Molecular evolution of the tissue-nonspecific alkaline phosphatase allows prediction and validation of missense mutations responsible for hypophosphatasia

Journal of Biological Chemistry

Volumn 289, Issue 35, 2014, Pages 24168-24179

  Silvent, Jéŕemie ^a,d   Gasse, Barbara ^a   Mornet, Etienne ^b,c   Sire, Jean Yves ^a  

^a Département de Biologie   (France)

^b LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^c CENTRE HOSPITALIER DE VERSAILLES   (France)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BONE; MAMMALS; MINERALOGY; MOLECULAR BIOLOGY; PHOSPHATASES; PROTEINS; TISSUE;

ALKALINE PHOSPHATASE; BIOLOGICAL FUNCTIONS; GENETIC DISORDERS; IN-SILICO MODELS; MOLECULAR EVOLUTION; PREDICTIVE POWER; PROTEIN FUNCTIONS; VARIOUS SUBSTRATES;

FORECASTING;

ALKALINE PHOSPHATASE; ASPARTIC ACID; GLUTAMIC ACID; HISTIDINE; METHIONINE; PHENYLALANINE; SERINE; THREONINE; TISSUE NONSPECIFIC ALKALINE PHOSPHATASE; UNCLASSIFIED DRUG; PRIMER DNA;

ALPL GENE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; EXON; GENE; GENE MUTATION; HUMAN; HYPOPHOSPHATASIA; MISSENSE MUTATION; MOLECULAR EVOLUTION; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PREDICTION; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; ANIMAL; CHEMISTRY; CLASSIFICATION; GENETICS; MOLECULAR GENETICS; VALIDATION STUDY;

ALKALINE PHOSPHATASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; DNA PRIMERS; EVOLUTION, MOLECULAR; HUMANS; HYPOPHOSPHATASIA; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PHYLOGENY; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84906860668     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.576843     Document Type: Article

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