Expression of epidermal growth factor receptor, p53, Bcl2, vascular endothelial growth factor, cyclooxygenase-2, cyclin D1, human epidermal receptor-2 and Ki-67: Association with clinicopathological profiles and outcomes in gallbladder carcinoma

Journal of Carcinogenesis

Volumn 13, Issue 1, 2014, Pages 10-

  Doval, Dinesh ^a   Azam, Saud ^a   Sinha, Rupal ^a   Batra, Ullas ^a   Mehta, Anurag ^a  

^a RAJIV GANDHI CANCER INSTITUTE AND RESEARCH CENTRE   (India)

Author keywords

Cyclin D1; epidermal growth factor receptor; gallbladder carcinoma; human epidermal receptor 2; p53; vascular endothelial growth factor

Indexed keywords

CYCLIN D1; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN P53; VASCULOTROPIN;

ARTICLE; CANCER STAGING; CHOLECYSTECTOMY; DISEASE ASSOCIATION; DISEASE SEVERITY; FOLLOW UP; GALLBLADDER BIOPSY; GALLBLADDER CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LABELING INDEX; MAJOR CLINICAL STUDY; MORPHOLOGY; PREDICTION; PROTEIN EXPRESSION; SURVIVAL RATE;

EID: 84906727853     PISSN: 09746773     EISSN: 14773163     Source Type: Journal    
DOI: 10.4103/1477-3163.139450     Document Type: Article

References (50)

