Neutrophil gelatinase-associated lipocalin protects renal tubular epithelial cells in hypoxia-reperfusion by reducing apoptosis

International Urology and Nephrology

Volumn 46, Issue 8, 2014, Pages 1673-1679

  Zang, Xiujuan ^a   Zheng, Feng ^a   Hong, Hai Juan ^a   Jiang, Yan ^a   Song, Ying ^a   Xia, Yanping ^a  

^a SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

Author keywords

Acute kidney injury (AKI); Apoptosis; Hypoxia reperfusion, 24p3R; Megalin; Neutrophil gelatinase associated lipocalin (NGAL)

Indexed keywords

24P3R PROTEIN; FAS LIGAND; MEGALIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; 24P3R RECEPTOR, RAT; ACUTE PHASE PROTEIN; BAX PROTEIN, RAT; CELL SURFACE RECEPTOR; FAS ANTIGEN; LIPOCALIN; MESSENGER RNA; NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN PROTEIN, RAT; ONCOPROTEIN; TNFRSF6 PROTEIN, RAT;

APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; KIDNEY TUBULE CELL; MTT ASSAY; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; WESTERN BLOTTING; ANIMAL; CELL HYPOXIA; CELL LINE; DRUG EFFECTS; GENETICS; KIDNEY TUBULE; METABOLISM; PHYSIOLOGY; RAT; UPREGULATION;

ACUTE-PHASE PROTEINS; ANIMALS; ANTIGENS, CD95; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL HYPOXIA; CELL LINE; CELL PROLIFERATION; DOWN-REGULATION; EPITHELIAL CELLS; FAS LIGAND PROTEIN; KIDNEY TUBULES; LIPOCALINS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-2; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECEPTORS, CELL SURFACE; REPERFUSION INJURY; RNA, MESSENGER; UP-REGULATION;

EID: 84906935062     PISSN: 03011623     EISSN: 15732584     Source Type: Journal    
DOI: 10.1007/s11255-014-0749-3     Document Type: Article

References (28)

