Management of anemia with erythropoietic-stimulating agents in children with chronic kidney disease

Pediatric Nephrology

Volumn 29, Issue 9, 2014, Pages 1493-1505

  Warady, Bradley A ^b   Silverstein, Douglas M ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b CHILDREN S MERCY HOSPITAL   (United States)

Author keywords

Anemia; Biosimilar; Erythropoietin; Hemoglobin

Indexed keywords

AKB 6548; ANTIANEMIC AGENT; CNTO 528; CNTO 530; CONTINUOUS ERYTHROPOIESIS RECEPTOR ACTIVATOR; EPOPEN; ERITROGEN; GSK 1278863; HEMOGLOBIN; MOLIDUSTAT; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; PEGINESATIDE; RATIOEPO; RECOMBINANT ERYTHROPOIETIN; RETRACIT; ROXADUSTAT; SOTATERCEPT; UNCLASSIFIED DRUG;

ANEMIA; CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; COMORBIDITY; DIALYSIS; DRUG EFFICACY; END STAGE RENAL DISEASE; HEMOGLOBIN BLOOD LEVEL; HUMAN; PRIORITY JOURNAL; REVIEW; SURVIVAL RATE; TREATMENT OUTCOME; CHILD; CHRONIC KIDNEY FAILURE; COMPLICATION;

ANEMIA; CHILD; HEMATINICS; HUMANS; RENAL INSUFFICIENCY, CHRONIC;

EID: 84906838632     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-013-2557-x     Document Type: Review

References (125)

1. Department of Health and Human Services, Centers for Medicare & Medicaid Services, Office of Clinical Standards & Quality (2005) 2005 Annual Report, End Stage Renal Disease Clinical Performance Measures Project. Baltimore, Maryland
2. Staples AO, Wong CS, Smith JM, Gipson DS, Filler G, Warady BA, Martz K, Greenbaum LA (2008) Anemia and risk of hospitalization in pediatric chronic kidney disease. Clin J Am Soc Nephrol 4:48-56
3. Atkinson MA, Martz K, Warady BA, Neu AM (2010) Risk for anemia in pediatric chronic kidney disease patients: a report of NAPRTCS. Pediatr Nephrol 25:1699-1706
4. Wong H, Mylrea K, Feber J, Drukker A, Filler G (2006) Prevalence of complications in children with chronic kidney disease according to KDOQI. Kidney Int 70:585-590 (Pubitemid 44141587)
5. McGonigle RJ, Wallin JD, Shadduck RK, Fisher JW (1984) Erythropoietin deficiency and inhibition of erythropoiesis in renal insufficiency. Kidney Int 25:437-444 (Pubitemid 14142834)
6. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW (1987) Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. N Engl J Med 316:73-78
7. Kidney Disease: Improving Global Outcomes (KDIGO) Anemia Work Group (2012) KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Kidney Int 2:279-335
8. National Kidney Foundation (2006) K/DOQI clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease. Am J Kidney Dis 47:S1-S146
9. World Health Organization (2008) de Benoist B, McLean E, Egli I and Cogswell M (eds) Worldwide Prevalence of Anaemia 1993-2005; WHO Global Database on Anaemia (available at whqlibdoc.who.int/publications/2008/9789241596657-eng. pdf)
10. Nangaku M, Eckardt KU (2006) Pathogenesis of renal anemia. Semin Nephrol 26:261-268 (Pubitemid 44722454)
11. Atkinson MA, Furth SL (2011) Anemia in children with chronic kidney disease. Nat Rev Nephrol 7:635-641
12. Atkinson MA, Pierce CB, Zack RM, Barletta GM, Yadin O, Mentser M, Warady BA, Furth SL (2010) Hemoglobin differences by race in children with CKD. Am J Kidney Dis 55:1009-1017
13. Donnelly S (2001) Why is erythropoietin made in the kidney? The kidney functions as a critmeter. Am J Kidney Dis 38:415-425
14. Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, Yamamura K-I, Nagoshi N, Shibata S, Rao TN, Fehling HJ, Fukatsu A, Minegishi N, Kita T, Kimura T, Okano H, Yamamoto M, Yanagita M (2011) Dysfunction of fibroblasta of extrarenal origin underlies renal fibrosis and renal anemia in mice. J Clin Invest 121:3981-3990
15. Mitsnefes MM, Kimball TR, Kartal J, Witt SA, Glascock BJ, Khoury PR, Daniels SR (2006) Progression of left ventricular hypertrophy in children with early chronic kidney disease: 2-year follow-up study. J Pediatr 149:671-675 (Pubitemid 44692241)
16. Mitsnefes M, Flynn J, Cole S, Samuels J, Blydt-Hansen T, Saland J, Kimball T, Furth S, Warady B, CKiD Study Group (2010) Masked hypertension associates with left ventricular hypertrophy in children with CKD. J Am Soc Nephrol 21:137-144
17. Schaefer F (2008) Cardiac disease in children with mild-to moderate chronic kidney disease. Curr Opin Nephrol Hypertens 17:292-297
18. Gerson A, Hwang W, Fiorenza J, Barth K, Kaskel F, Weiss L, Zelikovsky N, Fivush B, Furth S (2004) Anemia and health-related quality of life in adolescents with chronic kidney disease. Am J Kidney Dis 44:1017-1023 (Pubitemid 39556481)
19. Borzych-Buzalka D, Bilginer Y, Ha IS, Bak M, Rees L, Cano F, Munarriz RL, Chua A, Pesle S, Emre S, Urzykowska A, Quiroz L, Ruscasso JD, White C, Pape L, Ramela V, Printza N, Vogel A, Kuzmanovska D, Simkova E, Muller-Wiefel DE, Sander A, Warady BA, Schaefer F, International Pediatric Peritoneal Dialysis Network (IPPN) Registry (2013) Management of anemia in children receiving chronic peritoneal dialysis. J Am Soc Nephrol 24:665-676
20. Furth SL, Cole SR, Fadrowski JJ, Gerson A, Pierce CB, Chandra M, Weiss R, Kaskel F, Council of Pediatric Nephrology and Urology, New York/New Jersey; Kidney and Urology Foundation of America (2007) The association of anemia and hypoalbuminemia with accelerated decline in GFR among adolescents with chronic kidney disease. Pediatr Nephrol 22:265-271 (Pubitemid 44964328)
21. Wuhl E, Schaefer F (2008) Therapeutic strategies to slow chronic kidney disease progression. Pediatr Nephrol 23:705-716
22. Filler G, Mylrea K, Feber J, Wong H (2007) How to define anemia in children with chronic kidney disease? Pediatr Nephrol 22:702-707 (Pubitemid 46691527)
23. Amaral S, Hwang W, Fivush B, Neu A, Frankenfield D, Furth S (2006) Association of mortality and hospitalization with achievement of adult hemoglobin targets in adolescents maintained on hemodialysis. J Am Soc Nephrol 17:2878-2885 (Pubitemid 44484678)
24. Warady BA, Ho M (2003) Morbidity and mortality in children with anemia at initiation of dialysis. Pediatr Nephrol 18:1055-1062 (Pubitemid 37236222)
25. Maxwell PH, Ferguson DJ, Nicholls LG, Iredale JP, Pugh CW, Johnson MH, Ratcliffe PJ (1997) Sites of erythropoietin production. Kidney Int 51:393-401 (Pubitemid 27088149)
26. Nangaku M, Eckardt KU (2007) Hypoxia and the HIF system in kidney disease. J Mol Med (Berl) 85:1325-1330 (Pubitemid 50004091)
27. Silva M, Grillot D, Benito A, Richard C, Nunez G, Fernandez-Luna JL (1996) Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2. Blood 88:1576-1582 (Pubitemid 26307051)
28. Pregi N, Wenker S, Vittori D, Leiros CP, Nesse A (2009) TNF-alpha-induced apoptosis is prevented by erythropoietin treatment on SH-SY5Y cells. Exp Cell Res 315:419-431
