Olfactory dysfunction: Common in later life and early warning of neurodegenerative disease;Riechstörungen: Häufig im alter und wichtiges frühsymptom neurodegenerativer erkrankungen

Deutsches Arzteblatt International

Volumn 110, Issue 1-2, 2013, Pages 1-8

  Hüttenbrink, Karl Bernd ^a,d   Hummel, Thomas ^b   Berg, Daniela ^c   Gasser, Thomas ^c   Hähner, Antje ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; COGNITIVE DEFECT; DEGENERATIVE DISEASE; HUMAN; HUNTINGTON CHOREA; MOTOR DYSFUNCTION; ODOR RECOGNITION TEST; PARKINSON DISEASE; PARKINSONISM; SMELLING DISORDER; COMPLICATION; EARLY DIAGNOSIS; NEURODEGENERATIVE DISEASES; OLFACTION DISORDERS; RISK ASSESSMENT;

ANTIINFLAMMATORY AGENT;

ANTI-INFLAMMATORY AGENTS; EARLY DIAGNOSIS; HUMANS; NEURODEGENERATIVE DISEASES; OLFACTION DISORDERS; RISK ASSESSMENT;

EID: 84906329119     PISSN: 18660452     EISSN: None     Source Type: Journal    
DOI: 10.3238/arztebl.2013.0001     Document Type: Article

References (47)

