-
1
-
-
84859832981
-
2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
-
[PMID: 22473917 DOI: 10.1002/acr.21773]
-
Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, Moreland LW, O'Dell J, Winthrop KL, Beukelman T, Bridges SL, Chatham WW, Paulus HE, Suarez-Almazor M, Bombardier C, Dougados M, Khanna D, King CM, Leong AL, Matteson EL, Schousboe JT, Moynihan E, Kolba KS, Jain A, Volkmann ER, Agrawal H, Bae S, Mudano AS, Patkar NM, Saag KG. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken) 2012; 64: 625-639 [PMID: 22473917 DOI: 10.1002/acr.21773]
-
(2012)
Arthritis Care Res (Hoboken
, vol.64
, pp. 625-639
-
-
Singh, J.A.1
Furst, D.E.2
Bharat, A.3
Curtis, J.R.4
Kavanaugh, A.F.5
Kremer, J.M.6
Moreland, L.W.7
O'Dell, J.8
Winthrop, K.L.9
Beukelman, T.10
Bridges, S.L.11
Chatham, W.W.12
Paulus, H.E.13
Suarez-Almazor, M.14
Bombardier, C.15
Dougados, M.16
Khanna, D.17
King, C.M.18
Leong, A.L.19
Matteson, E.L.20
Schousboe, J.T.21
Moynihan, E.22
Kolba, K.S.23
Jain, A.24
Volkmann, E.R.25
Agrawal, H.26
Bae, S.27
Mudano, A.S.28
Patkar, N.M.29
Saag, K.G.30
more..
-
2
-
-
84906082338
-
-
Xeljanz (package insert). New York: Pfizer
-
Xeljanz (package insert). New York: Pfizer, 2012
-
(2012)
-
-
-
3
-
-
84877847008
-
A pharmacokinetic and clinical assessment of tofacitinib for the treatment of rheumatoid arthritis
-
[PMID: 23570265 DOI: 10.1517/17425255.2013.789500]
-
Bannwarth B, Kostine M, Poursac N. A pharmacokinetic and clinical assessment of tofacitinib for the treatment of rheumatoid arthritis. Expert Opin Drug Metab Toxicol 2013; 9: 753-761 [PMID: 23570265 DOI: 10.1517/17425255.2013.789500]
-
(2013)
Expert Opin Drug Metab Toxicol
, vol.9
, pp. 753-761
-
-
Bannwarth, B.1
Kostine, M.2
Poursac, N.3
-
4
-
-
84878789296
-
Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis
-
[PMID: 23574525 DOI: 10.2174/15680266113139990094]
-
Gomez-Puerta JA, Mócsai A. Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis. Curr Top Med Chem 2013; 13: 760-773 [PMID: 23574525 DOI: 10.2174/15680266113139990094]
-
(2013)
Curr Top Med Chem
, vol.13
, pp. 760-773
-
-
Gomez-Puerta, J.A.1
Mócsai, A.2
-
5
-
-
84862122620
-
Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data
-
[PMID: 22233204 DOI: 10.1111/j.1365-2125.2012.04168.x]
-
Gupta P, Alvey C, Wang R, Dowty ME, Fahmi OA, Walsky RL, Riese RJ, Krishnaswami S. Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data. Br J Clin Pharmacol 2012; 74: 109-115 [PMID: 22233204 DOI: 10.1111/j.1365-2125.2012.04168.x]
-
(2012)
Br J Clin Pharmacol
, vol.74
, pp. 109-115
-
-
Gupta, P.1
Alvey, C.2
Wang, R.3
Dowty, M.E.4
Fahmi, O.A.5
Walsky, R.L.6
Riese, R.J.7
Krishnaswami, S.8
-
6
-
-
67650093218
-
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo
-
[PMID: 19565475 DOI: 10.1002/art.24567]
-
Kremer JM, Bloom BJ, Breedveld FC, Coombs JH, Fletcher MP, Gruben D, Krishnaswami S, Burgos-Vargas R, Wilkinson B, Zerbini CA, Zwillich SH. The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo. Arthritis Rheum 2009; 60: 1895-1905 [PMID: 19565475 DOI: 10.1002/art.24567]
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1895-1905
-
-
Kremer, J.M.1
Bloom, B.J.2
Breedveld, F.C.3
Coombs, J.H.4
Fletcher, M.P.5
Gruben, D.6
Krishnaswami, S.7
Burgos-Vargas, R.8
