In vivo vitamin C deficiency in guinea pigs increases ascorbate transporters in liver but not kidney and brain

Nutrition Research

Volumn 34, Issue 7, 2014, Pages 639-645

  Søgaard, Ditte ^a   Lindblad, Maiken M ^a   Paidi, Maya D ^a   Hasselholt, Stine ^a   Lykkesfeldt, Jens ^a   Tveden Nyborg, Pernille ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Ascorbic acid D02.241.511.902.107 ; Brain A08.186.211 ; Deficiency diseases C18.654.521.500 ; Guinea pig; Malnutrition C18.654.521

Indexed keywords

ASCORBIC ACID; MESSENGER RNA; SODIUM ASCORBIC ACID COTRANSPORTER; SODIUM DEPENDENT VITAMIN C TRANSPORTER 1; SODIUM DEPENDENT VITAMIN C TRANSPORTER 2; UNCLASSIFIED DRUG; VITAMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCORBIC ACID DEFICIENCY; BRAIN REGION; DEPLETION; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GUINEA PIG; HOMEOSTASIS; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SEQUENCE ANALYSIS; SVCT1 GENE; SVCT2 GENE; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; UPREGULATION; VITAMIN BLOOD LEVEL; VITAMIN DEPLETION; ANIMAL; BLOOD; BRAIN; CEREBROSPINAL FLUID; DIET; GENETICS; KIDNEY; LIVER; METABOLISM;

ANIMALS; ASCORBIC ACID; ASCORBIC ACID DEFICIENCY; BRAIN; DIET; FEMALE; GUINEA PIGS; HOMEOSTASIS; KIDNEY; LIVER; RNA, MESSENGER; SODIUM-COUPLED VITAMIN C TRANSPORTERS; TISSUE DISTRIBUTION; VITAMINS;

EID: 84906345586     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2014.07.004     Document Type: Article

References (30)

1. Tveden-Nyborg P., Lykkesfeldt J. Does vitamin C deficiency increase lifestyle-associated vascular disease progression?-evidence based on experimental and clinical studies. Antioxid Redox Signal 2013, 19:2084-2104.
2. Smith J.L., Hodges R.E. Serum levels of vitamin-C in relation to dietary and supplemental intake of vitamin-C in smokers and nonsmokers. Ann N Y Acad Sci 1987, 498:144-152.
3. Frikke-Schmidt H., Tveden-Nyborg P., Lykkesfeldt J. Vitamin C in human nutrition 2011, 323-347. De Gruyter. W. Hermann, R. Obeid (Eds.).
4. Lykkesfeldt J. Smoking depletes vitamin C: should smokers be recommended to take supplements?. Cigarette smoke and oxidative stress 2006, 237-260. Springer Verlag. B. Halliwell, H.E. Poulsen (Eds.).
5. Lindblad M., Tveden-Nyborg P., Lykkesfeldt J. Regulation of vitamin C homeostasis during deficiency. Nutrients 2013, 5:2860-2879.
6. Wilson J.X. Regulation of vitamin C transport. Annu Rev Nutr 2005, 25:105-125.
7. Dhariwal K.R., Hartzell W.O., Levine M. Ascorbic acid and dehydroascorbic acid measurements in human plasma and serum. Am J Clin Nutr 1991, 54:712-716.
8. Frikke-Schmidt H., Tveden-Nyborg P., Birck M.M., Lykkesfeldt J. High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigs. Br J Nutr 2011, 105:54-61.
9. Lykkesfeldt J., Trueba G.P., Poulsen H.E., Christen S. Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain. Br J Nutr 2007, 98:1116-1119.
10. Harrison F.E., Dawes S.M., Meredith M.E., Babaev V.R., Li L., May J.M. Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2. Free Radic Biol Med 2010, 49:821-829.
11. Harrison F.E., May J.M. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med 2009, 46:719-730.
12. Sotiriou S., Gispert S., Cheng J., Wang Y.H., Chen A., Hoogstraten-Miller S., et al. Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med 2002, 8:514-517.
13. Tveden-Nyborg P., Johansen L.K., Raida Z., Villumsen C.K., Larsen J.O., Lykkesfeldt J. Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs. Am J Clin Nutr 2009, 90:540-546.
14. Tveden-Nyborg P., Vogt L., Schjoldager J.G., Jeannet N., Hasselholt S., Paidi M.D., et al. Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. PLoS One 2012, 7:e48488.
15. Amano A., Aigaki T., Maruyama N., Ishigami A. Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice. Arch Biochem Biophys 2010, 496:38-44.
16. Meredith M.E., Harrison F.E., May J.M. Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion. Biochem Biophys Res Commun 2011, 414:737-742.
17. Tveden-Nyborg P., Hasselholt S., Miyashita N., Moos T., Poulsen H.E., Lykkesfeldt J. Chronic vitamin C deficiency does not accelerate oxidative stress in ageing brains of guinea pigs. Basic Clin Pharmacol Toxicol 2012, 110:524-529.
18. Hughes R.E., Hurley R.J., Jones P.R. The retention of ascorbic acid by guinea-pig tissues. Br J Nutr 1971, 26:433-438.
19. Lykkesfeldt J. Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: validity of clinical data depends on vacutainer system used. Nutr Res 2012, 32:66-69.
20. Lykkesfeldt J. Ascorbate and dehydroascorbic acid as reliable biomarkers of oxidative stress: analytical reproducibility and long-term stability of plasma samples subjected to acidic deproteinization. Cancer Epidemiol Biomarkers Prev 2007, 16:2513-2516.
21. Clark A.G., Rohrbaugh A.L., Otterness I., Kraus V.B. The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. Matrix Biol 2002, 21:175-184.
22. Bradford M.M. Rapid and Sensitive Method for Quantitation of Microgram Quantities of Protein Utilizing Principle of Protein-Dye Binding. Anal Biochem 1976, 72:248-254.
23. Reidling J.C., Rubin S.A. Promoter analysis of the human ascorbic acid transporters SVCT1 and 2: mechanisms of adaptive regulation in liver epithelial cells. J Nutr Biochem 2011, 22:344-350.
24. Harrison F.E., Green R.J., Dawes S.M., May J.M. Vitamin C distribution and retention in the mouse brain. Brain Res 2010, 1348:181-186.
25. Rice M.E., Lee E.J., Choy Y. High levels of ascorbic acid, not glutathione, in the CNS of anoxia-tolerant reptiles contrasted with levels in anoxia-intolerant species. J Neurochem 1995, 64:1790-1799.
26. Rice M.E., Russo-Menna I. Differential compartmentalization of brain ascorbate and glutathione between neurons and glia. Neuroscience 1998, 82:1213-1223.
27. Rice M.E. Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci 2000, 23:209-216.
28. Spector R. Nutrient transport systems in brain: 40 years of progress. J Neurochem 2009, 111:315-320.
29. Spector R., Johanson C. Micronutrient and urate transport in choroid plexus and kidney: implications for drug therapy. Pharm Res 2006, 23:2515-2524.
30. Villalpando S., Montalvo-Velarde I., Zambrano N., Garcia-Guerra A., Ramirez-Silva C.I., Shamah-Levy T., et al. Vitamins A, and C and folate status in Mexican children under 12 years and women 12-49 years: a probabilistic national survey. Salud Publica Mex 2003, 45:S508-S519.