메뉴 건너뛰기




Volumn 21, Issue 8, 2014, Pages 340-348

Tumor-specific oncolytic adenoviruses expressing granulocyte macrophage colony-stimulating factor or anti-CTLA4 antibody for the treatment of cancers

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; ONCOLYTIC ADENOVIRUS; RETINOBLASTOMA PROTEIN; SKL 001; SKL 002; SKL 004; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; MONOCLONAL ANTIBODY; ONCOLYTIC VIRUS;

EID: 84906307026     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2014.34     Document Type: Article
Times cited : (44)

References (40)
  • 1
    • 84875225339 scopus 로고    scopus 로고
    • Randomized dosefinding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer
    • Heo J, Reid T, Ruo L, Breitbach CJ, Rose S, Bloomston M et al. Randomized dosefinding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer. Nat Med 2013; 19: 329-336.
    • (2013) Nat Med , vol.19 , pp. 329-336
    • Heo, J.1    Reid, T.2    Ruo, L.3    Breitbach, C.J.4    Rose, S.5    Bloomston, M.6
  • 2
    • 74549180404 scopus 로고    scopus 로고
    • Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant in prostate and pancreatic cancers
    • Oberg D, Yanover E, Adam V, Sweeney K, Costas C, Lemoine NR et al. Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant in prostate and pancreatic cancers. Clin Cancer Res 2010; 16: 541-553.
    • (2010) Clin Cancer Res , vol.16 , pp. 541-553
    • Oberg, D.1    Yanover, E.2    Adam, V.3    Sweeney, K.4    Costas, C.5    Lemoine, N.R.6
  • 3
    • 57649125119 scopus 로고    scopus 로고
    • An oncolytic adenovirus expressing granulocyte macrophage colony-stimulating factor shows improved specificity and efficacy for treating human solid tumors
    • Lei N, Shen FB, Chang JH, Wang L, Li H, Yang C et al. An oncolytic adenovirus expressing granulocyte macrophage colony-stimulating factor shows improved specificity and efficacy for treating human solid tumors. Cancer Gene Ther 2009; 16: 33-43.
    • (2009) Cancer Gene Ther , vol.16 , pp. 33-43
    • Lei, N.1    Shen, F.B.2    Chang, J.H.3    Wang, L.4    Li, H.5    Yang, C.6
  • 4
    • 0033782862 scopus 로고    scopus 로고
    • An adenovirus E1A mutant that demonstrates potent and selective systemic antitumoral efficacy
    • Heise C, Hermiston T, Johnson L, Brooks G, Sampson-Johannes A, Williams A et al. An adenovirus E1A mutant that demonstrates potent and selective systemic antitumoral efficacy. Nat Med 2000; 6: 1134-1139.
    • (2000) Nat Med , vol.6 , pp. 1134-1139
    • Heise, C.1    Hermiston, T.2    Johnson, L.3    Brooks, G.4    Sampson-Johannes, A.5    Williams, A.6
  • 5
    • 77953160443 scopus 로고    scopus 로고
    • Oncolytic adenovirus coding for granulocyte macrophage colony-stimulating factor induces antitumoral immunity in cancer patients
    • Cerullo V, Pesonen S, Diaconu I, Escutenaire S, Arstila PT, Ugolini M et al. Oncolytic adenovirus coding for granulocyte macrophage colony-stimulating factor induces antitumoral immunity in cancer patients. Cancer Res 2010; 70: 4297-4309.
    • (2010) Cancer Res , vol.70 , pp. 4297-4309
    • Cerullo, V.1    Pesonen, S.2    Diaconu, I.3    Escutenaire, S.4    Arstila, P.T.5    Ugolini, M.6
  • 6
    • 84859376777 scopus 로고    scopus 로고
    • Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: Assessment of safety and immunologic responses in patients
    • Pesonen S, Diaconu I, Kangasniemi L, Ranki T, Kanerva A, Pesonen SK et al. Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: assessment of safety and immunologic responses in patients. Cancer Res 2010; 72: 1621-1631.