Wilkinson, B.9
Zerbini, C.A.10
Zwillich, S.H.11
-
7
-
-
84860388892
-
Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate
-
[PMID: 21584942 DOI: 10.1002/acr.20494]
-
Tanaka Y, Suzuki M, Nakamura H, Toyoizumi S, Zwillich SH. Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate. Arthritis Care Res (Hoboken) 2011; 63: 1150-1158 [PMID: 21584942 DOI: 10.1002/acr.20494]
-
(2011)
Arthritis Care Res (Hoboken)
, vol.63
, pp. 1150-1158
-
-
Tanaka, Y.1
Suzuki, M.2
Nakamura, H.3
Toyoizumi, S.4
Zwillich, S.H.5
-
8
-
-
84857761516
-
Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs
-
[PMID: 21952978 DOI: 10.1002/art.33383]
-
Fleischmann R, Cutolo M, Genovese MC, Lee EB, Kanik KS, Sadis S, Connell CA, Gruben D, Krishnaswami S, Wallenstein G, Wilkinson BE, Zwillich SH. Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs. Arthritis Rheum 2012; 64: 617-629 [PMID: 21952978 DOI: 10.1002/art.33383]
-
(2012)
Arthritis Rheum
, vol.64
, pp. 617-629
-
-
Fleischmann, R.1
Cutolo, M.2
Genovese, M.C.3
Lee, E.B.4
Kanik, K.S.5
Sadis, S.6
Connell, C.A.7
Gruben, D.8
Krishnaswami, S.9
Wallenstein, G.10
Wilkinson, B.E.11
Zwillich, S.H.12
-
9
-
-
84866156845
-
A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone
-
[PMID: 22006202 DOI: 10.1002/art.33419]
-
Kremer JM, Cohen S, Wilkinson BE, Connell CA, French JL, Gomez-Reino J, Gruben D, Kanik KS, Krishnaswami S, Pascual-Ramos V, Wallenstein G, Zwillich SH. A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone. Arthritis Rheum 2012; 64: 970-981 [PMID: 22006202 DOI: 10.1002/art.33419]
-
(2012)
Arthritis Rheum
, vol.64
, pp. 970-981
-
-
Kremer, J.M.1
Cohen, S.2
Wilkinson, B.E.3
Connell, C.A.4
French, J.L.5
Gomez-Reino, J.6
Gruben, D.7
Kanik, K.S.8
Krishnaswami, S.9
Pascual-Ramos, V.10
Wallenstein, G.11
Zwillich, S.H.12
-
10
-
-
75749127860
-
Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial
-
[PMID: 19587388 DOI: 10.1136/ard.2009.108159]
-
Coombs JH, Bloom BJ, Breedveld FC, Fletcher MP, Gruben D, Kremer JM, Burgos-Vargas R, Wilkinson B, Zerbini CA, Zwillich SH. Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 2010; 69: 413-416 [PMID: 19587388 DOI: 10.1136/ard.2009.108159]
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 413-416
-
-
Coombs, J.H.1
Bloom, B.J.2
Breedveld, F.C.3
Fletcher, M.P.4
Gruben, D.5
Kremer, J.M.6
Burgos-Vargas, R.7
Wilkinson, B.8
Zerbini, C.A.9
Zwillich, S.H.10
-
11
-
-
84864716411
-
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
-
[PMID: 22873530 DOI: 10.1056/NEJMoa1109071]
-
Fleischmann R, Kremer J, Cush J, Schulze-Koops H, Connell CA, Bradley JD, Gruben D, Wallenstein GV, Zwillich SH, Kanik KS. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N Engl J Med 2012; 367: 495-507 [PMID: 22873530 DOI: 10.1056/NEJMoa1109071]
-
(2012)
N Engl J Med
, vol.367
, pp. 495-507
-
-
Fleischmann, R.1
Kremer, J.2
Cush, J.3
Schulze-Koops, H.4
Connell, C.A.5
Bradley, J.D.6
Gruben, D.7
Wallenstein, G.V.8
Zwillich, S.H.9
Kanik, K.S.10
-
12
-
-
84873707288
-
Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial
-
[PMID: 23294500 DOI: 10.1016/S0140-6736(12)61424-X]
-
