 2002.
2. Bock, H. A. Steroid-resistant kidney transplant rejection: diagnosis and treatment. J. Am. Soc. Nephrol. 12:848-52; 2001.
3. Braun, W. E. Renal transplantation: Basic concepts and evolution of therapy. J. Clin. Apheresis 18:141-152; 2003.
4. Dudley, J.; Truman, C.; McGraw, M.; Tizard, J.; Haque, G.; Bradley, B. Estimation of individual sensitivity to cyclosporin in children awaiting renal transplantation. Nephrol. Dial. Transplant. 18:403-410; 2003.
5. Gopalswamy, N.; Mehta, V.; Barde, C. J. Risks of intra-abdominal nonshunt surgery in cirrhotics. Dig. Dis. 16:225-231; 1998.
6. Gremion, C.; Cerny, A. Hepatitis C virus and the immune system: A concise review. Rev. Med. Virol. 15:235-268; 2005.
7. Haczku, A.; Alexander, A.; Brown, P.; Assoufi, B.; Li, B.; Kay, A. B.; Corrigan, C. The effect of dexamethasone, cyclosporine, and rapamycin on T-lymphocyte proliferation in vitro: Comparison of cells from patients with glucocorticoid-sensitive and glucocorticoid-resistant chronic asthma. J. Allergy. Clin. Immunol. 93:510-519; 1994.
8. Haycock, K. A.; Roth, R.; Gagnon, J. Statview. Berkeley, CA: Abacus Concepts; 1994.
9. Hearing, S. D.; Norman, M.; Probert, C. S.; Haslam, N.; Dayan, C. M. Predicting therapeutic outcome in severe ulcerative colitis by measuring in vitro steroid sensitivity of proliferating peripheral blood lymphocytes. Gut 45:382-388; 1999.
10. Hirano, T.; Akashi, T.; Keira, T.; Oka, K.; Ihoya, N.; Yoshida, M. Clinical impact of cyclosporine cellular-pharmacodynamics in minimal change nephrotic syndrome. Clin. Pharmacol. Ther. 68:532-554; 2000.
11. Hirano, T.; Oka, K.; Takeuchi, H.; Sakurai, E.; Matsuno, N.; Tamaki, T.; Kozaki, M. Clinical significance of glucocorticoid pharmacodynamics assessed by anti-lymphocyte action in kidney transplantation: Marked difference between prednisolone and methylprednisolone. Transplantation 57:1341-1348; 1994.
12. Hirano, T.; Oka, K.; Takeuchi, H.; Kozaki, K.; Matsuno, N.; Nagao, T.; Kozaki, M.; Ichikawa, M.; Yoshida, M.; Umezawa, Y.; Hirata, M.; Oh-I, T.; Koga, M. Immunosuppressant pharmacodynamics on lymphocytes from healthy subjects and patients with chronic renal failure, nephrosis and psoriasis: Possible implications for individual therapeutic efficacy. Clin. Pharmacol. Ther. 62:652-664; 1997.
13. Hirano, T.; Oka, K.; Tamaki, T. Gramicidin as a potent immunosuppressant for organ transplantation: Suppression of human lymphocyte blastogenesis in vitro and prolongation of heart allograft survival in the rat. J. Pharmacol. Exp. Ther. 273:223-229; 1995.
14. Hirano, T.; Oka, K.; Umezawa, Y.; Hirata, M.; Oh-I, T.; Koga, M. Individual pharmacodynamics assessed by anti-lymphocyte action predicts clinical cyclosporine-efficacy in psoriasis. Clin. Pharmacol. Ther. 63:465-470; 1998.
15. Kakumu, S.; Ito, S.; Ishikawa, T.; Mita, Y.; Tagaya, T.; Fukuzawa, Y.; Yoshioka, K. Decreased function of peripheral blood dendritic cells in patients with hepatocellular carcinoma with hepatitis B and C virus infection. J. Gastroenterol. Hepatol. 15:431-436; 2000.
16. Kirkham, B. W.; Corkill, M. M.; Davison, S. C.; Panayi, G. S. Response to glucocorticoid treatment in rheumatoid arthritis: In vitro cell mediated immune assay predicts in vivo responses. J. Rheumatol. 18:821-825; 1991.
17. Mackenjee, M. K.; Kiepiela, P.; Cooper, R.; Coovadia, H. M. Clinically important immunological processes in acute and fulminant hepatitis, mainly due to hepatitis B virus. Arch. Dis. Child. 57:277-282; 1982.
18. Pearce, D.; Yamamoto, K. R. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science 259:1161-1165; 1993.
19. Plosker, G. L.; Foster, R. H. Tacrolimus: A further update of its pharmacology and therapeutic use in the management of organ transplantation. Drugs 59:324-389; 2000.
20. Reichenspurner, H. Overview of tacrolimus-based immunosuppression after heart or lung transplantation. J. Heart Lung Transplant. 24:119-130; 2005.
21. Schreiber, S. L.; Crabtree, G. R. The mechanism of action of cyclosporin A and FK506. Immunol. Today 13:136-142; 1992.
22. Takeuchi, H.; Hirano, T.; Oka, K.; et al. Lymphocyte-sensitivities to cyclosporine and tacrolimus in chronic renal failure patients and their significance on renal transplantation. Transplant. Proc. 30:36-39; 1998.
23. Tanabe, K. Calcineurin inhibitors in renal transplantation: What is the best option? Drugs 63:1535-1548; 2003.
24. Weston, S. J.; Leistikow, R. L.; Reddy, K. R.; et al. Reconstitution of hepatitis C virus-specific T-cell mediated immunity after liver transplantation. Hepatology 41:72-81; 2005.