The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice

British Journal of Pharmacology

Volumn 171, Issue 18, 2014, Pages 4289-4299

  De Moura, Juliana Cavalcante ^a   Noroes, Maíra MacEdo ^a   Rachetti, Vanessa De Paula Soares ^a   Soares, Bruno Lobão ^a   Preti, Delia ^b   Nassini, Romina ^c   Materazzi, Serena ^c   Marone, Ilaria Maddalena ^c   Minocci, Daiana ^c   Geppetti, Pierangelo ^c   Gavioli, Elaine Cristina ^a   André, Eunice ^d  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE; ACETANILIDE DERIVATIVE; ACROLEIN; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CINNAMALDEHYDE; DIAZEPAM; NORTRIPTYLINE; PURINE DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, MOUSE;

ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; ANXIETY; DEPRESSION; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SWIMMING;

ACETANILIDES; ACROLEIN; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; ANXIETY; BEHAVIOR, ANIMAL; DEPRESSION; DIAZEPAM; DISEASE MODELS, ANIMAL; MALE; MICE, KNOCKOUT; NORTRIPTYLINE; PURINES; SIGNAL TRANSDUCTION; SWIMMING; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84906830179     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12786     Document Type: Article

References (53)

1. Aguiar DC, Terzian AL, Guimaraes FS, Moreira FA, (2009). Anxiolytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the medial prefrontal cortex of rats. Psychopharmacology (Berl) 205: 217-225.
2. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al. (2013). The Concise Guide to PHARMACOLOGY 2013/14: Ion channels. Br J Pharmacol 170: 1607-1646.
3. Amiel JM, Mathew SJ, (2007). Glutamate and anxiety disorders. Curr Psychiatry Rep 9: 278-283.
4. Andersson DA, Gentry C, Moss S, Bevan S, (2008). Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci 28: 2485-2494.
5. Andre E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, et al. (2008). Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest 118: 2574-2582.
6. Atoyan R, Shander D, Botchkareva NV, (2009). Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. J Invest Dermatol 129: 2312-2315.
7. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, et al. (2004). Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41: 849-857.
8. Baraldi PG, Preti D, Materazzi S, Geppetti P, (2010). Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem 53: 5085-5107.
9. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, et al. (2006). TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124: 1269-1282.
10. Berton O, Nestler EJ, (2006). New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 7: 137-151.
11. Biro T, Kovacs L, (2009). An 'ice-cold' TR(i)P to skin biology: the role of TRPA1 in human epidermal keratinocytes. J Invest Dermatol 129: 2096-2099.
12. Campos AC, Guimaraes FS, (2009). Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids. Prog Neuropsychopharmacol Biol Psychiatry 33: 1517-1521.
13. Cateran MJ, Julius D, (2001). The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 24: 487-517.
14. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D, (1997). The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389: 816-824.
15. Chahl LA, (2011). TRP channels and psychiatric disorders. Adv Exp Med Biol 704: 987-1009.
16. da Costa DS, Meotti FC, Andrade EL, Leal PC, Motta EM, Calixto JB, (2010). The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation. Pain 148: 431-437.
17. Doihara H, Nozawa K, Kawabata-Shoda E, Kojima R, Yokoyama T, Ito H, (2009). Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs. Eur J Pharmacol 617: 124-129.
18. Eid SR, Crown ED, Moore EL, Liang HA, Choong KC, Dima S, et al. (2008). HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain 4: 1744-8069.
19. Fu M, Xie Z, Zuo H, (2009). TRPV1: a potential target for antiepileptogenesis. Med Hypotheses 73: 100-102.
20. Hinman A, Chuang HH, Bautista DM, Julius D, (2006). TRP channel activation by reversible covalent modification. Proc Natl Acad Sci U S A 103: 19564-19568.
21. Kaneko Y, Szallasi A, (2013). Transient receptor potential (TRP) channels: a clinical perspective. Br J Pharmacol 2013: 12414.
22. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160: 1577-1579.
23. Kim YS, Son JY, Kim TH, Paik SK, Dai Y, Noguchi K, et al. (2010). Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn. J Comp Neurol 518: 687-698.
24. Leuner K, Kazanski V, Muller M, Essin K, Henke B, Gollasch M, et al. (2007). Hyperforin-a key constituent of St. John's wort specifically activates TRPC6 channels. FASEB J 21: 4101-4111.