    • (2010) Cancer Res , vol.72 , pp. 1621-1631
    • Pesonen, S.1    Diaconu, I.2    Kangasniemi, L.3    Ranki, T.4    Kanerva, A.5    Pesonen, S.K.6
  • 7
    • 29344455240 scopus 로고    scopus 로고
    • Dual promoter-controlled oncolytic adenovirus CG5757 has strong tumor selectivity and significant antitumor efficacy in preclinical models
    • Li Y, Idamakanti N, Arroyo T, Thorne S, Reid T, Nichols S et al. Dual promoter-controlled oncolytic adenovirus CG5757 has strong tumor selectivity and significant antitumor efficacy in preclinical models. Clin Cancer Res 2005; 11: 8845-8855.
    • (2005) Clin Cancer Res , vol.11 , pp. 8845-8855
    • Li, Y.1    Idamakanti, N.2    Arroyo, T.3    Thorne, S.4    Reid, T.5    Nichols, S.6
  • 8
    • 23744473063 scopus 로고    scopus 로고
    • Combination of gemcitabine and Ad5/3-D 24, a tropism modified conditionally replicating adenovirus, for the treatment of ovarian cancer
    • Raki M, Kanerva A, Ristimaki A, Desmond RA, Chen DT, Ranki T et al. Combination of gemcitabine and Ad5/3-D 24, a tropism modified conditionally replicating adenovirus, for the treatment of ovarian cancer. Gene Ther 2005; 12: 1198-1205.
    • (2005) Gene Ther , vol.12 , pp. 1198-1205
    • Raki, M.1    Kanerva, A.2    Ristimaki, A.3    Desmond, R.A.4    Chen, D.T.5    Ranki, T.6
  • 9
    • 66849141991 scopus 로고    scopus 로고
    • Effective gene-viral therapy of leukemia by a new fiber chimeric oncolytic adenovirus expressing TRAIL: In vitro and in vivo evaluation
    • Jin J, Liu H, Yang C, Li G, Liu X, Qian Q et al. Effective gene-viral therapy of leukemia by a new fiber chimeric oncolytic adenovirus expressing TRAIL: in vitro and in vivo evaluation. Mol Cancer Ther 2009; 8: 1387-1396.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1387-1396
    • Jin, J.1    Liu, H.2    Yang, C.3    Li, G.4    Liu, X.5    Qian, Q.6
  • 10
    • 77957571590 scopus 로고    scopus 로고
    • Treatment of cancer patients with a serotype 5/3 chimeric oncolytic adenovirus expressing GMCSF
    • Koski A, Kangasniemi L, Escutenaire S, Pesonen S, Cerullo V, Diaconu I et al. Treatment of cancer patients with a serotype 5/3 chimeric oncolytic adenovirus expressing GMCSF. Mol Ther 2010; 18: 1874-1884.
    • (2010) Mol Ther , vol.18 , pp. 1874-1884
    • Koski, A.1    Kangasniemi, L.2    Escutenaire, S.3    Pesonen, S.4    Cerullo, V.5    Diaconu, I.6
  • 11
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony stimulating factor stimulates potent, specific and long lasting antitumor immunity
    • Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony stimulating factor stimulates potent, specific and long lasting antitumor immunity. Proc Natl Acad Sci USA 1993; 90: 3539-3543.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3539-3543
    • Dranoff, G.1    Jaffee, E.2    Lazenby, A.3    Golumbek, P.4    Levitsky, H.5    Brose, K.6
  • 12
    • 31544478298 scopus 로고    scopus 로고
    • CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor -armed oncolytic adenovirus for the treatment of bladder cancer
    • Ramesh N, Ge Y, Ennist DL, Zhu M, Mina M, Ganesh S et al. CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor -armed oncolytic adenovirus for the treatment of bladder cancer. Clin Cancer Res 2006; 12: 305-312.
    • (2006) Clin Cancer Res , vol.12 , pp. 305-312
    • Ramesh, N.1    Ge, Y.2    Ennist, D.L.3    Zhu, M.4    Mina, M.5    Ganesh, S.6
  • 13
    • 0036645430 scopus 로고    scopus 로고
    • Identification of human uroplakin ii promoter and its use in the construction of CG8840, a urotheliumspecific adenovirus variant that eliminates established bladder tumors in combination with docetaxel
    • Zhang J, Ramesh N, Chen Y, Li Y, Dilley J, Working P et al. Identification of human uroplakin ii promoter and its use in the construction of CG8840, a urotheliumspecific adenovirus variant that eliminates established bladder tumors in combination with docetaxel. Cancer Res 2002; 62: 3743-3750.
