The difference in immune response and IL-12p35 methylation between newborns and adults

Journal of Biomedical Science

Volumn 21, Issue 1, 2014, Pages

  Chen, Chia Jung ^a   Hou, Jia Woei ^a   Chiang, Bor Luen ^b,c,d  

^a CATHAY GENERAL HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Interleukin 12; Methylation; Newborn

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR; CHROMATIN; IL12A PROTEIN, HUMAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DNA METHYLATION; GENE EXPRESSION; GENE SEQUENCE; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NEWBORN; NEWBORN PERIOD; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROMOTER REGION; PROTEIN SYNTHESIS; AGING; CHROMATIN; CLINICAL TRIAL; COMPARATIVE STUDY; CYTOLOGY; FEMALE; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; MALE; TH1 CELL; TH2 CELL;

ADULT; AGING; CHROMATIN; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; HUMANS; INFANT, NEWBORN; INTERLEUKIN-12 SUBUNIT P35; MALE; TH1 CELLS; TH2 CELLS;

EID: 84906921946     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-014-0076-0     Document Type: Article

References (50)

1. Vaccination in the neonatal period and early infancy. CA Siegrist, Int Rev Immunol 2000 19 2-3 195 219 10.3109/08830180009088505
2. Defective IL2 gene expression in newborn is accompanied with impaired tyrosine-phosphorylation in T cells. H Ansart-Pirenne, N Soulimani, E Tartour, P Blot, G Sterkers, Pediatr Res 1999 45 3 409 413 10.1203/00006450-199903000-00020
3. Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells. GP White, PM Watt, BJ Holt, PG Holt, J Immunol 2002 168 6 2820 2827 10.4049/jimmunol.168.6.2820
4. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. MK Gately, LM Renzetti, J Magram, AS Stern, L Adorini, U Gubler, DH Presky, Annu Rev Immunol 1998 16 495 521 10.1146/annurev.immunol.16.1.495
5. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. M Kobayashi, L Fitz, M Ryan, RM Hewick, SC Clark, S Chan, R Loudon, F Sherman, B Perussia, G Trinchieri, J Exp Med 1989 170 3 827 845 10.1084/jem.170.3.827
6. Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. M Wysocka, M Kubin, LQ Vieira, L Ozmen, G Garotta, P Scott, G Trinchieri, Eur J Immunol 1995 25 3 672 676 10.1002/eji.1830250307
7. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. SF Wolf, PA Temple, M Kobayashi, D Young, M Dicig, L Lowe, R Dzialo, L Fitz, C Ferenz, RM Hewick, K Kelleher, SH Herrmann, SC Clark, L Azzoni, SC Chan, G Trinchieri, B Perussia, J Immunol 1991 146 9 3074 3081
8. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. R Manetti, P Parronchi, MG Giudizi, MP Piccinni, E Maggi, G Trinchieri, S Romagnani, J Exp Med 1993 177 4 1199 1204 10.1084/jem.177.4.1199
9. Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. MP Hayes, J Wang, MA Norcross, Blood 1995 86 2 646 650
10. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. A Snijders, CM Hilkens, TC van der Pouw Kraan, M Engel, LA Aarden, ML Kapsenberg, J Immunol 1996 156 3 1207 1212
11. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. O Schulz, AD Edwards, M Schito, J Aliberti, S Manickasingham, A Sher, C Reis e Sousa, Immunity 2000 13 4 453 462 10.1016/S1074-7613(00)00045-5
12. Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. E Seki, H Tsutsui, NM Tsuji, N Hayashi, K Adachi, H Nakano, S Futatsugi-Yumikura, O Takeuchi, K Hoshino, S Akira, J Fujimoto, K Nakanishi, J Immunol 2002 169 7 3863 3868 10.4049/jimmunol.169.7.3863
13. Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering. AD Edwards, SP Manickasingham, R Sporri, SS Diebold, O Schulz, A Sher, T Kaisho, S Akira, C Reis e Sousa, J Immunol 2002 169 7 3652 3660 10.4049/jimmunol.169.7.3652
