Vergence eye movements in patients with schizophrenia

Vision Research

Volumn 102, Issue , 2014, Pages 64-70

  Bolding, Mark S ^a,c   Lahti, Adrienne C ^b   White, David ^b   Moore, Claire ^a   Gurler, Demet ^a   Gawne, Timothy J ^c   Gamlin, Paul D ^d  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Convergence insufficiency; Schizophrenia; Smooth pursuit; Vergence

Indexed keywords

ADULT; ARTICLE; BINOCULAR CONVERGENCE; CLINICAL ARTICLE; CONTROLLED STUDY; ETHNICITY; EYE TRACKING; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PSYCHOPHYSICS; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA; SENSORIMOTOR INTEGRATION; SMOOTH PURSUIT EYE MOVEMENT; SOCIAL STATUS; TASK PERFORMANCE; CASE CONTROL STUDY; MIDDLE AGED; MOVEMENT PERCEPTION; PATHOPHYSIOLOGY; PHOTOSTIMULATION; PHYSIOLOGY; PROCEDURES;

ADULT; CASE-CONTROL STUDIES; CONVERGENCE, OCULAR; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTION PERCEPTION; PHOTIC STIMULATION; PURSUIT, SMOOTH; SCHIZOPHRENIA;

EID: 84906213511     PISSN: 00426989     EISSN: 18785646     Source Type: Journal    
DOI: 10.1016/j.visres.2014.07.008     Document Type: Article

References (63)