Burmester GR, Blanco R, Charles-Schoeman C, Wollenhaupt J, Zerbini C, Benda B, Gruben D, Wallenstein G, Krishnaswami S, Zwillich SH, Koncz T, Soma K, Bradley J, Mebus C. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. Lancet 2013; 381: 451-460 [PMID: 23294500 DOI: 10.1016/S0140-6736(12)61424-X]
-
(2013)
Lancet
, vol.381
, pp. 451-460
-
-
Burmester, G.R.1
Blanco, R.2
Charles-Schoeman, C.3
Wollenhaupt, J.4
Zerbini, C.5
Benda, B.6
Gruben, D.7
Wallenstein, G.8
Krishnaswami, S.9
Zwillich, S.H.10
Koncz, T.11
Soma, K.12
Bradley, J.13
Mebus, C.14
-
13
-
-
84864703156
-
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
-
[PMID: 22873531 DOI: 10.1056/NEJMoa1112072]
-
van Vollenhoven RF, Fleischmann R, Cohen S, Lee EB, García Meijide JA, Wagner S, Forejtova S, Zwillich SH, Gruben D, Koncz T, Wallenstein GV, Krishnaswami S, Bradley JD, Wilkinson B. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N Engl J Med 2012; 367: 508-519 [PMID: 22873531 DOI: 10.1056/NEJMoa1112072]
-
(2012)
N Engl J Med
, vol.367
, pp. 508-519
-
-
van Vollenhoven, R.F.1
Fleischmann, R.2
Cohen, S.3
Lee, E.B.4
García Meijide, J.A.5
Wagner, S.6
Forejtova, S.7
Zwillich, S.H.8
Gruben, D.9
Koncz, T.10
Wallenstein, G.V.11
Krishnaswami, S.12
Bradley, J.D.13
Wilkinson, B.14
-
14
-
-
84882266430
-
Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial
-
[PMID: 24026258 DOI: 10.7326/0003-4819-159-4-201308200-00006]
-
Kremer J, Li ZG, Hall S, Fleischmann R, Genovese M, Martin-Mola E, Isaacs JD, Gruben D, Wallenstein G, Krishnaswami S, Zwillich SH, Koncz T, Riese R, Bradley J. Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial. Ann Intern Med 2013; 159: 253-261 [PMID: 24026258 DOI: 10.7326/0003-4819-159-4-201308200-00006]
-
(2013)
Ann Intern Med
, vol.159
, pp. 253-261
-
-
Kremer, J.1
Li, Z.G.2
Hall, S.3
Fleischmann, R.4
Genovese, M.5
Martin-Mola, E.6
Isaacs, J.D.7
Gruben, D.8
Wallenstein, G.9
Krishnaswami, S.10
Zwillich, S.H.11
Koncz, T.12
Riese, R.13
Bradley, J.14
-
15
-
-
84874402383
-
Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic study
-
[PMID: 23348607 DOI: 10.1002/art.37816]
-
van der Heijde D, Tanaka Y, Fleischmann R, Keystone E, Kremer J, Zerbini C, Cardiel MH, Cohen S, Nash P, Song YW, Tegzová D, Wyman BT, Gruben D, Benda B, Wallenstein G, Krishnaswami S, Zwillich SH, Bradley JD, Connell CA. Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic study. Arthritis Rheum 2013; 65: 559-570 [PMID: 23348607 DOI: 10.1002/art.37816]
-
(2013)
Arthritis Rheum
, vol.65
, pp. 559-570
-
-
van der Heijde, D.1
Tanaka, Y.2
Fleischmann, R.3
Keystone, E.4
Kremer, J.5
Zerbini, C.6
Cardiel, M.H.7
Cohen, S.8
Nash, P.9
Song, Y.W.10
Tegzová, D.11
Wyman, B.T.12
Gruben, D.13
Benda, B.14
Wallenstein, G.15
Krishnaswami, S.16
Zwillich, S.H.17
Bradley, J.D.18
Connell, C.A.19
-
16
-
-
84874229077
-
Radiographic, clinical and functional comparison of tofacitinib monotherapy versus methotrexate in methotrexate-naïve patients with rheumatoid arthritis [ACR abstract 2486]
-
Lee EB, Fleishmann RM, Hall S, van Vollenhoven RF, Bradley J, Gruben D, Koncz T, Krishnaswami S, Wallenstein G, Zwillich SH, Wilkinson BE. Radiographic, clinical and functional comparison of tofacitinib monotherapy versus methotrexate in methotrexate-naïve patients with rheumatoid arthritis [ACR abstract 2486]. Arthritis Rheum 2012; 64 (suppl): S1049
-
(2012)
Arthritis Rheum
, vol.64
, Issue.SUPPL.
