Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  Liu, Ji ^a   Lau, Eunice Yuen Ting ^b   Chen, Jiezhong ^c   Yong, Joan ^a   Tang, Kai Dun ^a   Lo, Jessica ^b   Ng, Irene Oi Lin ^b   Lee, Terence Kin Wah ^b   Ling, Ming Tat ^a,d  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d TRANSLATIONAL RESEARCH INSTITUTE   (Australia)

Author keywords

AMPK; Polysaccharopeptide; Prostate cancer; Tocotrienol

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ANTINEOPLASTIC AGENT; GAMMA TOCOTRIENOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NATURAL PRODUCT; POLYSACCHAROPEPTIDE; SERINE; UNCLASSIFIED DRUG; ALPHA TOCOPHEROL; CHROMAN DERIVATIVE; DRUG DERIVATIVE; PLASTOCHROMANOL 8; POLYSACCHARIDE PEPTIDE; PROTEOGLYCAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER STEM CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INACTIVATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTEIN PHOSPHORYLATION; TARGET CELL; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; NUDE MOUSE; PHOSPHORYLATION; PROSTATE TUMOR;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CHROMANS; DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEOGLYCANS; VITAMIN E;

EID: 84906825194     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-303     Document Type: Article

References (16)

1. de Wit R. Shifting paradigms in prostate cancer; docetaxel plus low-dose prednisone - finally an effective chemotherapy. Eur J Cancer 2005, 41(4):502-507. 10.1016/j.ejca.2004.12.007, 15737553.
2. Luk SU, Yap WN, Chiu YT, Lee DT, Ma S, Lee TK, Vasireddy RS, Wong YC, Ching YP, Nelson C, Yap YL, Ling MT. Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population. Int J Cancer 2011, 128(9):2182-2191. 10.1002/ijc.25546, 20617516.
3. Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation. Hepatology 2011, 53(1):160-170. 10.1002/hep.24000, 20979057.
4. Luk SU, Lee TK, Liu J, Lee DT, Chiu YT, Ma S, Ng IO, Wong YC, Chan FL, Ling MT. Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population. PLoS One 2011, 6(5):e19804. 10.1371/journal.pone.0019804, 3095629, 21603625.
5. Yap WN, Chang PN, Han HY, Lee DT, Ling MT, Wong YC, Yap YL. Gamma-Tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. Br J Cancer 2008, 99(11):1832-1841. 10.1038/sj.bjc.6604763, 2600692, 19002171.
6. Ahn KS, Sethi G, Krishnan K, Aggarwal BB. Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. J Biol Chem 2007, 282(1):809-820. 10.1074/jbc.M610028200, 17114179.
7. Samant GV, Sylvester PW. Gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. Cell Prolif 2006, 39(6):563-574. 10.1111/j.1365-2184.2006.00412.x, 17109639.
8. Wong CK, Bao YX, Wong EL, Leung PC, Fung KP, Lam CW. Immunomodulatory activities of Yunzhi and Danshen in post-treatment breast cancer patients. Am J Chin Med 2005, 33(3):381-395. 10.1142/S0192415X05002990, 16047556.
9. Ho CY, Kim CF, Leung KN, Fung KP, Tse TF, Chan H, Lau CB. Differential anti-tumor activity of coriolus versicolor (Yunzhi) extract through p53- and/or Bcl-2-dependent apoptotic pathway in human breast cancer cells. Cancer Biol Ther 2005, 4(6):638-644. 10.4161/cbt.4.6.1721, 15908782.
10. Chow LW, Lo CS, Loo WT, Hu XC, Sham JS. Polysaccharide peptide mediates apoptosis by up-regulating p21 gene and down-regulating cyclin D1 gene. Am J Chin Med 2003, 31(1):1-9. 10.1142/S0192415X03000758, 12723750.
11. Wan JM, Sit WH, Louie JC. Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30. Int J Oncol 2008, 32(3):689-699.
12. Dong Y, Kwan CY, Chen ZN, Yang MM. Antitumor effects of a refined polysaccharide peptide fraction isolated from Coriolus versicolor: in vitro and in vivo studies. Res Commun Mol Pathol Pharmacol 1996, 92(2):140-148.
13. Hsieh TC, Wu JM. Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom Trametes versicolor in androgen-dependent and androgen-insensitive human prostate cancer cells. Int J Oncol 2001, 18(1):81-88.
14. Sen CK, Khanna S, Roy S. Tocotrienols: Vitamin E beyond tocopherols. Life Sci 2006, 78(18):2088-2098. 10.1016/j.lfs.2005.12.001, 1790869, 16458936.
15. Chang PN, Yap WN, Lee DT, Ling MT, Wong YC, Yap YL. Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells. Nutr Cancer 2009, 61(3):357-366. 10.1080/01635580802567166, 19373609.
16. Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011, 13(9):1016-1023. 10.1038/ncb2329, 3249400, 21892142.