    • (2002) Cancer Res , vol.62 , pp. 3743-3750
    • Zhang, J.1    Ramesh, N.2    Chen, Y.3    Li, Y.4    Dilley, J.5    Working, P.6
  • 14
    • 0035417931 scopus 로고    scopus 로고
    • A hepatocellular carcinomaspecific adenovirus variant, CV890, eliminates distant human liver tumors in combination with doxorubicin
    • Li Y, Yu DC, Chen Y, Amin P, Zhang H, Nguyen N et al. A hepatocellular carcinomaspecific adenovirus variant, CV890, eliminates distant human liver tumors in combination with doxorubicin. Cancer Res 2001; 61: 6428-6436.
    • (2001) Cancer Res , vol.61 , pp. 6428-6436
    • Li, Y.1    Yu, D.C.2    Chen, Y.3    Amin, P.4    Zhang, H.5    Nguyen, N.6
  • 15
    • 76349109690 scopus 로고    scopus 로고
    • Therapeutic and tumor-specific immunity induced by combination of dendritic cells and oncolytic adenovirus expressing IL-12 and 4-1BBL
    • Huang JH, Zhang SN, Choi KJ, Choi IK, Kim JH, Lee MG et al. Therapeutic and tumor-specific immunity induced by combination of dendritic cells and oncolytic adenovirus expressing IL-12 and 4-1BBL. Mol Ther 2010; 2: 264-274.
    • (2010) Mol Ther , vol.2 , pp. 264-274
    • Huang, J.H.1    Zhang, S.N.2    Choi, K.J.3    Choi, I.K.4    Kim, J.H.5    Lee, M.G.6
  • 16
    • 33750332951 scopus 로고    scopus 로고
    • Enhanced antitumor effect of oncolytic adenovirus expressing interleukin-12 and B7-1in an immunocompetent murine model
    • Lee YS, Kim JH, Choi KJ, Choi IK, Kim H, Cho S et al. Enhanced antitumor effect of oncolytic adenovirus expressing interleukin-12 and B7-1in an immunocompetent murine model. Clin Cancer Res 2006; 12: 5859-5868.
    • (2006) Clin Cancer Res , vol.12 , pp. 5859-5868
    • Lee, Y.S.1    Kim, J.H.2    Choi, K.J.3    Choi, I.K.4    Kim, H.5    Cho, S.6
  • 17
    • 33845336115 scopus 로고    scopus 로고
    • A phase i study of OncoVEXGM-CSF,a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor
    • Hu JC, Coffin RS, Davis CJ, Graham NJ, Groves N, Guest PJ et al. A phase I study of OncoVEXGM-CSF,a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor. Clin Cancer Res 2006; 12: 6737-6747.
    • (2006) Clin Cancer Res , vol.12 , pp. 6737-6747
    • Hu, J.C.1    Coffin, R.S.2    Davis, C.J.3    Graham, N.J.4    Groves, N.5    Guest, P.J.6
  • 18
    • 0034721737 scopus 로고    scopus 로고
    • Structure of murine CTLA-4 and its role in modulating T cell responsiveness
    • Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science 2000; 290: 816-819.
    • (2000) Science , vol.290 , pp. 816-819
    • Ostrov, D.A.1    Shi, W.2    Schwartz, J.C.3    Almo, S.C.4    Nathenson, S.G.5
  • 20
    • 15844380367 scopus 로고    scopus 로고
    • Regulation of CTLA-4 expression during T cell activation
    • Perkins D, Wang Z, Donovan C, He H, Mark D, Guan G et al. Regulation of CTLA-4 expression during T cell activation. J Immunol 1996; 156: 4154-4159.
    • (1996) J Immunol , vol.156 , pp. 4154-4159
    • Perkins, D.1    Wang, Z.2    Donovan, C.3    He, H.4    Mark, D.5    Guan, G.6
  • 21
    • 0036214017 scopus 로고    scopus 로고
    • The B7 family of ligands and its receptors: New pathways for costimulation and inhibition of immune responses
    • Carreno BM, Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu Rev Immunol 2002; 20: 29-53.
    • (2002) Annu Rev Immunol , vol.20 , pp. 29-53
    • Carreno, B.M.1    Collins, M.2
  • 22
    • 33747878218 scopus 로고    scopus 로고
    • 2006Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma
    • Maker AV, Yang JC, Sherry RM, Topalian SL, Kammula US, Royal RE et al. 2006Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma. J Immunother 1997; 29: 455-463.