1. Randi G, Malvezzi M, Levi F, Ferlay J, Negri E, Franceschi S, et al. Epidemiology of biliary tract cancers: An update. Ann Oncol 2009;20:146-59.
2. Pandey M, Shukla M, Shukla V. Diet and gall bladder cancer. Indian J Med Paediatr Oncol 2008;29:6-7.
3. International Agency for Research on Cancer, GLOBOCAN 2008. Available from: http://www.globocan.iarc.fr/. [Last accessed on 2013 Jun 26].
4. Randi G, Franceschi S, La Vecchia C. Gallbladder cancer worldwide: Geographical distribution and risk factors. Int J Cancer 2006;118:1591-602.
5. Three Year Report of Population Based Cancer Registries (2006-2008). National Cancer Registry Programme, Indian Council of Medical Research; 2010.
6. Sharma A. Be optimistic, persistence pays: Therapy of gall bladder cancer. Trop Gastroenterol 2010;31:73-4.
7. Jayaraman S, Jarnagin WR. Management of gallbladder cancer. Gastroenterol Clin North Am 2010;39:331-42.
8. Bartlett DL, Ramanathan RK, Ben-Josef E. Cancer of the biliary tree. In: De Vita VT, Lawrence TS, Rosenberg SA, editors. Cancer Principles and Practice of Oncology. Philadelphia: Lippincott Williams and Wilkins; 2008. p. 1156-86.
9. Takehana T, Kunitomo K, Suzuki S, Kono K, Fujii H, Matsumoto Y, et al. Expression of epidermal growth factor receptor in gastric carcinomas. Clin Gastroenterol Hepatol 2003;1:438-45.
10. Hirashima N, Takahashi W, Yoshii S, Yamane T, Ooi A. Protein overexpression and gene amplification of c-erb B-2 in pulmonary carcinomas: A comparative immunohistochemical and fluorescence in situ hybridization study. Mod Pathol 2001;14:556-62.
11. Ooi A, Takehana T, Li X, Suzuki S, Kunitomo K, Iino H, et al. Protein overexpression and gene amplification of HER-2 and EGFR in colorectal cancers: An immunohistochemical and fluorescent in situ hybridization study. Mod Pathol 2004;17:895-904.
12. Zhu Z, Bohlen P, Witte L. Clinical development of angiogenesis inhibitors to vascular endothelial growth factor and its receptors as cancer therapeutics. Curr Cancer Drug Targets 2002;2:135-56.
13. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 1994;54:4855-78.
14. Lu QL, Abel P, Foster CS, Lalani EN. bcl-2: Role in epithelial differentiation and oncogenesis. Hum Pathol 1996;27:102-10.
15. Sinicrope FA, Ruan SB, Cleary KR, Stephens LC, Lee JJ, Levin B. Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res 1995;55:237-41.
16. Lauwers GY, Scott GV, Karpeh MS. Immunohistochemical evaluation of bcl-2 protein expression in gastric adenocarcinomas. Cancer 1995;75:2209-13.
17. Nishida N, Fukuda Y, Komeda T, Kita R, Sando T, Furukawa M, et al. Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res 1994;54:3107-10.
18. Moon WS, Park HS, Lee H, Pai R, Tarnawski AS, Kim KR, et al. Co-expression of cox-2, C-met and beta-catenin in cells forming invasive front of gallbladder cancer. Cancer Res Treat 2005;37:171-6.
19. Hui AM, Shi YZ, Li X, Sun L, Guido T, Takayama T, et al. Proliferative marker Ki-67 in gallbladder carcinomas: High expression level predicts early recurrence after surgical resection. Cancer Lett 2002;176:191-8.
20. Shrestha ML, Miyake H, Kikutsuji T, Tashiro S. Prognostic significance of Ki-67 and p53 antigen expression in carcinomas of bile duct and gallbladder. J Med Invest 1998;45:95-102.
21. Mc Shane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM, et al. REporting recommendations for tumor MARKer prognostic studies (REMARK). Nat Clin Pract Oncol 2005;2:416-22.
22. Wolff AC, Hammond ME, Schwartz JN, Hagerty KL, Allred DC, Cote RJ, et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol 2007;25:118-45.
23. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
24. Gallbladder. In: Edge SB, Byrd DR, Compton CC, fritz AG, Greene FL, Trotti A 3 rd, editors. AJCC Cancer Staging Manual. 7 th ed. New York: Springer; 2010. p. 211-7.
25. Unisa S, Jagannath P, Dhir V, Khandelwal C, Sarangi L, Roy TK. Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB (Oxford) 2011;13:117-25.
26. Nakazawa K, Dobashi Y, Suzuki S, Fujii H, Takeda Y, Ooi A. Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. J Pathol 2005;206:356-65.
27. Sergeant G, Lerut E, Ectors N, Hendrickx T, Aerts R, Topal B. The prognostic relevance of tumor hypoxia markers in resected carcinoma of the gallbladder. Eur J Surg Oncol 2011;37:80-6.
