Cytomegalovirus retinitis: The neglected disease of the AIDS pandemic

PLoS Medicine

Volumn 4, Issue 12, 2007, Pages 1845-1851

  Heiden, David ^a,b   Ford, Nathan ^c   Wilson, David ^c   Rodriguez, William R ^d   Margolis, Todd ^e   Janssens, Bart ^f   Bedelu, Martha ^c   Tun, Nini ^c   Goemaere, Eric ^g   Saranchuk, Peter ^c   Sabapathy, Kalpana ^c   Smithuis, Frank ^c   Luyirika, Emmanuel ^h   Drew, W Lawrence ^e,i  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^b Seva Foundation   (United States)

^c MÉDECINS SANS FRONTIÈRES   (Switzerland)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f International Committee of the Red Cross   (Switzerland)

^g Médecins Sans Frontières ^*  (South Africa)

^h MILDMAY UGANDA   (Uganda)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; GANCICLOVIR; VALGANCICLOVIR; ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; DRUG DERIVATIVE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; BLINDNESS; BONE MARROW SUPPRESSION; CAMBODIA; CD4 LYMPHOCYTE COUNT; CHINA; CYTOMEGALOVIRUS; DRUG COST; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; MORBIDITY; MORTALITY; MYANMAR; NON PROFIT ORGANIZATION; OPHTHALMOSCOPY; PANDEMIC; RETINITIS; REVIEW; SCREENING; SOUTH AFRICA; THAILAND; UGANDA; WORLD HEALTH ORGANIZATION; AFRICA SOUTH OF THE SAHARA; AIDS RELATED COMPLEX; ARTICLE; CYTOMEGALOVIRUS RETINITIS; DEVELOPING COUNTRY; ECONOMICS; EPIDEMIC; HEALTH CARE DELIVERY; IMMUNOLOGY; MASS SCREENING; PROGRAM DEVELOPMENT; SOUTHEAST ASIA; TREATMENT OUTCOME; VIROLOGY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AFRICA SOUTH OF THE SAHARA; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTI-RETROVIRAL AGENTS; ANTIVIRAL AGENTS; ASIA, SOUTHEASTERN; BLINDNESS; CD4 LYMPHOCYTE COUNT; CYTOMEGALOVIRUS RETINITIS; DEVELOPING COUNTRIES; DISEASE OUTBREAKS; DRUG COSTS; GANCICLOVIR; HEALTH SERVICES ACCESSIBILITY; HUMANS; MASS SCREENING; OPHTHALMOSCOPY; PROGRAM DEVELOPMENT; TREATMENT OUTCOME;

EID: 38049018033     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.0040334     Document Type: Review

References (58)

