Diagnosing the severity of dry eye: A clear and practical algorithm

British Journal of Ophthalmology

Volumn 98, Issue 9, 2014, Pages 1168-1176

  Baudouin, Christophe ^a,b,c   Aragona, Pasquale ^d   Van Setten, Gysbert ^e   Rolando, Maurizio ^f   Irkeç, Murat ^g   Del Castillo, José Benítez ^h   Geerling, Gerd ⁱ   Labetoulle, Marc ^j   Bonini, Stefano ^k  

^a CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^d UNIVERSITY OF MESSINA   (Italy)

^e ST ERIK S EYE HOSPITAL   (Sweden)

^f UNIVERSITY OF GENOA   (Italy)

^g HACETTEPE UNIVERSITY   (Turkey)

^h HOSPITAL CLÍNICO SAN CARLOS   (Spain)

ⁱ HEINRICH HEINE UNIVERSITY   (Germany)

^j Paris South University   (France)

^k UNIVERSITY CAMPUS BIO MEDICO   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GELATINASE B; HLA DR ANTIGEN;

ABERROMETRY; ALGORITHM; BLEPHAROSPASM; CONFOCAL MICROSCOPY; CONJUNCTIVAL STAINING; CORNEAL FLUORESCEIN STAINING; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST; DISEASE SEVERITY; DRY EYE; EUROPE; EYE EXAMINATION; EYELID DISEASE; FILAMENTARY KERATITIS; FLUORESCENCE ANALYSIS; HUMAN; IMPRESSION CYTOLOGY; INFLAMMATION; KERATITIS; PRIORITY JOURNAL; REVIEW; SCHIRMER TEST; SCORING SYSTEM; SYMPTOMATOLOGY; TEAR BREAK UP TIME; TEAR HYPEROSMOLARITY; TREATMENT RESPONSE; VISUAL IMPAIRMENT; VISUAL SYSTEM PARAMETERS;

ALGORITHMS; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; DISEASE PROGRESSION; DRY EYE SYNDROMES; HUMANS; SEVERITY OF ILLNESS INDEX;

EID: 84906938639     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjophthalmol-2013-304619     Document Type: Review

References (49)