29. Yang B, Hosgood SA, Bagul A, Waller HL, Nicholson ML (2011) Erythropoietin regulates apoptosis inflammation and tissue remodelling via caspase-3 and IL-1β in isolated hemoperfused kidneys. Eur J Pharmacol 660:420-430
30. Lin FK, Suggs S, Lin CH, Browne JK, Smalling R, Egrie JC, Chen KK, Fox GM, Martin F, Stabinsky Z, Badrawi SM, Lai P, Goldwasser E (1985) Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci USA 82:7580-7584 (Pubitemid 16204391)
31. Sikole A, Spasovski G, Zafirov D, Polenakovic M (2002) Epoetin omega for treatment of anemia in maintenance hemodialysis patients. Clin Nephrol 57:237-245 (Pubitemid 34213663)
32. Spinowitz BS, Pratt RD, Epoetin Delta 2002 Study Group (2006) Epoetin delta is effective for the management of anaemia associated with chronic kidney disease. Curr Med Res Opin 22:25072513
33. United States Renal Data System (2009) USRDS 2009 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. Bethesda, 2009 (available at http://www.usrds. org/atlas09.aspx)
34. North American Pediatric Renal Trials and Collaborative Studies (2011) (NAPRTCS) 2011 Annual Dialysis Report (available at https://web.emmes.com/study/ ped/annlrept/annualrept2011.pdf)
35. Egrie JC, Dwyer E, Browne JK, Hitz A, Lykos MA (2003) Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin. Exp Hematol 31:290-299 (Pubitemid 36407605)
36. Egrie JC, Browne JK (2001) Development and characterisation of novel erythropoiesis-stimulating protein (NESP). Nephrol Dial Transplant 16(Suppl 3):3-13 (Pubitemid 32591159)
37. Debeljak N, Sytkowski AJ (2012) Erythropoietin and erythropoiesis- stimulating agents. Drug Test Anal 4:805-812
38. Warady BA, Arar MY, Lerner G, Nakanishi AM, Stehman-Breen C (2006) Darbepoetin alfa for the treatment of anemia in pediatric patients with chronic kidney disease. Pediatr Nephrol 21:1144-1152 (Pubitemid 44083889)
39. De Palo T, Giordano M, Palumbo F, Bellantuono R, Messina G, Colella V, Caringella AD (2004) Clinical experience with darbepoetin alfa (NESP) in children undergoing hemodialysis. Pediatr Nephrol 19:337-340 (Pubitemid 38313021)
40. Besarab A, Bolton WK, Browne JK, Egrie JC, Nissenson AR, Okamoto DM, Schwab SJ, Goodkin DA (1998) The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. N Engl J Med 339:584-590 (Pubitemid 28385655)
41. Drueke TB, Locatelli F, Clyne N, Eckardt KU, Macdougall IC, Tsakiris D, Burger HU, Scherhag A, CREATE Investigators (2006) Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 355:2071-2084 (Pubitemid 44749316)
42. Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, Reddan D, CHOIR Investigators (2006) Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 355:2085-2098 (Pubitemid 44749317)
43. Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, Feyzi JM, Ivanovich P, Kewalramani R, Levey AS, Lewis EF, McGill JB, McMurray JJ, Parfrey P, Parving HH, Remuzzi G, Singh AK, Solomon SD, Toto R, TREAT Investigators (2009) A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 361:2019-2032
44. Koulouridis I, Alfayez M, Trikalinos TA, Balk EM, Jaber BL (2013) Dose of erythropoiesis-stimulating agents and adverse outcomes in CKD: a metaregression analysis. Am J Kidney Dis 61:44-56
45. Kliger AS, Fishbane S, Finkelstein FO (2012) Erythropoietic-stimulating agents and quality of a patient's life: individualizing anemia treatment. Clin J Am Soc Nephrol 7:354-357