1. Holbrook JT, Jabs DA, Weinberg DV, Lewis RA, Davis MD, et al. (2003) Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy. Arch Ophthalmol 121: 99-107.
2. Yust I, Fox Z, Burke M, Johnson A, Turner D, et al. (2004) Retinal and extra ocular cytomegalovirus end-organ disease in HIV-infected patients in Europe: a EuroSIDA study, 1994-2001. Eur J Clin Microbiol Infect Dis 23: 550-559.
3. Ledergerber B, Egger M, Erard V, Weber R, Hirschel B, et al. (1999) AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy: the Swiss HIV Cohort Study. JAMA 282: 2220-2226.
4. Jacobson MA, Stanley H, Holtzer C, Margolis TP, Cunningham ET (2000) Natural history and outcome of new AIDS-related cytomegalovirus retinitis diagnosed in the era of highly active antiretroviral therapy. Clin Infect Dis 30: 231-233.
5. Kestelyn PG, Cunningham ET (2001) HIV/AIDS and blindness. Bull World Health Organ 79: 208-213.
6. Guex-Crosier Y, Telenti A (2001) An epidemic of blindness: a consequence of improved HIV care? Bull World Health Organ 79: 181.
7. Pathanapitoon K, Ausayakhum S, Kunavisarut P, Wattanakikorn S, Ausayakhum S, et al. (2007) Blindness and low vision in a tertiary ophthalmologic center in Thailand: the importance of cytomegalovirus retinitis. Retina 27: 635-640.
8. Ghebrekidan H, Ruden U, Cox S, Wahren B, Grandien M (1999) Prevalence of herpes simplex virus types 1 and 2, cytomegalovirus, and varicella-zooster virus infections in Eritrea. J Clin Virol 12: 53-64.
9. Urwijeitaroon Y, Teawpatanataworn S, Kitjareontarm A (1993) Prevalence of cytomegalovirus antibody in Thai-northeastern blood donors. Southeast Asian J Trop Med Public Health 24 (Suppl 1): 180-182.
10. Liu Z, Wang E, Taylor W, Yu H, Wu T, et al. (1990) Prevalence survey of cytomegalovirus infection in children in Chengdu. Am J Epidemiol 131: 143-150.
11. Carmichael TR, Sher R (2002) Screening for cytomegalovirus retinitis at an AIDS clinic. S Afr Med J 92: 445-447.
12. Ausayakhun S, Watananikorn S, Ittipunkul N, Chaidaroon W, Patikulsi, et al. (2003) Epidemiology of the ocular complications of HIV infection in Chiang Mai. J Med Assoc Thai 86: 399-406.
13. Biswas J, Madhavan HN, George AE, Kumarasamy N, Solomon S (2000) Ocular lesions associated with HIV infection in India: a series of 100 consecutive patients evaluated at a referral center. Am J Ophthalmol 129: 9-15.
14. Pichith K, Chanroeun H, Bunna P, Nyvanny N, Thavary S, et al. (2001) [Clinical aspects of AIDS at the Calmette hospital in Phnom Penh, Kingdom of Cambodia. A report on 356 patients hospitalized in the Medicine "B" Department of the Calmette Hospital] Sante 11: 17-23.
15. Kestelyn P (1999) The epidemiology of CMV in Africa. Ocul Immunol Inflamm 7: 173-177.
16. Balo KP, Amoussou YP, Bechetoille A, Mihluedo H, Djagnikpo PA, et al. (1999) [Cytomegalovirus retinitis and ocular complications in AIDS patients in Togo]. J Fr Ophthalmol 22: 1042-1046.
17. Hodge WG, Boivin JF, Shapiro SH, Lalonde RG, Shah KC, et al. (2004) Laboratory-based risk factors for cytomegalovirus retinitis. Can J Ophthalmol 39: 733-745.
18. van der Meer JT, Drew WL, Bowden RA, Galasso GJ, Griffiths PD, et al. (1996) Summary of the International Consensus Symposium on advances in the Diagnosis, Treatment and Prophylaxis of Cytomegalovirus infection. Antiviral Res 32: 119-140.
19. Palestine AG, Rodrigues MM, Macher AM, Chan CC, Lane HC, et al. (1984) Ophthalmic involvement in acquired immunodeficiency syndrome. Ophthalmology 91: 1092-1099.
20. Bowen EF, Wilson P, Atkins M, Madge S, Griffiths PD, et al. (1995) Natural history of untreated cytomegalovirus retinitis. Lancet. 346: 1671-1673.