1. Akao T., Kurkin S.A., Fukushima J., Fukushima K. Visual and vergence eye movement-related responses of pursuit neurons in the caudal frontal eye fields to motion-in-depth stimuli. Experimental Brain Research 2005, 164(1):92-108.
2. Akao T., Mustari M.J., Fukushima J., Kurkin S., Fukushima K. Discharge characteristics of pursuit neurons in MST during vergence eye movements. Journal of Neurophysiology 2005, 93:2415-2434.
3. Bolding M.S., Lahti A.C., Gawne T.J., Hopkins K.B., Gurler D., Gamlin P.D. Ocular convergence deficits in schizophrenia. Frontiers in Psychiatry 2012, 3:86.
4. Butler P.D., Javitt D.C. Early-stage visual processing deficits in schizophrenia. Current Opinion in Psychiatry 2005, 18:151-157.
5. Cerbone A., Sautter F.J., Manguno-Mire G., Evans W.E., Tomlin H., Schwartz B., et al. Differences in smooth pursuit eye movement between posttraumatic stress disorder with secondary psychotic symptoms and schizophrenia. Schizophrenia Research 2003, 63(1-2):59-62.
6. Chen Y., Levy D.L., Nakayama K., Matthysse S., Palafox G., Holzman P.S. Dependence of impaired eye tracking on deficient velocity discrimination in schizophrenia. Archives of General Psychiatry 1999, 56:155-161.
7. Chen Y., Nakayama K., Levy D., Matthysse S., Holzman P. Processing of global, but not local, motion direction is deficient in schizophrenia. Schizophrenia Research 2003, 61:215-227.
8. Clementz B.A., McDowell J.E., Dobkins K.R. Compromised speed discrimination among schizophrenia patients when viewing smooth pursuit targets. Schizophrenia Research 2007, 95:61-64.
9. Cottereau B.R., McKee S.P., Ales J.M., Norcia A.M. Disparity-tuned population responses from human visual cortex. Journal of Neuroscience 2011, 31:954-965.
10. Cottereau B.R., McKee S.P., Norcia A.M. Dynamics and cortical distribution of neural responses to 2D and 3D motion in human. Journal of Neurophysiology 2014, 111:533-543.
11. Diefendorf A.R., Dodge R. An experimental study of the ocular reactions of the insane from photographic records. Brain 1908, 31(3):451. (Oxford Univ. Press).
12. Ettinger U., Kumari V., Crawford T.J., Davis R.E., Sharma T., Corr P.J., et al. Reliability of smooth pursuit, fixation, and saccadic eye movements. Psychophysiology 2003, 40(4):620-628.
13. Flechtner K.M., Steinacher B., Sauer R., Mackert A. Smooth pursuit eye movements in schizophrenia and affective disorder. Psychological Medicine 1997, 27(6):1411-1419.
14. Friedman L., Jesberger J.A., Meltzer H.Y. A model of smooth pursuit performance illustrates the relationship between gain, catch-up saccade rate, and catch-up saccade amplitude in normal controls and patients with schizophrenia. Biological Psychiatry 1991, 30(6):537-556.
15. Friedman L., Jesberger J.A., Meltzer H.Y. Effect of typical antipsychotic medications and clozapine on smooth pursuit performance in patients with schizophrenia. Psychiatry Research 1992, 41(1):25-36. 10.1016/0165-1781(92)90015-U.
16. Fukushima K., Yamanobe T., Shinmei Y., Fukushima J., Kurkin S. Role of the frontal eye fields in smooth-gaze tracking. Progress in Brain Research 2004, 143:391-401.
17. Fukushima K., Yamanobe T., Shinmei Y., Fukushima J., Kurkin S., Peterson B.W. Coding of smooth eye movements in three-dimensional space by frontal cortex. Nature 2002, 419(6903):157-162.
18. Gamlin P.D. Neural mechanisms for the control of vergence eye movements. Annals of the New York Academy of Sciences 2002, 956:264-272.
19. Gamlin P.D., Clarke R.J. Single-unit activity in the primate nucleus reticularis tegmenti pontis related to vergence and ocular accommodation. Journal of Neurophysiology 1995, 73:2115-2119.
20. Gamlin P.D., Yoon K. An area for vergence eye movement in primate frontal cortex. Nature 2000, 407(6807):1003-1007.
21. Goldman-Rakic P.S., Selemon L.D. Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophrenia Bulletin 1997, 23(3):517-519.
22. Gottlieb J.P., Bruce C.J., MacAvoy M.G. Smooth eye movements elicited by microstimulation in the primate frontal eye field. Journal of Neurophysiology 1993, 69:786-799.
23. Gurler D., Bolding M.S., Denhollander J.A., Ward M.K., Gamlin P.D. Oculomotor networks for conjugate and disconjugate eye movements in humans. Program no. 379.13 2011, Society for Neuroscience, (Online).
24. Haarmeier T. Impaired analysis of moving objects due to deficient smooth pursuit eye movements. Brain 1999, 122(8):1495-1505.
25. Holzman P.S. Eye movements and the search for the essence of schizophrenia. Brain Research. Brain Research Reviews 2000, 31(2-3):350-356.
26. Holzman P.S., Levy D.L., Uhlenhuth E.H., Proctor L.R., Freedman D.X. Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital. Psychopharmacologia 1975, 44(2):112-115.
27. Hong L.E., Avila M.T., Thaker G.K. Response to unexpected target changes during sustained visual tracking in schizophrenic patients. Experimental Brain Research 2005, 165(1):125-131.
28. Hong L.E., Turano K.A., O'Neill H., Hao L., Wonodi I., McMahon R.P., et al. Refining the predictive pursuit endophenotype in schizophrenia. Biological Psychiatry 2008, 63:458-464.
29. Huk A.C. Multiplexing in the primate motion pathway. Vision Research 2012, 62:173-180.
30. Hutton S.B., Crawford T.J., Gibbins H., Cuthbert I., Barnes T.R., Kennard C., et al. Short and long term effects of antipsychotic medication on smooth pursuit eye tracking in schizophrenia. Psychopharmacology 2001, 157(3):284-291.
31. Leigh R.J., Zee D.S. The neurology of eye movements 2006, Oxford University Press, New York. 4th ed.
32. Lencer R., Keedy S.K., Reilly J.L., McDonough B.E., Harris M.S., Sprenger A., et al. Altered transfer of visual motion information to parietal association cortex in untreated first-episode psychosis: Implications for pursuit eye tracking. Psychiatry Research 2011, 194:30-38.
