Is there a role for physical activity in preventing cognitive decline in people with mild cognitive impairment?

Age and Ageing

Volumn 41, Issue 1, 2012, Pages 5-8

  Barber, Sally E ^a   Clegg, Andrew P ^a   Young, John B ^a  

^a BRADFORD INSTITUTE FOR HEALTH RESEARCH   (United Kingdom)

Author keywords

Ageing; Cognition; Dementia; Exercise therapy; Prevention

Indexed keywords

ARTICLE; CARDIOVASCULAR RISK; CLINICAL EFFECTIVENESS; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; DEGENERATIVE DISEASE; DEMENTIA; FEASIBILITY STUDY; HEALTH BEHAVIOR; HEALTH PROGRAM; HIGH RISK PATIENT; HUMAN; HYPERCHOLESTEROLEMIA; HYPERHOMOCYSTEINEMIA; INSULIN RESISTANCE; MILD COGNITIVE IMPAIRMENT; NEUROANATOMY; NEUROPROTECTION; NONHUMAN; OBESITY; OBSERVATIONAL STUDY; PHYSICAL ACTIVITY; PHYSICAL PERFORMANCE; PILOT STUDY; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; PROGRAM DEVELOPMENT; THERAPY EFFECT; TREATMENT OUTCOME; WALKING;

AGED; AGED, 80 AND OVER; DEMENTIA; FEMALE; HUMANS; MALE; MILD COGNITIVE IMPAIRMENT; MOTOR ACTIVITY; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 83455201563     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afr138     Document Type: Article

References (26)

1. Petersen RC, Roberts RO, Knopman DS et al. Mild cognitive impairment: ten years later. Arch Neurol 2009; 66: 1447-55.
2. Mitchell AJ, Shiri-Feshki M. Rate of progression of mild cognitive impairment to dementia: meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand 2009; 119: 252-65.
3. Schneider JA, Arvanitakis Z, Leurgans SE, Bennett DA. The neuropathology of probable Alzheimer's disease and mild cognitive impairment. Ann Neurol 2009; 66: 200-8.
4. Morris JC, Storandt M, Miller JP et al. Mild cognitive impairment represents early-stage Alzheimers disease. Arch Neurol 2001; 58: 1705-6.
5. Knapp M, Prince M. Dementia UK: a report into the prevalence and cost of dementia prepared by the Personal Social Services Research Unit (PSSRU) at the London School of Economics and the Institute of Psychiatry at King's College London, for the Alzheimer's Society. The full report. London: The Alzheimer's Society, 2007. Weblink: http://www.pssru.ac.uk/pdf/dp2418.pdf (accessed on 24 December 2010).
6. Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise and physical fitness: definitions and distinctions for health-related research. Public Health Rep 1985; 100: 126-31.
7. Van Pragg H. Exercise and the brain: something to chew on. Trends Neurosci 2009; 32: 283-90.
8. Kumari U, Heese K. Cardiovascular dementia: a different perspective. Open Biochem J 2010; 4: 29-52.
9. Uchida S, Suzuki A, Kagitani F, Hotta H. Responses of acetylcholine release and regional blood flow in the hippocampus during walking in aged rats. J Physiol Sci 2006; 56: 253-7.
10. Aarsland D, Sardahaee S, Anderssen S, Ballard C, the Alzheimer's Society Systematic Review Group. Is physical activity a potential preventative factor for vascular dementia? A systematic review. Aging Mental Health 2010; 14: 386-95.
11. Joyner MJ, Green DJ. Exercise protects the cardiovascular system: effects beyond traditional risk factors. J Physiol 2009; 578: 5551-8.
12. Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus? A systematic review. Lancet Neurol 2006; 5: 64-74.
13. Radak Z, Kumagai S, Taylor AW, Naito H, Goto S. Effects of exercise on brain function: role of free radicals. Appl Physiol Nutr Metab 2007; 32: 942-6.
14. Ennezar PV, Malendowicz LS, Testa M et al. Physical training in patients with chronic heart failure enhances the expression of genes antioxidative enzymes. J Am Coll Cardiol 2001; 38: 194-8.
15. Stranahan AM, Zhou Y, Martin B, Maudsley S. Pharmacomimetics of exercise: novel approaches for hippocampally-targeted neuroprotective agents. Curr Med Chem 2009; 16: 4668-78.
16. Colcombe SJ, Erickson KI, Raz N et al. Aerobic fitness reduces brain tissue loss in aging humans. J Gerontol A Bio Sci Med Sci 2003; 58: 176-80.
17. Marks BL, Madden DJ, Bucur B et al. Role of aerobic fitness and aging on cerebral white matter integrity. Ann N Y Acad Sci 2007; 1097: 171-4.
18. Geda YE, Roberts RO, Knopman DS et al. Physical exercise, aging and mild cognitive impairment. A population based study. Arch Neurol 2010; 67: 80-6.
19. Verghese J, Lipton RB, Katz MJ et al. Leisure activities and the risk of dementia in the elderly. N Engl J Med 2003; 348: 2508-16.
20. Hamer M, Chida Y. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol Med 2009; 39: 3-11.
21. Sofi F, Valecchi D, Bacci D et al. Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J Intern Med 2011; 269: 107-17.
22. Baker LD, Frank LL, Forster-Schubert K et al. Effects of aerobic exercise on mild cognitive impairment. Arch Neurol 2010; 67: 71-9.
23. Van Uffelen JGZ, Chinapaw MJM, Van Mechelen W, Hopman-Rock M. Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trail. Br J Sports Med 2008; 42: 344-51.
24. Lautenschlager NT, Cox KL, Flicker L et al. Effects of physical activity on cognitive function in older adults at risk for Alzheimer's disease. JAMA 2008; 300: 1027-37.
25. Trost SG, Owen N, Bauman AE, Sallis JF, Brown W. Correlates of adults' participation in physical activity: review and update. Med Sci Sports Exerc 2002; 34: 1996-2001.
26. Logsdon RG, McCurry SM, Pike K, Teri L. Making physical activity accessible to older adults with memory loss: a feasibility study. Gerontologist 2009; 49: S94-9.