21. Kempen JH, Jabs DA, Dunn JP, West SK, Tonascia J (2001) Retinal detachment risk in CMV retinitis related to the acquired immunodeficiency syndrome. Arch Ophthalmol 119: 33-40.
22. Kempen JH, Min Y, Freeman WR, Holland GN, Friedberg DN, et al. (2006) Risk of immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis. Ophthalmology 113(4) :684-94
23. Freeman WR, Friedberg DN, Berry C, Quiceno JI, Behette M, et al. (1993) Risk factors for development of rhegmatogenous retinal detachment in patients with cytomegalovirus retinitis. Am J Ophthalmol 116: 713-720.
24. Karavellas MP, Azen SP, MacDonald JC, Shufelt CL, Lowder CY, et al. (2001) Immune recovery vitiritis and uveitis in AIDS: clinical predictors, sequelae, and treatment outcomes. Retina 21: 1-9.
25. Wei LL, Park SS, Skiest DJ (2002) Prevalence of visual symptoms among patients with newly diagnosed cytomegalovirus retinitis. Retina 22: 278-282.
26. Egbert PR, Pollard RB, Gallagher JG, Merigan TC (1980) Cytomegalovirus retinitis in immunosuppressed hosts. II. Ocular manifestations. Ann Intern Med 93: 664-670.
27. Gellrich MM, Lagreze WD, Rump JA, Hansen LL (1996) [Indications for eye examination of HIV patients - screening parameters for cytomegalovirus retinitis.] Klin Monatsbl Augenheilkd 209: 72-78.
28. Janssens B, Heiden D, Sarin S, Zachariah R () Cytomegalovirus retinitis is an important problem that is being missed in HIV-positive individuals attending routine clinics in Cambodia: is there a need to introduce routine CMV screening [abstract THPE0053]. XVI International AIDS Conference; 13-18 August 2006; Toronto, Canada.
29. Vrabec TR, Baldassano VF, Whitcup SM (1998) Discontinuation of maintenance therapy in patients with quiescent cytomegalovirus retinitis and elevated CD4+ counts. Ophthalmology 105: 1259-1264.
30. Wohl DA, Kendall MA, Owens S, Holland G, Nokta M, et al. (2005) The safety of discontinuation of maintenance therapy for cytomegalovirus (CMV) retinitis and incidence of immune recovery uveitis following potent antiretroviral therapy. HIV Clin Trials 6: 136-146.
31. Spector SA, Weingeist T, Pollard RB, Dieterich DT, Samo T, et al. (1993) A randomized, controlled study of intravenous ganciclovir therapy for cytomegalovirus peripheral retinitis in patients with AIDS. J. Infect Dis 168: 557-563.
32. [No authors listed] (1994) Foscarnet-Ganciclovir cytomegalovirus retinitis trial. 4. Visual outcomes. Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group. Ophthalmology 101: 1250-161.
33. Martin DF, Sierra-Madero J, Walmsley S, Wolitz RA, Macey K, et al. (2002) A controlled trial of valganciclovir as induction therapy for cytomegalovirus retinitis. N Engl J Med 346: 1119-1126.
34. Jacobson MA (1997) Treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. N Engl J Med 337: 105-114.
35. Drew WL, Ehrlich KS (2007) Management of virus infections (cytomegalovirus, herpes simpex virus, varicella-zooster virus). In Volberding P, Sande M, Lange, J, Greene W, Gallant J, editors. Global HIV/ AIDS medicine. Elsevier. pp. 437-461.
36. American Academy of Pediatrics (2006) Red Book: 2006 Report of the Committee on Infectious Diseases. 27th edition. American Academy of Pediatrics. 992 p.
37. Ausayakhun S, Yuvaves P, Ngamtiphakorn S, Prasitsilp J ( 2005) Treatment of cytomegalovirus retinitis in AIDS patieints with intravitreal ganciclovir. J Med Assoc Thai 88 (Suppl 9): S15-S20.
38. Ausayakhun S, Watananikorn S, Ngamtiphakorn S, Prasitsilp J (2005) Intravitreal foscarnet for cytomegalovirus retinitis in patients with AIDS. J Med Assoc Thai 88: 103-107.