28. Xuan YH, Choi YL, Shin YK, Kook MC, Chae SW, Park SM, et al. An immunohistochemical study of the expression of cell-cycle-regulated proteins p53, cyclin D1, RB, p27, Ki67 and MSH2 in gallbladder carcinoma and its precursor lesions. Histol Histopathol 2005;20:59-66.
29. Kim WB, Han HJ, Lee HJ, Park SS, Song TJ, Kim HK, et al. Expression and clinical significance of cell cycle regulatory proteins in gallbladder and extrahepatic bile duct cancer. Ann Surg Oncol 2009;16:23-34.
30. Kawamoto T, Krishnamurthy S, Tarco E, Trivedi S, Wistuba II, Li D, et al. HER receptor family: Novel candidate for targeted therapy for gallbladder and extrahepatic bile duct cancer. Gastrointest Cancer Res 2007;1:221-7.
31. Yoshikawa D, Ojima H, Iwasaki M, Hiraoka N, Kosuge T, Kasai S, et al. Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. Br J Cancer 2008;98:418-25.
32. Kaufman M, Mehrotra B, Limaye S, White S, Fuchs A, Lebowicz Y, et al. EGFR expression in gallbladder carcinoma in North America. Int J Med Sci 2008;5:285-91.
33. Harder J, Waiz O, Otto F, Geissler M, Olschewski M, Weinhold B, et al. EGFR and HER2 expression in advanced biliary tract cancer. World J Gastroenterol 2009;15:4511-7.
34. Puhalla H, Wrba F, Kandioler D, Lehnert M, Huynh A, Gruenberger T, et al. Expression of p21(Wafl/Cip1), p57(Kip2) and HER2/neu in patients with gallbladder cancer. Anticancer Res 2007;27:1679-84.
35. Chaube A, Tewari M, Garbyal RS, Singh U, Shukla HS. Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients manuscript id: 8962091628764582. BMC Cancer 2006;6:126.
36. Suzuki T, Takano Y, Kakita A, Okudaira M. An immunohistochemical and molecular biological study of c-erbB-2 amplification and prognostic relevance in gallbladder cancer. Pathol Res Pract 1993;189:283-92.
37. Kim YW, Huh SH, Park YK, Yoon TY, Lee SM, Hong SH. Expression of the c-erb-B2 and p53 protein in gallbladder carcinomas. Oncol Rep 2001;8:1127-32.
38. Yue SQ, Yang YL, Zhou JS, Li KZ, Dou KF. Relationship between urokinase-type plasminogen activator receptor and vascular endothelial growth factor expression and metastasis of gallbladder cancer. World J Gastroenterol 2004;10:2750-2.
39. Quan ZW, Wu K, Wang J, Shi W, Zhang Z, Merrell RC. Association of p53, p16, and vascular endothelial growth factor protein expressions with the prognosis and metastasis of gallbladder cancer. J Am Coll Surg 2001;193:380-3.
40. Okita S, Kondoh S, Shiraishi K, Kaino S, Hatano S, Okita K. Expression of vascular endothelial growth factor correlates with tumor progression in gallbladder cancer. Int J Oncol 1998;12:1013-8.
41. Tian Y, Ding RY, Zhi YH, Guo RX, Wu SD. Analysis of p53 and vascular endothelial growth factor expression in human gallbladder carcinoma for the determination of tumor vascularity. World J Gastroenterol 2006;12:415-9.
42. Jarnagin WR, Klimstra DS, Hezel M, Gonen M, Fong Y, Roggin K, et al. Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: Correlation with anatomic site, pathologic variables, and clinical outcome. J Clin Oncol 2006;24:1152-60.
43. Hui AM, Li X, Shi YZ, Takayama T, Torzilli G, Makuuchi M. Cyclin D1 overexpression is a critical event in gallbladder carcinogenesis and independently predicts decreased survival for patients with gallbladder carcinoma. Clin Cancer Res 2000;6:4272-7.
44. Srivastava V, Patel B, Kumar M, Shukla M, Pandey M. Cyclin D1, retinoblastoma and p16 protein expression in carcinoma of the gallbladder. Asian Pac J Cancer Prev 2013;14:2711-5.
45. Kanthan R, Radhi JM, Kanthan SC. Gallbladder carcinomas: An immunoprognostic evaluation of P53, Bcl-2, CEA and alpha-fetoprotein. Can J Gastroenterol 2000;14:181-4.
46. Dursun N, Escalona OT, Roa JC, Basturk O, Bagci P, Cakir A, et al. Mucinous carcinomas of the gallbladder: Clinicopathologic analysis of 15 cases identified in 606 carcinomas. Arch Pathol Lab Med 2012;136:1347-58.
47. Legan M, Luzar B, Ferlan-Marolt V, Cör A. Cyclooxygenase-2 expression determines neo-angiogenesis in gallbladder carcinomas. Bosn J Basic Med Sci 2006;6:58-63.
48. Legan M, Luzar B, Marolt VF, Cor A. Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions. World J Gastroenterol 2006;12:3425-9.
49. Artico M, Bronzetti E, Alicino V, Ionta B, Bosco S, Grande C, et al. Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3. Eur J Histochem 2010;54:e10.
50. Hidalgo Grau LA, Badia JM, Salvador CA, Monsó TS, Canaleta JF, Nogués JM, et al. Gallbladder carcinoma: The role of p53 protein overexpression and Ki-67 antigen expression as prognostic markers. HPB (Oxford) 2004;6:174-80.