1. El Sabbahy M, Vaidya VS (2011) Ischemic kidney injury and mechanisms of tissue repair. Wiley Interdiscip Rev Syst Biol Med 3(5):606-618. doi:10.1002/wsbm.133
2. Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A (2009) Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis 54(6):1012-1024. doi:10.1053/j.ajkd.2009.07.020
3. Kanbay M, Kasapoglu B, Perazella MA (2010) Acute tubular necrosis and pre-renal acute kidney injury: utility of urine microscopy in their evaluation - a systematic review. Int Urol Nephrol 42(2):425-443. doi:10.1007/s11255-009- 9673-3
4. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C (2005) Ending supportive therapy for the kidney I (2005) acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294(7):813-818. doi:10.1001/jama.294.7.813 (Pubitemid 41175724)
5. Mehta RL, Pascual MT, Soroko S, Savage BR, Himmelfarb J, Ikizler TA, Paganini EP, Chertow GM (2004) Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int 66(4):1613-1621. doi:10.1111/j.1523-1755.2004.00927.xKID927 (Pubitemid 39298397)
6. Supavekin S, Zhang W, Kucherlapati R, Kaskel FJ, Moore LC, Devarajan P (2003) Differential gene expression following early renal ischemia/reperfusion. Kidney Int 63(5):1714-1724. doi:10.1046/j.1523-1755.2003.00928.x (Pubitemid 36513317)
7. Waikar SS, Bonventre JV (2008) Biomarkers for the diagnosis of acute kidney injury. Nephron Clin Pract 109(4):c192-c197. doi:10.1159/000142928
8. Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365(9466):1231-1238. doi:10.1016/S0140-6736(05) 74811-X (Pubitemid 40469655)
9. Devarajan P, Mishra J, Supavekin S, Patterson LT, Steven Potter S (2003) Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics. Mol Genet Metab 80(4):365-376 (Pubitemid 37491197)
10. Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14(10):2534-2543 (Pubitemid 37169339)
11. Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P (2004) Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 24(3):307-315. doi:10.1159/000078452 (Pubitemid 39070114)
12. Mishra J, Mori K, Ma Q, Kelly C, Yang J, Mitsnefes M, Barasch J, Devarajan P (2004) Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 15(12):3073-3082. doi:10.1097/01.ASN.0000145013.44578.45 (Pubitemid 39578839)
13. Mori K, Lee HT, Rapoport D, Drexler IR, Foster K, Yang J, Schmidt-Ott KM, Chen X, Li JY, Weiss S, Mishra J, Cheema FH, Markowitz G, Suganami T, Sawai K, Mukoyama M, Kunis C, D'Agati V, Devarajan P, Barasch J (2005) Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Investig 115(3):610-621. doi:10.1172/JCI23056 (Pubitemid 40322235)
14. Schmidt-Ott KM, Mori K, Kalandadze A, Li JY, Paragas N, Nicholas T, Devarajan P, Barasch J (2006) Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr Opin Nephrol Hypertens 15(4):442-449. doi:10.1097/01.mnh.0000232886.81142.58 (Pubitemid 44297988)
15. Devarajan P (2008) Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease. Scand J Clin Lab Investig Suppl 241:89-94. doi:10.1080/00365510802150158
16. Basile DP, Liapis H, Hammerman MR (1997) Expression of bcl-2 and bax in regenerating rat renal tubules following ischemic injury. Am J Physiol Renal Physiol 272(5 Pt 2):F640-F647
17. Ortiz A, Lorz C, Egido J (1999) The Fas ligand/Fas system in renal injury. Nephrol Dial Transplant 14(8):1831-1834 (Pubitemid 29358871)
18. Watkins MT, Haudenschild CC, al-Badawi H, Velazquez FR, Larson DM (1995) Immediate responses of endothelial cells to hypoxia and reoxygenation: an in vitro model of cellular dysfunction. Am J Physiol Heart Circ Physiol 268(2 Pt 2):H749-H758
19. Tominaga K, Kondo C, Johmura Y, Nishizuka M, Imagawa M (2004) The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis. FEBS Lett 577(1-2):49-54. doi:10.1016/j.febslet.2004.09.062 (Pubitemid 39452359)
20. Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C (T) method. Nat Protoc 3(6):1101-1108. doi:10.1038/nprot.2008.73 (Pubitemid 351818697)
21. Devireddy LR, Gazin C, Zhu X, Green MR (2005) A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 123(7):1293-1305. doi:10.1016/j.cell.2005.10.027 (Pubitemid 41821786)
22. Hvidberg V, Jacobsen C, Strong RK, Cowland JB, Moestrup SK, Borregaard N (2005) The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett 579(3):773-777. doi:10.1016/j.febslet.2004.12.031
23. Chen Z, Chua CC, Ho YS, Hamdy RC, Chua BH (2001) Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Am J Physiol Heart Circ Physiol 280(5):H2313-H2320
24. Kirshenbaum LA, de Moissac D (1997) The bcl-2 gene product prevents programmed cell death of ventricular myocytes. Circulation 96(5):1580-1585 (Pubitemid 27375355)
25. Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, Cohen DJ, Devarajan P, Barasch J (2007) Dual action of neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 18(2):407-413. doi:10.1681/ASN.2006080882 (Pubitemid 46193306)
26. Yang J, Goetz D, Li JY, Wang W, Mori K, Setlik D, Du T, Erdjument-Bromage H, Tempst P, Strong R, Barasch J (2002) An iron delivery pathway mediated by a lipocalin. Mol Cell 10(5):1045-1056 (Pubitemid 35453824)
27. Yang J, Mori K, Li JY, Barasch J (2003) Iron, lipocalin, and kidney epithelia. Am J Physiol Renal Physiol 285(1):F9-F18. doi:10.1152/ajprenal.00008. 2003 (Pubitemid 36818457)
28. Ferris CD, Jaffrey SR, Sawa A, Takahashi M, Brady SD, Barrow RK, Tysoe SA, Wolosker H, Baranano DE, Dore S, Poss KD, Snyder SH (1999) Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol 1(3):152-157. doi:10.1038/11072 (Pubitemid 129656019)