Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation

Circulation Research

Volumn 115, Issue 5, 2014, Pages 525-532

  Freed, Julie K ^a   Beyer, Andreas M ^a   Logiudice, John A ^a   Hockenberry, Joseph C ^a   Gutterman, David D ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

ceramides; mitochondria; nitric oxide; reactive oxygen species; sphingomyelin phosphodiesterase

Indexed keywords

3,3' (1,4 PHENYLENE)BIS[N [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ACRYLAMIDE]; ARGININE METHYL ESTER; CATALASE; CERAMIDE; HYDROGEN PEROXIDE; MACROGOL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PAPAVERINE; ROTENONE; ANTIOXIDANT; ENZYME INHIBITOR; N-ACETYLSPHINGOSINE; NITRIC OXIDE SYNTHASE; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE;

ADULT; AGED; ARTERIOLE; ARTICLE; BLOOD VESSEL DIAMETER; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; FLOW INDUCED DILATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MEDIATOR; MICROCIRCULATION; MITOCHONDRION; PRIORITY JOURNAL; VASODILATATION; VIDEO MICROSCOPY; ADIPOSE TISSUE; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BLOOD FLOW; CASE CONTROL STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY BLOOD VESSEL; DRUG EFFECTS; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; TIME FACTOR; VASCULARIZATION;

ADIPOSE TISSUE; ADULT; AGED; ANTIOXIDANTS; ARTERIOLES; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; CORONARY CIRCULATION; CORONARY VESSELS; ENZYME INHIBITORS; FEMALE; HUMANS; HYDROGEN PEROXIDE; MALE; MICROCIRCULATION; MICROSCOPY, VIDEO; MIDDLE AGED; MITOCHONDRIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; TIME FACTORS; VASODILATION;

EID: 84906100241     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.303881     Document Type: Article

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