Patient with gorlin syndrome and metastatic basal cell carcinoma refractory to smoothened inhibitors

JAMA Dermatology

Volumn 150, Issue 8, 2014, Pages 877-879

  Zhu, Gefei A ^a   Li, Angela S ^a   Chang, Anne Lynn S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CHLORMETHINE; CISPLATIN; ETOPOSIDE; FLUORODEOXYGLUCOSE; FLUOROURACIL; PATIDEGIB; SARIDEGIB; UNCLASSIFIED DRUG; VISMODEGIB;

ADULT; ARTICLE; BASAL CELL CARCINOMA; BASAL CELL NEVUS SYNDROME; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER SIZE; CASE REPORT; CHRONIC KIDNEY DISEASE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; DYSPNEA; FACIAL NERVE; FOLLOW UP; HEAD; HUMAN; HUMAN TISSUE; LIMB; LUNG METASTASIS; MALE; MEDICAL HISTORY; MIDDLE AGED; NECK; NEUROPATHY; PRIORITY JOURNAL; TESTIS CANCER; THORAX PAIN; TREATMENT RESPONSE; TRUNK; TUMOR BIOPSY;

ANILIDES; ANTINEOPLASTIC AGENTS; BASAL CELL NEVUS SYNDROME; CARCINOMA, BASAL CELL; DRUG RESISTANCE, NEOPLASM; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PYRIDINES; RECEPTORS, G-PROTEIN-COUPLED; SKIN NEOPLASMS; TREATMENT FAILURE; VERATRUM ALKALOIDS;

EID: 84906771668     PISSN: 21686068     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamadermatol.2013.8744     Document Type: Article

References (11)

1. Evans DG, Howard E, Giblin C, et al. Birth incidence and prevalence of tumor-prone syndromes: estimates from a UK family genetic register service. Am J Med Genet A. 2010;152A(2):327-332.
2. Hahn H, Wicking C, Zaphiropoulous PG, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell. 1996;85(6):841-851.
3. Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science. 1996;272(5268):1668- 1671.
4. Lam C, Ou JC, Billingsley EM. "PTCH"-ing it together: a basal cell nevus syndrome review. Dermatol Surg. 2013;39(11):1557-1572.
5. Taylor WB, Anderson DE, Howell JB, Thurston CS. The nevoid basal cell carcinoma syndrome: autopsy findings. Arch Dermatol. 1968;98(6):612-614.
6. Winkler PA, Guyuron B. Multiple metastases from basal cell naevus syndrome. Br J Plast Surg. 1987;40(5):528-531.
7. Lamon T, Gerard S, Meyer N, et al. Exceptional bone metastasis of basal cell carcinoma in Gorlin-Goltz syndrome. Dermatology. 2010;220(1):57-59.
8. Metcalfe C, de Sauvage FJ. Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists. Cancer Res. 2011;71(15):5057-5061.
9. Chang AL, Oro AE. Initial assessment of tumor regrowth after vismodegib in advanced Basal cell carcinoma. Arch Dermatol. 2012;148(11):1324-1325.
10. Jimeno A, Weiss GJ, Miller WH Jr, et al. Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors. Clin Cancer Res. 2013;19(10):2766-2774.
11. Chang AL, Atwood SX, Tartar DM, Oro AE. Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced basal cell carcinoma and resistant basal carcinomas in Gorlin syndrome. JAMA Dermatol. 2013;149(5):639-641.