14. c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription. R Grumont, H Hochrein, M O'Keeffe, R Gugasyan, C White, I Caminschi, W Cook, S Gerondakis, J Exp Med 2001 194 8 1021 1032 10.1084/jem.194.8.1021
15. Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. S Sanjabi, A Hoffmann, HC Liou, D Baltimore, ST Smale, Proc Natl Acad Sci U S A 2000 97 23 12705 12710 10.1073/pnas.230436397
16. Human IL-12(p35) gene activation involves selective remodeling of a single nucleosome within a region of the promoter containing critical Sp1-binding sites. S Goriely, D Demonte, S Nizet, D De Wit, F Willems, M Goldman, C Van Lint, Blood 2003 101 12 4894 4902 10.1182/blood-2002-09-2851
17. Deficient IL-12(p35) gene expression by dendritic cells derived from neonatal monocytes. S Goriely, B Vincart, P Stordeur, J Vekemans, F Willems, M Goldman, D De Wit, J Immunol 2001 166 3 2141 2146 10.4049/jimmunol.166.3.2141
18. Neonatal dendritic cells are intrinsically biased against Th-1 immune responses. CL Langrish, JC Buddle, AJ Thrasher, D Goldblatt, Clin Exp Immunol 2002 128 1 118 123 10.1046/j.1365-2249.2002.01817.x
19. A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells. S Goriely, C Van Lint, R Dadkhah, M Libin, D De Wit, D Demonte, F Willems, M Goldman, J Exp Med 2004 199 7 1011 1016 10.1084/jem.20031272
20. DNA methylation: regulation of gene expression and role in the immune system. R Mostoslavsky, Y Bergman, Biochim Biophys Acta 1997 1333 1 29 F50
21. Innate immunity of the newborn: basic mechanisms and clinical correlates. O Levy, Nat Rev Immunol 2007 7 5 379 390 10.1038/nri2075
22. Elevated circulating IL-1beta and TNF-alpha, and unaltered IL-6 in first-trimester pregnancies complicated by threatened abortion with an adverse outcome. N Vitoratos, C Papadias, E Economou, E Makrakis, C Panoulis, G Creatsas, Mediators Inflamm 2006 2006 4 30485
23. Passive and active components of neonatal innate immune defenses. MA Firth, PE Shewen, DC Hodgins, Anim Health Res Rev 2005 6 2 143 158 10.1079/AHR2005107
24. Innate cellular immune responses in newborns. L Marodi, Clin Immunol 2006 118 2-3 137 144 10.1016/j.clim.2005.10.012
25. House dust extracts have both TH2 adjuvant and tolerogenic activities. N Ng, D Lam, P Paulus, G Batzer, AA Horner, J Allergy Clin Immunol 2006 117 5 1074 1081 10.1016/j.jaci.2006.03.025
26. The effect of infections on susceptibility to autoimmune and allergic diseases. JF Bach, N Engl J Med 2002 347 12 911 920 10.1056/NEJMra020100
27. Renaissance of the hygiene hypothesis. AH Liu, DY Leung, J Allergy Clin Immunol 2006 117 5 1063 1066 10.1016/j.jaci.2006.03.027
28. The relationship between anthropometric measurements at birth: asthma and atopy in childhood. A Gregory, I Doull, N Pearce, S Cheng, P Leadbitter, S Holgate, R Beasley, Clin Exp Allergy 1999 29 3 330 333 10.1046/j.1365-2222.1999.00485.x
29. Relationship between fetal growth and the development of asthma and atopy in childhood. P Leadbitter, N Pearce, S Cheng, MR Sears, MD Holdaway, EM Flannery, GP Herbison, R Beasley, Thorax 1999 54 10 905 910 10.1136/thx.54.10.905
30. Perinatal risk factors for asthma in Finnish adolescent twins. M Rasanen, J Kaprio, T Laitinen, T Winter, M Koskenvuo, LA Laitinen, Thorax 2000 55 1 25 31 10.1136/thorax.55.1.25
31. Association between antenatal cytokine production and the development of atopy and asthma at age 6 years. C Macaubas, NH de Klerk, BJ Holt, C Wee, G Kendall, M Firth, PD Sly, PG Holt, Lancet 2003 362 9391 1192 1197 10.1016/S0140-6736(03)14542-4
32. Development of allergen-specific T-cell memory in atopic and normal children. SL Prescott, C Macaubas, T Smallacombe, BJ Holt, PD Sly, PG Holt, Lancet 1999 353 9148 196 200 10.1016/S0140-6736(98)05104-6
33. Fetal and neonatal IL-13 production during pregnancy and at birth and subsequent development of atopic symptoms. TJ Williams, CA Jones, EA Miles, JO Warner, JA Warner, J Allergy Clin Immunol 2000 105 5 951 959 10.1067/mai.2000.106211
