Parasexuality and mosaic aneuploidy in Leishmania: Alternative genetics

Trends in Parasitology

Volumn 30, Issue 9, 2014, Pages 429-435

  Sterkers, Yvon ^a,b   Crobu, Lucien ^a,b   Lachaud, Laurence ^a   Pagès, Michel ^a   Bastien, Patrick ^a,b  

^a UNIV MONTPELLIER   (France)

^b MONTPELLIER UNIVERSITY HOSPITAL   (France)

Author keywords

Aneuploidy; Automixis; Chromosome copy number variation; Genetic exchange; Leishmania; Sexuality parasexuality

Indexed keywords

ALLELE; ANEUPLOIDY; CANDIDA ALBICANS; CELL DIVISION; CELL FUSION; GAMETE; GENETIC RECOMBINATION; GENETIC VARIABILITY; GENETICS; GENOTYPE; HETEROZYGOSITY LOSS; HOMOZYGOSITY; INTERPHASE; LEISHMANIA; MEIOSIS; MOSAIC ANEUPLOIDY; MOSAICISM; NONHUMAN; PARASEXUALITY; PARASITE PHENOMENA AND FUNCTIONS; PROGENY; REVIEW; TRYPANOSOMA BRUCEI;

ANEUPLOIDY; AUTOMIXIS; CHROMOSOME COPY-NUMBER VARIATION; GENETIC EXCHANGE; LEISHMANIA; SEXUALITY/PARASEXUALITY;

ANEUPLOIDY; GENETIC HETEROGENEITY; HOMOZYGOTE; LEISHMANIA; MOSAICISM; RECOMBINATION, GENETIC;

EID: 84906794994     PISSN: 14714922     EISSN: 14715007     Source Type: Journal    
DOI: 10.1016/j.pt.2014.07.002     Document Type: Review

References (49)