46. Keithi-Reddy SR, Singh AK (2009) Hemoglobin target in chronic kidney disease: a pediatric perspective. Pediatr Nephrol 24:431-434
47. Koshy SM, Geary DF (2008) Anemia in children with chronic kidney disease. Pediatr Nephrol 23:209-219
48. Foley RN (2008) Erythropoietin: physiology and molecular mechanisms. Heart Fail Rev 13:405-414
49. Port RE, Mehls O (2009) Erythropoietin dosing in children with chronic kidney disease: based on body size or on hemoglobin deficit? Pediatr Nephrol 24:435-437
50. Port RE, Kiepe D, Van Guilder M, Jelliffe RW, Mehls O (2004) Recombinant human erythropoietin for the treatment of renal anaemia in children: no justification for bodyweight-adjusted dosage. Clin Pharmacokinet 43:57-70 (Pubitemid 38186933)
51. Morris KP, Sharp J, Watson S, Coulthard MG (1993) Non-cardiac benefits of human recombinant erythropoietin in end-stage renal failure and anaemia. Arch Dis Child 69:580-586 (Pubitemid 23355854)
52. Jabs K (1996) The effects of recombinant human erythropoietin on growth and nutritional status. Pediatr Nephrol 10:324-327
53. Van Damme-Lombaerts R, Broyer M, Businger J, Baldauf C, Stocker H (1994) A study of recombinant human erythropoietin in the treatment of anemia of chronic renal failure in children on hemodialysis. Pediatr Nephrol 8:338-342 (Pubitemid 24162276)
54. Yalcinkaya F, Tumer N, Cakar N, Ozkaya N (1997) Low-dose erythropoietin is effective and safe in children on continuous ambulatory peritoneal dialysis. Pediatr Nephrol 11:350-352 (Pubitemid 27230824)
55. Gagnadoux MF, Loirat C, Berthélémé JP, Maisin A, Kamoun A, Dabout D, Poisson D, Broyer M (1994) Treatment of anemia in hemodialyzed children using recombinant human erythropoietin (Eprex). Results of a French multicenter clinical trial. Nephrologie 15:207-211
56. Chavers BM, Roberts TL, Herzog CA, Collins AJ, St Peter WL (2004) Prevalence of anemia in erythropoietin-treated pediatric as compared to adult chronic dialysis patients. Kidney Int 65:266-273 (Pubitemid 38037513)
57. van Stralen KJ, Krischock L, Schaefer F, Verrina E, Groothoff JW, Evans J, Heaf J, Ivanov D, Kostic M, Maringhini S, Podracka L, Printza N, Pundziene B, Reusz GS, Vondrak K, Jager KJ, Tizard EJ, ESPN/ERA-EDTA Registry (2012) Prevalence and predictors of the sub-target Hb level in children on dialysis. Nephrol Dial Transplant 27:3950-3957
58. Opelz G, Graver B, Mickey MR, Terasaki PI (1981) Lymphocytotoxic antibody responses to transfusions in potential kidney transplant recipients. Transplantation 32:177-183 (Pubitemid 11004244)
59. Opelz G, Vanrenterghem Y, Kirste G, Gray DW, Horsburgh T, Lachance JG, Largiader F, Lange H, Vujaklija-Stipanovic K, Alvarez-Grande J, Schott W, Hoyer J, Schnuelle P, Descoeudres C, Ruder H, Wujciak T, Schwarz V (1997) Prospective evaluation of pretransplant blood transfusions in cadaver kidney recipients. Transplantation 63:964-967 (Pubitemid 27173018)
60. Sinai-Trieman L, Salusky IB, Fine RN (1989) Use of subcutaneous recombinant human erythropoietin in children undergoing continuous cycling peritoneal dialysis. J Pediatr 114:550-554 (Pubitemid 19098284)
61. Kokot F, Wiecek A, Grzeszczak W (1991) Decreased need for blood transfusion during one year after discontinued erythropoietin treatment in haemodialyzed patients. Nephron 58:246-247