39. Morinelli EN, Dugel PU, Lee M, Klatt EC, Rao NA (1992) Opportunistic intraocular infections in AIDS. Trans Am Ophthalmol Soc 90: 97-108; discussion 108-109.
40. Binquet C, Saillour F, Bernard N, Rougier MB, Leger F, et al. (2000) Prognostic factors of survival of HIV-infected patients with cytomegalovirus disease: Aquitaine Cohort, 1986-1997. Groupe d'Epidemiologie Clinique du SIDA en Aquitaine (GECSA). Eur J Epidemiol 16: 425-432.
41. Kempen JH, Jabs DA, Wilson LA, Dunn JP, West SK, et al. (2003) Mortality risk for patients with cytomegalovirus retinitis and acquired immune deficiency syndrome. Clin Infect Dis 37: 1365-1573.
42. Murray HW, Know DL, Green WR, Susel RM (1977) Cytomegalovirus retinitis in adults. A manifestation of disseminated viral infection. Am J Med 63: 574-584.
43. Pecorella I, Ciardi A, Credendino A, Marasco A, Di Tondo U, et al. (1999) Ocular, cerebral and systemic interrelationships of cytomegalovirus infection in a post-mortem study of AIDS patients. Eye 13 (Part 6): 781-785.
44. Wallace JM, Hannah J (1987) Cytomegalovirus pneumonitis in patients with AIDS. Findings in an autopsy series. Chest 92: 198-203.
45. Mohar A, Romo J, Salido F, Jessurun J, Ponce de Leon S, et al. (1992) The spectrum of clinical and pathological manifestations of AIDS in a consecutive series of autopsied patients in Mexico. AIDS 6: 467-473.
46. Lang W, Miklossy J, Deruaz JP, Pizzolato GP, Probst A, et al. (1989) Neuropathology of the acquired immune deficiency syndrome (AIDS): a report of 135 consecutive autopsy cases from Switzerland. Acta Neuropathol (Berl) 77: 379-390.
47. Chimelli L, Rosemberg S, Hahn MD, Lopes MB, Netto MB (1992) Pathology of the central nervous system in patients infected with the human immunodeficiency virus (HIV): a report of 252 autopsy cases from Brazil. Neuropathol Appl Neurobiol 18: 478-488.
48. Drlicek M, Liszka U, Wondrusch E, Jellinger K, Lintner F, et al. (1993) [Pathology of the central nervous system in AIDS. An overview of 184 patients.] Wien Klin Wochenschr 105: 467-471.
49. Bylsma SS, Achim CL, Wiley CA, Gonzalez C, Kuppermann BD, et al. (1995) The predictive value of cytomegalovirus retinitis for cytomegalovirus encephalitis in acquired immunodeficiency syndrome. Arch Ophthalmol 113: 89-95.
50. Ansari NA, Kombe AH, Kenyon TA, Hone NM, Tappero JW, et al. (2002) Pathology and causes of death in a group of 128 predominantly HIV-positive patients in Botswana, 1997-1998. Int J Tuberc Lung Dis 6: 55-63.
51. Leger F, Vital C, Vital A, Morlat P, Ragnaud JM, et al. (1997) Pathologic correlations between ocular and cerebral lesions in 36 AIDS patient. Clin Neuropathol 16: 45-48.
52. Chua A, Wilson D, Ford N (2005) HIV and cytomegalovirus in Thailand. Lancet Infect Dis 5: 328-329.
53. Sommer A (2007) Global access to eye care. Arch Ophthalmol 125: 399-400.
54. Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, et al. (2004) Global data on visual impairment in the year 2002. Bull World Health Organ 82: 844-851.
55. Ford N, Wilson D, Lotrowska M, Chaves GC, Kijtiwatchakul K (2007) Sustaining access to antiretroviral therapy in the less developed world: lessons from Brazil and Thailand. AIDS 21 (Suppl 4): S21-S29.
56. Over M, Revenga A, Masaki E, Peerapatanapokin W, Gold J, et al. (2007) The economics of effective AIDS treatment in Thailand. AIDS 21 (Suppl 4): S105-S116.
57. Lyttleton C, Beesey A, Sitthikriengkrai M (2007) Expanding community through ARV provision in Thailand. AIDS Care 19: S44-S53.
58. [No authors listed] (2004) Practitioners' guideline for OI and ARV management in people with HIV/AIDS. Nonthaburi (Thailand): Bureau of AIDS, TB and STI, Ministry of Public Health and the Thai AIDS Society.