CD8+ granulomatous cutaneous T-cell lymphoma: A potential association with immunodeficiency

Journal of the American Academy of Dermatology

Volumn 71, Issue 3, 2014, Pages 555-560

  Gammon, Bryan ^a,b   Robson, Alistair ^c   Deonizio, Janyana ^a   Arkin, Lisa ^a   Guitart, Joan ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Luminous Dermatology   (United States)

^c ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

common variable immunodeficiency; cutaneous T cell lymphoma; cytotoxic; granulomatous; immunodeficiency; mycosis fungoides; X linked agammaglobulinemia

Indexed keywords

ADALIMUMAB; BEXAROTENE; CD3 ANTIGEN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; DEXAMETHASONE; ETOPOSIDE; GEMCITABINE; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN G; METHOTREXATE; PREDNISONE;

ADULT; AGED; ARTICLE; CASE REPORT; CD3+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL FEATURE; COMMON VARIABLE IMMUNODEFICIENCY; CROHN DISEASE; CUTANEOUS T CELL LYMPHOMA; DISEASE ASSOCIATION; DRUG WITHDRAWAL; FEMALE; FINE NEEDLE ASPIRATION BIOPSY; FOLLOW UP; GRANULOMATOSIS; GRANULOMATOUS CUTANEOUS T CELL LYMPHOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNE DEFICIENCY; IMMUNOTHERAPY; LYMPHOCYTIC INFILTRATION; MALE; MEDICAL RECORD REVIEW; MIDDLE AGED; PAPULE; PATIENT HISTORY OF THERAPY; PHYSICAL EXAMINATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUNCH BIOPSY; RECURRENT DISEASE; REMISSION; RHEUMATOID ARTHRITIS; SKIN BIOPSY; SKIN NODULE; SKIN TUMOR; X LINKED AGAMMAGLOBULINEMIA; AGAMMAGLOBULINEMIA; DISEASE COURSE; GRANULOMA; IMMUNOCOMPROMISED PATIENT; IMMUNOLOGY; METABOLISM; MYCOSIS FUNGOIDES; PATHOLOGY; RETROSPECTIVE STUDY; X CHROMOSOME LINKED DISORDER;

ADULT; AGAMMAGLOBULINEMIA; AGED; CD8-POSITIVE T-LYMPHOCYTES; COMMON VARIABLE IMMUNODEFICIENCY; DISEASE PROGRESSION; GENETIC DISEASES, X-LINKED; GRANULOMA; HUMANS; IMMUNOCOMPROMISED HOST; LYMPHOMA, T-CELL, CUTANEOUS; MALE; MIDDLE AGED; MYCOSIS FUNGOIDES; RETROSPECTIVE STUDIES; SKIN NEOPLASMS;

EID: 84906314870     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2014.03.028     Document Type: Article

References (23)

