Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity

European Journal of Medicinal Chemistry

Volumn 86, Issue , 2014, Pages 31-38

  Yule, Ian A ^a   Czaplewski, Lloyd G ^b   Pommier, Stephanie ^b   Davies, David T ^b   Narramore, Sarah K ^a   Fishwick, Colin W G ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b Biota Europe Ltd   (United Kingdom)

Author keywords

Bacterial resistance; DNA gyrase; Molecular modelling; Pyridine 3 carboxamide

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTIBIOTIC AGENT; BACTERIAL DNA; BENZATHIAZOL 2 YL UREA DERIVATIVE; BENZIMIDAZOL 2 YL UREA DERIVATIVE; IMIDAZOPYRIDIN 2 YL UREA DERIVATIVE; ISOQUINOLIN 3 YL UREA DERIVATIVE; PYRIDIN 3 YL UREA DERIVATIVE; TRIAZOLOPYRIDINE 5 CARBOXAMIDE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE; AMIDE; DNA TOPOISOMERASE (ATP HYDROLYSING); PYRIDINE 3 CARBOXAMIDE 6 YL UREA; PYRIDINE DERIVATIVE; ANTIINFECTIVE AGENT; GYRASE INHIBITOR; UREA;

ANTIMICROBIAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; HYDROGEN BOND; IN VITRO STUDY; NONHUMAN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; ANTIBACTERIAL ACTIVITY; DRUG INHIBITION; GRAM POSITIVE BACTERIUM; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; BACTERIUM; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BACTERIA; DNA GYRASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS; UREA;

EID: 84906238517     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.08.025     Document Type: Article

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