Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus

Journal of Antibiotics

Volumn 67, Issue 8, 2014, Pages 549-553

  Hensler, Mary E ^a   Jang, Kyoung Hwa ^b   Thienphrapa, Wdee ^a   Vuong, Lisa ^a   Tran, Dan N ^a   Soubih, Evaristus ^a   Lin, Leo ^a   Haste, Nina M ^c   Cunningham, Mark L ^d   Kwan, Bryan P ^d   Shaw, Karen Joy ^d   Fenical, William ^b   Nizet, Victor ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d Trius Therapeutics   (United States)

Author keywords

anthracimycin; methicillin resistant; novel antibiotic; Staphylococcus aureus

Indexed keywords

ANTHRACIMYCIN; ANTIBIOTIC AGENT; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; METICILLIN; POLYKETIDE; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ANTIMICROBIAL THERAPY; ARTICLE; BACTERIAL PERITONITIS; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; CARCINOMA CELL; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG POTENCY; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MACROMOLECULE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEIC ACID SYNTHESIS; POSTANTIBIOTIC EFFECT; PRIORITY JOURNAL; RIBONUCLEIC ACID SYNTHESIS INHIBITION; RNA SYNTHESIS; SINGLE DRUG DOSE; VANCOMYCIN RESISTANT STAPHYLOCOCCUS AUREUS; ANIMAL; ANTIBIOTIC RESISTANCE; CHEMICAL STRUCTURE; DRUG EFFECTS; HELA CELL LINE; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOUSE; PENICILLIN RESISTANCE; PERITONITIS; STAPHYLOCOCCAL INFECTIONS;

ANIMALS; ANTI-BACTERIAL AGENTS; HELA CELLS; HUMANS; METHICILLIN; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PERITONITIS; POLYKETIDES; STAPHYLOCOCCAL INFECTIONS; VANCOMYCIN; VANCOMYCIN RESISTANCE;

EID: 84906652937     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2014.36     Document Type: Article

References (12)

1. David, M. Z., Medvedev, S., Hohmann, S. F., Ewigman, B. & Daum, R. S. Increasing burden of methicillin-resistant Staphylococcus aureus hospitalizations at US academic medical centers, 2003-2008. Infect. Control. Hosp. Epidemiol. 33, 782-789 (2012).
2. Klein, E. Y., Sun, L., Smith, D. L. & Laxminarayan, R. The changing epidemiology of methicillin-resistant Staphylococcus aureus in the United States: a national observational study. Am. J. Epidemiol. 177, 666-674 (2013).
3. Uhlemann, A. C., Otto, M., Lowy, F. D. & Deleo, F. R. Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus. Infect. Genet. Evol. 21, 563-574 (2013).
4. Oh, D. C., Kauffman, C. A., Jensen, P. R. & Fenical, W. Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture. J. Nat. Prod. 70, 515-520 (2007).
5. Hughes, C. C., Prieto-Davo, A., Jensen, P. R. & Fenical, W. The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp. Org. Lett. 10, 629-631 (2008).
6. Asolkar, R. N., Kirkland, T. N., Jensen, P. R. & Fenical, W. Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. J. Antibiot. 63, 37-39 (2010).
7. Sun,P. et al. Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp. Bioorg. Med. Chem. 19, 6557-6562 (2011).
8. Sakoulas, G. et al. Novel bacterial metabolite merochlorin A demonstrates in vitro activity against multi-drug resistant methicillin-resistant Staphylococcus aureus. PLoS One 7, e29439 (2012).
9. Jang, K. H. et al. Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete. Angew. Chem. Int. Ed. Engl. 52, 7822-7824 (2013).
10. Haste, N. M. et al. Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 55, 3305-3312 (2011).
11. Cunningham, M. L., Kwan, B. P., Nelson, K. J., Bensen, D. C. & Shaw, K. J. Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay. J. Biomol. Screen. 18, 1018-1026 (2013).
12. Sakoulas, G. et al. Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faecium. Antimicrob. Agents Chemother. 56, 838-844 (2012).