메뉴 건너뛰기




Volumn 59, Issue 8, 2014, Pages 430-436

Genetic variations in RORα are associated with chronic obstructive pulmonary disease

Author keywords

[No Author keywords available]

Indexed keywords

RETINOID RELATED ORPHAN RECEPTOR ALPHA; RORA PROTEIN, HUMAN;

EID: 84906698334     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2014.48     Document Type: Article
Times cited : (7)

References (44)
  • 1
    • 0029907597 scopus 로고    scopus 로고
    • Evidence-based health policy-lessons from the Global Burden of Disease Study
    • Murray, C. J. & Lopez, A. D. Evidence-based health policy-lessons from the Global Burden of Disease Study. Science 274, 740-743 (1996).
    • (1996) Science , vol.274 , pp. 740-743
    • Murray, C.J.1    Lopez, A.D.2
  • 2
    • 35348970821 scopus 로고    scopus 로고
    • Prevalence of chronic obstructive pulmonary disease in China: A large, population-based survey
    • Zhong, N., Wang, C., Yao, W., Chen, P., Kang, J., Huang, S. et al. Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey. Am. J. Respir. Crit. Care. Med. 176, 753-760 (2007).
    • (2007) Am. J. Respir. Crit. Care. Med. , vol.176 , pp. 753-760
    • Zhong, N.1    Wang, C.2    Yao, W.3    Chen, P.4    Kang, J.5    Huang, S.6
  • 3
    • 4143051640 scopus 로고    scopus 로고
    • Burden and clinical features of chronic obstructive pulmonary disease (COPD)
    • Pauwels, R. A. & Rabe, K. F. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 364, 613-620 (2004).
    • (2004) Lancet , vol.364 , pp. 613-620
    • Pauwels, R.A.1    Rabe, K.F.2
  • 4
    • 0021796202 scopus 로고
    • Familial aggregation in chronic obstructive pulmonary disease: Use of the loglinear model to analyze intermediate environmental and genetic risk factors
    • Khoury, M. J., Beaty, T. H., Tockman, M. S., Self, S. G. & Cohen, B. H. Familial aggregation in chronic obstructive pulmonary disease: use of the loglinear model to analyze intermediate environmental and genetic risk factors. Genet. Epidemiol. 2, 155-166 (1985).
    • (1985) Genet. Epidemiol. , vol.2 , pp. 155-166
    • Khoury, M.J.1    Beaty, T.H.2    Tockman, M.S.3    Self, S.G.4    Cohen, B.H.5
  • 5
    • 73149099640 scopus 로고    scopus 로고
    • Mechanisms of lung development: Contribution to adult lung disease and relevance to chronic obstructive pulmonary disease
    • Shi, W., Chen, F. & Cardoso, W. V. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 6, 558-563 (2009).
    • (2009) Proc. Am. Thorac. Soc. , vol.6 , pp. 558-563
    • Shi, W.1    Chen, F.2    Cardoso, W.V.3
  • 6
    • 77949911882 scopus 로고    scopus 로고
    • The COPD genetic association compendium: A comprehensive online database of COPD genetic associations
    • Castaldi, P. J., Cho, M. H., Cohn, M., Langerman, F., Moran, S., Tarragona, N. et al. The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Hum. Mol. Genet. 19, 526-534 (2010).
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 526-534
    • Castaldi, P.J.1    Cho, M.H.2    Cohn, M.3    Langerman, F.4    Moran, S.5    Tarragona, N.6
  • 8
    • 63449101907 scopus 로고    scopus 로고
    • A genome-wide association study in chronic obstructive pulmonary disease (COPD): Identification of two major susceptibility loci
    • Pillai, S. G., Ge, D., Zhu, G., Kong, X., Shianna, K. V., Need, A. C. et al. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet. 5, e1000421 (2009).
    • (2009) PLoS Genet. , vol.5
    • Pillai, S.G.1    Ge, D.2    Zhu, G.3    Kong, X.4    Shianna, K.V.5    Need, A.C.6
  • 9
    • 63449099623 scopus 로고    scopus 로고
    • A genome-wide association study of pulmonary function measures in the Framingham Heart Study
    • Wilk, J. B., Chen, T. H., Gottlieb, D. J., Walter, R. E., Nagle, M. W., Brandler, B. J. et al. A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet. 5, e1000429 (2009).
    • (2009) PLoS Genet. , vol.5
    • Wilk, J.B.1    Chen, T.H.2    Gottlieb, D.J.3    Walter, R.E.4    Nagle, M.W.5    Brandler, B.J.6
  • 10
    • 80053414310 scopus 로고    scopus 로고
    • Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function
