Co-administration of the JAK inhibitor CP-690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis without need for dose adjustment

British Journal of Clinical Pharmacology

Volumn 69, Issue 2, 2010, Pages 143-151

  Cohen, Stanley ^a   Zwillich, Samuel H ^b   Chow, Vincent ^c   Labadie, Robert R ^b   Wilkinson, Bethanie ^b  

^a METROPLEX CLINICAL RESEARCH CENTER   (United States)

^b PFIZER INC   (United States)

^c AMGEN INC   (United States)

Author keywords

CP 690,550; Methotrexate; Rheumatoid arthritis

Indexed keywords

4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; METHOTREXATE; ANTIRHEUMATIC AGENT; JANUS KINASE 3; PIPERIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; TOFACITINIB;

ADULT; AGED; ANEMIA; AREA UNDER THE CURVE; ARTHRALGIA; ARTICLE; BACKACHE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DISORIENTATION; DIZZINESS; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EXPOSURE; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; DRUG URINE LEVEL; DRUG WITHDRAWAL; DYSGEUSIA; EXTREMITY PAIN; FEMALE; HEADACHE; HOT FLUSH; HUMAN; JAW PAIN; MALE; MIGRAINE; MUSCLE FATIGUE; MUSCULOSKELETAL CHEST PAIN; MUSCULOSKELETAL STIFFNESS; NAUSEA; PAIN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SINUSITIS; SYNCOPE; TENSION HEADACHE; UNSPECIFIED SIDE EFFECT; ANTAGONISTS AND INHIBITORS; ARTHRITIS, RHEUMATOID; DOSE RESPONSE; DRUG COMBINATION; DRUG INTERACTION; MIDDLE AGED; TREATMENT OUTCOME;

ADULT; AGED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; JANUS KINASE 3; MALE; METHOTREXATE; MIDDLE AGED; PIPERIDINES; PROTEIN KINASE INHIBITORS; PYRIMIDINES; PYRROLES; TREATMENT OUTCOME;

EID: 75149141026     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2009.03570.x     Document Type: Article

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