Olfactory dysfunction in neurodegenerative disorders;Riechstörungen bei neurodegenerativen Erkrankungen

HNO

Volumn 58, Issue 7, 2010, Pages 644-649

  Hahner A ^a   Welge Lussen A ^b  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Alzheimer's disease; Early diagnosis; Neurodegeneration; Olfactory dysfunction; Parkinson's disease

Indexed keywords

ARTICLE; DEGENERATIVE DISEASE; HUMAN; PATHOPHYSIOLOGY; SMELLING DISORDER;

HUMANS; NEURODEGENERATIVE DISEASES; OLFACTION DISORDERS;

EID: 77954425855     PISSN: 00176192     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00106-010-2122-x     Document Type: Article

References (30)

1. Ansari KA, Johnson A (1975) Olfactory function in patients with Parkinson's disease. J Chron Dis 28:493-497
2. Doty RL, Deems D, Steller S (1988) Olfactory dysfunction in Parkinson's disease: A general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 38:1237-1244
3. Hawkes C (2006) Olfaction in neurodegenerative disorder. Adv Otorhinolaryngol 63:133-151
4. Haehner A, Boesveldt S, Berendse HW et al (2009) Prevalence of smell loss in Parkinson's disease - a multicenter study. Parkinsonism Relat Disord 15:490-494
5. Hummel T, Kobal G, Gudziol H, Mackay-Sim A (2007) Normative data for the Sniffin'Sicksincluding tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 264:237-243
6. Lötsch J, Reichmann H, Hummel T (2008) Different odor tests contribute differently to the evaluation of olfactory loss. Chem Senses 33:17-21
7. Barz S, Hummel T, Pauli E et al (1997) Chemosensory event-related potentials in response to trigeminal and olfactory stimulation in idiopathic Parkinson's disease. Neurology 49:1424-1431
8. Welge-Lüssen A, Wattendorf E, Schwerdtfeger U, Fuhr P et al (2009) Olfactory-induced brain activity in Parkinson's disease relates to the expression of event-related potentials: a functional magnetic resonance imaging study. Neudoscience 162(2):537-543
9. Wattendorf E, Welge-Lüssen A, Fiedler K, Bilecen D et al (2009) Olfactory impairment predicts brain atrophy in Parkinson's disease. Int J Neurosci 29(49):15410-15413
10. Haehner A, Hummel T, Hummel C, Sommer U et al (2007) Olfactory loss may be a first sign of idiopathic Parkinson's disease. Mov Disord 22:839-842
11. Ponsen MM, Stoffers D, Booij J, Eck-Smit BL van et al (2004) Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann Neurol 56:173-181
12. Webster Ross G, Petrovitch H, Abbott R, Tanner CM et al (2008) Association of olfactory dysfunction with risk for future Parkinson's disease. Ann Neurol 63:167-173
13. Braak H, Del Tredici K, Rub U, Vos RA de et al (2003) Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24:197-211
14. Witt M, Bormann K, Gudziol V, Pehlke K et al (2009) Biopsies of olfactory epithelium in patients with Parkinson's disease. Mov Disord 24(6):906-914
15. Müller A, Abolmaali ND, Hakimi AR, Gloeckler T et al (2005) Olfactory bulb volumes in patients with Idiopathic Parkinson's Disease - a pilot study. J Neural Transm 112(10):1363-1370
16. Westermann B, Wattendorf E, Schwerdtfeger U, Husner A et al (2008) Functional imaging of the cerebral olfactory system in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 79:19-24
17. Hummel T, Konnerth CG, Rosenheim K, Kobal G (2001) Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patients with olfactory loss. Ann Otol Rhinol Laryngol 110:976-981
18. Wenning GK, Shephard B, Hawkes C, Petruckevitch A et al (1995) Olfactory function in atypical parkinsonian syndromes. Acta Neurol Scand 91:247-250
19. Müller A, Mungersdorf M, Reichmann H, Strehle G et al (2002) Olfactory function in Parkinsonian syndromes. J Clin Neurosci 9:521-524
20. Katzenschlager R, Lees AJ (2004) Olfaction and Parkinson's syndromes: its role in differential diagnosis. Curr Opin Neurol 17:417-423
21. Krüger S, Haehner A, Thiem C, Hummel T (2008) Neuroleptic-induced parkinsonism is associated with olfactory dysfunction. J Neurol 255:1574-1579
22. Müller A, Reuner U, Landis B, Kitzler H et al (2006) Extrapyramidal symptoms in Wilson's disease are associated with olfactory dysfunction. Mov Disord 21:1311-1316
23. Mesholam RI, Moberg PJ, Mahr RN, Doty RL (1998) Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Arch Neurol 55:84-90
24. Thomann PA, Dos Santos V, Toro P et al (2009) Reduced olfactory bulb and tract volume in early Alzheimer's disease - a MRI study. Neurobiol Aging 30(5):838-841
25. Wilson RS, Arnold SE, Schneider JA, Boyle PA et al (2009) Olfactory impairment in presymptomatic Alzheimer's disease. Ann N Y Acad Sci 1170:730-735
26. Moberg PJ, Doty RL (1997) Olfactory function in Huntington's disease patients and at-risk offspring. Int J Neurosci 89(1-2):133-139
27. Connelly T, Farmer JM, Lynch DR, Doty RL (2003) Olfactory dysfunction in degenerative ataxias. J Neurol Neurosurg Psychiatry 74(10):1435-1437
28. Hummel T, Jahnke U, Sommer U, Reichmann H et al (2005) Olfactory function in patients with idiopathic Parkinson's disease: Effects of deep brain stimulation in the subthalamic nucleus. J Neural Transm 112:669-676
29. Sobel N, Thomason ME, Stappen I et al (2001) An impairment in sniffing contributes to the olfactory impairment in Parkinson's disease. Proc Natl Acad Sci U S A 98:4154-4159
30. AWMF (2007) Riechstörungen - Leitlinie zur Epidemiologie, Pathophysiologie, Klassifikation, Diagnose und Therapie. AWMF online, http://www.uni-duesseldorf.de/AWMF/ll/017-050.htm55(6):1143-1147