1. Stevenson RJ: An initial evaluation of the functions of human olfac-tion. Chem Senses 2010; 35: 3-20.
2. Hummel T, Nordin S: Olfactory disorders and their consequences for quality of life-a review. Acta Oto-Laryngol 2005; 125: 116-21.
3. Murphy C, Schubert CR, Cruickshanks KJ, Klein BE, Klein R, Non-dahl DM: Prevalence of olfactory impairment in older adults. JAMA 2002; 288: 2307-12.
4. Vennemann MM, Hummel T, Berger K: The association between smoking and smell and taste impairment in the general population. J Neurol 2008; 255: 1121-6.
5. Brämerson A, Johansson L, Ek L, Nordin S, Bende M: Prevalence of olfactory dysfunction: The Skövde population-based study. Laryngoscope 2004; 114: 733-7.
6. Shepherd GM: Perspectives on olfactory processing, conscious perception, and orbitofrontal cortex. Ann N Y Acad Sci 2007; 1121: 87-101.
7. DeMaria S, Ngai J: The cell biology of smell. J Cell Biol 2010; 191: 443-52.
8. Wilson RS, Yu L, Bennett DA: Odor identification and mortality in old age. Chem Senses 2010; 36: 63-7.
9. Buck L, Axel R: A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 1991; 65: 175-87.
10. Firestein S: How the olfactory system makes sense of scents. Nature 2001; 413: 211-8.
11. Gottfried JA: Smell: central nervous processing. Adv Otorhinolaryn-gol 2006; 63: 44-69.
12. Welge-Lüssen A, Hummel T: Praktisches Vorgehen bei Patienten mit Riechstörungen. In: Hummel T, Welge-Luessen A (eds.): Riech-und Schmeckstörungen. Stuttgart: Georg Thieme Verlag 2009: 3-10.
13. Hummel T, Landis BN, Hüttenbrink KB: Störungen des Riechens und Schmeckens. Laryngo-Rhino-Otol 2011; 90: 44-55.
14. Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester A F, et al.: Smell and taste disorders: a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otorhi-nolaryngol Head Neck Surg 1991; 117: 519-28.
15. Damm M, Temmel A, Welge-Lüssen A, Eckel HE, Kreft M P, Kluss-mann J P, et al.: Epidemiologie und Therapie von Riechstörungen in Deutschland, Österreich und der Schweiz. HNO 2004; 52: 112-20.
16. Hedner M, Larsson M, Arnold N, Zucco GM, Hummel T: Cognitive factors in odor detection, odor discrimination, and odor identifica-tion tasks. J Clin Exp Neuropsychol 2010; 30: 1-6.
17. Doty RL, Deems D, Steller S: Olfactory dysfunction in Parkinson's disease: A general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 1988; 38: 1237-44.
18. Müller A, Mungersdorf M, Reichmann H, et al.: Olfactory function in Parkinsonian syndromes. J Clin Neurosci 2002; 9: 521-4.
19. Hawkes C: Olfaction in neurodegenerative disorder. Adv Otorhinola-ryngol 2006; 63: 133-51.
20. Haehner A, Boesveldt S, Berendse HW, et al.: Prevalence of smell loss in Parkinsońs disease-a multicenter study. Parkinsonism Relat Disord 2009; 15: 490-4.
21. Hummel T, Kobal G, Gudziol H, Mackay-Sim A: Normative data for the., Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3, 000 subjects. Eur Arch Otorhinolaryngol 2007; 264: 237-43.
22. Barz S, Hummel T, Pauli E, Majer M, Lang CJ, Kobal G: Chemosen-sory event-related potentials in response to trigeminal and olfactory stimulation in idiopathic Parkinson's disease. Neurology 1997; 49: 1424-31.
23. Berendse HW, Roos DS, Raijmakers P, Doty R: Motor and non-motor correlates of olfactory dysfunction in Parkinson's disease. J Neurol Sci 2011; 310: 21-4.
24. Ponsen MM, Stoffers D, Booij J, et al.: Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann Neurol 2004; 56: 173-81.
25. Ross GW, Petrovitch H, Abbott RD, Tanner CM, Popper J, Masaki K, Launer L, White LR: Association of olfactory dysfunction with risk for future Parkinson's disease. Ann Neurol 2008; 63: 67-73.
26. Braak H, Del Tredici K, Rub U, et al.: Staging of brain pathology relat ed to sporadic Parkinson's disease. Neurobiol Aging 2003; 24: 97-211.
27. Katzenschlager R, Zijlmans J, Evans A, Watt H, et al.: Olfactory function distinguishes vascular parkinsonism from Parkinson's disease. J Neurol Neurosurg Psychiatry 2004; 75: 1749-52.
28. Krüger S, Haehner A, Thiem C, Hummel T: Neuroleptic-induced parkinsonism is associated with olfactory dysfunction. J Neurol 2008; 255: 1574-9.
29. Müller A, Reuner U, Landis B, Kitzler H, Reichmann H, Hummel T: Extrapyramidal symptoms in Wilsons disease are associated with olfactory dysfunction. Mov Disord 2006; 21: 1311-6.
30. Mesholam RI, Moberg PJ, Mahr RN, Doty RL: Olfaction in neurode-generative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Arch Neurol 1998; 55: 84-90.
31. Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239-59.
32. Wilson RS, Arnold SE, Schneider JA, Boyle PA, et al.: Olfactory impairment in presymptomatic Alzheimeŕs disease. Ann N Y Acad Sci 2009; 1170: 730-5.
33. Larsson M, Lundin A, Robins Wahlin TB: Olfactory functions in asymptomatic carriers of the Huntington disease mutation. J Clin Exp Neuropsychol 2006; 28: 1373-80.
34. Le Pichon CE, Valley MT, Polymenidou M, et al.: Olfactory behavior and physiology are disrupted in prion protein knockout mice. Nat Neurosci 2009; 12: 60-9.
35. Reden J, Müller A, Mueller C, Konstantinidis I, Landis BN, Hummel T: Recovery of olfactory function following closed head injury or infections of upper respiratory tract. Arch Otolaryngol Head Neck Surg 2006; 132: 265-9.
36. Pade J, Hummel T: Olfactory function following nasal surgery. Laryngoscope 2008; 118: 1260-4.
37. Blomqvist EH, Lundblad L, Bergstedt H, Stjarne P: Placebo-controll-ed, randomized, double-blind study evaluating the efficacy of fluti-casone propionate nasal spray for the treatment of patients with hy-posmia/anosmia. Acta Otolaryngol 2003; 123: 862-8.
38. Hummel T, Rissom K, Hähner A, Reden J, Weidenbecher M, Hütten-brink KB: Effects of olfactory training in patients with olfactory loss. Laryngoscope 2009; 119: 496-9.
39. Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf-und Hals-Chirurgie: Riechstörungen: Leitlinie zur Epidemiologie, Pathophysi-ologie, Klassifikation, Diagnose und Therapie. www.awmf.org/uploads/tx-szleitlinien/017-050-S2-Riechstoerungen-mit-Algorithmus- 05-2007-05-2011-01.pdf (last accessed 7 December 2012).
40. Knecht M, Hüttenbrink KB, Hummel T: Störungen des Riechens und Schmeckens. Schweiz Med Wochenschr 1999; 129: 1039-46.
41. Delank KW: Aerodynamik im Bereich des Riechorgans. In: Wolfgang Stoll (eds.): Klinik der menschlichen Sinne, Springer Verlag, Wien 2008; 51-8.
42. Brockmann K, Gröger A, Di Santo A, Liepelt I, Schulte C, Klose U, Maetzler W, Hauser AK, Hilker R, Gomez-Mancilla B, Berg D, Gasser T: Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers. Mov Disord 2011; 26: 2335-42.
43. Moberg PJ, Doty RL: Olfactory function in Huntingtońs disease patients and at-risk offspring. Int J Neurosci 1997; 89: 133-9.
44. Jafek BW, Moran DT, Eller PM, Rowley JC, 3rd, Jafek TB: Steroid-dependent anosmia. Arch Otolaryngol Head Neck Surg 1987; 113: 547-9.
45. Shu CH, Lee PL, Chen KT, Lan MY: Topical corticosteroid applied with a squirt system being more effective than with nasal spray for steroid-dependent olfactory impairment. Rhinology 2012; (in press).
46. Hummel T, Jahnke U, Sommer U, Reichmann H, Müller A: Olfactory function in patients with idiopathic Parkinson's disease: Effects of deep brain stimulation in the subthalamic nucleus. J Neural Transm 2005; 112: 669-76.
47. Hähner A, Welge-Lüssen A: Riechstörungen bei neurodegene-rativen Erkrankungen. HNO 2012; 7: 644-9.