33. Levin S., Luebke A., Zee D.S., Hain T.C., Robinson D.A., Holzman P.S. Smooth pursuit eye movements in schizophrenics: Quantitative measurements with the search-coil technique. Journal of Psychiatric Research 1988, 22(3):195-206.
34. Levy D.L., Holzman P.S., Matthysse S., Mendell N.R. Eye tracking and schizophrenia: A selective review. Schizophrenia Bulletin 1994, 20(1):47-62.
35. Levy D.L., Sereno A.B., Gooding D.C., O'Driscoll G.A. Eye tracking dysfunction in schizophrenia: Characterization and pathophysiology. Current topics in behavioral neurosciences 2010, (pp. 311-347), Radcliffe Publishing.
36. Likova L.T., Tyler C.W. Stereomotion processing in the human occipital cortex. Neuroimage 2007, 38:293-305.
37. MacAvoy M.G., Gottlieb J.P., Bruce C.J. Smooth-pursuit eye movement representation in the primate frontal eye field. Cerebral Cortex 1991, 1:95-102.
38. Mahaffy S., Krauzlis R.J. Inactivation and stimulation of the frontal pursuit area change pursuit metrics without affecting pursuit target selection. Journal of Neurophysiology 2011, 106:347-360.
39. Nagel M., Sprenger A., Steinlechner S., Binkofski F., Lencer R. Altered velocity processing in schizophrenia during pursuit eye tracking. PLoS ONE 2012, 7:e38494.
40. Nitta T., Akao T., Kurkin S., Fukushima K. Involvement of the cerebellar dorsal vermis in vergence eye movements in monkeys. Cerebral Cortex 2008, 18(5):1042-1057.
41. Nurnberger J.I., Blehar M.C., Kaufmann C.A., York-Cooler C., Simpson S.G., Harkavy-Friedman J., et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH genetics initiative. Archives of General Psychiatry 1994, 51(11):849-859. discussion 863-864.
42. O'Driscoll G.A., Callahan B.L. Smooth pursuit in schizophrenia: A meta-analytic review of research since 1993. Brain and Cognition 2008, 68(3):359-370.
43. Overall J.E., Gorham D.R. The brief psychiatric rating scale. Psychological Reports 1962, 10(3):799-812.
44. Rambold H., Sander T., Sprenger A., Helmchen C. Why do patients with impaired vergence not show "saccadic" vergence?. Annals of the New York Academy of Sciences 2009, 1164:440-443.
45. Randolph C., Tierney M.C., Mohr E., Chase T.N. The repeatable battery for the assessment of neuropsychological status (RBANS): Preliminary clinical validity. Journal of Clinical and Experimental Neuropsychology 1998, 20(3):310-319.
46. Rashbass C., Westheimer G. Independence of conjugate and disjunctive eye movements. Journal of Physiology 1961, 159:361-364.
47. Regan D., Erkelens C.J., Collewijn H. Visual field defects for vergence eye movements and for stereomotion perception. Investigative Ophthalmology & Visual Science 1986, 27(5):806-819.
48. Reilly J.L., Lencer R., Bishop J.R., Keedy S., Sweeney J.A., Manuscript A. Pharmacological treatment effects on eye movement control. Brain and Cognition 2008, 68(3):415-435.
49. Rokers B., Cormack L.K., Huk A.C. Disparity- and velocity-based signals for three-dimensional motion perception in human MT+. Nature Neuroscience 2009, 12:1050-1055.
50. Rommelse N.N., Van der Stigchel S., Sergeant J.A. A review on eye movement studies in childhood and adolescent psychiatry. Brain and Cognition 2008, 68(3):391-414.
51. Ross D.E., Buchanan R.W., Lahti A.C., Medoff D., Bartko J.J., Compton A.D., et al. The relationship between smooth pursuit eye movements and tardive dyskinesia in schizophrenia. Schizophrenia Research 1998, 31(2-3):141-150.
52. Semmlow J.L., Hung G.K., Ciuffreda K.J. Quantitative assessment of disparity vergence components. Investigative Ophthalmology & Visual Science 1986, 27(4):558-564.
53. Semmlow J., Pedrono C., Alvarez T.L. Saccadic behavior during the response to pure vergence stimuli. Conference proceedings: Annual international conference of the IEEE engineering in medicine and biology society. IEEE Engineering in Medicine and Biology Society Conference 2007, 2007:4854-4857. 10.1109/IEMBS.2007.4353427.
54. Semmlow J.L., Yuan W., Alvarez T.L. Evidence for separate control of slow version and vergence eye movements: Support for Hering's Law. Vision Research 1998, 38(8):1145-1152.
55. Smyrnis N. Metric issues in the study of eye movements in psychiatry. Brain and Cognition 2008, 68(3):341-358.
56. Smyrnis N., Evdokimidis I., Mantas A., Kattoulas E., Stefanis N.C., Constantinidis T.S., et al. Smooth pursuit eye movements in 1,087 men: Effects of schizotypy, anxiety, and depression. Experimental Brain Research 2007, 179(3):397-408.
57. Spering M., Dias E.C., Sanchez J.L., Schütz A.C., Javitt D.C. Efference copy failure during smooth pursuit eye movements in schizophrenia. Journal of Neuroscience 2013, 33:11779-11787.
58. Sweeney J.A., Haas G.L., Li S., Weiden P.J., Sweeley J.A. Selective effects of antipsychotic medications on eye-tracking performance in schizophrenia. Psychiatry Research 1994, 54(2):185-198.
59. Sweeney J.A., Luna B., Srinivasagam N.M., Keshavan M.S., Schooler N.R., Haas G.L., et al. Eye tracking abnormalities in schizophrenia: Evidence for dysfunction in the frontal eye fields. Biological Psychiatry 1998, 44(8):698-708.
60. Tadin D., Kim J., Doop M.L., Gibson C., Lappin J.S., Blake R., et al. Weakened center-surround interactions in visual motion processing in schizophrenia. Journal of Neuroscience 2006, 26:11403-11412.
61. Tanaka M., Lisberger S.G. Regulation of the gain of visually guided smooth-pursuit eye movements by frontal cortex. Nature 2001, 409:191-194.
62. Thaker G.K., Ross D.E., Buchanan R.W., Adami H.M., Medoff D.R. Smooth pursuit eye movements to extra-retinal motion signals: Deficits in patients with schizophrenia. Psychiatry Research 1999, 88:209-219.
63. Turetsky B.I., Calkins M.E., Light G.A., Olincy A., Radant A.D., Swerdlow N.R. Neurophysiological endophenotypes of schizophrenia: The viability of selected candidate measures. Schizophrenia Bulletin 2007, 33:69-94.