Olfactory assays for mouse models of neurodegenerative disease

Journal of Visualized Experiments

Volumn , Issue 90, 2014, Pages

  Lehmkuhl, Andrew M ^a   Dirr, Emily R ^b,c   Fleming, Sheila M ^a,b  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c WRIGHT STATE UNIVERSITY   (United States)

Author keywords

Detection; Discrimination; Issue 90; Mouse; Neuroscience; Olfaction; Parkinson's disease; Sniffing

Indexed keywords

EID: 84906748689     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/51804     Document Type: Article

References (30)

1. Hawkes, C. Olfaction in neurodegenerative disorder. Adv. Otorhinolaryngol. 63, 133-151, (2006).
2. Ward, C., Hess, W., Calne, D. Olfactory impairment in Parkinson's disease. Neurology. 33, 943-946, (1983).
3. Doty, R., Stern, M., Pfeiffer, C., Gollomp, S., Hurtig, H. Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson's disease. J. Neurol. Neurosurg. Psychiatry. 55, 138-142, (1992).
4. Doty, R., Deems, D., Stellar, S. Olfactory dysfunction in parkinsonism: a general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology. 38, 1237-1244, doi: 10. 1212, (1988).
5. Tissingh, G. et al. Loss of olfaction in de novo and treated Parkinson's disease: possible implications for early diagnosis. Movement Disorders. 16 (1), 41-46, (2001).
6. Montgomery, E., Baker, K., Lyons K., Koller, W. Abnormal performance on the PD test battery by asymptomatic first-degree relatives. Neurology. 52, 757-762, doi: 10. 1212, (1999).
7. Berendse, H. et al. Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell. Ann. Neurol. 50 (1), 34-41, (2001).
8. Ponsen, M., Stoffers, D., Booij, J., van Eck-Smit, B., Wolters, E., Berendse, H. Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann. Neurol. 56, 173-181, (2004).
9. Langston, J. The Parkinson's complex: parkinsonism is just the tip of the iceberg. Ann. Neurol. 59 (4), 591-6, (2006).
10. Ross, G. et al. Association of olfactory dysfunction with risk for future Parkinson's disease. Ann. Neurol. 63, 167-173, doi: 10. 1002, (2008).
11. Fleming, S. et al. Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein. J. Neurosci. 24, 9434-9440, doi: 10. 1523, (2004).
12. Fleming, S., Ekhator, O., Ghisays, V. Assessment of sensorimotor function in mouse models of Parkinson's disease. J. Vis. Exp. 76, e50303, doi: 10. 3791, (2013).
13. Schallert, T., Tillerson, J. L. Intervention strategies for degeneration of DA neurons in parkinsonism: Optimizing behavioral assessment of outcome. Central Nervous System Diseases. 131-151 (2000).
14. Whishaw, I., O'Connor, W., Dunnett, S. The contributions of motor cortex, nigrostriatal dopamine and caudate-putamen to skilled forelimb use in the rat. Brain. 109 (5), 805-843, doi: 10. 1093/brain/109. 5. 805, (1986).
15. Schwarting, R., Huston, J. 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments. Prog Neurobiol. 49(3), 215-266, (1996).
16. Glasl, L. et al. Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb. Experimental Neurology. 235, 214-227, doi: 10. 1016, (2012).
17. Kim, Y., Lussier, S., Rane, A., Choi, S., Andersen, J. Inducible dopaminergic glutathione depletion in an α-synuclein transgenic mouse model results in age-related olfactory dysfunction. Neuroscience. 172, 379-386, (2011).
18. Fleming, S., Tetreault, N., Mulligan, C., Huston, C., Masliah, E., Chesselet, M. Olfactory deficits in mice overexpressing human wildtype alpha-synuclein. The European Journal of Neuroscience. 28(2), 247-56, (2008).
19. Nuber, S. et al. A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats. Brain. 136(2), 412-432, doi: 10. 1093, (2013).
20. Macknin, J., Higuchi, M., Lee, V., Trojanowski, J., Doty, R. Olfactory dysfunction occurs in transgenic mice overexpressing human tau protein. Brain Res. 1000, 174-178, doi: 10. 1016, (2004).
21. Lazic, S. et al. Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients. Brain Res. 1151, 219-226, doi: 10. 1016, (2007).
22. Wesson, D., Wilson, D., Nixon, R. Should olfactory dysfunction be used as a biomarker of Alzheimer's disease?. Expert Review of Neurotherapeutics. 10(5), 633-635, (2010).
23. Taylor, T., Caudle, W., Miller, G. VMAT2-deficient mice display nigral and extranigral pathology and motor and nonmotor symptoms of Parkinson's disease. Parkinsons Dis. 2011, 124-165, doi: 10. 4061, (2011).
24. Tillerson, J., Caudle, W., Parent, J., Gong, C., Schallert, T., Miller, G. Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor. Behav. Brain Res. 172, 97-105, doi: 10. 1016, (2006).
25. Fleming, S. et al. A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions. Mol. Cell. Neurosci. 4, 597-606, doi: 10. 1016, (2011).
26. Crawley, J. What's Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice. Wiley-Liss, NY. (2000).
27. Nathan, B., Yost, J., Litherland, M., Struble, R., Switzer, P. Olfactory function in apoE knockout mice. Behav. Brain Res. 150, 1-7, (2004).
28. Spinetta, M. A simple and sensitive odor recognition test for rats and mice detects retrograde amnesia caused by ethanol or other drugs that interfere with memory consolidation. Society for Neuroscience. Washington, D. C., (2005).
29. Spinetta, M. et al. Alcohol-induced retrograde memory impairment in rats: prevention by caffeine. Psychopharmacology. 201(3), 361-371, doi: 10. 1007, (2008).
30. Bielsky, I., Hu, S., Szegda, K., Westphal, H., Young, L. Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Neuropsychopharmacology. 29, 483-493, (2004).