1. J.Y. Li, M.P. Pulitzer, P.L. Myskowski, S.W. Dusza, S. Horwitz, and A. Moskowitz et al. A case-control study of clinicopathologic features, prognosis, and therapeutic responses in patients with granulomatous mycosis fungoides J Am Acad Dermatol 69 2013 366 374
2. P.J. Gregg, G.R. Kantor, G.H. Telang, S.R. Lessin, P.C. Nowell, and E.C. Vonderheid Sarcoidal tissue reaction in Sezary syndrome J Am Acad Dermatol 43 2000 372 376
3. A. Ruiz-de-Casas, A. Carrizosa-Esquivel, A. Herrera-Saval, J.J. Rios-Martin, and F. Camacho Sezary syndrome associated with granulomatous lesions during treatment with bexarotene Br J Dermatol 154 2006 372 374
4. M. Steinhoff, M. Beyer, J. Roewert-Huber, A. Lukowsky, C. Assaf, and W. Sterry Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate J Am Acad Dermatol 58 5 suppl 1 2008 S88 S91
5. S. Haruyama, K. Sugita, C. Kawakami, M. Nakamura, and Y. Tokura Development of a prominent granulomatous eruption after interferon-gamma therapy in a patient with mycosis fungoides Acta Derm Venereol 90 2010 190 191
6. P. Gerami, and J. Guitart The spectrum of histopathologic and immunohistochemical findings in folliculotropic mycosis fungoides Am J Surg Pathol 31 2007 1430 1438
7. J.A. Plaza, A.L. Feldman, and C. Magro Cutaneous CD30-positive lymphoproliferative disorders with CD8 expression: a clinicopathologic study of 21 cases J Cutan Pathol 40 2013 236 247
8. F. Rongioletti, L. Cerroni, C. Massone, M. Basso, A. Ciambellotti, and A. Rebora Different histologic patterns of cutaneous granulomas in systemic lymphoma J Am Acad Dermatol 51 2004 600 605
9. M. Ishida, M. Hotta, M. Takikita-Suzuki, F. Kojima, and H. Okabe CD8-positive granulomatous mycosis fungoides: a case report with review of the literature J Cutan Pathol 37 2010 1072 1076
10. K. Mizuno, A. Suzuki, N. Kato, T. Isei, and H. Okamoto CD8-positive granulomatous mycosis fungoides mimicking generalized granuloma annulare J Dermatol 39 2012 1068 1069
11. W. Kempf, S. Ostheeren-Michaelis, M. Paulli, M. Lucioni, J. Wechsler, and H. Audring et al. Granulomatous mycosis fungoides and granulomatous slack skin: a multicenter study of the Cutaneous Lymphoma Histopathology Task Force Group of the European Organization For Research and Treatment of Cancer (EORTC) Arch Dermatol 144 2008 1609 1617
12. J. Ashworth, A.T. Coady, R. Guy, and S.M. Breathnach Brawny cutaneous induration and granulomatous panniculitis in large cell non-Hodgkin's (T suppressor/cytotoxic cell) lymphoma Br J Dermatol 120 1989 563 569
13. O. Ardeniz, and C. Cunningham-Rundles Granulomatous disease in common variable immunodeficiency Clin Immunol 133 2009 198 207
14. L.Y. Chiam, M.M. Verhagen, A. Haraldsson, N. Wulffraat, G.J. Driessen, and M.G. Netea et al. Cutaneous granulomas in ataxia telangiectasia and other primary immunodeficiencies: reflection of inappropriate immune regulation? Dermatology 223 2011 13 19
15. A. Gotz, F. Eckert, and M. Landthaler Ataxia-telangiectasia (Louis-Bar syndrome) associated with ulcerating necrobiosis lipoidica J Am Acad Dermatol 31 1994 124 126
16. M.G. Fleming, A.T. Gewurz, and R.W. Pearson Caseating cutaneous granulomas in a patient with X-linked infantile hypogammaglobulinemia J Am Acad Dermatol 24 1991 629 633
17. S. Paradela, F. Sacristan, M. Almagro, V.G. Prieto, S.M. Kantrow, and E. Fonseca Necrotizing vasculitis with a polyarteritis nodosa-like pattern and selective immunoglobulin A deficiency: case report and review of the literature J Cutan Pathol 35 2008 871 875
18. M.J. Murphy Necrotizing palisaded granulomatous dermatitis as a manifestation of familial hemophagocytic lymphohistiocytosis J Cutan Pathol 37 2010 907 910
19. C. Schuetz, K. Huck, S. Gudowius, M. Megahed, O. Feyen, and B. Hubner et al. An immunodeficiency disease with RAG mutations and granulomas N Engl J Med 358 2008 2030 2038
20. S. Gregoriou, G. Trimis, C. Charissi, D. Kalogeromitros, K. Stefanaki, and D. Rigopoulos Cutaneous granulomas with predominantly CD8(+) lymphocytic infiltrate in a child with severe combined immunodeficiency J Cutan Med Surg 12 2008 246 248
21. M. de Jager, W. Blokx, A. Warris, M. Bergers, M. Link, and C. Weemaes et al. Immunohistochemical features of cutaneous granulomas in primary immunodeficiency disorders: a comparison with cutaneous sarcoidosis J Cutan Pathol 35 2008 467 472
22. A.V. Marzano, E. Berti, E. Alessi, and R. Caputo Clonal CD8 infiltration of the skin in common variable immunodeficiency: a prelymphomatous stage? J Am Acad Dermatol 44 2001 710 713
23. C.M. Magro, A.E. Cruz-Inigo, H. Votava, M. Jacobs, D. Wolfe, and A.N. Crowson Drug-Associated reversible granulomatous T cell dyscrasia: a distinct subset of the interstitial granulomatous drug reaction J Cutan Pathol 37 suppl 1 2010 96 111