    • Soler Artigas, M., Wain, L. V., Repapi, E., Obeidat, M., Sayers, I., Burton, P. R. et al. Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am. J. Respir. Crit. Care. Med. 184, 786-795 (2011).
    • (2011) Am. J. Respir. Crit. Care. Med. , vol.184 , pp. 786-795
    • Soler Artigas, M.1    Wain, L.V.2    Repapi, E.3    Obeidat, M.4    Sayers, I.5    Burton, P.R.6
  • 12
    • 84897470317 scopus 로고    scopus 로고
    • APOM and high-density lipoprotein are associated with lung function and percent emphysema
    • Burkart, K. M., Manichaikul, A., Wilk, J. B., Ahmed, F. S., Burke, G. L., Enright, P. et al. APOM and high-density lipoprotein are associated with lung function and percent emphysema. Eur. Respir. J. 43, 1007-1017 (2013).
    • (2013) Eur. Respir. J. , vol.43 , pp. 1007-1017
    • Burkart, K.M.1    Manichaikul, A.2    Wilk, J.B.3    Ahmed, F.S.4    Burke, G.L.5    Enright, P.6
  • 13
    • 79955799687 scopus 로고    scopus 로고
    • Advanced chronic obstructive pulmonary disease is associated with high levels of high-density lipoprotein cholesterol
    • Reed, R. M., Iacono, A., DeFilippis, A., Eberlein, M., Girgis, R. E. & Jones, S. Advanced chronic obstructive pulmonary disease is associated with high levels of high-density lipoprotein cholesterol. J. Heart Lung Transplant. 30, 674-678 (2011).
    • (2011) J. Heart Lung Transplant. , vol.30 , pp. 674-678
    • Reed, R.M.1    Iacono, A.2    Defilippis, A.3    Eberlein, M.4    Girgis, R.E.5    Jones, S.6
  • 14
    • 0031466740 scopus 로고    scopus 로고
    • Serum total cholesterol and risk of hospitalization, and death from respiratory disease
    • Iribarren, C., Jacobs, D. R. Jr., Sidney, S., Claxton, A. J., Gross, M. D., Sadler, M. et al. Serum total cholesterol and risk of hospitalization, and death from respiratory disease. Int. J. Epidemiol. 26, 1191-1202 (1997).
    • (1997) Int. J. Epidemiol. , vol.26 , pp. 1191-1202
    • Iribarren, C.1    Jacobs, Jr.D.R.2    Sidney, S.3    Claxton, A.J.4    Gross, M.D.5    Sadler, M.6
  • 15
    • 0019428094 scopus 로고
    • Increased high density lipoprotein cholesterol in obstructive pulmonary disease (predominant emphysematous type)
    • Tisi, G. M., Conrique, A., Barrett-Connor, E. & Grundy, S. M. Increased high density lipoprotein cholesterol in obstructive pulmonary disease (predominant emphysematous type). Metabolism 30, 340-346 (1981).
    • (1981) Metabolism , vol.30 , pp. 340-346
    • Tisi, G.M.1    Conrique, A.2    Barrett-Connor, E.3    Grundy, S.M.4
  • 16
    • 0028197552 scopus 로고
    • Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors
    • Giguere, V., Tini, M., Flock, G., Ong, E., Evans, R. M. & Otulakowski, G. Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. Genes Dev. 8, 538-553 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 538-553
    • Giguere, V.1    Tini, M.2    Flock, G.3    Ong, E.4    Evans, R.M.5    Otulakowski, G.6
  • 17
    • 84869489534 scopus 로고    scopus 로고
    • Action of RORs and their ligands in (patho)physiology
    • Solt, L. A. & Burris, T. P. Action of RORs and their ligands in (patho)physiology. Tr e n d s Endocrinol. Metab. 23, 619-627 (2012).
    • (2012) Tr e N D S Endocrinol. Metab. , vol.23 , pp. 619-627
    • Solt, L.A.1    Burris, T.P.2
  • 18
    • 1842848068 scopus 로고    scopus 로고
    • X-ray structure of the hRORalpha LBD at 1.63 A: Structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha
    • Kallen, J. A., Schlaeppi, J. M., Bitsch, F., Geisse, S., Geiser, M., Delhon, I. et al. X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha. Structure 10, 1697-1707 (2002).
    • (2002) Structure , vol.10 , pp. 1697-1707
    • Kallen, J.A.1    Schlaeppi, J.M.2    Bitsch, F.3    Geisse, S.4    Geiser, M.5    Delhon, I.6
  • 20
    • 0035951788 scopus 로고    scopus 로고
    • Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORa
    • Raspé, E., Duez, H., Gervois, P., Fiévet, C., Fruchart, J.-C., Besnard, S. et al. Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORa. J. Biol. Chem. 276, 2865-2871 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 2865-2871