62. Grimm PC, Sinai-Trieman L, Sekiya NM, Robertson LS, Robinson BJ, Fine RN, Ettenger RB (1990) Effects of recombinant human erythropoietin on HLA sensitization and cell mediated immunity. Kidney Int 38:12-18 (Pubitemid 20209426)
63. Berland Y, Baz M, Di Stefano D, Merzouk T, Bartoli JM, Dussol B, Kasbarian M (1992) Recombinant human erythropoietin treatment reverses hepatic iron overload in hemodialysis patients. Nephrol Dial Transplant 7:366-367
64. Warady BA, Sabath RJ, Smith CA, Alon U, Hellerstein S (1991) Recombinant human erythropoietin in pediatric patients receiving long-term peritoneal dialysis. Pediatr Nephrol 5:718-723
65. Burke JR (1995) Low-dose subcutaneous recombinant erythropoietin in children with chronic renal failure. Australian and New Zealand Paediatric Nephrology Association. Pediatr Nephrol 9:558-561
66. Montini G, Zacchello G, Baraldi E, Zanconato S, Suppiej A, Fabris F, Andreetta B, Pavanello L, Zacchello F (1990) Benefits and risks of anemia correction with recombinant human erythropoietin in children maintained by hemodialysis. J Pediatr 117:556-560 (Pubitemid 20332094)
67. Bamgbola OF (2011) Pattern of resistance to erythropoietin-stimulating agents in chronic kidney disease. Kidney Int 80:464-474
68. Kalantar-Zadeh K, Höffken B, Wünsch H, Fink H, Kleiner M, Luft FC (1995) Diagnosis of iron deficiency anemia in renal failure patients during the post-erythropoietin era. Am J Kidney Dis 26:292-299
69. Warady BA, Kausz A, Lerner G, Brewer ED, Chadha V, Brugnara C, Dahl NV, Watkins SL (2004) Iron therapy in the pediatric hemodialysis population. Pediatr Nephrol 19:655-661 (Pubitemid 38771738)
70. Warady BA, Zobrist RH, Wu J, Finan E, Ferrlecit Pediatric Study Group (2005) Sodium ferric gluconate complex therapy in anemic children on hemodialysis. Pediatr Nephrol 20:1320-1327 (Pubitemid 41222981)
71. Goldstein S, Morris D, Warady BA (2013) Comparison of the safety and efficacy of 3 iron sucrose iron maintenance regimens in children, adolescents, and young adults with CKD: a randomized controlled trial. Am J Kidney Dis 61:588-597
72. Young B, Zaritsky J (2009) Hepcidin for clinicians. Clin J Am Soc Nephrol 4:1384-1387
73. Atkinson MA, White CT (2012) Hepcidin in anemia of chronic kidney disease: review for the pediatric nephrologist. Pediatr Nephrol 27:33-40
74. Bamgbola O (2012) Resistance to erythropoietin-stimulating agents: etiology, evaluation, and therapeutic considerations. Pediatr Nephrol 27:195-205
75. Macdougall I, Cooper A (2002) Erythropoietin resistance: the role of inflammation and pro-inflammatory cytokines. Nephrol Dial Transplant 17:S39-S43
76. Rattanasompattikul M, Molnar MZ, Zaritsky JJ, Hatamizadeh P, Jing J, Norris KC, Kovesdy CP, Kalantar-Zedeh K (2012) Association of malnutrition-inflammation complex and responsiveness to erythropoiesis- stimulating agents in long-term hemodialysis patients. Nephrol Dial Transplant. doi:10.1093/ndt/gfs368
77. Gallieni M, Corsi C, Brancaccio D (2000) Hyperparathyroidism and anemia in renal failure. Am J Nephrol 20:89-96 (Pubitemid 30224017)
78. Diskin CJ, Stokes TJ, Dansby LM, Radcliff L, Carter TB (2006) Can acidosis and hyperphosphataemia result in increased erythropoietin dosing in haemodialyzed patients? Nephrology 11:394-399 (Pubitemid 44470086)