    • (1997) J Immunother , vol.29 , pp. 455-463
    • Maker, A.V.1    Yang, J.C.2    Sherry, R.M.3    Topalian, S.L.4    Kammula, U.S.5    Royal, R.E.6
  • 23
    • 0030853610 scopus 로고    scopus 로고
    • Enhanced induction of anti-tumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: The effect is manifested only at the restricted tumor-bearing stages
    • Yang YF, Zou JP, Mu J, Wijesuriya R, Ono S, Walunas T et al. Enhanced induction of anti-tumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages. Cancer Res 1997; 57: 4036-4041.
    • (1997) Cancer Res , vol.57 , pp. 4036-4041
    • Yang, Y.F.1    Zou, J.P.2    Mu, J.3    Wijesuriya, R.4    Ono, S.5    Walunas, T.6
  • 24
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996; 271: 1734-1736.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 26
    • 33646886997 scopus 로고    scopus 로고
    • Biologic and immunomodulatory events after CTLA-4 blockade with ticilimumab in patients with advanced malignant melanoma
    • Reuben JM, Lee BN, Li C, Gomez-Navarro J, Bozon VA, Parker CA et al. Biologic and immunomodulatory events after CTLA-4 blockade with ticilimumab in patients with advanced malignant melanoma. Cancer 2006; 106: 2437-2444.
    • (2006) Cancer , vol.106 , pp. 2437-2444
    • Reuben, J.M.1    Lee, B.N.2    Li, C.3    Gomez-Navarro, J.4    Bozon, V.A.5    Parker, C.A.6
  • 27
    • 3242882924 scopus 로고    scopus 로고
    • Granulocyte- macrophage colony stimulating factor: An adjuvant for cancer vaccines
    • Chang DZ, Lomazow W, Joy Somberg C, Stan R, Perales MA. Granulocyte- macrophage colony stimulating factor: an adjuvant for cancer vaccines. Hematology 2004; 9: 207-215.
    • (2004) Hematology , vol.9 , pp. 207-215
    • Chang, D.Z.1    Lomazow, W.2    Joy Somberg, C.3    Stan, R.4    Perales, M.A.5
  • 28
    • 30344449182 scopus 로고    scopus 로고
    • Functions of granulocyte-macrophage colony-stimulating factor
    • Fleetwood AJ, Cook AD, Hamilton JA. Functions of granulocyte-macrophage colony-stimulating factor. Crit Rev Immunol 2005; 25: 405-428.
    • (2005) Crit Rev Immunol , vol.25 , pp. 405-428
    • Fleetwood, A.J.1    Cook, A.D.2    Hamilton, J.A.3
  • 29
    • 44249090471 scopus 로고    scopus 로고
    • Local secretion of anti-CTLA-4 enhances the therapeutic efficacy of a cancer immunotherapy with reduced evidence of systemic autoimmunity
    • Simmons AD, Moskalenko M, Creson J, Fang J, Yi S, VanRoey MJ et al. Local secretion of anti-CTLA-4 enhances the therapeutic efficacy of a cancer immunotherapy with reduced evidence of systemic autoimmunity. Cancer Immunol Immunother 2008; 57: 1263-1270.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 1263-1270
    • Simmons, A.D.1    Moskalenko, M.2    Creson, J.3    Fang, J.4    Yi, S.5    Vanroey, M.J.6
  • 30
    • 33745851479 scopus 로고    scopus 로고
    • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
    • Quezada SA, Peggs KS, Curran MA, Allison JP. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J Clin Invest 2006; 116: 1935-1945.
    • (2006) J Clin Invest , vol.116 , pp. 1935-1945
    • Quezada, S.A.1    Peggs, K.S.2    Curran, M.A.3    Allison, J.P.4
  • 31
    • 42949105127 scopus 로고    scopus 로고
    • Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
    • Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A et al. Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci USA 2008; 105: 3005-3010.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3005-3010
    • Hodi, F.S.1    Butler, M.2    Oble, D.A.3    Seiden, M.V.4    Haluska, F.G.5    Kruse, A.6
  • 32
    • 28844444483 scopus 로고    scopus 로고
    • Recent progress in the battle between oncolytic viruses and tumours
    • Parato KA, Senger D, Forsyth PA, Bell JC. Recent progress in the battle between oncolytic viruses and tumours. Nat Rev Cancer 2005; 5: 965-976.