25. Li HB, Mao RR, Zhang JC, Yang Y, Cao J, Xu L, (2008). Antistress effect of TRPV1 channel on synaptic plasticity and spatial memory. Biol Psychiatry 64: 286-292.
26. Lister RG, (1987). The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl) 92: 180-185.
27. Lodge NJ, Li YW, (2008). Ion channels as potential targets for the treatment of depression. Curr Opin Drug Discov Devel 11: 633-641.
28. Macpherson LJ, Geierstanger BH, Viswanath V, Bandell M, Eid SR, Hwang S, et al. (2005). The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol 15: 929-934.
29. Marinelli S, Di Marzo V, Berretta N, Matias I, Maccarrone M, Bernardi G, et al. (2003). Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors. J Neurosci 23: 3136-3144.
30. Masamoto Y, Kawabata F, Fushiki T, (2009). Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice. Biosci Biotechnol Biochem 73: 1021-1027.
31. Materazzi S, Nassini R, Andre E, Campi B, Amadesi S, Trevisani M, et al. (2008). Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A 105: 12045-12050.
32. McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, et al. (2007). TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A 104: 13525-13530.
33. Mezey E, Toth ZE, Cortright DN, Arzubi MK, Krause JE, Elde R, et al. (2000). Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc Natl Acad Sci U S A 97: 3655-3660.
34. Mico JÁ, Prieto R, (2012). Elucidating the mechanism of action of pregabalin: alpha(2)delta as a therapeutic target in anxiety. CNS Drugs 26: 637-648.
35. Morelli MB, Amantini C, Liberati S, Santoni M, Nabissi M, (2013). TRP channels: new potential therapeutic approaches in CNS neuropathies. CNS Neurol Disord Drug Targets 12: 274-293.
36. Nagata K, Duggan A, Kumar G, Garcia-Anoveros J, (2005). Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci 25: 4052-4061.
37. Nassini R, Pedretti P, Moretto N, Fusi C, Carnini C, Facchinetti F, et al. (2012). Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. PLoS ONE 7: 14.
38. Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al. (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucl. Acids Res 42 (Database Issue): D1098-1106.
39. Paxinos G, Franklin KBJ, (2008). The Mouse Brain in Stereotaxic Coordinates, 3rd edn. Academic Press: San Diego.
40. Porsolt RD, Le Pichon M, Jalfre M, (1977). Depression: a new animal model sensitive to antidepressant treatments. Nature 266: 730-732.
41. Reny-Palasse V, Constans M, Rips R, (1989). Potentiation by TRH of the effect of antidepressants in the forced-swimming test, involvement of dopaminergic and opioid systems. Br J Pharmacol 97: 197-205.
42. Roberts JC, Davis JB, Benham CD, (2004). [3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution. Brain Res 995: 176-183.
43. Santos CJ, Stern CA, Bertoglio LJ, (2008). Attenuation of anxiety-related behaviour after the antagonism of transient receptor potential vanilloid type 1 channels in the rat ventral hippocampus. Behav Pharmacol 19: 357-360.
44. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, et al. (2003). ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112: 819-829.
45. Streng T, Axelsson HE, Hedlund P, Andersson DA, Jordt SE, Bevan S, et al. (2008). Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol 53: 391-399.
46. Sun B, Bang SI, Jin YH, (2009). Transient receptor potential A1 increase glutamate release on brain stem neurons. Neuroreport 20: 1002-1006.
47. Szallasi A, (2013). Targeting TRP channels for pain relief. Eur J Pharmacol 2999: 173-178.
48. Szallasi A, Cortright DN, Blum CA, Eid SR, (2007). The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 6: 357-372.
49. Taylor-Clark TE, Undem BJ, Macglashan DW Jr, Ghatta S, Carr MJ, McAlexander MA, (2008). Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1). Mol Pharmacol 73: 274-281.
50. Terzian AL, Aguiar DC, Guimaraes FS, Moreira FA, (2009). Modulation of anxiety-like behaviour by transient receptor potential vanilloid type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray. Eur Neuropsychopharmacol 19: 188-195.
51. Toth A, Boczan J, Kedei N, Lizanecz E, Bagi Z, Papp Z, et al. (2005). Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain. Brain Res Mol Brain Res 135: 162-168.
52. Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, et al. (2007). 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A 104: 13519-13524.
53. You IJ, Jung YH, Kim MJ, Kwon SH, Hong SI, Lee SY, et al. (2012). Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT(1)A, GABA(A), and NMDA receptors. Neuropharmacology 62: 1034-1043.