34. Development of interleukin-12-producing capacity throughout childhood. JW Upham, PT Lee, BJ Holt, T Heaton, SL Prescott, MJ Sharp, PD Sly, PG Holt, Infect Immun 2002 70 12 6583 6588 10.1128/IAI.70.12.6583-6588.2002
35. Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. G Yap, M Pesin, A Sher, J Immunol 2000 165 2 628 631 10.4049/jimmunol.165.2.628
36. Sustained expression of CD154 (CD40L) and proinflammatory cytokine production by alloantigen-stimulated umbilical cord blood T cells. NC Matthews, M Wadhwa, C Bird, FE Borras, CV Navarrete, J Immunol 2000 164 12 6206 6212 10.4049/jimmunol.164.12.6206
37. The generation of Th memory in neonates versus adults: prolonged primary Th2 effector function and impaired development of Th1 memory effector function in murine neonates. B Adkins, Y Bu, P Guevara, J Immunol 2001 166 2 918 925 10.4049/jimmunol.166.2.918
38. Analysis of neonatal T cell and antigen presenting cell functions. HN Trivedi, KT HayGlass, V Gangur, JG Allardice, JE Embree, FA Plummer, Hum Immunol 1997 57 2 69 79 10.1016/S0198-8859(97)00202-4
39. Maturation of human neonatal CD4+ and CD8+ T lymphocytes into Th1/Th2 effectors. G Delespesse, LP Yang, Y Ohshima, C Demeure, U Shu, DG Byun, M Sarfati, Vaccine 1998 16 14-15 1415 1419 10.1016/S0264-410X(98)00101-7
40. Phenotype of fetal monocytes and B lymphocytes during the third trimester of pregnancy. CA Jones, JA Holloway, JO Warner, J Reprod Immunol 2002 56 1-2 45 60 10.1016/S0165-0378(02)00022-0
41. Defective macrophage function in neonates and its impact on unresponsiveness of neonates to polysaccharide antigens. RL Chelvarajan, SM Collins, IE Doubinskaia, S Goes, J Van Willigen, D Flanagan, WJ De Villiers, JS Bryson, S Bondada, J Leukoc Biol 2004 75 6 982 994 10.1189/jlb.0403179
42. Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. O Levy, EE Suter, RL Miller, MR Wessels, Blood 2006 108 4 1284 1290 10.1182/blood-2005-12-4821
43. Interferon-gamma-dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA-containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus-transformed lymphoblastoid cells. MP Hayes, FJ Murphy, PR Burd, Blood 1998 91 12 4645 4651
44. An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment. L Zhou, AA Nazarian, J Xu, D Tantin, LM Corcoran, ST Smale, Mol Cell Biol 2007 27 7 2698 2712 10.1128/MCB.00788-06
45. IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis. T Kobayashi, K Matsuoka, SZ Sheikh, SM Russo, Y Mishima, C Collins, EF deZoeten, CL Karp, JP Ting, RB Sartor, SE Plevy, J Immunol 2012 189 4 1792 1799 10.4049/jimmunol.1200042
46. Acquisition of adult-like TLR4 and TLR9 responses during the first year of life. M Nguyen, E Leuridan, T Zhang, D De Wit, F Willems, P Van Damme, M Goldman, S Goriely, PLoS One 2010 5 4 10407 10.1371/journal.pone.0010407
47. Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life. ME Belderbos, GM van Bleek, O Levy, MO Blanken, ML Houben, L Schuijff, JL Kimpen, L Bont, Clin Immunol 2009 133 2 228 237 10.1016/j.clim.2009.07.003
48. Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression. B Schaub, M Campo, H He, D Perkins, MW Gillman, DR Gold, S Weiss, E Lieberman, PW Finn, Respir Res 2006 7 40 10.1186/1465-9921-7-40
49. The interferon-alpha and interleukin-10 responses in neonates differ from adults, and their production remains partial throughout the first 18 months of life. O Vosters, C Lombard, F Andre, G Sana, EM Sokal, F Smets, Clin Exp Immunol 2010 162 3 494 499 10.1111/j.1365-2249.2010.04267.x
50. Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors. ME Belderbos, O Levy, F Stalpers, JL Kimpen, L Meyaard, L Bont, PLoS One 2012 7 3 33419 10.1371/journal.pone.0033419