Potential of a renin inhibitory peptide from the red seaweed palmaria palmata as a functional food ingredient following confirmation and characterization of a hypotensive effect in spontaneously hypertensive rats

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 33, 2014, Pages 8352-8356

  Fitzgerald, Ciaran ^a   Aluko, Rotimi E ^b   Hossain, Mohammad ^a   Rai, Dilip K ^a   Hayes, Maria ^a  

^a TEAGASC FOOD RESEARCH CENTRE   (Ireland)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

in vitro simulated gastrointestinal digestion; red macroalga; renin inhibitory peptides; spontaneously hypertensive rats

Indexed keywords

BLOOD PRESSURE; DROPS; HYDROLYSIS; MASS SPECTROMETRY; SEAWEED; PROTEINS; RATS;

ANGIOTENSIN I-CONVERTING ENZYME; ANTIHYPERTENSIVE EFFECT; GASTROINTESTINAL DIGESTION; INHIBITORY PEPTIDES; MACRO ALGAE; MASS SPECTROMETRY ANALYSIS; SPONTANEOUSLY HYPERTENSIVE RATS; SYSTOLIC BLOOD PRESSURE(SBP);

PEPTIDES;

ANIMALIA; PALMARIA PALMATA; RATTUS;

ANTIHYPERTENSIVE AGENT; OLIGOPEPTIDE; PLANT EXTRACT; RENIN INHIBITORY PEPTIDE;

ANALYSIS; ANIMAL; BLOOD PRESSURE; CHEMISTRY; DRUG EFFECTS; FEMALE; FUNCTIONAL FOOD; HUMAN; HYPERTENSION; ISOLATION AND PURIFICATION; MALE; PATHOPHYSIOLOGY; RAT; RED ALGA; SEAWEED; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; FEMALE; FUNCTIONAL FOOD; HUMANS; HYPERTENSION; MALE; OLIGOPEPTIDES; PLANT EXTRACTS; RATS; RATS, INBRED SHR; RHODOPHYTA; SEAWEED;

EID: 84906342407     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf500983n     Document Type: Article

References (19)

1. Lien, S.; Lowman, H. B. Therapeutic peptides Trends Biotechnol. 2003, 21, 556-562
2. Callow, A. D. Cardiovascular disease 2005 - The global picture Vasc. Pharmacol. 2006, 45, 302-307
3. Gradman, A. H.; Kad, R. Renin inhibition in hypertension J. Am. Coll. Cardiol. 2008, 51, 519-528
4. Gradman, A. H.; Schmieder, R. E.; Lins, R. L.; Nussberger, J.; Chiang, Y.; Bedigian, M. P. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients Circulation 2005, 111, 1012-1018
5. Tigerstedt, R.; Bergman, P. Niere und Kreislauf Skand. Arch. Physiol. 1898, 8, 223-271
6. Skeggs, L. T.; Kahn, J. R.; Lentz, K.; Shumway, N. P. The preparation, purification, and amino acid sequence of a polypeptide renin substrate J. Exp. Med. 1957, 106, 439-453
7. Wu, J.; Ding, X. Characterization of inhibition and stability of soy-protein-derived angiotensin I-converting enzyme inhibitory peptides Food Res. Int. 2002, 35, 367-375
8. Ma, M.-S.; Bae, I. Y.; Lee, H. G.; Yang, C.-B. Purification and identification of angiotensin I-converting enzyme inhibitory peptide from buckwheat (Fagopyrum esculentum Moench) Food Chem. 2006, 96, 36-42
9. Kim, S.-K.; Wijesekara, I. Development and biological activities of marine-derived bioactive peptides: A review J. Funct. Foods 2010, 2, 1-9
10. Suetsuna, K.; Nakano, T. Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida) J. Nutr. Biochem. 2000, 11, 450-454
11. Li, H.; Aluko, R. E. Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate J. Agric. Food Chem. 2010, 58, 11471-11476
12. Girgih, A. T.; Udenigwe, C. C.; Li, H.; Adebiyi, A. P.; Aluko, R. E. Kinetics of enzyme inhibition and antihypertensive effects of hemp seed (Cannabis sativa L.) protein hydrolysates J. Am. Oil Chem. Soc. 2011, 88, 1767-1774
13. Fitzgerald, C.; Mora-Soler, L.; Gallagher, E.; O'Connor, P.; Prieto, J.; Soler-Vila, A.; Hayes, M. Isolation and characterization of bioactive pro-peptides with in vitro renin inhibitory activities from the macroalga Palmaria palmata J. Agric. Food Chem. 2012, 60, 7421-7427
14. Gasteiger, E.; Hoogland, C.; Gattiker, A.; Wilkins, M. R.; Appel, R. D.; Bairoch, A. Protein identification and analysis tools on the ExPASy server. In The Proteomics Protocols Handbook; Springer: New York, 2005; pp 571-607.
15. Vermeirssen, V.; van der Bent, A.; Van Camp, J.; van Amerongen, A.; Verstraete, W. A quantitative in silico analysis calculates the angiotensin I converting enzyme (ACE) inhibitory activity in pea and whey protein digests Biochimie 2004, 86, 231-239
16. Yang, B.; Dong, W.; Zhang, A.; Sun, H.; Wu, F.; Wang, P.; Wang, X. Ultra performance liquid chromatography coupled with electrospray ionization/ quadrupole-time of-flight mass spectrometry for rapid analysis of constituents of Suanzaoren decoction J. Sep. Sci. 2011, 34, 3208-15
17. Li, H.; Prairie, N.; Udenigwe, C. C.; Adebiyi, A. P.; Tappia, P. S.; Aukema, H. M.; Jones, P. J.; Aluko, R. E. Blood pressure lowering effect of a pea protein hydrolysate in hypertensive rats and humans J. Agric. Food. Chem. 2011, 59, 9854-60
18. Li, C. H.; Matsui, T.; Matsumoto, K.; Yamasaki, R.; Kawasaki, T. Latent production of angiotensin I-converting enzyme inhibitors from buckwheat protein J. Pept. Sci. 2002, 8, 267-74
19. Fitzgerald, C.; Gallagher, E.; O'Connor, P.; Prieto, J.; Mora-Soler, L.; Grealy, M.; Hayes, M. Development of a seaweed derived platelet activating factor acetylhydrolase (PAF-AH) inhibitory hydrolysate, synthesis of inhibitory peptides and assessment of their toxicity using the Zebrafish larvae assay Peptides 2013, 50c, 119-124