1. Torres E.M., et al. Aneuploidy: cells losing their balance. Genetics 2008, 179:737-746.
2. Tang Y.C., Amon A. Gene copy-number alterations: a cost-benefit analysis. Cell 2013, 152:394-405.
3. Hassold T., Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat.Rev.Genet. 2001, 2:280-291.
4. Stankiewicz P., Lupski J.R. Structural variation in the human genome and its role in disease. Annu.Rev.Med. 2010, 61:437-455.
5. Lv L., et al. Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells. Cell Cycle 2012, 11:2864-2875.
6. Chester M., et al. Extensive chromosomal variation in a recently formed natural allopolyploid species, Tragopogon miscellus (Asteraceae). Proc. Natl. Acad. Sci. U.S.A. 2012, 109:1176-1181.
7. Selmecki A., et al. Genomic plasticity of the human fungal pathogen Candida albicans. Eukaryot. Cell 2010, 9:991-1008.
8. Bastien P. Leishmaniases control: what part for development and what part for research?. Clin. Microbiol. Infect. 2011, 17:1449-1450.
9. Banuls A.L., et al. Clinical pleiomorphism in human leishmaniases, with special mention of asymptomatic infection. Clin. Microbiol. Infect. 2011, 17:1451-1461.
10. Ivens A.C., et al. The genome of the kinetoplastid parasite, Leishmania major. Science 2005, 309:436-442.
11. Clayton C., Shapira M. Post-transcriptional regulation of gene expression in trypanosomes and leishmanias. Mol. Biochem. Parasitol. 2007, 156:93-101.
12. Goringer H.U. 'Gestalt,' composition and function of the Trypanosoma brucei editosome. Annu. Rev. Microbiol. 2012, 66:65-82.
13. Bastien P., et al. Leishmania: sex, lies and karyotype. Parasitol. Today 1992, 8:174-177.
14. Iovannisci D.M., Beverley S.M. Structural alterations of chromosome 2 in Leishmania major as evidence for diploidy, including spontaneous amplification of the mini-exon array. Mol. Biochem. Parasitol. 1989, 34:177-188.
15. Ravel C., et al. The complete chromosomal organization of the reference strain of the Leishmania Genome Project, L. major; Friedlin'. Parasitol. Today 1998, 14:301-303.
16. Sunkin S.M., et al. The size difference between Leishmania major friedlin chromosome one homologues is localized to sub-telomeric repeats at one chromosomal end. Mol. Biochem. Parasitol. 2000, 109:1-15.
17. Sterkers Y., et al. FISH analysis reveals aneuploidy and continual generation of chromosomal mosaicism in Leishmania major. Cell. Microbiol. 2011, 13:274-283.
18. Sterkers Y., et al. Novel insights into genome plasticity in Eukaryotes: mosaic aneuploidy in Leishmania. Mol. Microbiol. 2012, 86:15-23.
19. Rogers M.B., et al. Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania. Genome Res. 2011, 21:2129-2142.
20. Lachaud L., et al. Constitutive mosaic aneuploidy is a unique genetic feature widespread in the Leishmania genus. Microbes Infect. 2014, 16:61-66.
21. Downing T., et al. Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance. Genome Res. 2011, 21:2143-2156.
22. Urena F. Ultrastructure of the mitotic nucleus in Leishmania mexicana sp. tridimensional reconstruction of the mitotic spindle and dense plaques. Microsc. Electron. Biol. Celular. 1985, 9:51-65.
23. Akopyants N.S., et al. Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector. Science 2009, 324:265-268.
24. Inbar E., et al. The Mating Competence of Geographically Diverse Leishmania major Strains in Their Natural and Unnatural Sand Fly Vectors. PLoS Genet. 2013, 9:e1003672.
25. Rougeron V., et al. 'Everything you always wanted to know about sex (but were afraid to ask)' in Leishmania after two decades of laboratory and field analyses. PLoS Pathog. 2010, 6:e1001004.
26. Blaineau C., et al. Multiple forms of chromosome I, II and V in a restricted population of Leishmania infantum contrasting with monomorphism in individual strains suggest haploidy or automixy. Mol. Biochem. Parasitol. 1992, 50:197-204.
27. Forche A., et al. The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains. PLoS Biol. 2008, 6:e110.
28. Bennett R.J., Johnson A.D. Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains. EMBO J. 2003, 22:2505-2515.
29. Duncan A.W., et al. The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature 2010, 467:707-710.
30. Jones K.T., Lane S.I. Molecular causes of aneuploidy in mammalian eggs. Development 2013, 140:3719-3730.
31. Holland A.J., Cleveland D.W. Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep. 2012, 13:501-514.
32. Bessat M., Ersfeld K. Functional characterization of cohesin SMC3 and segregation of large and minichromosomes in Trypanosoma brucei. Mol. Microbiol. 2009, 71:1371-1385.
33. Otto S.P., Gerstein A.C. The evolution of haploidy and diploidy. Curr. Biol. 2008, 18:R1121-R1124.
34. Zeyl C., et al. An evolutionary advantage of haploidy in large yeast populations. Science 2003, 299:555-558.
35. Ravel C., et al. First report of genetic hybrids between two very divergent Leishmania species: Leishmania infantum and Leishmania major. Int. J. Parasitol. 2006, 36:1383-1388.
36. El Baidouri F., et al. Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us. PLoS Negl. Trop. Dis. 2013, 7:e2255.
37. Lukes J., et al. Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:9375-9380.
38. Peacock L., et al. Identification of the meiotic life cycle stage of Trypanosoma brucei in the tsetse fly. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:3671-3676.
39. Heitman J. Evolution of eukaryotic microbial pathogens via covert sexual reproduction. Cell Host Microbe 2010, 8:86-99.
40. Hickman M.A., et al. The 'obligate diploid' Candida albicans forms mating-competent haploids. Nature 2013, 494:55-59.
41. Birky C.W. Giardia sex? Yes, but how and how much?. Trends Parasitol. 2010, 26:70-74.
42. Peacock L., et al. Meiosis and haploid gametes in the pathogen Trypanosoma brucei. Curr. Biol. 2014, 24:181-186.
43. Mannaert A., et al. Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania. Trends Parasitol. 2012, 28:370-376.
44. Lanotte G., Rioux J.A. Cell fusion in Leishmania (Kinetoplastida, Trypanosomatidae). C. R. Acad. Sci. III 1990, 310:285-288. (in French).
45. Flot J.F., et al. Genomic evidence for ameiotic evolution in the bdelloid rotifer Adineta vaga. Nature 2013, 500:453-457.
46. Pratlong F., et al. Simultaneous presence in dogs of 2 zymodemes of the Leishmania infantum complex. Ann. Parasitol. Hum. Comp. 1989, 64:312-314. (in French).
47. Clayton C.E. Life without transcriptional control? From fly to man and back again. EMBO J. 2002, 21:1881-1888.
48. McConnell M.J., et al. Mosaic copy number variation in human neurons. Science 2013, 342:632-637.
49. Duncan A.W. Aneuploidy, polyploidy and ploidy reversal in the liver. Semin. Cell Dev. Biol. 2013, 24:347-356.