79. Bamgbola OF, Kaskel F (2005) Role of folate deficiency on erythropoietin resistance in pediatric and adolescent patients on chronic dialysis. Pediatr Nephrol 20:1622-1629 (Pubitemid 41554477)
80. Casadevall N, Nataf J, Viron B, Kolta A, Kiladjian JJ, Martin-Dupont P, Michaud P, Papo T, Ugo V, Teyssandier I, Varet B, Mayeux P (2002) Pure red cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin. N Eng J Med 346:469-475 (Pubitemid 34441737)
81. Macdougall IC, Roger SD, de Francisco A, Goldsmith DJ, Schellekens H, Ebbers H, Jelkmann W, London G, Casadevall N, Hörl WH, Kemeny DM, Pollock C (2012) Antibody-mediated pure red cell aplasia in chronic kidney disease patients receiving erythropoiesis-stimulating agents: new insights. Kidney Int 81:727-732
82. Mattison P, Upadhyay K, Wilcox JE, Moudgil A, Silverstein DM (2010) Anti-erythropoietin antibodies followed by endogenous erythropoietin production in a dialysis patient. Pediatr Nephrol 25:971-976
83. Cournoyer D, Toffelmire EB, Wells GA, Barber DL, Barrett BJ, Delage R, Forrest DL, Gagnon RF, Harvey EA, Laneuville P, Patterson BJ, Poon MC, Posen GA, Messner HA, Canadian PRCA Focus Group (2004) Anti-erythropoietin antibody-mediated pure red cell aplasia after treatment with recombinant erythropoietin products: recommendations for minimization of risk. J Am Soc Nephrol 15:2728-2734 (Pubitemid 41103380)
84. Shimizu H, Saitoh T, Ota F, Jimbo T, Tsukada Y, Murakami H, Nojima Y (2011) Pure red cell aplasia induced only by intravenous administration of recombinant human erythropoietin. Acta Haematol 126:114-118
85. Verhelst D, Rossert J, Casadevall N, Krüger A, Eckardt KU, Macdougall IC (2004) Treatment of erythropoietin-induced pure red cell aplasia: a retrospective study. Lancet 363:1768-1771
86. Andrade J, Taylor PA, Love JM, Levin A (2005) Successful reintroduction of a different erythropoiesis-stimulating agent after pure red cell aplasia: relapse after successful therapy with prednisone. Nephrol Dial Transplant 20:2548-2551 (Pubitemid 41548887)
87. Macdougall IC, Rossert J, Casadevall N, Stead RB, Duliege AM, Froissart M, Eckardt KU (2009) A peptide-based erythropoietin-receptor agonist for pure red-cell aplasia.NEngl JMed 361:1848-1855
88. Palmer SC, Navaneethan SD, Craig JC, Johnson DW, Tonelli M, Garg AX, Pellegrini F, Ravani P, Jardine M, Perkovic V, Graziano G, McGee R, Nicolucci A, Tognoni G, Strippoli GF (2010) Metaanalysis: erythropoiesis-stimulating agents in patients with chronic kidney disease. Ann Intern Med 153:23-33
89. Brandt JR, Avner ED, Hickman RO, Watkins SL (1999) Safety and efficacy of erythropoietin in children with chronic renal failure. Pediatr Nephrol 13:143-147 (Pubitemid 29206242)
90. Coyne DW (2012) The health-related quality of life was not improved by targeting higher hemoglobin in the Normal Hematocrit Trial. Kidney Int 82:235-241
91. Goodkin DA, Fuller DS, Robinson BM, Combe C, Fluck R, Mendelssohn D, Akizawa T, Pisoni RL, Port FK (2011) Naturally occurring higher hemoglobin concentration does not increase mortality among hemodialysis patients. J Am Soc Nephrol 22:358-365
92. Chaknos CM, Berns JS (2013) Erythropoiesis-stimulating agents on trial: are higher dosages causing harm? Am J Kidney Dis 61:6-8
93. Smith KJ, Bleyer AJ, Little WC, Sane DC (2003) The cardiovascular effects of erythropoietin. Cardiovasc Res 59:538-548 (Pubitemid 38368670)
