Hyperhomocysteinemia-induced monocyte chemoattractant protein-1 promoter DNA methylation by nuclear factor-κB/DNA methyltransferase 1 in apolipoprotein E-deficient mice

BioResearch Open Access

Volumn 2, Issue 2, 2013, Pages 118-127

  Wang, Ju ^a   Jiang, Yideng ^a   Yang, Anning ^a   Sun, Weiwei ^a   Ma, Changjian ^a   Ma, Shengchao ^a   Gong, Huihui ^a   Shi, Yingkang ^b   Wei, Jun ^a  

^a NINGXIA MEDICAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

atherosclerosis; DNA methylation; hyperhomocysteinemia; monocyte chemoattractant protein 1

Indexed keywords

APOLIPOPROTEIN E; DNA METHYLTRANSFERASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHIONINE; MONOCYTE CHEMOTACTIC PROTEIN 1; PYRROLIDINE DITHIOCARBAMATE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELL INFILTRATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FOAM CELL; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HYPERHOMOCYSTEINEMIA; IN VITRO STUDY; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TISSUE SECTION; WILD TYPE;

MUS;

EID: 84906925333     PISSN: None     EISSN: 21647860     Source Type: Journal    
DOI: 10.1089/biores.2012.0300     Document Type: Article

References (38)