    • (2005) Nat Rev Cancer , vol.5 , pp. 965-976
    • Parato, K.A.1    Senger, D.2    Forsyth, P.A.3    Bell, J.C.4
  • 33
    • 33846650370 scopus 로고    scopus 로고
    • Clinical trial results with oncolytic virotherapy: A century of promise, a decade of progress
    • Liu TC, Galanis E, Kirn D. Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress. Nat Clin Pract Oncol 2007; 4: 101-117.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 101-117
    • Liu, T.C.1    Galanis, E.2    Kirn, D.3
  • 34
    • 0022445670 scopus 로고
    • Rapid colorimetric assay for cell growth and survival modifications to the tetrazolium dye procedure giving improved sensitivity and eliability
    • Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival modifications to the tetrazolium dye procedure giving improved sensitivity and eliability. J Immunol Methods 1986; 89: 271-277.
    • (1986) J Immunol Methods , vol.89 , pp. 271-277
    • Denizot, F.1    Lang, R.2
  • 35
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percent endpoints
    • Reed L, Muench H. A simple method of estimating fifty percent endpoints. Am J Hyg 1938; 27: 493-497.
    • (1938) Am J Hyg , vol.27 , pp. 493-497
    • Reed, L.1    Muench, H.2
  • 36
    • 60549100362 scopus 로고    scopus 로고
    • Antitumoral immune response by recruitment and expansion of dendritic cells in tumors infected with telomerase-dependent oncolytic viruses
    • Edukulla R, Woller N, Mundt B, Knocke S, Gürlevik E, Saborowski M et al. Antitumoral immune response by recruitment and expansion of dendritic cells in tumors infected with telomerase-dependent oncolytic viruses. Cancer Res 2009; 69: 1448-1458.
    • (2009) Cancer Res , vol.69 , pp. 1448-1458
    • Edukulla, R.1    Woller, N.2    Mundt, B.3    Knocke, S.4    Gürlevik, E.5    Saborowski, M.6
  • 37
    • 84867399393 scopus 로고    scopus 로고
    • Targeted cancer immunotherapy with oncolytic adenovirus coding for a fully human monoclonal antibody specific for CTLA-4
    • Dias JD, Hemminki O, Diaconu I, Hirvinen M, Bonetti A, Guse K et al. Targeted cancer immunotherapy with oncolytic adenovirus coding for a fully human monoclonal antibody specific for CTLA-4. Gene Therapy 2011; 10: 1-11.
    • (2011) Gene Therapy , vol.10 , pp. 1-11
    • Dias, J.D.1    Hemminki, O.2    Diaconu, I.3    Hirvinen, M.4    Bonetti, A.5    Guse, K.6
  • 38
    • 0023878440 scopus 로고
    • Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation
    • Kaushansky K, Lin N, Adamson JW. Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation. J Clin Invest 1988; 81: 92-97.
    • (1988) J Clin Invest , vol.81 , pp. 92-97
    • Kaushansky, K.1    Lin, N.2    Adamson, J.W.3
  • 39
    • 84869095632 scopus 로고    scopus 로고
    • A first in human phase 1 study of CG0070, a GM-CSF expressing oncolytic adenovirus, for the treatment of nonmuscle invasive bladder cancer
    • Burke JM, Lamm DL, Meng MV, Nemunaitis JJ, Stephenson JJ, Arseneau JC et al. A first in human phase 1 study of CG0070, a GM-CSF expressing oncolytic adenovirus, for the treatment of nonmuscle invasive bladder cancer. J Urol 2012; 188: 2391-2397.
    • (2012) J Urol , vol.188 , pp. 2391-2397
    • Burke, J.M.1    Lamm, D.L.2    Meng, M.V.3    Nemunaitis, J.J.4    Stephenson, J.J.5    Arseneau, J.C.6
  • 40
    • 58349090027 scopus 로고    scopus 로고
    • Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF
    • Fong L, Kwek SS, O'Brien S, Kavanagh B, McNeel DG, Weinberg V et al. potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF. Cancer Res 2009; 69: 609-615.
    • (2009) Cancer Res , vol.69 , pp. 609-615
    • Fong, L.1    Kwek, S.S.2    O'brien, S.3    Kavanagh, B.4    McNeel, D.G.5    Weinberg, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.