Ileal interposition reduces blood glucose levels and decreases insulin resistance in a type 2 diabetes mellitus animal model by up-regulating glucagon-like peptide-1 and its receptor

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 7, 2014, Pages 4136-4142

  Sun, Xu ^a   Zheng, Meizhu ^a   Song, Maomin ^b   Bai, Rixing ^b   Cheng, Shi ^b   Xing, Ying ^b   Yuan, Huisheng ^b   Wang, Pilin ^b  

^a SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Glucagon like peptide 1 (GLP 1); Glucagon like peptide 1 receptor (GLP 1R); Ileal interposition; Type 2 diabetes mellitus (T2DM)

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GLUCOSE BLOOD LEVEL;

ANIMAL; BIOSYNTHESIS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE BLOOD LEVEL; ILEUM; INSULIN RESISTANCE; JEJUNOILEAL BYPASS; MALE; METABOLISM; PANCREAS ISLET BETA CELL; PHYSIOLOGY; RAT; UPREGULATION; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUCAGON-LIKE PEPTIDE 1; ILEUM; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; JEJUNOILEAL BYPASS; MALE; RATS; RATS, WISTAR; RECEPTORS, GLUCAGON; UP-REGULATION;

EID: 84906240283     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Brolin RE. Update: NIH consensus conference. Gastrointestinal surgery for severe obesity. Nutrition 1996; 12: 403-404.
2. Rubino F. Bariatric surgery: effects on glucose homeostasis. Curr Opin Clin Nutr Metab Care 2006; 9: 497-507.
3. Meneghini LF. Impact of bariatric surgery on type 2 diabetes. Cell Biochem Biophys 2007; 48: 97-102.
4. Cummings DE, Overduin J, Foster-Schubert KE. Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab 2004; 89: 2608-2615.
5. Rubino F, Marescaux J. Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann Surg 2004; 239: 1-11.
6. Cummings BP, Strader AD, Stanhope KL, Graham JL, Lee J, Raybould HE, Baskin DG, Havel PJ. Ileal interposition surgery improves glucose and lipid metabolism and delays diabetes onset in the UCD-T2DM rat. Gastroenterology 2010; 138: 2441-2446.
7. Ikezawa F, Shibata C, Kikuchi D, Imoto H, Miura K, Naitoh T, Ogawa H, Sasaki I, Tsuchiya T. Effects of ileal interposition on glucose metabolism in obese rats with diabetes. Surgery 2012; 151: 822-830.
8. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132: 2131-2157.
9. Drucker DJ. The biology of incretin hormones. Cell Metab 2006; 3: 153-165.
10. Culnan DM, Albaugh V, Sun M, Lynch CJ, Lang CH, Cooney RN. Ileal interposition improves glucose tolerance and insulin sensitivity in the obese Zucker rat. Am J Physiol Gastrointest Liver Physiol 2010; 299: G751-G760.
11. Li SQ, Zhou Y, Wang Y, Liu Y, Geng DH, Liu JG. Upregulation of IRS-1 expression in Goto-Kakizaki rats following Roux-en-Y gastric bypass surgery: resolution of type 2 diabetes? Tohoku J Exp Med 2011; 225: 179-186.
12. Liu S, Zhang G, Wang L, Sun D, Chen W, Yan Z, Sun Y, Hu S. The entire small intestine mediates the changes in glucose homeostasis after intestinal surgery in goto-kakizaki rats. Ann Surg 2012; 256: 1049-1058.
13. Ikezawa F, Shibata C, Kikuchi D, Imoto H, Miura K, Naitoh T, Ogawa H, Sasaki I, Tsuchiya T. Effects of ileal interposition on glucose metabolism in obese rats with diabetes. Surgery 2012; 151: 822-830.
14. Patriti A, Facchiano E, Annetti C, Aisa MC, Galli F, Fanelli C, Donini A. Early improvement of glucose tolerance after ileal transposition in a non-obese type 2 diabetes rat model. Obes Surg 2005; 15: 1258-1264.
15. Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF. Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 1986; 261: 11880-11889.
16. Tornehave D, Kristensen P, Romer J, Knudsen LB, Heller RS. Expression of the GLP-1 receptor in mouse, rat, and human pancreas. J Histochem Cytochem 2008; 56: 841-851.
17. Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet 2009; 18: 2388-2399.
18. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52: 102-110.
19. Liu Y, Zhou Y, Wang Y, Geng D, Liu J. Roux-en-Y gastric bypass-induced improvement of glucose tolerance and insulin resistance in type 2 diabetic rats are mediated by glucagon-like peptide-1. Obes Surg 2011; 21: 1424-1431.