94. Vaziri ND, Zhou XJ (2009) Potential mechanisms of adverse outcomes in trials of anemia correction with erythropoietin in chronic kidney disease. Nephrol Dial Transplant 24:1082-1088
95. Morakkabati N, Gollnick F, Meyer R, Fandrey J, Jelkmann W (1997) Erythropoietin induces Ca2+ mobilization and contraction in rat mesangial and aortic smooth muscle cultures. Exp Hematol 24:392-397
96. Covic A, Cannata-Andia J, Cancarini G, Coppo R, Frazão JM, Goldsmith D, Ronco P, Spasovski GB, Stenvinkel P, Utas C, Wiecek A, Zoccali C, London G (2011) Biosimilars and biopharmaceuticals: what nephrologists need to know - a position paper by the ERAEDTA Council. Nephrol Dial Transplant 23:3731-3737
97. Jelkmann W (2012) Biosimilar recombinant human erythropoietins ("epoetins") and future erythropoiesis-stimulating treatments. Expert Opin Biol Ther 12:581-592
98. Wish JB (2011) Erythropoiesis-stimulating agents and pure redcell aplasia: you can't fool Mother Nature. Kidney Int 80:11-13
99. Ahmed I (2011) Biosimilars in the US - Guidance from the European Experience. US Nephrol 6:84-90
100. Macdougall IC (2012) New anemia therapies: translating novel strategies from bench to bedside. Am J Kidney Dis 59:444-451
101. Praditpornsilpa K, Tiranathanagul K, Kupatawintu P, Jootar S, Intragumtornchai T, Tungsanga K, Teerapornlertratt T, Lumlertkul D, Townamchai N, Susantitaphong P, Katavetin P, Kanjanabuch T, Avihingsanon Y, Eiam-Ong S (2011) Biosimilar recombinant human erythropoietin induces the production of neutralizing antibodies. Kidney Int 80:88-92
102. Macdougall IC, Ashenden M (2009) Current and upcoming erythropoiesis-stimulating agents, iron products, and other novel anemia medications. Adv Chron Kidney Dis 16:117-130
103. Wrighton NC, Farrell FX, Chang R, Kashyap AK, Barbone FP, Mulcahy LS, Johnson DL, Barrett RW, Jolliffe LK, Dower WJ (1996) Small peptides as potent mimetics of the protein hormone erythropoietin. Science 273:458-464
104. Fan Q, Leuther KK, Holmes CP, Fong KL, Zhang J, Velkovska S, Chen MJ, Mortensen RB, Leu K, Green JM, Schatz PJ, Woodburn KW (2006) Preclinical evaluation of hematide, a novel erythropoiesis-stimulating agent, for the treatment of anemia. Exp Hematol 34:1303-1311 (Pubitemid 44389891)
105. Del Vecchio L, Locatelli F (2011) New treatment approaches in chronic kidney disease-associated anemia. US Nephrol 6:91-94
106. Macdougall IC, Wiecek A, Tucker B, Yaqoob M, Mikhail A, Nowicki M, MacPhee I, Mysliwiec M, Smolenski O, Sułowicz W, Mayo M, Francisco C, Polu KR, Schatz PJ, Duliege AM (2011) Dose-finding study of peginesatide for anemia correction in chronic kidney disease patients. Clin J Am Soc Nephrol 6:2579-2586
107. Locatelli F, Vecchio L (2011) New erythropoiesis-stimulating agents and new iron formulations. In: Ronco C, Rosner M (eds) Hemodialysis: New methods and future technology. Karger, Basel, pp 255-260
108. Fishbane S, Roger SD, Martin E, Runyan G, O'Neil J, Qiu P, Locatelli F (2012) Peginesatide for maintenance treatment of anemia in hemodialysis and nondialysis patients previously treated with darbepoetin alfa. Clin J Am Soc Nephrol 8:538-545
109. Pérez-Ruixo JJ, Krzyzanski W, Bouman-Thio E, Miller B, Jang H, Bai SA, Zhou H, Yohrling J, Cohen A, Burggraaf J, Franson K, Davis HM (2009) Pharmacokinetics and pharmacodynamics of the erythropoietin Mimetibody construct CNTO 528 in healthy subjects. Clin Pharmacokinet 48:601-613