1. Kalhan SC, Marczewski SE. Methionine, homocysteine, one carbon metabolism and fetal growth. Rev Endocr Metab Disord. 2012;15 (abstract).
2. Woo KS, Sanderson JE, Sun YY, et al. Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation. 2000;101:116.
3. Soehnlein O. Multiple roles for neutrophils in atherosclerosis. Circ Res. 2012;110:875-888.
4. Catalgol B, Kartal Ozer N. Lipid rafts and redox regulation of cellular signaling in cholesterol induced atherosclerosis. Curr Cardiol Rev. 2010;6:309-324.
5. Tuttolomondo A, Di Raimondo D, Pecoraro R, et al. Atherosclerosis as an inflammatory disease. Curr Pharm Des. 2012; 29 (abstract).
6. Poddar R, Sivasubramanian N, DiBello PM, et al. Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. Circulation. 2001;103: 2717-2723.
7. Satiroglu O, Uydu HA, Demir A, et al. Association between plasma monocyte chemoattractant protein-1 levels and the extent of atherosclerotic peripheral artery disease. Tohoku J Exp Med. 2011;224:301-306.
8. Schepers A, Eefting D, Bonta PI, et al. Anti-MCP-1 gene therapy inhibits vascular smooth muscle cells proliferation and attenuates vein graft thickening both in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2006;26:2063-2069.
9. Lu Q, Ma D, Zhao S. DNA methylation changes in cervical cancers. Methods Mol Biol. 2012;863:155-176.
10. Vo AT, Millis RM. Epigenetics and breast cancers. Obstet Gynecol Int. 2012;2012:602720.
11. Meehan RR, Stancheva I. DNA methylation and control of gene expression in vertebrate development. Essays Biochem. 2001;37:59-70.
12. Dudziec E, Gogol-Döring A, Cookson V, et al. Integrated epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells. PLoS One. 2012;7:e32750.
13. Turunen MP, Aavik E, Ylä-Herttuala S. Epigenetics and atherosclerosis. Biochim Biophys Acta. 2009;1790:886-891.
14. Yideng J, Jianzhong Z, Ying H, et al. Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs. DNA Cell Biol. 2007;26:603-611.
15. Yideng J, Zhihong L, Jiantuan X, et al. Homocysteinemediated PPARalpha,gamma DNA methylation and its potential pathogenic mechanism in monocytes. DNA Cell Biol. 2008;27:143-150.
16. Mitra S, Khaidakov M, Lu J, et al. Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation. Am J Physiol Heart Circ Physiol. 2011;301:H506-513.
17. Stark GR, Wang Y, Lu T. Lysine methylation of promoterbound transcription factors and relevance to cancer. Cell Res. 2011;21:375-380.
18. Hwang SY, Woo CW, Au-Yeung KK, et al. Homocysteine stimulates monocyte chemoattractant protein-1 expression in the kidney via nuclear factor-jB activation. Am J Physiol Renal Physiol. 2008;294:236-244.
19. Gupta SC, Sundaram C, Reuter S, Aggarwal BB. Inhibiting NF-jB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta. 2010;1799:775-787.
20. Liu Y, Mayo MW, Nagji AS, et al. Phosphorylation of RelA/p65 promotes DNMT-1 recruitment to chromatin and represses transcription of the tumor metastasis suppressor gene BRMS1. Oncogene. 2012;31:1143-1154.
21. Liu S, Liu Z, Xie Z, et al. Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-jB-dependent DNAmethyltransferase activity in acute myeloid leukemia. Blood. 2008;10:2364-2373.
22. Marumo T, Schini-Kerth VB, Fisslthaler B, Busse R. Plateletderived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-jB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells. Circulation. 1997;96: 2361-2367.
23. Ravaglia G, Forti P, Maioli F, et al. Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly. Am J Clin Nutr. 2006;84:1473-1480.
24. Tehlivets O. Homocysteine as a risk factor for atherosclerosis: is its conversion to s-adenosyl-L-homocysteine the key to deregulated lipid metabolism? J Lipids. 2011;2011: 702853.
25. Veeranna V, Zalawadiya SK, Niraj A, et al. Homocysteine and reclassification of cardiovascular disease risk. J Am Coll Cardiol. 2011;58:1025-1033.
26. Sahinarslan A, Kocaman SA, Topal S, et al. The relation of serum monocyte chemoattractant protein-1 level with coronary atherosclerotic burden and collateral degree in stable coronary artery disease. Turk Kardiyol Dern Ars. 2011;39: 269-275.
27. Liu XL, Zhang PF, Ding SF, et al. Local gene silencing of monocyte chemoattractant protein-1 prevents vulnerable plaque disruption in apolipoprotein e-knockout mice. PLoS One. 2012;7:33497.
28. Tse KP, Tsang NM, Chen KD, et al. MCP-1 promoter polymorphism at 2518 is associated with metastasis of nasopharyngeal carcinoma after treatment. Clin Cancer Res. 2007; 13:6320-6326.
29. Liu ZH, Chen LL, Deng XL, et al. Source methylation status of CpG sites in the MCP-1 promoter is correlated to serum MCP-1 in type 2 diabetes. J Endocrinol Invest. 2011;3 (abstract).
30. Li XQ, Guo YY, De W. DNA methylation and microRNAs in cancer. World J Gastroenterol. 2012;18:882-888.
31. Shu S, Mahadeo DC, Liu X, et al. S-adenosylhomocysteine hydrolase is localized at the front of chemotaxing cells, suggesting a role for transmethylation during migration. Proc Natl Acad Sci USA. 2006;103:19788-19793.
32. Caudill MA, Wang JC, Melnyk S, et al. Intracellular S- adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. J Nutr. 2001;131:2811- 2818.
33. Li L, Xie J, Zhang M, Wang S. Homocysteine harasses the imprinting expression of IGF2 and H19 by demethylation of differentially methylated region between IGF2/H19 genes. Acta Biochim Biophys Sin. 2009;41:464-471.
34. Castro R, Rivera I, Martins C, et al. Intracellular S- adenosylhomocysteine increased levels are associated with DNA hypomethylation in HUVEC. J Mol Med. 2005;83:831-836.
35. Bressler J, Shimmin LC, Boerwinkle E, Hixson JE. Global DNA methylation and risk of subclinical atherosclerosis in young adults: The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Atherosclerosis. 2011;219: 958-962.
36. Au-Yeung KK, Woo CW, Sung FL, et al. Hyperhomocysteinemia activates nuclear factor-kappaB in endothelial cells via oxidative stress. Circ Res. 2004;94:28-36.
37. Skurk C, Walsh K. Death receptor induced apoptosis: a new mechanism of homocysteine-mediated endothelial cell cytotoxicity. Hypertension. 2004;43:1168-1170.
38. Suhara T, Fukuo K, Yasuda O, et al. Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways. Hypertension. 2004;43:1208-1213.