    • Raspé, E.1    Duez, H.2    Gervois, P.3    Fiévet, C.4    Fruchart, J.-C.5    Besnard, S.6
  • 21
    • 0030884232 scopus 로고    scopus 로고
    • Transcriptional regulation of apolipoprotein AI gene expression by the nuclear receptor RORa
    • Vu-Dac, N., Gervois, P., Grötzinger, T., De Vos, P., Schoonjans, K., Fruchart, J.-C. et al. Transcriptional regulation of apolipoprotein AI gene expression by the nuclear receptor RORa. J. Biol. Chem. 272, 22401-22404 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 22401-22404
    • Vu-Dac, N.1    Gervois, P.2    Grötzinger, T.3    De Vos, P.4    Schoonjans, K.5    Fruchart, J.-C.6
  • 22
    • 49649099595 scopus 로고    scopus 로고
    • The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: Staggerer (SG/SG) mice are resistant to diet-induced obesity
    • Lau, P., Fitzsimmons, R. L., Raichur, S., Wang, S. C., Lechtken, A. & Muscat, G. E. The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity. J. Biol. Chem. 283, 18411-18421 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 18411-18421
    • Lau, P.1    Fitzsimmons, R.L.2    Raichur, S.3    Wang, S.C.4    Lechtken, A.5    Muscat, G.E.6
  • 23
    • 0345698769 scopus 로고    scopus 로고
    • Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha
    • Mamontova, A., Seguret-Mace, S., Esposito, B., Chaniale, C., Bouly, M., Delhaye-Bouchaud, N. et al. Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. Circulation 98, 2738-2743 (1998).
    • (1998) Circulation , vol.98 , pp. 2738-2743
    • Mamontova, A.1    Seguret-Mace, S.2    Esposito, B.3    Chaniale, C.4    Bouly, M.5    Delhaye-Bouchaud, N.6
  • 24
    • 84864681464 scopus 로고    scopus 로고
    • Association between fibroblast growth factor 7 and the risk of chronic obstructive pulmonary disease
    • Xu, S. C., Kuang, J. Y., Liu, J., Ma, C. L., Feng, Y. L. & Su, Z. G. Association between fibroblast growth factor 7 and the risk of chronic obstructive pulmonary disease. Acta. Pharmacol. Sin. 33, 998-1003 (2012).
    • (2012) Acta. Pharmacol. Sin. , vol.33 , pp. 998-1003
    • Xu, S.C.1    Kuang, J.Y.2    Liu, J.3    Ma, C.L.4    Feng, Y.L.5    Su, Z.G.6
  • 25
    • 84870341107 scopus 로고    scopus 로고
    • Genetic variations in ADIPOQ gene are associated with chronic obstructive pulmonary disease
    • Yuan, Y., Jiang, H., Kuang, J., Hou, X., Feng, Y. & Su, Z. Genetic variations in ADIPOQ gene are associated with chronic obstructive pulmonary disease. PLoS ONE 7, e50848 (2012).
    • (2012) PLoS ONE , vol.7
    • Yuan, Y.1    Jiang, H.2    Kuang, J.3    Hou, X.4    Feng, Y.5    Su, Z.6
  • 27
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barrett, J. C., Fry, B., Maller, J. & Daly, M. J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265 (2005).
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 28
    • 85007745189 scopus 로고    scopus 로고
    • Statistics notes. The odds ratio
    • Bland, J. M. & Altman, D. G. Statistics notes. The odds ratio. BMJ 320, 1468 (2000).
    • (2000) BMJ , vol.320 , pp. 1468
    • Bland, J.M.1    Altman, D.G.2
  • 29
    • 84858999738 scopus 로고    scopus 로고
    • How to obtain the confidence interval from a P value
    • Altman, D. G. & Bland, J. M. How to obtain the confidence interval from a P value. BMJ 343, d2090 (2011).
    • (2011) BMJ , vol.343
    • Altman, D.G.1    Bland, J.M.2
  • 30
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Series B. Stat. Methodol. 57, 289-300 (1995).
    • (1995) J. R. Stat. Soc. Series B. Stat. Methodol. , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 31
    • 18944381751 scopus 로고    scopus 로고
    • SHEsis a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci
    • Shi, Y. Y. & He, L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell. Res. 15, 97-98 (2005).
    • (2005) Cell. Res. , vol.15 , pp. 97-98
    • Shi, Y.Y.1    He, L.2
  • 32
    • 0036792816 scopus 로고    scopus 로고
    • On the advantage of haplotype analysis in the presence of multiple disease susceptibility alleles
    • Morris, R. W. & Kaplan, N. L. On the advantage of haplotype analysis in the presence of multiple disease susceptibility alleles. Genet. Epidemiol. 23, 221-233 (2002).