1. Clegg JP, Guest JF, Lehman A, et al. The annual cost of dry eye syndrome in France, Germany, Italy, Spain, Sweden and the United Kingdom among patients managed by ophthalmologists. Ophthalmic Epidemiol 2006;13:263-74. (Pubitemid 44180007)
2. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye Workshop. Ocul Surf 2007;5:93-107.
3. Sjögren H. Zur Kenntnis dur keratoconjunctivitis sicca (keratitis filiformis bei hypofunktion der Tranendrüsen). Acta Ophthalmol 1933;(11 Suppl 2):1-151.
4. Lemp MA. Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J 1995;21:221-32.
5. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop. Ocul Surf 2007;5:75-92.
6. Yokoi N, Kinoshita S, Sakai R, et al. A Comparative Study between Short Breakup Time Dry Eye and Other Disorders Giving Rise to a Short Breakup. Invest Ophthalmol Vis Sci 2011;52: E-Abstract 3854.
7. Sullivan DA, Hammitt KM, Schaumberg DA, et al. Report of the TFOS/ARVO Symposium on global treatments for dry eye disease: an unmet need. Ocul Surf 2012;10:108-16.
8. Savini G, Pinita P, Takashi K, et al. The challenge of dry eye diagnosis. Clin Ophthalmol 2008;2:31-55.
9. Sullivan BD, Whitmer D, Nichols KK, et al. An objective approach to dry eye disease severity. Invest Ophthalmol Vis Sci 2010;51:6125-30.
10. Schein OD, Tielsch JM, Munoz B, et al. Relation between signs and symptoms of dry eye in the elderly. Ophthalmology 1997;104:1395-401.
11. Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop. Ocul Surf 2007;5:108-52.
12. Lemp MA, Baudouin C, Amrane M, et al. Poor correlation between dry eye disease (DED) signs and symptoms in a phase III randomized clinical trial [abstract]. Invest Ophthalmol Vis Sci 2011;52:3821.
13. Foulks GN. Challenges and pitfalls in clinical trials of treatments for dry eye. Ocul Surf 2003;1:20-30. (Pubitemid 41263854)
14. Bron AJ. Diagnosis of dry eye. Surv Ophthalmol 2001;45:S221-6.
15. Goto T, Zheng X, Klyce SD, et al. A new method for tear film stability using videokeratography. Am J Ophthalmol 2003;135:607-12. (Pubitemid 36457965)
16. Murube J. Tear osmolarity. Ocul Surf 2006;1:62-73. (Pubitemid 351902296)
17. Tomlinson A, Khanal S, Ramaesh K, et al. Tear film osmolarity: determination of a referent for dry eye diagnosis. Invest Ophthalmol Vis Sci 2006;47:4309-15. (Pubitemid 46579353)
18. Pflugfelder SC, Jones D, Ji Z, et al. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren 's syndrome keratoconjunctivitis sicca. Curr Eye Res 1999;19:201-11. (Pubitemid 29500267)
19. Tsubota K, Fujihara T, Saito K, et al. Conjunctival epithelium expression of HLA-DR in dry eye patients. Ophthalmologica 1999;213:16-19. (Pubitemid 28561779)
20. Calonge M, Enríquez-de-Salamanca A, Diebold Y, et al. Dry eye disease as an inflammatory disorder. Ocul Immunol Inflamm 2010;18:244-53.
21. Research in dry eye: report of the Research Subcommittee of the International Dry Eye Workshop. Ocul Surf 2007;5:179-93.
22. Baudouin C. The vicious circle in dry eye syndrome: a mechanistic approach. J Fr Ophtalmol 2007;3:239-46.
23. Baudouin C, Aragona P, Messmer EM, et al. Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting. Ocul Surf 2013;11:246-58.
24. Belmonte C, Acosta MC, Gallar J. Neural basis of sensation in intact and injured corneas. Exp Eye Res 2004;78:513-25. (Pubitemid 38183329)
25. Begley CG, Chalmers RL, Abetz L, et al. The relationship between habitual patient-reported symptoms and clinical signs among patients with dry eye of varying severity. Invest Ophthalmol Vis Sci 2003;44:4753-61. (Pubitemid 37315288)
26. Rosenthal P, Borsook D. The corneal pain system. Part I: the missing piece of the dry eye puzzle. Ocul Surf 2012;10:2-14.
27. Nichols KK, Nichols JJ, Mitchell GL. The lack of association between signs and symptoms in patients with dry eye disease. Cornea 2004a;23:762-70. (Pubitemid 39447304)
28. Viso E, Rodríguez-Ares MT, Abelenda D, et al. Prevalence of asymptomatic and symptomatic meibomian gland dysfunction in the general population of Spain. Invest Ophthalmol Vis Sci 2012;53:2601-6.
29. Lemp AM. Advances in understanding and managing dry eye disease. Am J Ophthalmol 2008;146:350-6.
30. Adatia FA, Michaeli-Cohen A, Naor J, et al. Correlation between corneal sensitivity, subjective dry eye symptoms and corneal staining in Sjögren's syndrome. Can J Ophthalmol 2004;39:767-71. (Pubitemid 40115579)
31. Bourcier T, Acosta MC, Borderie V, et al. Decreased corneal sensitivity in patients with dry eye. Invest Ophthalmol Vis Sci 2005;46:2341-5. (Pubitemid 43119478)
32. M'garrech M, Rousseau A, Kaswin G, et al. Impairment of Lacrimal secretion in the unaffected fellow eye of patients with recurrent unilateral Herpetic keratitis. Ophthalmology 2013;120:1959-67.
33. Behrens A, Doyle JJ, Stern L, et al. Dysfunctional tear syndrome study group. Dysfunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea 2006;25:900-7. (Pubitemid 44763848)
34. Varma R, Richman EA, Ferris FL III, et al. Use of patient-reported outcomes in medical product development: a report from the 2009 NEI/FDA Clinical Trial Endpoints Symposium. Invest Ophthalmol Vis Sci 2010;51:6095-103.
35. Begley C, Caffery B, Chalmers R, et al. Use of the Dry Eye Questionnaire to measure symptoms of ocular irritation in patients with aqueous tear deficiency. Cornea 2002;21:664-70.
36. Abetz L, Rajagopalan K, Mertzanis P, et al. Impact of Dry Eye on Everyday Life (IDEEL) Study Group. Development and validation of the impact of dry eye on everyday life (IDEEL) questionnaire, a patient-reported outcomes (PRO) measure for the assessment of the burden of dry eye on patients. Health Qual Life Outcomes 2011;9:111.
37. McMonnies C, Ho A, Wakefield D. Optimum dry eye classification using questionnaire responses. Adv Exp Med Biol 1998;438:835-8. (Pubitemid 28303827)
38. Nichols KK, Nichols JJ, Mitchell GL. The reliability and validity of McMonnies Dry Eye Index. Cornea 2004b;23:365-71. (Pubitemid 38544053)
39. Gothwal VK, Pesudovs K, Wright TA, et al. McMonnies questionnaire: enhancing screening for dry eye syndromes with Rasch analysis. Invest Ophthalmol Vis Sci 2010;51:1401-7.
40. Miller KL, Walt JG, Mink DR, et al. Minimal clinically important difference for the ocular surface disease index. Arch Ophthalmol 2010;128:94-101.
41. Savini G, Barboni P, Zanini M. The incidence and risk factors for developing dry eye after myopic LASIK. Am J Ophthalmol 2006;142:355-6. (Pubitemid 44107303)
42. Aragona P, Rolando M. Towards a dynamic customised therapy for ocular surface dysfunctions. Br J Ophthalmol 2013;97:955-60.
43. Murube J, Benitez del Castillo JM, Chenghou L, et al. The Madrid triple classification system. Arch Soc Esp Oftalmol 2003;78:587-93.
44. Murube J, Nemeth J, Hoh H, et al. The triple classification of dry eye for practical clinical use. Eur J Ophthalmol 2005;15:660-7. (Pubitemid 43074689)
45. Uchino Y, Uchino M, Dogru M, et al. Changes in dry eye diagnostic status following implementation of revised Japanese dry eye diagnostic criteria. Jpn J Ophthalmol 2012;56:8-13.
46. Miyawak IS, Nishiyama S. Classification criteria for Sjogrens syndrome - sensitivity and specificity of criteria of the Japanese Ministry of Health and Welfare (1977) and criteria of European community (1993). Nippon Rinsho 1995;53:2371-5.
47. Yamamoto Y, Yokoi N, Higashihara H, et al. Clinical characteristics of short tear film breakup time (BUT) -type dry eye. Nihon Ganka Gakkai Zasshi 2012;116:1137-43.
48. Singh R, Joseph A, Umapathy T, et al. Impression cytology of the ocular surface. Br J Ophthalmol 2005;89:1655-9. (Pubitemid 41729915)
49. Sambursky R, Davitt WF III, Latkany R, et al. Sensitivity and specificity of a point-of-care matrix metalloproteinase 9 immunoassay for diagnosing inflammation related to dry eye. JAMA Ophthalmol 2013;131:24-8.