-
-
Lee, E.B.1
Fleishmann, R.M.2
Hall, S.3
van Vollenhoven, R.F.4
Bradley, J.5
Gruben, D.6
Koncz, T.7
Krishnaswami, S.8
Wallenstein, G.9
Zwillich, S.H.10
Wilkinson, B.E.11
-
17
-
-
80051774422
-
A supratherapeutic dose of the Janus kinase inhibitor tasocitinib (CP-690,550) does not prolong QTc interval in healthy participants
-
[PMID: 21148043 DOI: 10.1177/0091270010379809]
-
Krishnaswami S, Kudlacz E, Wang R, Chan G. A supratherapeutic dose of the Janus kinase inhibitor tasocitinib (CP-690,550) does not prolong QTc interval in healthy participants. J Clin Pharmacol 2011; 51: 1256-1263 [PMID: 21148043 DOI: 10.1177/0091270010379809]
-
(2011)
J Clin Pharmacol
, vol.51
, pp. 1256-1263
-
-
Krishnaswami, S.1
Kudlacz, E.2
Wang, R.3
Chan, G.4
-
18
-
-
75149141026
-
Co-administration of the JAK inhibitor CP-690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis without need for dose adjustment
-
[PMID: 20233177 DOI: 10.1111/j.1365-2125.2009.03570.x]
-
Cohen S, Zwillich SH, Chow V, Labadie RR, Wilkinson B. Co-administration of the JAK inhibitor CP-690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis without need for dose adjustment. Br J Clin Pharmacol 2010; 69: 143-151 [PMID: 20233177 DOI: 10.1111/j.1365-2125.2009.03570.x]
-
(2010)
Br J Clin Pharmacol
, vol.69
, pp. 143-151
-
-
Cohen, S.1
Zwillich, S.H.2
Chow, V.3
Labadie, R.R.4
Wilkinson, B.5
-
19
-
-
84861043518
-
Risk of tuberculosis reactivation with tofacitinib (CP-690550)
-
[PMID: 22474037 DOI: 10.1093/infdis/jis269]
-
Maiga M, Lun S, Guo H, Winglee K, Ammerman NC, Bishai WR. Risk of tuberculosis reactivation with tofacitinib (CP-690550). J Infect Dis 2012; 205: 1705-1708 [PMID: 22474037 DOI: 10.1093/infdis/jis269]
-
(2012)
J Infect Dis
, vol.205
, pp. 1705-1708
-
-
Maiga, M.1
Lun, S.2
Guo, H.3
Winglee, K.4
Ammerman, N.C.5
Bishai, W.R.6
-
20
-
-
84885311733
-
The effectiveness of tofacitinib, a novel Janus kinase inhibitor, in the treatment of rheumatoid arthritis: a systematic review and meta-analysis
-
[PMID: 23877486 DOI: 10.1007/s10067-013-2329-9]
-
Kawalec P, Mikrut A, Wisniewska N, Pilc A. The effectiveness of tofacitinib, a novel Janus kinase inhibitor, in the treatment of rheumatoid arthritis: a systematic review and meta-analysis. Clin Rheumatol 2013; 32: 1415-1424 [PMID: 23877486 DOI: 10.1007/s10067-013-2329-9]
-
(2013)
Clin Rheumatol
, vol.32
, pp. 1415-1424
-
-
Kawalec, P.1
Mikrut, A.2
Wisniewska, N.3
Pilc, A.4
-
21
-
-
84885491518
-
Efficacy and safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis
-
[PMID: 24139404 DOI: 10.1186/1471-2474-14-298]
-
He Y, Wong AY, Chan EW, Lau WC, Man KK, Chui CS, Worsley AJ, Wong IC. Efficacy and safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord 2013; 14: 298 [PMID: 24139404 DOI: 10.1186/1471-2474-14-298]
-
(2013)
BMC Musculoskelet Disord
, vol.14
, pp. 298
-
-
He, Y.1
Wong, A.Y.2
Chan, E.W.3
Lau, W.C.4
Man, K.K.5
Chui, C.S.6
Worsley, A.J.7
Wong, I.C.8
-
22
-
-
84893772728
-
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
-
[PMID: 24161836 DOI: 10.1136/annrheumdis-2013-204573]
-
Smolen JS, Landewé R, Breedveld FC, Buch M, Burmester G, Dougados M, Emery P, Gaujoux-Viala C, Gossec L, Nam J, Ramiro S, Winthrop K, de Wit M, Aletaha D, Betteridge N, Bijlsma JW, Boers M, Buttgereit F, Combe B, Cutolo M, Damjanov N, Hazes JM, Kouloumas M, Kvien TK, Mariette X, Pavelka K, van Riel PL, Rubbert-Roth A, Scholte-Voshaar M, Scott DL, Sokka-Isler T, Wong JB, van der Heijde D. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis 2014; 73: 492-509 [PMID: 24161836 DOI: 10.1136/annrheumdis-2013-204573]
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 492-509
-
-
Smolen, J.S.1
Landewé, R.2
Breedveld, F.C.3
Buch, M.4
Burmester, G.5
Dougados, M.6
Emery, P.7
Gaujoux-Viala, C.8
Gossec, L.9
Nam, J.10
Ramiro, S.11
Winthrop, K.12
de Wit, M.13
Aletaha, D.14
Betteridge, N.15
Bijlsma, J.W.16
Boers, M.17
Buttgereit, F.18
Combe, B.19
Cutolo, M.20
Damjanov, N.21
Hazes, J.M.22
Kouloumas, M.23
Kvien, T.K.24
Mariette, X.25
Pavelka, K.26
van Riel, P.L.27
Rubbert-Roth, A.28
Scholte-Voshaar, M.29
Scott, D.L.30
Sokka-Isler, T.31
Wong, J.B.32
van der Heijde, D.33
more..
|