    • (2002) Genet. Epidemiol. , vol.23 , pp. 221-233
    • Morris, R.W.1    Kaplan, N.L.2
  • 33
    • 0027738642 scopus 로고
    • Stimulation of gene expression by introns: Conversion of an inhibitory intron to a stimulatory intron by alteration of the splice donor sequence
    • Korb, M., Ke, Y. B. & Johnson, L. F. Stimulation of gene expression by introns: conversion of an inhibitory intron to a stimulatory intron by alteration of the splice donor sequence. Nucl. Acids Res. 21, 5901-5908 (1993).
    • (1993) Nucl. Acids Res. , vol.21 , pp. 5901-5908
    • Korb, M.1    Ke, Y.B.2    Johnson, L.F.3
  • 35
    • 84863541347 scopus 로고    scopus 로고
    • An abundance of rare functional variants in 202 drug target genes sequenced in 14002 people
    • Nelson, M. R., Wegmann, D., Ehm, M. G., Kessner, D. St, Jean, P., Verzilli, C. et al. An abundance of rare functional variants in 202 drug target genes sequenced in 14002 people. Science 337, 100-104 (2012).
    • (2012) Science , vol.337 , pp. 100-104
    • Nelson, M.R.1    Wegmann, D.2    Ehm, M.G.3    Kessner, D.St.4    Jean, P.5    Verzilli, C.6
  • 36
    • 84879693217 scopus 로고    scopus 로고
    • New anti-inflammatory targets for chronic obstructive pulmonary disease
    • Barnes, P. J. New anti-inflammatory targets for chronic obstructive pulmonary disease. Nat. Rev. Drug Discov. 12, 543-559 (2013).
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 543-559
    • Barnes, P.J.1
  • 38
    • 66149096280 scopus 로고    scopus 로고
    • The repeatability of interleukin-6, tumor necrosis factor-Alpha, and C-reactive protein in COPD patients over one year
    • Kolsum, U., Roy, K., Starkey, C., Borrill, Z., Truman, N., Vestbo, J. et al. The repeatability of interleukin-6, tumor necrosis factor-Alpha, and C-reactive protein in COPD patients over one year. Int. J. Chron. Obstruct. Pulmon. Dis. 4, 149-156 (2009).
    • (2009) Int. J. Chron. Obstruct. Pulmon. Dis. , vol.4 , pp. 149-156
    • Kolsum, U.1    Roy, K.2    Starkey, C.3    Borrill, Z.4    Truman, N.5    Vestbo, J.6
  • 41
    • 79960416891 scopus 로고    scopus 로고
    • Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-Associated inflammation and hepatic steatosis
    • Kang, H. S., Okamoto, K., Takeda, Y., Beak, J. Y., Gerrish, K., Bortner, C. D. et al. Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-Associated inflammation and hepatic steatosis. Physiol. Genomics 43, 818-828 (2011).
    • (2011) Physiol. Genomics , vol.43 , pp. 818-828
    • Kang, H.S.1    Okamoto, K.2    Takeda, Y.3    Beak, J.Y.4    Gerrish, K.5    Bortner, C.D.6
  • 42
    • 0035095662 scopus 로고    scopus 로고
    • The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response
    • Delerive, P., Monte, D., Dubois, G., Trottein, F., Fruchart-Najib, J., Mariani, J. et al. The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response. EMBO Rep. 2, 42-48 (2001).
    • (2001) EMBO Rep. , vol.2 , pp. 42-48
    • Delerive, P.1    Monte, D.2    Dubois, G.3    Trottein, F.4    Fruchart-Najib, J.5    Mariani, J.6
  • 43
    • 84865825957 scopus 로고    scopus 로고
    • Retinoic acid-related orphan receptor-Alpha is induced in the setting of DNA damage and promotes pulmonary emphysema
    • Shi, Y., Cao, J., Gao, J., Zheng, L., Goodwin, A., An, C. H. et al. Retinoic acid-related orphan receptor-Alpha is induced in the setting of DNA damage and promotes pulmonary emphysema. Am. J. Respir. Crit. Care. Med. 186, 412-419 (2012).
    • (2012) Am. J. Respir. Crit. Care. Med. , vol.186 , pp. 412-419
    • Shi, Y.1    Cao, J.2    Gao, J.3    Zheng, L.4    Goodwin, A.5    An, C.H.6
  • 44
    • 40749105508 scopus 로고    scopus 로고
    • Variations in DNA elucidate molecular networks that cause disease
    • Chen, Y., Zhu, J., Lum, P. Y., Yang, X., Pinto, S., MacNeil, D. J. et al. Variations in DNA elucidate molecular networks that cause disease. Nature 452, 429-435 (2008).
    • (2008) Nature , vol.452 , pp. 429-435
    • Chen, Y.1    Zhu, J.2    Lum, P.Y.3    Yang, X.4    Pinto, S.5    MacNeil, D.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.