110. Locatelli F, Villa G, de Francisco AL, Albertazzi A, Adrogue HJ, Dougherty FC, Beyer U, BA 16286 Study Investigators (2007) Effect of a continuous erythropoietin receptor activator (C.E.R.A.) on stable haemoglobin in patients with CKD on dialysis: once monthly administration. Curr Med Res Opin 23:969-979 (Pubitemid 46799579)
111. Cano F, Alarcon C, Azocar M, Lizama C, Maria Lillo A, Delucchi A, Gonzalez M, Arellano P, Delgado I, Droguett MT (2011) Continuous EPO receptor activator therapy of anemia in children under peritoneal dialysis. Pediatr Nephrol 26:1303-1310
112. Beuck S, Schanzer W, Thevis M (2012) Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis. Drug Test Anal 4:830-845
113. Bernhardt WM, Wiesener MS, Scigalla P, Chou J, Schmieder RE, Günzler V, Eckardt KU (2010) Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD. J Am Soc Nephrol 21:2151-2156
114. Semenza GL, Wang GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12:5447-5454
115. Brill-Almon E, Stern B, Afik D, Kaye J, Langer N, Bellomo S, Shavit M, Pearlman A, Lippin Y, Panet A, Shani N (2005) Ex vivo transduction of human dermal tissue structures for autologous implantation production and delivery of therapeutic proteins. Mol Ther 12:274-282 (Pubitemid 41025097)
116. Wang G, Liu LN, Lee K, Buyaner D, Hendricks K, Kalfoglou CS, Bohnlein E, Junker U, Mosca JD (2009) Comparison of drug and cell-based delivery-engineering adult mesenchymal stem cells to deliver human erythropoietin. Gene Ther Mol Biol 13:321-330
117. Joung CH, Shin JY, Koo JK, Lim JJ, Wang JS, Lee SJ, Tan HK, Kim SL, Lim SM (2009) Production and characterization of long-acting recombinant human albumin-EPO fusion protein expressed in CHO cell. Protein Expr Purif 68:137-145
118. Schriebl K, Trummer E, Lattenmayer C, Weik R, Kunert R, Müller D, Katinger H, Vorauer-Uhl K (2006) Biochemical characterization of rhEPO-Fc fusion protein expressed in CHO cells. Protein Expr Purif 49:265-275 (Pubitemid 44416228)
119. Ingley E, Tilbrook PA, Klinken SP (2004) New insights into the regulation of erythroid cells. IUBMB Life 56:177-184 (Pubitemid 38828745)
120. Nakano Y, Imagawa S, Matsumoto K, Stockmann C, Obara N, Suzuki N, Doi T, Kodama T, Takahashi S, Nagasawa T, Yamamoto M (2004) Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease. Blood 104:4300-4351
121. Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Sugamele R, DeMol M, Martinez-Soria E, Maxwell PH, Lemke G, Goff SP, Matsushima GK, Earp HS, Chanson M, Collen D, Izui S, Schapira M, Conway EM, Carmeliet P (2008) Role of Gas6 in erythropoiesis and anemia in mice. J Clin Invest 118:583-596 (Pubitemid 351206548)
122. Sasu BJ, Cooke KS, Arvedson TL, Plewa C, Ellison AR, Sheng J, Winters A, Juan T, Li H, Begley CG, Molineux G (2010) Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia. Blood 115:3616-3624
123. Spaninger K, Debeljak N (2009) Erythropoietin, epoetins and detection. Pharm J Slov 60:279
124. Akebia Therapeutics Inc (2011) Akebia announces positive results for AKB-6548 phase 1 clinical study. Ref Type: Internet Communication
125. Bayer Healthcare (2011) Single dose group stratified study in renal impaired and healthy aged and gender matched subjects. Ref Type: Internet Communication