Total glucosides of Paeonia lactiflora pall suppress nitric oxide production and iNOS expression in lipopolysaccharide-stimulated RAW264.7 macrophages

Tropical Journal of Pharmaceutical Research

Volumn 13, Issue 8, 2014, Pages 1273-1278

  Chen, Gang ^a   Tan, Ming Liang ^a   Gao, Xue ^a   Kong, Shu Zhen ^a  

^a CHONGQING TECHNOLOGY AND BUSINESS UNIVERSITY   (China)

Author keywords

iNOs; Nitric oxide; Nuclear factor and B; Paeonia lactiflora; Total glucosides

Indexed keywords

EID: 84906877311     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: 10.4314/tjpr.v13i8.11     Document Type: Article

References (17)

1. Astry B, Harberts E, Moudgil KD. A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis. J Interferon Cytokine Res 2011; 31: 927-940.
2. Nagy G, Clark JM, Buzas EI, Gorman CL, Cope AP. Nitric oxide, chronic inflammation and autoimmunity. Immunol Lett 2007; 111: 1-5.
3. Grasemann H, Ratjen F. Nitric oxide and L-arginine deficiency in cystic fibrosis. Curr Pharm Des 2012; 18: 726-736.
4. Onur O, Akinci AS, Akbiyik F, Unsal I. Elevated levels of nitrate in rheumatoid arthritis. Rheumatol Int 2001; 20: 154-158.
5. Oates JC, Shaftman SR, Self SE, Gilkeson GS. Association of serum nitrate and nitrite levels with longitudinal assessments of disease activity and damage in systemic lupus erythematosus and lupus nephritis. Arthritis Rheum 2008; 58: 263-272.
6. Gonzalez-Gay MA, Llorca J, Sanchez E, Lopez-Nevot MA, Amoli MM, Garcia-Porrua C, Ollier WE, Martin J. Inducible but not endothelial nitric oxide synthase polymorphism is associated with susceptibility to rheumatoid arthritis in northwest Spain. Rheumatology (Oxford) 2004; 43: 1182-1185.
7. Oates JC, Levesque MC, Hobbs MR, Smith EG, Molano ID, Page GP, Hill BS, Weinberg JB, Cooper GS, Gilkeson GS. Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in African-Americans. J Rheumatol 2003; 30: 60-67.
8. Napetschnig J, Wu H. Molecular basis of NF-kappaB signaling. Annu Rev Biophys 2013; 42: 443-468.
9. Jayasooriya RGPT, Jang YJ, Kang CH, Dilshara MG, Moon DO, Nam TJ, Choi YH, Kim GY. Inhibition of Nitric Oxide and Prostaglandin E2 Expression by Methanol Extract of Polyopes affinis in Lipopolysaccharide-stimulated BV2 Microglial Cells through Suppression of Akt-dependent NF-kB Activity and MAPK Pathway. Tropical Journal of Pharmaceutical Research 2013; 12: 63-70.
10. Ruiz PA, Braune A, Holzlwimmer G, Quintanilla-Fend L, Haller D. Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J Nutr 2007; 137: 1208-1215.
11. Chen G, Jia P, Gao X. Effect and mechanism of shaoyao-gancao-tang on adjuvant-induced arthritis in rats. African Journal of Pharmacy and Pharmacology 2012; 6: 1611-1616.
12. Chen G, Tan ML, Gao X, Jia P. Dual Regulating Effect of Shaoyao-Gangcao-Tang on COX-2 Expression in Acute and Resolution Phases of Carrageenin-Induced Pleurisy in Rats. Tropical Journal of Pharmaceutical Research 2013; 12: 727-733.
13. Montecucco F, Mach F. Common inflammatory mediators orchestrate pathophysiological processes in rheumatoid arthritis and atherosclerosis. Rheumatology (Oxford) 2009; 48: 11-22.
14. Sakaguchi Y, Shirahase H, Ichikawa A, Kanda M, Nozaki Y, Uehara Y. Effects of selective iNOS inhibition on type II collagen-induced arthritis in mice. Life Sci 2004; 75: 2257-2267.
15. Jarvinen K, Vuolteenaho K, Nieminen R, Moilanen T, Knowles RG, Moilanen E. Selective iNOS inhibitor 1400W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage. Survey of the effects of 1400W on inflammatory mediators produced by OA cartilage as detected by protein antibody array. Clin Exp Rheumatol 2008; 26: 275-282.
16. Nagy G, Clark JM, Buzas E, Gorman CL, Geher P, Perl A, Falus A, Cope AP. Nitric oxide differentially regulates T-cell function in rheumatoid arthritis and systemic lupus erythematosus. Arthritis Research & Therapy 2007; 9: 26-27.
17. Robinson SM, Mann DA. Role of nuclear factor kappaB in liver health and disease. Clin Sci (Lond) 2010; 118: 691-705.